{"title":"Modeling and Simulation of Input Signal of STDP Synaptic System","authors":"Yumei Gong","doi":"10.1145/3523286.3524580","DOIUrl":"https://doi.org/10.1145/3523286.3524580","url":null,"abstract":"Spike-timing-dependent plasticity(STDP) mechanism is one of the important mechanisms to study the connection of brain neural network, and it is also necessary to take into account the mechanism when do neural modeling. The reasonable modeling and simulation of the STDP synaptic system input signal is a prerequisite for obtaining STDP synaptic system that more accord with biological mechanism. In this paper, two important input signals, glutamic acid signals and back propagating dendrictic signals of STDP synaptic system were simulated by molecular dynamic diffusion model and Hodgkin-Huxley model. The simulation results are consistent with the signals under the actual physiological mechanism.","PeriodicalId":268165,"journal":{"name":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","volume":"32 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123225576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study on the Causal Relationship of Cardiovascular Disease Influencing Factors Based on Bayesian Causal Network","authors":"Jin Wang, Yaping Wan","doi":"10.1145/3523286.3524529","DOIUrl":"https://doi.org/10.1145/3523286.3524529","url":null,"abstract":"The WHO MONICA dataset was used as an example, and a logistic regression model was used to statistically analyze the data, and then a Bayesian causal network model was constructed using the MMHC hybrid algorithm to analyze the causal relationships among cardiovascular disease risk factors, and Bayesian estimation was used to learn the conditional probabilities of each node of the network so as to predict the survival of patients, and to compare the Bayesian causal network model with respect to logistic regression model in the field of chronic diseases. Bayesian causal network model results showed that hospitalization status, age at diagnosis, and angina status were direct causes of cardiovascular mortality, while previous myocardial infarction, sex, and smoking had indirect effects on cardiovascular mortality through other variables. Compared to logistic regression models, Bayesian causal networks based on the MMHC algorithm are more applicable in clinical research because they can intuitively and effectively identify and define the complex causal relationships between survival outcomes and cardiovascular disease and cardiovascular disease with each other. By analyzing this relationship, we are able to implement timely and targeted preventive and therapeutic measures and avoid possible mortality outcomes in high-risk populations.","PeriodicalId":268165,"journal":{"name":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","volume":"318 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123503130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ke Liu, Ran Zhang, Yixuan Wang, Liuqing Shen, Peipei Han, Zhe Chen, YiJun Qi, Shegan Gao
{"title":"Application of Convolutional Neural Network in COVID-19 Diagnosis","authors":"Ke Liu, Ran Zhang, Yixuan Wang, Liuqing Shen, Peipei Han, Zhe Chen, YiJun Qi, Shegan Gao","doi":"10.1145/3523286.3523287","DOIUrl":"https://doi.org/10.1145/3523286.3523287","url":null,"abstract":"Since the outbreak and spread of COVID-19 in large areas of the world, the importance of rapid diagnosis of COVID-19 has increased. In the first week after the onset of COVID-19, the density of lesions is uneven, and chest CT is often difficult to show local subpleural ground-glass shadows, resulting in missed diagnosis. The COVID-19 intelligent diagnosis system based on the convolutional neural network algorithm can not only accurately identify the feature points, reduce the workload of doctors and improve the diagnosis efficiency, but also reduce the rate of missed diagnosis and misdiagnosis, which is conducive to epidemic control.","PeriodicalId":268165,"journal":{"name":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125215821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autonomous DNA Neuron Learning Algorithm Based on DNA Strand Displacement","authors":"Xuedong Zheng, Yang Ru","doi":"10.1145/3523286.3524540","DOIUrl":"https://doi.org/10.1145/3523286.3524540","url":null,"abstract":"DNA neuron learning, or weight update of DNA neurons, is an important research content in the construction of a DNA neural network. In this work, we propose a DNA reaction network to implement the autonomous weight update of DNA neurons based on DNA strand displacement. The DNA reaction network consists of four modules: weight update module, calculation module, synchronization module, and feedback adjustment module to achieve the effectiveness and consistency of multiple training data in DNA neuron learning. Especially, the learning and the testing of DNA neurons are in the same DNA strand displacement reaction system. The simulation results show that the DNA neuron can classify test data correctly, which proves that the algorithm adopted in this work is effective.","PeriodicalId":268165,"journal":{"name":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127728340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ecological efficiency in ethnic regions based on super efficiency SBM-Malmquist model","authors":"Lin Hou","doi":"10.1145/3523286.3524601","DOIUrl":"https://doi.org/10.1145/3523286.3524601","url":null,"abstract":"Based on the super efficiency SBM-Malmquist model, the ecological efficiency and its change trend of eight provinces in ethnic regions were measured. The results showed that: (1) Inner Mongolia had the highest ecological efficiency, while Guangxi had the lowest. The low ecological efficiency areas are mostly economically underdeveloped areas. (2) The Malmquist index of ecological efficiency in ethnic areas ranged from 0.977 to 1.067, which was lower than 1 only in 2004 and greater than 1 in other years. In addition, ecological total factor productivity increased by 4.1% annually in 19 years.","PeriodicalId":268165,"journal":{"name":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127983641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Grading Prediction of Kidney Renal Clear Cell Carcinoma by Deep Learning","authors":"Kun Zhou, Liang Wei","doi":"10.1145/3523286.3524510","DOIUrl":"https://doi.org/10.1145/3523286.3524510","url":null,"abstract":"The grade of cancer is a way to classify cancer based on certain characteristics of cancer tissue. It is an important issue for the precise diagnosis, treatment, and mechanistic research of cancer. With the rapid development of genome sequencing technology, it has become possible to obtain large amounts of gene expression data, and large-scale genomic data to predict the grade of cancer is a challenging problem. In this study, we used gene expression data to propose a pathway-related deep neural network (K-Net) for predicting the grade of Kidney renal clear cell carcinoma (KIRC) tissues. K-Net provides the capability of model interpretability that most conventional fully-connected neural networks lack, describing which pathways play an important role in the process of predicting grade. The predictive performance of K-Net was evaluated with multiple cross-validation experiments. The K-Net prediction accuracy of 74%. More meaningfully, in contrast to using genes as features, this new classification model using enriched pathways as features can well explain which pathways play an important role in KIRC tissues from highly differentiated to poorly differentiated. Cancer development is a process of degradation of certain functions and enhancement of certain functions of tumor tissue, and understanding which pathways play an important role in cancer development can help explore research directions in cancer treatment.","PeriodicalId":268165,"journal":{"name":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121271103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research on central arterial pressure estimation algorithm based on clustering","authors":"Jiahao Zhang, Hui Ge","doi":"10.1145/3523286.3524554","DOIUrl":"https://doi.org/10.1145/3523286.3524554","url":null,"abstract":"Central arterial pressure (CAP) plays an important role in the detection and diagnosis of cardiovascular diseases. Although the traditional universal transfer function method has good accuracy in measuring central arterial pressure, it does not take into account the characteristic information contained in pulse wave shape, and the accuracy needs to be further improved.Therefore, a clustering based estimation algorithm for central arterial pressure is proposed. First of all, 5 layer Symlets wavelet and hard-soft compromised threshold was used to remove high-frequency noise of the data set. Secondly, in order to extract the characteristics of pulse waves themselves, k-means++ clustering was carried out for pulse waves in the training set. In order to reduce the over-fitting phenomenon, the initial number of cluster centers is selected as 1000. Finally, in each cluster, discrete Fourier transform is performed on pulse wave and central artery wave to obtain amplitude and phase data and train the transfer function. The test set was used for verification. Firstly, the corresponding clustering category of pulse wave was calculated, and then CAP was calculated by transfer function. The results showed that the absolute errors of systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) were 2.50±2.22mmHg, 4.47±2.72mmHg and 4.60±3.73mmHg respectively. Compared with other algorithms, our method has better accuracy.","PeriodicalId":268165,"journal":{"name":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126051608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Noise Pollution Loss Value Evaluation of Railway Transportation Based on Hedonic Price Method- The Case of Taiyuan City","authors":"J. Gong, Ya-nan Gao, Junliang Hao","doi":"10.1145/3523286.3524564","DOIUrl":"https://doi.org/10.1145/3523286.3524564","url":null,"abstract":"Noise pollution damages people's health and brings about value loss at the same time. This paper takes Taiyuan City as the research area, selects railway transportation noise as the research object, estimates the marginal implied price of noise, and then estimates the loss value of railway transportation noise pollution in Taiyuan City. The results show that: According to the monitoring results of railway transport noise, the maximum equivalent sound level of the selected residential sample points is 74dB, and the minimum equivalent sound level is 43dB. The noise of most residential buildings near the railway exceeds the Class 1 standard 55dB. In addition, there is a significant negative correlation between the railway transport noise and the unit price of residential buildings around the railway. The regression coefficient of the noise variable is -0.246%. The marginal loss of railway transport noise pollution is calculated according to the valuation formula. It is found that for every 1dB increase in noise value, the pollution loss value caused by noise pollution is 50.8 yuan/square meter, and the impact range of value loss caused by railway transportation noise pollution is about 500m.","PeriodicalId":268165,"journal":{"name":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125595600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Interplay between Grid and Place Cell Networks and Contextual Inputs","authors":"Jiarui Wang","doi":"10.1145/3523286.3524549","DOIUrl":"https://doi.org/10.1145/3523286.3524549","url":null,"abstract":"Place fields generated by place cells are hypothesized to give rise to a cognitive map in a given environment to support navigation and memory in rodents. Place fields have long been suggested to be triggered by inputs from grid cells in the entorhinal cortex. Studies that introduced hippocampal remapping, or the change in place fields, using only non-geometric contextual manipulations provide novel insights into the grid and place cell networks as well as the interaction between spatial and contextual signals. This review first presents evidence that supported or strengthened the classical view that contextual change acts on grid cell firing, which drives place cell remapping; studies that challenged this model are also included. In addition, other grid-and-place transformational models that demonstrate the role of contextual cues are discussed and criticized with previous computational, developmental, and inactivation studies.","PeriodicalId":268165,"journal":{"name":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123986874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Respiration and heartbeat signal separation algorithm using UWB radar platform","authors":"Jiawei Cai, Q. Fu, Xue-Feng Yuan, Xiangwei Zhu, Huifu Lin, Yinshen Huang","doi":"10.1145/3523286.3524556","DOIUrl":"https://doi.org/10.1145/3523286.3524556","url":null,"abstract":"The human chest wall fretting signal detected by ultra-wideband radar combines chest wall periodic motion caused by breathing and heartbeat. And the frequency and the amplitude of the respiration signal change at any time. We use the empirical model that chest wall motion caused by respiration movement changes sinusoidally to improve the separation effect of respiration and heartbeat waveforms. Based on the hypothesis, we propose an algorithm named adaptive sine wave fitting combined with the baseline drift elimination algorithm to eliminate the respiratory and its high-order harmonic in the time domain. Through our algorithm, the heartbeat spectrum is separable. And the average error of heart rate reduces to 1.586%, which is 24.770% of the high pass filter (HF) method and 13.188% of the CEEMD method. There is also some improvement in the matching effect between the heartbeat and the ECG waveform. Furthermore, we verify the feasibility and accuracy of the algorithm through different breathing patterns. And we find that the SWF algorithm performs more stable in the chest and abdominal breathing mode than the HF method and the CEEMD method.","PeriodicalId":268165,"journal":{"name":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115225537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}