{"title":"Modeling and Simulation of Input Signal of STDP Synaptic System","authors":"Yumei Gong","doi":"10.1145/3523286.3524580","DOIUrl":null,"url":null,"abstract":"Spike-timing-dependent plasticity(STDP) mechanism is one of the important mechanisms to study the connection of brain neural network, and it is also necessary to take into account the mechanism when do neural modeling. The reasonable modeling and simulation of the STDP synaptic system input signal is a prerequisite for obtaining STDP synaptic system that more accord with biological mechanism. In this paper, two important input signals, glutamic acid signals and back propagating dendrictic signals of STDP synaptic system were simulated by molecular dynamic diffusion model and Hodgkin-Huxley model. The simulation results are consistent with the signals under the actual physiological mechanism.","PeriodicalId":268165,"journal":{"name":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","volume":"32 5 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2022 2nd International Conference on Bioinformatics and Intelligent Computing","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1145/3523286.3524580","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Spike-timing-dependent plasticity(STDP) mechanism is one of the important mechanisms to study the connection of brain neural network, and it is also necessary to take into account the mechanism when do neural modeling. The reasonable modeling and simulation of the STDP synaptic system input signal is a prerequisite for obtaining STDP synaptic system that more accord with biological mechanism. In this paper, two important input signals, glutamic acid signals and back propagating dendrictic signals of STDP synaptic system were simulated by molecular dynamic diffusion model and Hodgkin-Huxley model. The simulation results are consistent with the signals under the actual physiological mechanism.
spike - time -dependent plasticity(STDP)机制是研究脑神经网络连接的重要机制之一,也是神经网络建模时必须考虑的机制。对STDP突触系统输入信号进行合理的建模和仿真是获得更符合生物机制的STDP突触系统的前提。本文采用分子动力学扩散模型和Hodgkin-Huxley模型对STDP突触系统的两个重要输入信号谷氨酸信号和反向传播的树突信号进行了模拟。仿真结果与实际生理机制下的信号一致。