基于贝叶斯因果网络的心血管疾病影响因素因果关系研究

Jin Wang, Yaping Wan
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引用次数: 0

摘要

以WHO MONICA数据集为例,采用logistic回归模型对数据进行统计分析,然后采用MMHC混合算法构建贝叶斯因果网络模型,分析心血管疾病危险因素之间的因果关系,并利用贝叶斯估计学习网络各节点的条件概率,从而预测患者的生存。将贝叶斯因果网络模型与慢性病领域的逻辑回归模型进行比较。贝叶斯因果网络模型结果显示,住院情况、诊断年龄、心绞痛状态是心血管死亡率的直接原因,既往心肌梗死、性别、吸烟等通过其他变量对心血管死亡率有间接影响。与逻辑回归模型相比,基于MMHC算法的贝叶斯因果网络可以直观有效地识别和定义生存结果与心血管疾病以及心血管疾病相互之间复杂的因果关系,因此更适用于临床研究。通过分析这种关系,我们能够及时实施有针对性的预防和治疗措施,避免高危人群可能出现的死亡结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study on the Causal Relationship of Cardiovascular Disease Influencing Factors Based on Bayesian Causal Network
The WHO MONICA dataset was used as an example, and a logistic regression model was used to statistically analyze the data, and then a Bayesian causal network model was constructed using the MMHC hybrid algorithm to analyze the causal relationships among cardiovascular disease risk factors, and Bayesian estimation was used to learn the conditional probabilities of each node of the network so as to predict the survival of patients, and to compare the Bayesian causal network model with respect to logistic regression model in the field of chronic diseases. Bayesian causal network model results showed that hospitalization status, age at diagnosis, and angina status were direct causes of cardiovascular mortality, while previous myocardial infarction, sex, and smoking had indirect effects on cardiovascular mortality through other variables. Compared to logistic regression models, Bayesian causal networks based on the MMHC algorithm are more applicable in clinical research because they can intuitively and effectively identify and define the complex causal relationships between survival outcomes and cardiovascular disease and cardiovascular disease with each other. By analyzing this relationship, we are able to implement timely and targeted preventive and therapeutic measures and avoid possible mortality outcomes in high-risk populations.
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