The 2nd International Electronic Conference on Biomedicines最新文献_第3页

Santolina chamaecyparissus L.: A Brief Overview of Its Medicinal Properties 金银花药用价值综述

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-24 DOI: 10.3390/ecb2023-14281

Tiago Azevedo, A. Faustino-Rocha, L. Barros, T. Finimundy, Manuela Matos, Paula A. Oliveira

引用次数: 0

A New Murine Highly Localized High-Dose Muscle Radiation Model as a Tool to Develop Innovative Countermeasures to Treat Radio-Induced Muscular Lesions 一种新的小鼠高度局部高剂量肌肉辐射模型，用于开发治疗放射性肌肉病变的创新对策

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-24 DOI: 10.3390/ecb2023-14280

N. Jullien, E. R. Graziosi, Michel Gauthier, M. Drouet, S. Francois, D. Riccobono

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Effects of Short-Wavelength Blue Light on Fibroblasts, Experimental Evidence in Wound Healing and Cutaneous Fibrosis 短波蓝光对成纤维细胞的影响，伤口愈合和皮肤纤维化的实验证据

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-21 DOI: 10.3390/ecb2023-14268

Giada Magni, F. Cherchi, M. Banchelli, F. Tatini, P. Nardini, D. Guasti, E. Coppi, A. Pugliese, M. Fraccalvieri, S. Bacci, F. Rossi

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Eco-Friendly One Pot Synthesis of Zinc Oxide Nanoparticles Using Catkin Extract of Piper longum: In Vitro Antibacterial, Antioxidant and Antibiofilm Potential against Multi Drug Resistant Enteroaggregative E. coli 长胡椒柳絮提取物一锅法合成氧化锌纳米颗粒:对多重耐药肠聚集性大肠杆菌的体外抗菌、抗氧化和抗生物膜潜力

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-21 DOI: 10.3390/ecb2023-14269

Varsha Unni, P. Abishad, Pokkittath Radhakrishnan Arya, Bibin Mohan, S. Juliet, Lijo John, P. Nambiar, V. K. Vinod, A. Karthikeyan, N. Kurkure, S. Barbuddhe, D. Rawool, J. Vergis

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In Silico Approach to Assessing the Polyphenols from Krishna Tulsi (Ocimum tenuiflorum L.) as a Keap1/Nrf2 Receptor for the Treatment of Inflammatory Bowel Disease 用计算机方法评估芫花多酚作为Keap1/Nrf2受体治疗炎症性肠病的作用

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-14 DOI: 10.3390/ecb2023-14207

Satish Kumar, B. Sarkar

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Reprogrammed CD8+ T-Cells Isolated from the Mouse Spleen Increase the Number of Immune Cells with Antitumor Activity and Decrease the Amount of Cancer Stem Cells 从小鼠脾脏分离的重编程CD8+ t细胞增加具有抗肿瘤活性的免疫细胞数量并减少癌症干细胞的数量

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-08 DOI: 10.3390/ecb2023-14132

E. Skurikhin, O. Pershina, M. Zhukova, A. Pakhomova, N. Ermakova, D. Widera, E. Pan, L. Sandrikina, L. Kogai, Nikolai Kushlinskii, Sergey Morozov, A. Kubatiev, A. Dygai

引用次数: 0

Multialgorithm-Based Docking Reveals Imidazolidinyl Urea as a Multitargeted Inhibitor for Lung Cancer 基于多算法的对接揭示咪唑烷酰脲作为肺癌多靶点抑制剂

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-08 DOI: 10.3390/ecb2023-14138

Shaban Ahmad, K. Raza

{"title":"Multialgorithm-Based Docking Reveals Imidazolidinyl Urea as a Multitargeted Inhibitor for Lung Cancer","authors":"Shaban Ahmad, K. Raza","doi":"10.3390/ecb2023-14138","DOIUrl":"https://doi.org/10.3390/ecb2023-14138","url":null,"abstract":": Lung cancer is one of the deadliest cancers, responsible for more than 1.80 million deaths annually worldwide, and it is on the priority list of the WHO. In the current scenario, when cancer cells become resistant to drugs, making them less effective and leaving the patient in vulnerable conditions. To overcome this situation, researchers are constantly working on new drugs and medications that can help ﬁght drug resistance and improve patients’ outcomes. In this study, we have taken ﬁve main proteins of lung cancer, namely RSK4 N-terminal kinase, guanylate kinase, cyclin-dependent kinase 2, kinase CK2 holoenzyme, and tumour necrosis factor-alpha, and screened the prepared Drug Bank library with 155,888 compounds against all using three Glide-based docking algorithms, namely HTVS, standard precision and extra precise, with a docking score ranging from − 5.422 to − 8.432 Kcal/mol. The poses were ﬁltered with the MM GBSA calculations, which helped to identify Imidazolidinyl urea C11H16N8O8 (DB14075) as a multitargeted inhibitor for lung cancer, validated with advanced computations such as ADMET and interaction pattern ﬁngerprints. Further, it is proposed to optimise the compound with Jaguar and MD Simulation for at least 100 ns with NPT ensemble class to analyse the deviation and ﬂuctuations and possible interactions for stability and experimental validation on the A549 cell line.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133438451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scheme 8-Isoprostane and Interleukin-8 Levels in Patients with Primary Biliary Cholangitis 方案8:原发性胆道性胆管炎患者异前列腺素和白细胞介素-8水平

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-08 DOI: 10.3390/ecb2023-14139

A. Bauer, A. Habior

引用次数: 0

Nuclear Tau as an Early Molecular Marker of Alzheimer’s Disease 核Tau蛋白是阿尔茨海默病的早期分子标志物

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-08 DOI: 10.3390/ecb2023-14131

Francesca Bruno, V. Sturiale, Desiree Brancato, Laura Gil, I. Olazabal, F. Pinedo, Ana B Rebolledo, S. Saccone, Concetta Federico

引用次数: 0

TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic Target 胰岛导管腺癌中TRP通道相互作用:一个潜在的治疗靶点

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-08 DOI: 10.3390/ecb2023-14133

A. Khalaf, Yuanyuan Wei, Samiah Yasmin Abdul Kadir, J. Zainol, Zahraa Oglah

{"title":"TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic Target","authors":"A. Khalaf, Yuanyuan Wei, Samiah Yasmin Abdul Kadir, J. Zainol, Zahraa Oglah","doi":"10.3390/ecb2023-14133","DOIUrl":"https://doi.org/10.3390/ecb2023-14133","url":null,"abstract":"Integral membrane proteins, known as Transient Receptor Potential (TRP), channels are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes. TRP channels with nine subfamilies are classified by sequence similarity, resulting in this superfamily’s tremendous physiological functional diversity. Pancreatic Ductal Adenocarcinoma (PDAC) is the most common and aggressive form of pancreatic cancer. Moreover, the development of effective treatment methods for pancreatic cancer has been hindered by the lack of understanding of the pathogenesis, partly due to the difficulty in studying human tissue samples. However, scientific research on this topic has witnessed steady development in the past few years in understanding the molecular mechanisms that underlie TRP channel disturbance. This brief review summarizes current knowledge of the molecular role of TRP channels in the development and progression of pancreatic ductal carcinoma to identify potential therapeutic interventions.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117143531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0