The 2nd International Electronic Conference on Biomedicines最新文献_第2页

A Review on Marvel Fruit: Annona muricata 神奇水果——凤仙花综述

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-04-21 DOI: 10.3390/ecb2023-14355

Hetakshi V. Patil, Mansi A. Dhankani, Amitkumar R. Dhankani

{"title":"A Review on Marvel Fruit: Annona muricata","authors":"Hetakshi V. Patil, Mansi A. Dhankani, Amitkumar R. Dhankani","doi":"10.3390/ecb2023-14355","DOIUrl":"https://doi.org/10.3390/ecb2023-14355","url":null,"abstract":": The purpose of this review is to delve into the essence of Annona muricata Linn. A. muricata , also known as soursop, guanabana, and graviola, is a member of the Annonaceae family and has a long history of traditional uses. This is an evergreen plant that grows in the tropical and subtropical regions of the world, primarily in Africa, South America, and Southeast Asia. The medicinal properties of the A. muricata plant are a blessing for humanity, and it has been widely used in folk medicine. A. muricata preparations on the market include candies, syrups, beverages, ice creams, and shakes. Several studies have concluded that the plant contains over 212 chemical constituents such as acetogenins, alkaloids, and phenols. The plant has antibacterial, antiviral, antifungal, antitumor, anthelminthic, analgesic, antiarthritic, hypotensive, anti-inﬂammatory, and immune-enhancing effects, as well as anti-diabetic activity. Although some toxicities have been reported, the extract of A. muricata has been found to be effective and safe. This review attempts to bring together the majority of the available information on A. muricata ’s phytochemistry, traditional uses, biological activities, and toxicity.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116462345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profiling of Antibacterial Compounds from Selective Medicinal Mangrove Species 红树药用植物抗菌成分分析

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-04-21 DOI: 10.3390/ecb2023-14357

Mahesh R. Doifode, Ashitosh S. Hosamani, D. Dasgupta, Prerona Boruah, M. Parab, Pramodkumar P. Gupta

{"title":"Profiling of Antibacterial Compounds from Selective Medicinal Mangrove Species","authors":"Mahesh R. Doifode, Ashitosh S. Hosamani, D. Dasgupta, Prerona Boruah, M. Parab, Pramodkumar P. Gupta","doi":"10.3390/ecb2023-14357","DOIUrl":"https://doi.org/10.3390/ecb2023-14357","url":null,"abstract":": Mangrove is an opulent and untapped ecosystem with great phytochemical diversity, making it suitable for the discovery of novel antimicrobial compounds. The goal of the study was to explore the pharmaceutical antibacterial and antioxidant resources from Bruguiera gymnorrhiza , Ceriops tagal , Rhizophora mucronata and Aegiceras corniculatum and gain insight into the diversity and novelty of compounds such as alkaloids, ﬂavanol, polyphenols etc. A liquid extract was obtained by subjecting fresh mangrove leaves to maceration and Soxhlet extraction. Plant DNA barcoding was utilized to authenticate the identity of the samples under study. A few of the obtained sequences have been communicated to GenBank (OQ696049.1, OQ696050.1, OQ692575.1, OQ679419.1). The phytochemical proﬁling revealed the presence of polyphenols (TPC = 8.71, 8.51, 8.77 and 5.52 mg/gm of plant tissue, respectively); ﬂavonoids (TFC = 12.42, 8.48, 5.26 and 13.903 mg/gm of plant tissue, respectively); and alkaloids (2.5, 3.81, 4.98 and 5.21 mg/gm of plant tissue, respectively). The antioxidant potential (radical scavenging activity) was scored to be 87.8%, 89.5%, 92.07% and 45.8% (DPPH assay was conducted), respectively. The antimicrobial analysis was performed on Staphylococcus aureus , Escherichia coli , Klebsiella pneumoniae and Bacillus subtilis . The MIC revealed maximum activity in Klebsiella pneumonia , while negligible activity was scored for Staphylococcus aureus and Escherichia coli . The analysis thus reveals that the plants under study may have better medicinal activity against respiratory tract organisms. In vitro biochemical analysis of different molecules present in the plants was performed using the Swiss ADME database. The present study thus reveals the preliminary compounds from selected mangrove plants that can be promising future anti-microbial therapeutics.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124022100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence as an Emerging Tool for Cardiologists 人工智能作为心脏病专家的新兴工具

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-04-13 DOI: 10.3390/ecb2023-14339

Łukasz Ledziński, G. Grześk

{"title":"Artificial Intelligence as an Emerging Tool for Cardiologists","authors":"Łukasz Ledziński, G. Grześk","doi":"10.3390/ecb2023-14339","DOIUrl":"https://doi.org/10.3390/ecb2023-14339","url":null,"abstract":": In the world of data, there is an urgent need to ﬁnd ways to extract knowledge and information for improving patient care. Artiﬁcial intelligence (AI) is an emerging tool that has the potential to provide cardiologists with new insights and knowledge. The healthcare industry has already begun the digital transformation of vast reams of data (Big Data) that are generated in routine clinical practice. AI has the potential to make a signiﬁcant impact on healthcare by improving the efﬁciency of clinical care, providing personalized treatment, and identifying new disease biomarkers. Machine learning (ML) and deep learning (DL) are AI techniques that utilize large datasets and computational power for analysis and decision making. There are three main ML techniques: supervised learning, unsupervised learning, and reinforcement learning. Another functional AI service that has been presented is natural language processing (NLP), and it is applicable for analyzing patient documentation. In this paper, the scope of AI workﬂow, the most often used algorithms, and their performance metrics are explained. Explainable artiﬁcial intelligence (XAI) has a prominent potential to be a useful tool for clinicians as it provides full transparency into an AI model’s decision-making process, but few applications have been reviewed. In this paper, the challenges and limitations of AI in cardiology are discussed in terms of ethical, methodological, and legal issues. Furthermore, the successful establishment of good practices toward the right development and deployment of automated ML-based systems will ensure a regulatory framework that can strengthen patients’ trust in AI/ML-based clinical decision support systems.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116013778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inter-Relationships of Pediatric Obesity and Mitochondrial Dysfunction 儿童肥胖与线粒体功能障碍的相互关系

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-04-12 DOI: 10.3390/ecb2023-14336

R. Saad, H. Qutob

{"title":"Inter-Relationships of Pediatric Obesity and Mitochondrial Dysfunction","authors":"R. Saad, H. Qutob","doi":"10.3390/ecb2023-14336","DOIUrl":"https://doi.org/10.3390/ecb2023-14336","url":null,"abstract":": Childhood (pediatric) obesity is becoming increasingly common at an alarming rate. Obese children are more likely to develop insulin resistance, relative insulin insufﬁciency, and type 2 diabetes. Recent research suggests that mitochondrial dysfunction is related to, and may be predictive of, insulin resistance among adult relatives of type 2 diabetes patients. Mitochondria produce ATP, which is used to create energy, especially in muscle tissue, and they play a role in glucose and fat metabolism. Mitochondrial dysfunction plays a role in the development of metabolic diseases. Affected tissues include adipose, liver, and skeletal muscle, which all contribute to food metabolism. Since cells require a balance between mitochondrial ATP generation through oxidative phosphorylation (OXPHOS) and proton gradient dissipation to avoid damage caused by reactive oxygen species (ROS), abnormal mitochondrial function leads to fat buildup and insulin resistance. Obesity, insulin resistance, and type 2 diabetes (T2D) are all caused by growth and transcription factors that inﬂuence mitochondrial gene expression. On the other hand, obesity and hypertension both impair heart mitochondrial biogenesis and function. By promoting the expression of chaperones, SIRT1, and antioxidants, moderate weight reduction reduces systemic inﬂammation and improves mitochondrial dysfunction. In this review, the variables that relate mitochondrial dysfunction to pediatric obesity are discussed.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133507222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro and In Vivo Effects of Conventional and Chitosan Nanoparticle-Encapsulated Miltefosine Drug for Treatment of Cutaneous Leishmaniasis 壳聚糖纳米颗粒包封米替福辛治疗皮肤利什曼病的体内外疗效观察

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-04-07 DOI: 10.3390/ecb2023-14334

R. U. Khan, Momin Khan, Q. Ullah, M. Z. Khan, A. Sohail, Rehmat Islam, H. Bilal, S. Ullah, A. Iqbal

引用次数: 0

Burgeoning Nanotechnology for Diabetic Wound Healing: A Novel Approach to the Future 新兴的纳米技术用于糖尿病伤口愈合:一种通往未来的新方法

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-29 DOI: 10.3390/ecb2023-14291

Debojyoti Mandal, J. Gupta

{"title":"Burgeoning Nanotechnology for Diabetic Wound Healing: A Novel Approach to the Future","authors":"Debojyoti Mandal, J. Gupta","doi":"10.3390/ecb2023-14291","DOIUrl":"https://doi.org/10.3390/ecb2023-14291","url":null,"abstract":": Diabetes mellitus (DM) is a widespread, long-term illness recognised as elevated blood sugar. Infection, inadequate blood ﬂow, neuropathy and insufﬁcient proliferative and cytokine signalling slow down wound healing in diabetics. Recent research has shown that the majority of wound treatments that are currently on the market are not sufﬁcient to meet patients’ needs. Advancements in nanotechnology can help researchers to establish new therapeutic methods or improve existing ones. Nanodrug delivery systems, in particular, have emerged as a major player in the area of dermal restoration due to their slow drug release and abilities to tether bioactive components to the targeted area and dramatically improve the effectiveness of medication. Manufactured agents in the ﬁeld of nanotherapy, such as nanoparticles and nanoscafolds, have recently shown promise for use in the management of diabetic wounds. Nanoparticles used in medicine have a large surface area relative to their size. Because of this, they have a better chance of interacting with living things and entering wounds. They work effectively in the slow, localised delivery of drugs that stimulate cell-to-cell communication, proliferation, blood vessel formation, signalling, and biomolecule production during wound healing. One or more therapeutic molecules can be released into the intended site slowly over time using nanoparticles. The promising results seen with nanoparticulate systems indicate that research into this technology’s capabilities will expand in the near future, expanding nanotechnology’s substantial medical beneﬁts. Focusing on diabetic wounds, we evaluated the viability and efﬁcacy of the most recently developed nanotechnology-based medications. In this article, we scrutinise the unmet needs of the wound-healing ﬁeld, as well as the future directions of the currently available technologies, while also discussing novel approaches that can advance the ﬁeld.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114105242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In Vitro Studies May Be Useful in Donor Selection and Evaluating the Effectiveness of CD8+ T-Cell Reprogramming: Experience of a Pilot Study 体外研究可能有助于供体选择和评估CD8+ t细胞重编程的有效性:一项试点研究的经验

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-29 DOI: 10.3390/ecb2023-14289

E. Skurikhin, M. Zhukova, N. Ermakova, L. Kogai, A. Dygai

引用次数: 0

Diagnostic Tool for Non-Small Cell Lung Cancer (NSCLC) Lyophilized Serum 非小细胞肺癌(NSCLC)冻干血清诊断工具

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-29 DOI: 10.3390/ecb2023-14293

M. S. Mohammed, A. Mohammed

引用次数: 0

Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing 胰岛素水凝胶促进伤口愈合的研究进展

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-29 DOI: 10.3390/ecb2023-14290

A. Ostróżka-Cieślik, M. Przybyła, Weronika Wójcik, Klaudia Birówka, Marta Majczyna, B. Dolińska

引用次数: 1

In Vivo Evidence of Blue LED Light Photobiomodulation 蓝光LED光生物调节的体内证据

The 2nd International Electronic Conference on Biomedicines Pub Date : 2023-03-29 DOI: 10.3390/ecb2023-14287

Giada Magni, F. Tatini, M. Rossi, G. de Siena, R. Cicchi, F. Pavone, S. Bacci, F. Rossi

引用次数: 0