"Medical & pharmaceutical journal "Pulse"最新文献

{"title":"EVELOPMENT OF THE COMPOSITION AND TECHNOLOGY OF ANESTHETIC EYE DROPS","authors":"Alekseeva I.V., Karpenko Yu.N., Novikova V.V., Golovanenko A.L., Oleshko O.A.","doi":"10.26787/nydha-2686-6838-2024-26-5-6-11","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2024-26-5-6-11","url":null,"abstract":"In modern ophthalmological practice, the use of local anesthetics for surface anesthesia of the eyeball becomes an integral stage in preparing the patient for diagnostic studies, therapeutic manipulations, surgical and laser interventions. The share of regional pain management methods is steadily increasing. However, at the same time, the list of requirements that local anesthetics must meet is also growing. According to them, the drug that combines high anesthetic activity and minimal toxicity should be considered the best. The local anesthetic anilocaine hydrochloride, developed according to the author's method in PGFA, exhibits high surface anesthetic activity with relatively low toxicity, and also has anti-inflammatory and moderate antimicrobial activity, which distinguishes it very favorably from the local anesthetics used and is an alternative to the use of expensive imported drugs. The purpose of this study is to develop the composition and technology of anesthetic eye drops. Materials and methods. The pharmaceutical substance anilocaine hydrochloride was used as a pharmacologically active component. The determination of the hydrogen index was carried out by the potentiometric method in accordance with the requirements of the OFS \"Ionometry\". To study the stability of eye drops, characterized by the indicator \"Related impurities\", a high-pressure liquid chromatograph \"ShimadzuLCProminence\" (Japan) was used. Statistical processing of the results of chemical studies was carried out according to generally accepted methods using standard EXCEL computer programs. Results and discussion. As a result of the conducted research, the composition of anesthetic eye drops based on anilocaine hydrochloride has been substantiated and developed. A technology for manufacturing eye drops has been developed to ensure the sterility of the resulting form. Conclusion. Based on technological and microbiological studies, the composition and technology of locally anesthetic eye drops based on anilocaine hydrochloride for surface (drip) anesthesia of the eyeball has been developed.","PeriodicalId":263577,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":" 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140990134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SOCIOLOGICAL ASSESSMENT OF THE CONSEQUENCES OF COVID-19 CORONAVIRUS INFECTION IN PATIENTS WITH DIABETES MELLITUS","authors":"Pletner O.I., Surskaya E.V., Yurchenko A.A.","doi":"10.26787/nydha-2686-6838-2024-26-5-115-121","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2024-26-5-115-121","url":null,"abstract":"In the modern world, herniated intervertebral discs are one of the most common pathologies, often occurring among the working-age population. Protrusion of the intervertebral disc beyond the cross-section of the vertebra can lead to severe pain (even disability) due to mechanical compression of the nerve root and, with extrusion of the nucleus pulposus, inflammatory reactions. Thus, to date, pain syndrome that has developed as a result of a hernia occurs in 9% of the world's population. Thus, the treatment of intervertebral hernias is one of the pressing problems of the modern world. Radical treatment - surgical, is associated with a number of complications and does not always lead to the desired results. For this reason, surgical treatment should be carried out only if conservative methods are ineffective, among which physiotherapy occupies a special place.\u0000The purpose of this work is a literary analysis of physiotherapy methods currently used for the treatment of herniated intervertebral discs and to determine their place in the complex therapy of this pathology.\u0000The review examines the nature of intervertebral hernias, some of the physiological reactions they cause, in particular, the mechanisms of pain syndrome formation are indicated. We also described in detail the main methods of physiotherapy currently used for herniated intervertebral discs, such as electrophoresis, balneological procedures, spinal traction; the mechanisms of their influence on the damaged intervertebral disc are indicated, allowing to eliminate or reduce the intensity of the pain syndrome; The need for an integrated approach in the treatment of the pathology under study was determined.","PeriodicalId":263577,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":" 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140993662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF TREATMENT RESULTS OF OSTEOCHONDRAL DEFECTS OF THE ARTICULAR SURFACE OF THE KNEE JOINT ASSOCIATED WITH DAMAGE TO THE ANTERIOR CRUCIATE LIGAMENT","authors":"Kotelnikov G.P., Lartsev Y.V., Kudashev D.S., Dolguskin D.A., Zuev-Ratnikov S.D., Shcherbatov N.D., Asatryan V.G., Knyazev A.A.","doi":"10.26787/nydha-2686-6838-2024-26-5-75-84","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2024-26-5-75-84","url":null,"abstract":"Purpose of work: to perform a comparative analysis of the results of treatment of patients with osteochondral defects of the articular surface associated with damage of the anterior cruciate ligament of the knee joint. Materials and Methods. Between 2015 and 2023 inclusive, 72 patients with anterior cruciate ligament injury accompanied by osteochondral defects of femoral condyles were treated. All patients were randomly divided into three groups: the first group - simultaneous ACL reconstruction and abrasive chondroplasty (ACh-ACL group) (n=24); the second group - ACL reconstruction and microfracturing (MF-ACL group) (n=24); the third group - ACL reconstruction and mosaic autochondroplasty (OAT-ACL group) (n=24). For the purpose of independent evaluation, a control group - anterior cruciate ligament reconstruction with intact articular cartilage (IAC-ACL group) (n=24) was introduced for comparison. Results and Discussion. Having analyzed the results of IKDC-2000 and Lysholm + Tegner questionnaires at 3, 6 and 12 months after the operation we noted the greatest positive dynamics in the early postoperative period (3 months) in all groups. From 6 to 12 months the dynamics changed its tendency and more pronouncedly passed into a \"plateau\" in groups 1 and 2, which was clinically determined by the restoration of passive movements with insufficient volume of active flexion-extension movements in the knee joint, as well as by the persistence of pain syndrome during loading. Conclusions. Simultaneous reconstruction of osteochondral lesions of the articular surface of the knee joint and reconstruction of the anterior cruciate ligament is the basis for full restoration of the function and bearing capacity of the knee joint. In this case, the use of organ-reconstructive methods of surgical intervention (bone-cartilage autochondroplasty and anterior cruciate ligament reconstruction (OAT-ACL)) allows achieving better clinical results compared to \"mesenchymal stimulation\" of the defect area, showing full functional recovery of the knee joint.","PeriodicalId":263577,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":" 75","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140991240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDYING THE INFLUENCE OF ORTHOPEDIC PRODUCTS ON THE TURNOVER OF PHARMACY ORGANIZATIONS","authors":"Beykhchan E.E., N. E.B., Kukudzhanova R.A., Krylova E.S.","doi":"10.26787/nydha-2686-6838-2024-26-5-40-45","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2024-26-5-40-45","url":null,"abstract":"Proper pharmaceutical care to the population is the most important task of our state. At the same time, the main role in resolving this issue belongs to retail pharmacy organizations, ensuring the availability of medicines and other pharmaceutical products for consumers. However, along with the need to provide timely and high-quality pharmaceutical services, retail pharmacy organizations are currently faced with a number of serious economic problems, among which the most pressing is the search for ways to increase competitiveness. As practice shows, one of the ways to solve this problem is to expand the functionality and range of pharmacy organizations, which, in particular, implies the creation of new and/or development of departments within them. One of the promising departments of a modern pharmacy organization is the orthopedic department. The market for orthopedic products has a noticeable and steady upward trend; the number of actual and potential consumers of these products, as well as the volume of their sales, increases every year. Orthopedic products for people with diseases of the musculoskeletal system are in particular demand, and demand is also growing among the group of consumers purchasing these products for sports and for the purpose of disease prevention. At the same time, an important issue is the organization of rational placement and comprehensive information to potential consumers about the properties, advantages and necessity of such goods. Integrated sales of medicines, other pharmaceutical products and orthopedic products can create an additional competitive advantage for a pharmacy organization in comparison with others and improve the economic and financial performance of the retail chain. The purpose of this study was to study the influence of orthopedic products on the turnover indicators of a pharmacy organization and to study the approaches used in practice for their placement in the sales area of a pharmacy.\u0000As a result of the research, comparative data on the influence of orthopedic products on the turnover indicators of a pharmacy organization were obtained and the approaches used in practice to their placement in the sales area of pharmacy organizations were studied. It has been established that orthopedic products occupy a significant portion of sales in the total turnover of pharmacy organizations. At the same time, the best economic indicators in this regard were demonstrated by a pharmacy that has a separate orthopedic department, which allows us to consider it expedient to create specialized units in this area in a pharmacy organization.","PeriodicalId":263577,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140992025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WEDGE DEFECTS OF TEETH","authors":"Shestukhina A.V.","doi":"10.26787/nydha-2686-6838-2024-26-5-140-145","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2024-26-5-140-145","url":null,"abstract":"Non-carious lesions are common diseases encountered by dentists. One of these diseases manifests itself in the form of a wedge-shaped defect in dental tissue. It is a lesion of tooth enamel of non-carious origin in the cervical area. This disease is easy to detect during the initial examination, since the tooth defect is wedge-shaped [1]. It is important to note that the pathology can have varying degrees of severity, from small depressions to more serious damage. The defect got its name due to the wedge-shaped shape of the lesion. Most often, a wedge-shaped defect appears in premolars or canines. It can affect both the upper and lower sides of the jaw. Research shows that the number of patients with this pathology is increasing every year. According to some authors, the prevalence of wedge-shaped dental defects among the population of the Russian Federation is up to 34% [4]. Many scientists attribute this to improper use of hygiene products and excessive consumption of acidic foods. Recent studies also indicate a connection between the development of wedge-shaped defects and dental overload caused by psycho-emotional tension and stress [3, 5]. This lesion not only affects the aesthetic appearance of the smile, but can also cause increased tooth sensitivity [2]. Scientists have not yet reached a consensus on treatment methods, but in many cases the disease can be prevented using simple preventative methods.","PeriodicalId":263577,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140993185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SYNTHESIS OF NEW O-THIETANE-SUBSTITUTED ACETAMIDE DERIVATIVES OF 6-METHYL-2-THIOPYRIMIDINE WITH ANTIOXIDANT ACTIVITY","authors":"Vinogradova Yu.I., M. S.A., Shumadalova A.V., Nazmieva K.A.","doi":"10.26787/nydha-2686-6838-2024-26-2-98-103","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2024-26-2-98-103","url":null,"abstract":"Aim: As is known, in connection with the observation of this trend in the world, currently many factors have a negative impact on the human body, provoking the production of reactive oxygen species, triggering the process of lipid peroxidation, which leads to the development of tumor, inflammatory processes, and the onset of aging of the body. Therefore, the search for new substances with antioxidant activity is relevant in modern pharmacy.\u0000Purpose: Synthesis of new O-thietane-substituted acetamide derivatives of 6-methyl-2-thiopyrimidine with antioxidant activity.\u0000Materials and Methods: New derivatives were obtained as a result of thiethanylation of the reaction products of ethyl 2-[6-methyl-4-(thietan-3-yloxy)pyrimidin-2-ylthio]acetate with aliphatic and alicyclic amines. The structure of the obtained biologically active substances was confirmed using standardized methods of physicochemical analysis. Individuality was controlled by thin layer chromatography.\u0000Conclusions: Methods for the synthesis of new O-thietane-substituted acetamide derivatives of 6-methyl-2-thiopyrimidine have been developed, and the antioxidant activity of the resulting compounds has been analyzed. Some structure-activity patterns of the synthesized compounds have been established.","PeriodicalId":263577,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"13 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140410096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF THE LEVEL OF AWARENESS AMONG HIGH SCHOOL STUDENTS AND MEDICAL UNIVERSITY STUDENTS ABOUT SOCIALLY SIGNIFICANT DISEASES AND STI PREVENTION ISSUES.","authors":"Nesterova E.I., Manerova O.A.","doi":"10.26787/nydha-2686-6838-2024-26-2-65-74","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2024-26-2-65-74","url":null,"abstract":"As is known, the sexually transmitted infection (STI) incidence continues to be a pertinent issue: high contagiousness and negative impact on public health puts STIs on the list of socially significant diseases.\u0000The consequences of these diseases directly affect the demographic situation in the country, due to the deterioration of the reproductive health of the population with a subsequent decrease in the birth rate. This issue becomes especially pronounced among teenagers.\u0000This paper demonstrates the results of a study on socially significant diseases and STI prevention issues conducted among high school and medical students in Moscow with the aim of studying and identifying youth awareness problems, differentiating the knowledge of STI prevention among high school and college students, as well as determining respondents’ interest in getting information on these diseases online.\u0000Purpose: To study and identify problems of youth awareness, determine the difference in the knowledge of STI prevention among the high school and college students, as well as determine the interest of respondents in obtaining information on these diseases online.\u0000Materials and methods of research: The study includes the results of anonymous questionnaires filled out by schoolchildren of 15-17 years (115 respondents) and 3rd year students of the Faculty of Medicine (134 respondents).\u0000Research methods: analytical, statistical, sociological.\u0000Results: Based on the research data, we identified a difference in the answers of schoolchildren and college students in several types of questions. Thus, medical school students clearly appear as more mature, independent and busy people with more extensive knowledge on the given topics.\u0000The vast majority of respondents showed interest and wanted to obtain information on socially significant diseases and STI prevention. The best way to do so is to communicate comprehensive, high-quality knowledge of socially significant diseases and STI prevention using online technologies.","PeriodicalId":263577,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"21 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PARTICIPATION OF A PROVIDING MEDICAL CARE SPECIALIST TO SCHOOLCHILD OF A GENERAL EDUCATIONAL ORGANIZATION IN THE FORMATION OF A HEALTH-SAVING ENVIRONMENT (USING THE EXAMPLE OF SCREENING AND PREVENTION OF FLAT FEET)","authors":"Manenkov M.P., Radchenko O.R.","doi":"10.26787/nydha-2686-6838-2024-26-2-25-33","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2024-26-2-25-33","url":null,"abstract":"One of the important tasks of medicine, education, state and municipal authorities is to protect the health of children and adolescents - students of general education institutions. The deterioration of indicators characterizing the health status of schoolchildren requires improving the organization of medical and preventive care for students, creating a favorable and safe environment for their harmonious growth and development. The results of ongoing preventive medical examinations show that functional deviations and chronic diseases of the musculoskeletal system (impaired posture, flat feet) have moved to the first ranking place.\u0000The purpose of this study was to improve the work on creating a health-preserving environment with the participation of a specialist in providing medical care to minor students (using the example of screening and prevention of flat feet) in a general education organization. To conduct the study, theoretical (analysis of reporting documentation) and experimental (observation, plantography) methods were used. The study was approved by the local ethics committee of the Kazan State Medical University (protocol №8 of October 18, 2022) and was conducted on the basis of two schools in Kazan in November-December 2023. The survey involved 383 children (whose parents signed voluntary informed consent) aged 8-12 years, of which: 257 girls and 126 boys. Statistical processing was carried out in the Microsoft Excel application package. Processing of the results included the calculation of average values and the proportion of the characteristic (%). When comparing the reliability of differences in proportions (p) of signs, Fisher's test with φ-transformation was used.\u0000The results obtained showed a high prevalence of morphofunctional foot disorders in first-graders. To improve the work of a general education organization in creating a health-preserving environment and preventing diseases (using the example of preventing flat feet), a work scheme for a specialist in providing medical care to minor students is proposed.","PeriodicalId":263577,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"12 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140410592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASPECTS OF THE APPLICATION OF INDEX ASSESSMENT OF THE CONDITION OF ORGANS AND TISSUES OF THE ORAL CAVITY IN PATIENTS WITH ORTHOPEDIC STRUCTURES MADE OF STRUCTURAL TITANIUM ALLOYS","authors":"Mikhailova M.V., Gilmanova N.S., Avdeenko O.E., Shirokova Ju.A, Rudova A.I.","doi":"10.26787/nydha-2686-6838-2024-26-2-46-51","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2024-26-2-46-51","url":null,"abstract":"The study is aimed at assessing the impact of orthopedic structures made of titanium alloys on the condition of organs and tissues of the oral cavity in patients. This study presents the results of an index assessment of the studied parameters, materials and methods of research, as well as conclusions based on the results obtained. Hygienic indices were assessed in three groups of patients with various orthopedic structures, the groups were divided depending on the structural material of the orthopedic structure, the third group was a control group, before the start of treatment and sanitation of the oral cavity, as well as after sanitation procedures carried out a month and six months later. These procedures were mandatory, as 76% of patients were found to have high plaque content upon admission to the clinic. This plaque ranged from thin to moderately dense and was visible to the naked eye. In some cases, there was a significant accumulation of plaque in the interdental spaces and gingival furrows. In patients of the first and second groups, we also evaluated the hygienic indices a month and six months after orthopedic treatment using titanium alloy structures.","PeriodicalId":263577,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140412186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPMENT OF THE COMPOSITION AND EVALUATION OF THE QUALITY OF A COMBINED MEDICINE FOR THE ORAL CAVITY","authors":"N. E.B., S. A.I., Burlakova V.V.","doi":"10.26787/nydha-2686-6838-2024-26-2-85-91","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2024-26-2-85-91","url":null,"abstract":"Inflammatory diseases of the oral cavity belong to the category of widespread pathologies and are characterized by a diverse etiology. For their treatment and prevention, herbal remedies that have the properties of a complex effect on the causes and nature of the development of the inflammatory process are quite often and quite reasonably used. Jujube leaves seem to be a promising source of biologically active substances (BAS) for inclusion in anti-inflammatory drugs for the oral cavity due to their significant content of flavonoids, phenolcarboxylic acids, triterpene compounds and other groups of BAS, which individually and in combination determine the target activity. In addition, according to the literature, compounds that cause an anesthetic effect in the oral cavity were found in the leaves of jujube. Free radical oxidation and subsequent disruption of the integrity of cell membranes play a significant role in the pathogenesis of oral diseases. In this regard, a promising direction in the comprehensive prevention and treatment of oral diseases is the use of antioxidant drugs, among which ethyl methylhydroxypyridine succinate (EMHPS) is quite popular in this regard. EMGPS inhibits the oxidation of biological membranes, increases the activity of antioxidant enzymes, and also participates in the regulation of metabolic activity of cells. It seemed appropriate to develop a composition and evaluate the quality of an oral product based on a complex of biologically active substances from jujube leaves and EMGPS with a predicted complex anti-inflammatory and antioxidant effect.\u0000Determination of commodity indicators of jujube leaves, dry residue, alcohol content in the alcohol extract and pH of the oral product was carried out using pharmacopoeial methods. pH was measured using a Mettler Toledo pH meter. An alcoholic extract from jujube leaves in the form of a tincture was obtained by fractional maceration using 40% ethyl alcohol, which selectively extracts flavonoids from this raw material. The quantitative content of flavonoids was determined by differential spectrophotometry using a Shimadzu UV-1800 spectrophotometer. Quantitative analysis of EMGPS was carried out titrimetrically using the non-aqueous titration method. It has been established that the developed oral product containing tincture of jujube leaves and EMGPS is characterized by satisfactory quality indicators. The proposed methods for the quantitative determination of active substances make it possible to statistically reliably control their content in the composition.","PeriodicalId":263577,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140412696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}