The Libyan Journal of Medicine最新文献

筛选
英文 中文
The value of assessing case difficulty and its effect on endodontic iatrogenic errors: a retrospective cross-sectional study 评估病例困难的价值及其对牙髓医源性错误的影响:一项回顾性横断面研究
The Libyan Journal of Medicine Pub Date : 2019-11-07 DOI: 10.1080/19932820.2019.1688916
Ruaa A Alamoudi, Afrah H Alharbi, G. Farie, O. Fahim
{"title":"The value of assessing case difficulty and its effect on endodontic iatrogenic errors: a retrospective cross-sectional study","authors":"Ruaa A Alamoudi, Afrah H Alharbi, G. Farie, O. Fahim","doi":"10.1080/19932820.2019.1688916","DOIUrl":"https://doi.org/10.1080/19932820.2019.1688916","url":null,"abstract":"ABSTRACT The American Association of Endodontists (AAE) released a case difficulty assessment form to help general dentists and students treat cases within their expertise or refer advanced cases to reduce the risk of iatrogenic errors. The purpose of this study was to determine the incidence of iatrogenic complications after the use of the case difficulty assessment form. Arandom sample of 1000 cases that received root canal treatment in undergraduate clinics during the academicyear (2016–2017) was selected. Case difficulty assessment was made for each case before treatment onset. Once the case was approved for treatment in the undergraduate clinics, the endodontic treatments were performed following the standard procedure the endodontic department of the Dentistry School of King Abdulaziz University mandates. Digital radiographs were obtained during routine root canal treatment and were evaluated by four observers to detect any iatrogenic errors, after which the data were analyzed statistically. Iatrogenic errors were correlated significantly with case difficulty (p= 0.003), and were detected in 22.1% of all teeth treated in the undergraduate clinics. Underfilling accounted for the highestpercent of errors detected (8.4%), followed by ledge formation (4.2%). Molar teeth had the highest frequency of errors, and mesio-buccal roots of maxillary molars showed the highest percentage of errors. The AAE developed asignificantly useful tool to determine the difficulty of each case treated in undergraduate clinics, and following their recommendations will minimize the risk of iatrogenic errors.","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125905850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Conducting publishable research under conditions of severely limited resources 在资源严重有限的情况下进行可发表的研究
The Libyan Journal of Medicine Pub Date : 2019-11-03 DOI: 10.1080/19932820.2019.1688126
A. Bredan
{"title":"Conducting publishable research under conditions of severely limited resources","authors":"A. Bredan","doi":"10.1080/19932820.2019.1688126","DOIUrl":"https://doi.org/10.1080/19932820.2019.1688126","url":null,"abstract":"ABSTRACT Doing research when resources are severely limited will always be challenging. But by sharing resources, collaborating internationally as well as locally, developing sustainable research lines and optimizing study concept and design, researchers can significantly increase their research output and enhance its quality.","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114838270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Prevalence and identification of arthropod-transmitted viruses in Kassala state, Eastern Sudan 苏丹东部卡萨拉州节肢动物传播病毒的流行和鉴定
The Libyan Journal of Medicine Pub Date : 2019-01-01 DOI: 10.1080/19932820.2018.1564511
Nahla Mohamed, M. Magzoub, R. A. Mohamed, F. Aleanizy, F. Alqahtani, B. Nour, Mubark M S Alkarsany
{"title":"Prevalence and identification of arthropod-transmitted viruses in Kassala state, Eastern Sudan","authors":"Nahla Mohamed, M. Magzoub, R. A. Mohamed, F. Aleanizy, F. Alqahtani, B. Nour, Mubark M S Alkarsany","doi":"10.1080/19932820.2018.1564511","DOIUrl":"https://doi.org/10.1080/19932820.2018.1564511","url":null,"abstract":"ABSTRACT Vector-borne diseases are responsible for more than 20% of the infectious diseases worldwide. The prevalence of arboviruses transmit diseases to humans in Sudan has not been investigated. Mosquito-borne viral diseases increase globally incidence, including the Sudan. Frequent unknown fever outbreaks have been reported in eastern region, Sudan. However, diagnosis was based exclusively on clinical signs and symptoms without confirmatory laboratory investigations. However, for accurate detection of these viruses in outbreaks, molecular technique is considered. The objective of this study was to determine the prevalence of six arboviruses in the Kassala state of east Sudan during unknown fever outbreak. A cross sectional hospital-based study was conducted in the Kassala, Teaching Hospital. Blood samples from 119 patients suffering from unknown fever were used for screening of six arboviruses, hepatitis E virus and malarial using molecular techniques and serology. The overall arboviruses seroprevelance was 61.3% (73/119). The highest positivity rate was 73.1% (52/73) chikungunya virus; 29 males and 20 females patients were chikungunya positive. Other arboviruses were circulating in low rate 20.5% (15/73), and 6.8% (5/73) for sindbis and rift valley fever viruses respectively. Hepatitis E virus was negative in all cases and malaria positivity rate 13.4% (16/119). The prevalence of arboviruses among unknown fever patients present to Kassala teaching hospital of eastern region in Sudan is significantly high (61.3%). The chikungunya virus is the predominant causative agent of arboviruses. Molecular techniques such as PCR are important for accurate and rapid diagnosis of this viral outbreak.","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125473708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Relevance of periodic evaluation of endodontically treated primary teeth 对经牙髓治疗的乳牙进行定期评估的相关性
The Libyan Journal of Medicine Pub Date : 2019-01-01 DOI: 10.1080/19932820.2019.1643208
Sally Kamal El-Din Mohamed, H. Abutayyem, Said Abdelnabi, J. Alkhabuli
{"title":"Relevance of periodic evaluation of endodontically treated primary teeth","authors":"Sally Kamal El-Din Mohamed, H. Abutayyem, Said Abdelnabi, J. Alkhabuli","doi":"10.1080/19932820.2019.1643208","DOIUrl":"https://doi.org/10.1080/19932820.2019.1643208","url":null,"abstract":"In spite of the advances in prevention of dental caries in dentistry, the emergence of primary teeth with pulp involvement is still a challenge causing premature loss of teeth. Pulpectomy of the irreversibly inflamed or necrotic pulp of primary teeth remains the common treatment approach with variable prognosis. The variation in prognosis by and large is due to the anatomical root variations and the complex canalicular system; making the debridement and biomechanical preparation of canals difficult to achieve [1]. Untreated carious primary teeth or failure of endodontically treated primary teeth may cause deleterious effects as a result of periapical infection spread to the hard and soft tissues in the vicinity. It is crucial to remember that the follicular tissues of the succedaneous teeth are very close to the bifurcation and apices of primary molars and an infection may easily reach the follicle of a developing tooth causing inflammation of the follicular tissues or development of a cyst. Dentigerous cyst (DC) is a developmental odontogenic cyst that invariably occurs between the second and third decade with low incidence in young individual. However, they may develop in association with unerupted premolars or supernumerary teeth [2,3]. Although the DCs are developmental in origin, there is a strong association between the DC development and the inflammation spreading from nonvital predecessor teeth [4]. In this report, we present a case of pulp therapy of primary tooth with no evidence of post-therapeutic follow up causing development of inflammatory DC in association with unerupted mandibular 2nd premolar and massive bone destruction in a 10year-old child. The child was presented to the pediatric department, RAKCODS clinic with severe pain and swelling on the left side of the mandible for 4 weeks before presentation. Extra-oral examination revealed a single diffuse swelling on the left side of the mandible. Intra-oral examination showed a bony hard swelling in the 74, 75 regions obliterating the buccal vestibule. Mandibular buccal cortex expansion was evident but not the lingual. The primary left 2nd mandibular molar tooth was nonvital, showing evidence of pulp therapy and composite filling. The involved tooth was slightly mobile and the adjacent soft tissues were normal with no signs of inflammation. The permanent first molar (36) was sound and the pulp vitality was not compromised. Orthopantamograph revealed an oval-shaped unilocular radiolucency around the developing second premolar with partial sclerotic border. The mesial root of 74 showed resorption with loss of bone in the bifurcation area. The cone beam computed tomography images revealed thinning of the buccal and lingual cortex [Figure 1–3]. A provisional diagnosis of dentigerous or bifurcation cyst was made. Owing to the behavior of the lesion, it was decided to refer the patient to the oral surgery department, Saqr hospital, RAK for enucleation of the cystic lesion including the ","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126593494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
S100A4 expression is associated with poor prognosis in patients with resectable gastrointestinal stromal tumor 在可切除的胃肠道间质瘤患者中,S100A4表达与预后不良相关
The Libyan Journal of Medicine Pub Date : 2019-01-01 DOI: 10.1080/19932820.2019.1659669
W. Shen, X. Tan, F. Hao
{"title":"S100A4 expression is associated with poor prognosis in patients with resectable gastrointestinal stromal tumor","authors":"W. Shen, X. Tan, F. Hao","doi":"10.1080/19932820.2019.1659669","DOIUrl":"https://doi.org/10.1080/19932820.2019.1659669","url":null,"abstract":"ABSTRACT S100A4 is particularly associated with the progression and metastasis of numerous human malignancies. This study was designed to examine the clinicopathologic significance of S100A4 in gastrointestinal stromal tumor (GISTs). The level of OPNS100A4 expression in a large cohort of resectable GISTs was evaluated with immunohistochemistry. Its correlation with the clinicopathologic parameters of patients with resectable GISTs was analyzed. A survival analysis was performed to evaluate the prognostic significance of S100A4 expression using Kaplan-Meier method. Results: In 108 patients with resectable GISTs, the most high-risk GISTs had a strong level of S100A4 expression. Strong S100A4 expression was significantly associated with tumor size, mitosis, and recurrence, but not gender and age. Patients with weak S100A4 expression had a relatively longer disease-free survival compared to patients with strong S100A4 expression.Therefore, S100A4 expression is a putative marker for tumor progression and an adverse prognosis in GISTs.","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127548820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Exploring critical factors influencing nurses’ intention to use tablet PC in Patients’ care using an integrated theoretical model 运用综合理论模型探讨影响护士在患者护理中使用平板电脑意愿的关键因素
The Libyan Journal of Medicine Pub Date : 2019-01-01 DOI: 10.1080/19932820.2019.1648963
Shu-Lung Sun, Hsin-Ginn Hwang, Bireswar Dutta, Mei-Hui Peng
{"title":"Exploring critical factors influencing nurses’ intention to use tablet PC in Patients’ care using an integrated theoretical model","authors":"Shu-Lung Sun, Hsin-Ginn Hwang, Bireswar Dutta, Mei-Hui Peng","doi":"10.1080/19932820.2019.1648963","DOIUrl":"https://doi.org/10.1080/19932820.2019.1648963","url":null,"abstract":"ABSTRACT The use of health information technology (HIT) is expected to deliver benefits for patients, nurses, physicians, and organizations, but the benefits of HIT can only be attained if nurses accept and intend to use it as they are the leading user-group. The use of the tablet is becoming commonplace in healthcare organizations to improve patient care. The current study incorporates Technology Acceptance Model2 (TAM2) with two antecedents, facilitating condition and personal, to identify and understand the factors that influence nurses’ intention to use the Tablet PC. The survey methodology was used to collect data from the nurses working in a regional healthcare center in Taiwan. The structural equation modeling (SEM) technique was employed to analyze the research framework. A total of 110 valid responses for analysis. The results suggest that the modified proposed research framework explains about 41.7% of the variance of nurses’ behavioral intention. The partial least squares (PLS) regression indicated that perceived usefulness, subjective norm, and personal a positive and significant influence on nurses’ intention to use the Tablet PC. But concerning the perceived ease of use, the insignificant path coefficient was reported. The finding also indicated that personal on the research model is much stronger than the subjective norm on Tablet PC performance. The proposed research framework contributes to the conclusive explanation for understanding nurses’ intention to use. The current study brings perspectives from the technological and attitudinal differences that have largely been missing in the existing literature of the nurses’ intention to use HIT. Thus, health care providers must take these factors into consideration as the findings of the current study advance theory and contribute to the basis for future study intended for enhancing our understanding of nurses’ adoption behavior regarding HIT.","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131957663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
The fifth combined school of the Arab Society for Pediatric Endocrinology and Diabetes (ASPED) and European Society for Paediatric Endocrinology (ESPE), 2018: a model for inter-societies collaboration 2018年,阿拉伯儿科内分泌与糖尿病学会(ASPED)和欧洲儿科内分泌学会(ESPE)第五届联合学院:跨学会合作的典范
The Libyan Journal of Medicine Pub Date : 2019-01-01 DOI: 10.1080/19932820.2019.1652059
A. Habeb, R. Hamza, A. Deeb
{"title":"The fifth combined school of the Arab Society for Pediatric Endocrinology and Diabetes (ASPED) and European Society for Paediatric Endocrinology (ESPE), 2018: a model for inter-societies collaboration","authors":"A. Habeb, R. Hamza, A. Deeb","doi":"10.1080/19932820.2019.1652059","DOIUrl":"https://doi.org/10.1080/19932820.2019.1652059","url":null,"abstract":"","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132623841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effect of duration of gonadotropin releasing hormone agonist on the outcome of in vitro fertilization-embryo transfer in a short-acting long regimen 促性腺激素释放激素激动剂持续时间对短效长期体外受精-胚胎移植结果的影响
The Libyan Journal of Medicine Pub Date : 2019-01-01 DOI: 10.1080/19932820.2019.1652058
Zhenni Mu, Zhengao Sun, Jingyan Song, Honggen Liu, Yan Qiao, Qing-chang Xia
{"title":"Effect of duration of gonadotropin releasing hormone agonist on the outcome of in vitro fertilization-embryo transfer in a short-acting long regimen","authors":"Zhenni Mu, Zhengao Sun, Jingyan Song, Honggen Liu, Yan Qiao, Qing-chang Xia","doi":"10.1080/19932820.2019.1652058","DOIUrl":"https://doi.org/10.1080/19932820.2019.1652058","url":null,"abstract":"ABSTRACT Objective: To investigate the effect of the duration of gonadotropin releasing hormone agonist (GnRH-a) use on the outcome of in vitro fertilization and embryo transfer (IVF-ET) during the short-acting long-term hyperstimulation cycle. Methodology: Clinical data from 776 patients receiving controlled ovarian stimulation (COS) after short-term regimen downregulation were retrospectively analyzed. According to the duration of GnRH-a, the patients were divided into 3 groups: Group A, 14 days for GnRH-a; Group B, 15–17 days for GnRH-a; and Group C, >18 days for GnRH-a. The clinical data, treatment and clinical outcomes were compared among the groups. Results: There were no significant differences in fertilization rate, implantation rate, clinical pregnancy rate, abortion rate, ovarian hyperstimulation syndrome (OHSS) rate(P > 0.05). The total costs in group A were significantly less than those in group B and C(P < 0.001). The number of eggs and quality embryos generated in group A was significantly higher than that in groups B and C (P = 0.014, P = 0.005). Conclusions: In the short-acting GnRH agonist long protocol, satisfactory IVF-ET pregnancy outcome was obtained with the use of GnRH-a for 14 days under the premise of lowering the receptor-regulating standard. Excessive application of GnRH-a will affect the number of eggs and embryos and increase the cost of medical treatment.","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127501345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Dietary salt consumption and the knowledge, attitudes and behavior of healthy adults: a cross-sectional study from Jordan. 膳食盐的摄入与健康成人的知识、态度和行为:来自约旦的横断面研究
IF 2.4
The Libyan Journal of Medicine Pub Date : 2018-12-01 DOI: 10.1080/19932820.2018.1479602
Izzat Alawwa, Rajaa Dagash, Akram Saleh, Abdelaziz Ahmad
{"title":"Dietary salt consumption and the knowledge, attitudes and behavior of healthy adults: a cross-sectional study from Jordan.","authors":"Izzat Alawwa,&nbsp;Rajaa Dagash,&nbsp;Akram Saleh,&nbsp;Abdelaziz Ahmad","doi":"10.1080/19932820.2018.1479602","DOIUrl":"https://doi.org/10.1080/19932820.2018.1479602","url":null,"abstract":"<p><p>High dietary sodium is recognized as a silent killer responsible for 2.3 million deaths worldwide in 2010 predominantly secondary to hypertension and its complications. Although high salt consumption is considered a worldwide public health problem, its magnitude is highly variable among different communities; therefore, it is important to study locally. This study aimed to evaluate habitual salt consumption, its important correlations, as well as the knowledge, attitude, and behavior of healthy Jordanian citizens. As potassium consumption is highly correlated and important we aimed to study both jointly. In this descriptive cross-sectional study we enrolled 103 healthy adult Jordanian citizens. All participants were interviewed for questionnaire filling, physical examination, and instructed on proper 24-hour urine collection procedure. We measured sodium and potassium concentration in the provided controlled 24-hour urine collection samples, as it is presently considered the gold standard for evaluating daily intake. The results showed an average sodium intake of 179 mmol (4.1 g) per day [higher in males at 186 mmol (4.3 g) vs. 173 mmol (4.0 g) for females], significantly above the current WHO recommendations, though only 8% regularly add salt to food. Ironically, most participants (82%) believe their salt consumption was appropriate and only 29% thought they may benefit from reducing salt intake. On the other hand, potassium intake is far below the current WHO recommendations. High sodium and low potassium intake have synergistic adverse effects on public health that is not currently addressed in Jordan. We conclude that Jordanian citizens currently consume high sodium and low potassium diet and are mostly unaware of its negative impact on their health. Hence, it is crucial for healthcare providers to intervene and adopt long-term strategies to control salt intake to reduce its negative effects in Jordan and elsewhere.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"1479602"},"PeriodicalIF":2.4,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19932820.2018.1479602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36190600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Study of changes in lipid profile and insulin resistance in Egyptian patients with chronic hepatitis C genotype 4 in the era of DAAs. DAAs时代埃及慢性丙型肝炎基因4型患者血脂和胰岛素抵抗变化的研究
IF 2.4
The Libyan Journal of Medicine Pub Date : 2018-12-01 DOI: 10.1080/19932820.2018.1435124
Ghada El Sagheer, Elwy Soliman, Asmaa Ahmad, Lamiaa Hamdy
{"title":"Study of changes in lipid profile and insulin resistance in Egyptian patients with chronic hepatitis C genotype 4 in the era of DAAs.","authors":"Ghada El Sagheer,&nbsp;Elwy Soliman,&nbsp;Asmaa Ahmad,&nbsp;Lamiaa Hamdy","doi":"10.1080/19932820.2018.1435124","DOIUrl":"https://doi.org/10.1080/19932820.2018.1435124","url":null,"abstract":"<p><p>Chronic hepatitis C virus (HCV) infection is associated with altered metabolism, including dyslipidemia and insulin resistance. These contribute to disease progression and influences the response to therapy. To investigate the relationships of new direct-acting antiviral drugs, simeprevir/sofosbuvir, with lipid profile and insulin resistance (IR). Eighty chronic hepatitis C genotype 4 patients were included; they were divided into four groups according to the severity of fibrosis as detected by fibroscan. Forty healthy persons volunteered as a control group. Lipid profile changes and IR were analyzed at baseline and after the end of treatment, and any effect of these changes on the response to treatment was studied. Before treatment, the levels of serum triglycerides were significantly higher in patients than in the control, and the levels of fasting insulin showed a progressive increase with advancing stage of fibrosis. At the end of treatment, there were a significant reduction in serum triglycerides, FBS, fasting insulin, and homeostasis model for the assessment of IR (P < 0.001), and a significant elevation of serum cholesterol and low-density lipoprotein (LDL)-c, high-density lipoprotein (HDL)-c, and LDL/HDL ratio (P = 0.001). An end-of-treatment response (week 12) was achieved in (99%) of the treated cases with 99% sustained viral response for 12 weeks post-treatment (week 24). Significant lipid profile changes were detected at the end of treatment. Serum lipid levels and IR are no longer predictors of response to DAAs. Follow-up of the lipid profile is warranted to avoid any possible remote effect of atherosclerotic heart disease.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"1435124"},"PeriodicalIF":2.4,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19932820.2018.1435124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35838486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信