The Libyan Journal of Medicine最新文献

{"title":"Age and clinical signs as predictors of COVID-19 symptoms and cycle threshold value.","authors":"Ismail Dergaa,&nbsp;Muneer Abubaker,&nbsp;Amine Souissi,&nbsp;Abdul Rafi Mohammed,&nbsp;Amit Varma,&nbsp;Sarah Musa,&nbsp;Abdullah Al Naama,&nbsp;Bessem Mkaouer,&nbsp;Helmi Ben Saad","doi":"10.1080/19932820.2021.2010337","DOIUrl":"https://doi.org/10.1080/19932820.2021.2010337","url":null,"abstract":"<p><p>Many COVID-19 infected people remain asymptomatic, and hence the diagnosis at first presentation remains a challenge. Assessment at a presentation in primary care settings is usually done by visual triaging and basic clinical examination. This retrospective study involved investigating the medical e-records of COVID-19 positive patients who presented to a COVID-19 centre in Qatar for July 2020. The presence (symptomatic group) or the absence (asymptomatic group) of symptoms along with objective vital examination (<b><i>ie</i></b>; heart-rate (HR), temperature, haemoglobin saturation (SpO₂)) were analysed and linked to the viral load (<b><i>ie</i></b>; cycle threshold (Ct)) of COVID-19 positive patients. Four hundred eighty-one symptomatic (230 males) and 216 asymptomatic (101 males) patients were included. Compared to the asymptomatic male group, the symptomatic male group was older, had lower Ct value and SpO₂, and higher temperature and HR. Compared to the females asymptomatic group, the symptomatic females group had lower Ct value, and higher temperature. Compared to the asymptomatic group, the symptomatic group had lower Ct value and SpO₂, and higher temperature and HR. Compared to the asymptomatic group, the symptomatic group had lower Ct values (age groups [21-30], [31-40], [41-50] and [51-60]), higher temperature (age groups [21-30] and [31-40], Ct ranges [20.01-25.00] and [25.01-30.00]), higher HR (age groups [21-30] and [31-40], Ct range [15.01-20.00]); and lower SpO₂ (age groups [41-50] and [51-60], Ct ranges [15.01-20.00] and [35.01-40.00]). Compared with asymptomatic patients, symptomatic patients with COVID-19 are most likely to be febrile, tachycardic, hypoxic and having higher viral load. Higher viral load was associated with higher HR, higher temperature, lower SpO₂, but there was no relation between viral load and age.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"2010337"},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/3a/ZLJM_17_2010337.PMC8667934.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39716333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forty-year Tunisian bibliometrics of general surgery theses in the four national faculties of medicine (1980-2019).","authors":"Mohamed Azzaza,&nbsp;Ghofrane Ben Mabrouk,&nbsp;Dhekra Chebil,&nbsp;Sarra Nouira,&nbsp;Sarra Melki,&nbsp;Nihel El Haddad,&nbsp;Ahmed Ben Abdelaziz","doi":"10.1080/19932820.2021.2009100","DOIUrl":"https://doi.org/10.1080/19932820.2021.2009100","url":null,"abstract":"<p><p>The objective of this work was to establish the bibliometric profile of Tunisian theses in 'general surgery' and to describe their themes, their study designs, and their writing quality. This is a retrospective descriptive bibliometric study, covering all the theses in medicine in the specialty of 'general surgery', defended in the four medical faculties of Tunisia, during the forty last years from 1980 to 2019. During the study period, 739 theses in 'general surgery' were discussed in Tunisia, with an average of 19 theses per year. The most studied research topic was emergencies (41%), followed by common surgical pathologies (26%) and digestive oncology (21.5%). Descriptive studies and case studies represented the majority of study designs with respective proportions of 56.9% and 40.6%. Only 20.7% of these theses had a scientific writing quality deemed satisfactory. The least respected elements in writing their summaries were statistical (confidence intervals and standard deviations) and documentary (keywords). Despite the plethora of themes of Tunisian theses in 'general surgery', their basic methodology and their editorial non conformity require the educational reform of the dissertations, both doctoral students and supervisors, by strengthening their skills in research methodology and scientific communication written.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"2009100"},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/b1/ZLJM_17_2009100.PMC8676683.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39716730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of pulmonary hypertension among children with atrial septal defects (ASD).","authors":"Josephat M Chinawa,&nbsp;Awoere T Chinawa,&nbsp;Edmund N Ossai,&nbsp;Chika O Duru","doi":"10.1080/19932820.2021.2007603","DOIUrl":"https://doi.org/10.1080/19932820.2021.2007603","url":null,"abstract":"<p><strong>Introduction: </strong>Atrial septal defect (ASD) is a common congenital heart disease in children that uncommonly presents with pulmonary hypertension. Much is not known about the exact predictor of PAH in children with ASD.</p><p><strong>Objectives: </strong>This study aimed to determine the predictors of pulmonary hypertension in children with ASD.</p><p><strong>Patients and methods: </strong>This was a descriptive analysis of children with ASD carried out in three different institutions over a five-year period. Data entry and analysis were done using IBM Statistical Package for Social Sciences (SPSS) statistical software, version 25.</p><p><strong>Results: </strong>The majority of the participants, 52.2%, had pulmonary hypertension and 62.5% of them occurred as mild pulmonary hypertension. There was a very weak positive correlation between pulmonary hypertension and the size of atrial septal defect, increases in size of atrial septal defect correlate with increases in pulmonary hypertension and this was found not to be statistically significant (n = 67, r = 0.193, p = 0.118). There was a positive correlation between the size of atrial septal defect and the age of participants in months, increases in age correlate with increases in size of atrial septal defect and this was found to be statistically significant (n = 67, r = 0.357, p = 0.003).The highest proportion of respondents who had pulmonary hypertension, 64.7%, was seen among children less than 1 year old while the least proportion, 27.3%, was within 1-5 years, and the difference in proportions was found to be statistically significant (χ² = 8.187, p = 0.017).</p><p><strong>Conclusion: </strong>Pulmonary hypertension in children with ASD occur usually in the mild form. Age is the only strong predictor of PAH in children with isolated ASD.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"2007603"},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/30/ZLJM_17_2007603.PMC8635614.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39739932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee meniscal retears after repair: A systematic review comparing diagnostic imaging modalities.","authors":"Saad Syed,&nbsp;Mohammed Nagdi Zaki,&nbsp;Jeyaseelan Lakshmanan,&nbsp;Rik Kundra","doi":"10.1080/19932820.2022.2030024","DOIUrl":"https://doi.org/10.1080/19932820.2022.2030024","url":null,"abstract":"<p><p>The meniscus is a relatively avascular fibrocartilaginous structure that provides a key role in shock absorption and load transmission. However, accurate diagnosis of meniscal retear can present a clinical challenge. The purpose of this study was to conduct a systematic review on the available literature, which compare the sensitivities, specificities, and accuracies of different diagnostic modalities of diagnosing knee meniscal retears in patients who have undergone surgical meniscal repair, such as Magnetic Resonance Imaging (MRI), Magnetic Resonance Arthrography with intraarticular contrast (direct MRA), and a combination of MRI and direct MRA. Two authors independently searched two databases (PubMed and Scopus) for literature related to knee meniscus retear according to the PRISMA guidelines. Four studies were found, which resulted in 291 patients with 293 menisci. All studies were published in 2008 and 2014. In our analysis, we calculated sensitivity to be 78.79% (95% CI, 64.07-93.51), specificity to be 56.58% (95% CI, 20.21-92.94), and overall accuracy to be 66.25% (95% CI, 54.29-78.22) for MRI and sensitivity to be 87.84% (95% CI, 83.93-91.74), specificity to be 88.68% (95% CI, 81.93-95.43), and overall accuracy to be 87.22% (95% CI, 82.22-91.62) for direct MRA. We recommend the use of direct MRA for the diagnosis of meniscal retears due to its higher sensitivity, specificity, and accuracy as compared to MRI and its reduced cost and invasive nature as compared to second-look arthroscopy. However, our review is limited by the number of studies available on this topic. More studies using study designs such as randomized controlled trials, involving MRI, direct MRA, and combinations of such techniques, should be performed to accurately assess the different techniques and aid in designing guidelines to guide the diagnosis of meniscal retears following meniscal repair.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"2030024"},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/ea/ZLJM_17_2030024.PMC8786236.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39835530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of assertive behaviors among a sample of first-year Tunisian medical students.","authors":"Dorra Ben Cherifa,&nbsp;Bochra Nourhene Saguem,&nbsp;Souad Chelbi,&nbsp;Amel Braham,&nbsp;Selma Ben Nasr,&nbsp;Helmi Ben Saad","doi":"10.1080/19932820.2022.2095727","DOIUrl":"https://doi.org/10.1080/19932820.2022.2095727","url":null,"abstract":"<p><p>Assertiveness is a constructive interpersonal behavior alternative to manipulation and aggression. Medical students (MSs) have daily interpersonal interactions with colleagues, patients and families. Yet, communication deficiencies due to hesitancy to speak-up assertively lead to adverse patient outcomes. This study aimed to assess levels of assertive behaviors (ABs), and to determine its predictors within a sample of first-year Tunisian MSs. This was a cross-sectional survey including 125 first-year MSs from Tunisia. ABs were measured by the Rathus assertiveness scale. Potential independent predictors of AB were evaluated using the following questionnaires: Rosenberg self-esteem scale, interpersonal communication skills inventory short-form-36quality of life questionnaire, and general health questionnaire. In addition, some MSs' characteristics were considered (<b><i>eg</i></b>; age, sex, living with family, assertiveness training, community work, personal medical field choice, smoking, and alcohol use). Univariate and multivariate analyses were performed. Among the 309 MSs, 125 (40.45%) responded to the survey. AB were found in 36.8% of MSs. Multiple linear regression models revealed that self-esteem global scores, sending clear messages, anxiety/depression and male sex were accountable for 31% in AB scores variance. Targeting self-esteem and interpersonal communication skills (sending clear messages) and identifying subgroups of students with anxiety/depression state would influence ABs.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"2095727"},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2c/f1/ZLJM_17_2095727.PMC9255220.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40563175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a structured health education on prevention of HIV risky behaviours among adolescents in Nigeria - a pragmatic randomized controlled trial.","authors":"Ijeoma O Maduakolam,&nbsp;Ngozi P Ogbonnaya,&nbsp;Ifeoma F Ndubuisi,&nbsp;Echezona N D Ekechukwu,&nbsp;Ijeoma L Okoronkwo,&nbsp;Obinna Onwujekwe","doi":"10.1080/19932820.2022.2128414","DOIUrl":"https://doi.org/10.1080/19932820.2022.2128414","url":null,"abstract":"<p><p>Infection with HIV/AIDS continues to be a major public health concern around the world, particularly in low- and middle-income nations. To assess the effectiveness of structured health education on the prevention of HIV/AIDS risky behaviours among adolescents in secondary school. A pretest-posttest-control group randomized controlled trial where a sample of 647 adolescents was drawn from the population of 2,890 secondary school students and was block-randomized into the intervention (n = 400) and control (n = 224) groups. Data were collected using a content-validated (CVI = 4.2/5) and reliable (k = 0.791) self-developed structured questionnaire. Data were analyzed using descriptive statistics and with inferential statistics of independent and paired t-tests at α = 0.05. Pre-intervention risky behaviours in both groups were below average though lower in the intervention than in the control group. Pre-intervention risky behaviour was significantly higher among males than females in the rural school (p < 0.001) and in both schools together (p < 0.001). Health education significantly affected risky behaviour with the intervention group being associated with lesser risky behaviour than the control group. There was no significant difference in the post-intervention risky behaviour between males and females in the rural (0.285), urban (0.179) and both schools together (p = 0.956). Post-intervention reduced risky behaviours more significantly in the intervention than in the control groups. HIV/AIDS health education should be part of schools' curriculum, guidance and counsellor teachers should be trained as HIV counsellors.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"2128414"},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/cf/ZLJM_17_2128414.PMC9543117.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40386157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of vitamin C and D on the mRNA expression of angiotensin converting enzyme 2 receptor, cathepsin L, and transmembrane serine protease in the mouse lungs.","authors":"Meshref A Alruwaili,&nbsp;Yazun Jarrar","doi":"10.1080/19932820.2022.2054111","DOIUrl":"https://doi.org/10.1080/19932820.2022.2054111","url":null,"abstract":"<p><p>Vitamins (Vit) C and D are widely used as immunogenic supplements among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. The SAR-CoV-2 virus enters into the pulmonary endothelial cells through attachment to angiotensin converting enzyme 2 receptor (Ace2) and the proteolytic activity of Cathepsin L (Ctsl) and transmembrane serine protease 2 (Tmprss2) enzymes. This study aimed to determine the influence of Vit C and D on the mRNA expression of <i>Ace2, Tmprss2</i>, and <i>Ctsl</i> genes in the mouse lungs. Vitamins C and D were administrated to different groups of mice through intra-peritoneal route in doses equivalent to human for 30 days. Then, the mRNA expression of SARS-CoV-2 entry gene was analyzed using qRT-PCR. It is found that Vit D, but not C, upregulated significantly (<i>P</i> < 0.05) the mRNA expression of <i>Ace2</i> by more than six folds, while downregulated the expression of <i>Ctsl</i> and <i>Tmprss2</i> genes by 2.8 and 2.2 folds, respectively. It can be concluded from this study that Vit D alters the mRNA expression of <i>Ace2, Tmprss</i>, and <i>Ctsl</i> genes in the mouse lungs. This finding can help us in understanding, at least in part, the molecular influence of Vit D on genes involved in the entry of SARS-CoV-2 into the cells.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"2054111"},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/19/ZLJM_17_2054111.PMC8942545.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40309493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient safety in medical education: Tunisian students' attitudes.","authors":"Olfa Ezzi,&nbsp;Mohamed Mahjoub,&nbsp;Nihel Omri,&nbsp;Asma Ammar,&nbsp;Dorra Loghmari,&nbsp;Souhir Chelly,&nbsp;Abir Mtira,&nbsp;Sana Rhimi,&nbsp;Mansour Njah","doi":"10.1080/19932820.2022.2122159","DOIUrl":"https://doi.org/10.1080/19932820.2022.2122159","url":null,"abstract":"<p><p>Health care delivery continues to be unsafe despite major patient safety (PS) improvement efforts over the past decade. Medical school education plays an important role in promoting this culture during initial training. To determine undergraduate medical students' attitudes toward PS at a Tunisian medical school. We carried out a cross-sectional study among undergraduate medical students at Ibn Al Jazzar Medical School in Sousse, Tunisia, using a self-administered questionnaire inspired from the valid tool: Attitudes to Patient Safety Questionnaire (APSQ III). A total of 178 medical students responded to the questionnaire. Medical students tend to have an overall positive perceptions of PS culture with a global mean score 5.33 ± 0.5. Among the individual domains 'Working hours as a cause of error' earned the highest score (6.38 ± 1.0) followed in order by 'Team functioning' (6.24 ± 0.8), 'Error inevitability' (5.91 ± 1.0) and 'Patient involvement in reducing error' (5.50 ± 1.0). The lowest score was for 'Professional incompetence as a cause of error' (4.01 ± 1.0). A PS domain's mean scores comparison based on socio-demographic variables: gender, age, academic year and on PS training revealed a statistically significant difference (p < 0.05) for five PS key dimensions: ' Error reporting confidence ', ' Working hours as a cause of error ', ' Professional incompetence as a cause of error ', ' Team functioning ' and 'PS training received'. Tunisian medical students showed positive attitude towards PS. Nevermore, intensive in terms of frequency and duration sessions, based on various teaching methods may be needed to fulfill students' educational needs.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"2122159"},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/af/ZLJM_17_2122159.PMC9481112.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33462490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of perinatal depression among working pregnant women: a hospital-based cross-sectional study.","authors":"Abdallah Jihed,&nbsp;Mohamed Ben Rejeb,&nbsp;Houyem Said Laatiri,&nbsp;Chekib Zedini,&nbsp;Manel Mallouli,&nbsp;Ali Mtiraoui","doi":"10.1080/19932820.2022.2114182","DOIUrl":"https://doi.org/10.1080/19932820.2022.2114182","url":null,"abstract":"<p><p>Perinatal depression is a major public health problem having serious negative impacts on personal, family, and child developmental outcomes. This study aimed to determine the prevalence of major depressive disorder (MDD) and its associated factors in working pregnant women. This descriptive, cross-sectional study was performed on 389 working pregnant women enrolled from four Tunisian public maternity hospitals. Data collection tools were the sociodemographic, obstetric, family relationships, and work environment questionnaire, and the Center for Epidemiologic Studies Depression Scale (CES-D). The mean score of depression was 27.39 ± 6.97 and 76.1% of women had major depressive symptoms using cutoff points on the CES-D ≥ 23. Family income, diagnosis with a chronic illness, history of depression, and employment categories were associated with major depressive symptoms. In multivariate analyses, family income and work posture were significantly associated with MDD. These results suggest an increased burden of MDD during pregnancy in Tunisian women. Prevention, early detection, and interventions are needed to reduce the prevalence of perinatal depression.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"2114182"},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bc/f4/ZLJM_17_2114182.PMC9415599.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40438037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical prognosis after idiopathic macular hole surgery: machine learning based-predection.","authors":"Hsouna Zgolli,&nbsp;Hamad H K El Zarrug,&nbsp;Moufid Meddeb,&nbsp;Sonya Mabrouk,&nbsp;Nawres Khlifa","doi":"10.1080/19932820.2022.2034334","DOIUrl":"https://doi.org/10.1080/19932820.2022.2034334","url":null,"abstract":"<p><p>To develop a machine learning (ML) model for the prediction of the idiopathic macular hole (MH) status at 9 months after vitrectomy and inverted flap internal limiting membrane (ILM) peeling surgery. This single center was conducted at Department A, Institute Hedi Raies of Ophthalmology, Tunis, Tunisia. The study included 114 patients. In total, 120 eyes underwent optical coherence tomography (OCT) and inverted flap ILM peeling for surgery. Then 510 B scan of macular OCT was acquired 9 months after surgery. MH diameter, basal MH diameter (b), nasal and temporal arm lengths and macular hole angle were measured. Indices including hole form factor, MH index, diameter hole index (DHI) and tractional hole, MH area index and MH volume index were calculated. Receiver operating characteristic (ROC) curves and cut‑off values were derived for each indices predicting closure or not of the MH. The area under the receiver operating characteristic curve (AUC) and kappa value were calculated to evaluate performance of the medical decision support system (MDSS) in predicting the MH closure. From the ROC curve analysis, it was derived that MH indices like MH diameter, diameter hole index (DHI), MH index, and hole formation factor were capable of successfully predicting MH closure while basal diameter, DHI and MH area index predicted none closure MH. The MDSS achieved an AUC of 0.984 with a kappa value of 0.934. Based on the preoperative OCT parameters, our ML model achieved remarkable accuracy in predicting MH outcomes after pars plana vitrectomy and inverted flap ILM peeling. Therefore, MDSS may help optimize surgical planning for full thickness macular hole patients in the future.</p>","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":" ","pages":"2034334"},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fa/e0/ZLJM_17_2034334.PMC8865103.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39644183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}