S100A4 expression is associated with poor prognosis in patients with resectable gastrointestinal stromal tumor

W. Shen, X. Tan, F. Hao
{"title":"S100A4 expression is associated with poor prognosis in patients with resectable gastrointestinal stromal tumor","authors":"W. Shen, X. Tan, F. Hao","doi":"10.1080/19932820.2019.1659669","DOIUrl":null,"url":null,"abstract":"ABSTRACT S100A4 is particularly associated with the progression and metastasis of numerous human malignancies. This study was designed to examine the clinicopathologic significance of S100A4 in gastrointestinal stromal tumor (GISTs). The level of OPNS100A4 expression in a large cohort of resectable GISTs was evaluated with immunohistochemistry. Its correlation with the clinicopathologic parameters of patients with resectable GISTs was analyzed. A survival analysis was performed to evaluate the prognostic significance of S100A4 expression using Kaplan-Meier method. Results: In 108 patients with resectable GISTs, the most high-risk GISTs had a strong level of S100A4 expression. Strong S100A4 expression was significantly associated with tumor size, mitosis, and recurrence, but not gender and age. Patients with weak S100A4 expression had a relatively longer disease-free survival compared to patients with strong S100A4 expression.Therefore, S100A4 expression is a putative marker for tumor progression and an adverse prognosis in GISTs.","PeriodicalId":256060,"journal":{"name":"The Libyan Journal of Medicine","volume":"133 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Libyan Journal of Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/19932820.2019.1659669","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

Abstract

ABSTRACT S100A4 is particularly associated with the progression and metastasis of numerous human malignancies. This study was designed to examine the clinicopathologic significance of S100A4 in gastrointestinal stromal tumor (GISTs). The level of OPNS100A4 expression in a large cohort of resectable GISTs was evaluated with immunohistochemistry. Its correlation with the clinicopathologic parameters of patients with resectable GISTs was analyzed. A survival analysis was performed to evaluate the prognostic significance of S100A4 expression using Kaplan-Meier method. Results: In 108 patients with resectable GISTs, the most high-risk GISTs had a strong level of S100A4 expression. Strong S100A4 expression was significantly associated with tumor size, mitosis, and recurrence, but not gender and age. Patients with weak S100A4 expression had a relatively longer disease-free survival compared to patients with strong S100A4 expression.Therefore, S100A4 expression is a putative marker for tumor progression and an adverse prognosis in GISTs.
在可切除的胃肠道间质瘤患者中,S100A4表达与预后不良相关
S100A4与许多人类恶性肿瘤的进展和转移特别相关。本研究旨在探讨S100A4在胃肠道间质瘤(gist)中的临床病理意义。采用免疫组织化学方法评估可切除gist患者中OPNS100A4的表达水平。分析其与可切除gist患者临床病理参数的相关性。采用Kaplan-Meier法进行生存分析,评估S100A4表达对预后的意义。结果:在108例可切除的gist患者中,S100A4的表达水平最高。S100A4强表达与肿瘤大小、有丝分裂和复发显著相关,但与性别和年龄无关。与S100A4强表达患者相比,S100A4弱表达患者的无病生存期相对较长。因此,S100A4的表达被认为是gist中肿瘤进展和不良预后的标志。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信