ACS Sensors最新文献_第9页

A Machine Learning-Assisted Liquid Crystal Droplet Array Platform for the Sensitive and Selective Detection of Per- and Polyfluoroalkyl Substances (PFAS) in Water 机器学习辅助液晶液滴阵列平台对水中全氟烷基和多氟烷基物质（PFAS）的敏感和选择性检测

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-09-25 DOI: 10.1021/acssensors.5c00907

Fengrui Wang, Shiyi Qin, Zhao Yang, Leena M. Edwards-Medina, Benjamin L. Chiu, Claribel Acevedo-Vélez, Christina K. Remucal, Reid C. Van Lehn, Victor M. Zavala, David M. Lynn

{"title":"A Machine Learning-Assisted Liquid Crystal Droplet Array Platform for the Sensitive and Selective Detection of Per- and Polyfluoroalkyl Substances (PFAS) in Water","authors":"Fengrui Wang, Shiyi Qin, Zhao Yang, Leena M. Edwards-Medina, Benjamin L. Chiu, Claribel Acevedo-Vélez, Christina K. Remucal, Reid C. Van Lehn, Victor M. Zavala, David M. Lynn","doi":"10.1021/acssensors.5c00907","DOIUrl":"https://doi.org/10.1021/acssensors.5c00907","url":null,"abstract":"We report a machine learning (ML)-assisted liquid crystal (LC) droplet array platform for the detection of per- and polyfluoroalkyl substances (PFAS) in water. Our approach uses an autoencoder network to process thousands of images obtained from arrays of microscale droplets of thermotropic LCs. The latent space obtained using the autoencoder contains significant information that enables sensitive and selective detection of two amphiphilic PFAS [perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS)] at concentrations as low as parts-per-trillion (ppt) in ultrapure water, municipal tap water, and simulated river water containing dissolved organic matter. Despite the absence of visually discernible changes in the optical outputs of LC arrays at low PFAS concentrations, this approach accurately predicts their presence, even in water containing interfering molecules. We also demonstrate the use of transfer learning to differentiate between PFOA, PFOS, and PFOA/PFOS mixtures, showcasing the potential for practical environmental monitoring. This platform permits identification of PFOA and PFOS below the maximum contaminant levels (4 ppt) established by the U.S. Environmental Protection Agency. Our approach is compatible with automated printing, treatment, and high-throughput optical and ML analysis and could provide a basis for the development of low-cost sensors to monitor PFAS and other amphiphilic contaminants in real-world water samples.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"22 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrocatalytic Oxygen Reduction Activity of E. coli O157:H7 under H2O2 Stress for Biosensing Application. H2O2胁迫下大肠杆菌O157:H7的电催化氧还原活性及其生物传感应用

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-09-24 DOI: 10.1021/acssensors.5c02329

Fengyang Wang,Panpan Liu,Mengjuan Li,Yunlong Liu,Yan Qi,Xiaohui Xiong,Yuanjian Liu

{"title":"Electrocatalytic Oxygen Reduction Activity of E. coli O157:H7 under H2O2 Stress for Biosensing Application.","authors":"Fengyang Wang,Panpan Liu,Mengjuan Li,Yunlong Liu,Yan Qi,Xiaohui Xiong,Yuanjian Liu","doi":"10.1021/acssensors.5c02329","DOIUrl":"https://doi.org/10.1021/acssensors.5c02329","url":null,"abstract":"The electrocatalytic activity of environmental stressed bacteria is closely related to their cellular activity. In this study, the electrocatalytic activity toward oxygen reduction of E. coli O157:H7 under physical, chemical, and biological environmental stress was explored through cyclic voltammetry (CV). Interestingly, when E. coli O157:H7 was stimulated under 5 mM H2O2 stress for 30 min, a distinct reduction peak and a reduction current at the mA level could be observed, indicating that the electrocatalytic oxygen reduction ability of E. coli O157:H7 was significantly enhanced. Then, the electrocatalytic mechanism of the E. coli O157:H7 under H2O2 stress was systematically analyzed from the growth dynamics, microscopic morphology, oxidative stress response, and metabolomics, and the electron transfer mechanism of its respiratory chain was clarified. Furthermore, metabolic pathway enrichment analysis showed that tricarboxylic acid (TCA) cycle and respiratory chain promoted NADH and ATP synthesis. The L-fucose synthesis indicated that ubiquinone (UQ, the core electron carrier of biocatalytic reaction) pathway was upregulated, enhancing bacterial cell catalytic activity and electron transport efficiency. Moreover, an electrochemical sensor utilizing H2O2 stress was developed for E. coli O157:H7 detection. The sensor demonstrated exceptional performance, displaying a maximum variation of 9.34 times in the ECL signal under H2O2 stress and achieving a remarkably low detection limit of 10 CFU E. coli O157:H7 in 1 mL sample volume. This study provides a new solution for the sensitive screening of electrochemically active bacteria, with broad application prospects.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"40 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Self-Adaptive Hydrogel Platform for Integrated Electrical Stimulation Therapy and Clinical Monitoring of Postoperative Wound. 生物活性自适应水凝胶平台的综合电刺激治疗和术后伤口临床监测。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-09-24 DOI: 10.1021/acssensors.5c02154

Ying Fang,Ke Xu,Xiaochang Lu,Xiaochen Feng,Yicheng Wang,Jiawei Lin,Biaoqi Chen,Ranjith Kumar Kankala,Aizheng Chen,Shibin Wang,Yanan Wang,Chaoping Fu

{"title":"Bioactive Self-Adaptive Hydrogel Platform for Integrated Electrical Stimulation Therapy and Clinical Monitoring of Postoperative Wound.","authors":"Ying Fang,Ke Xu,Xiaochang Lu,Xiaochen Feng,Yicheng Wang,Jiawei Lin,Biaoqi Chen,Ranjith Kumar Kankala,Aizheng Chen,Shibin Wang,Yanan Wang,Chaoping Fu","doi":"10.1021/acssensors.5c02154","DOIUrl":"https://doi.org/10.1021/acssensors.5c02154","url":null,"abstract":"Postoperative wound management remains clinically challenging due to delayed healing, subcutaneous infections, and the absence of systems capable of real-time therapeutic and diagnostic integration. Addressing this need, we developed a bioactive, self-adaptive hydrogel platform that combines electrical stimulation (ES) therapy with resistance-based bioelectronic sensing for personalized postoperative wound care. The hydrogel is constructed from dynamic borate ester-cross-linked poly(vinyl alcohol) (PVA), with wool keratin for hemostasis and tissue remodeling and tannic acid for adhesion, antioxidative protection, and enhanced biocompatibility. This composition imparts excellent stretchability, self-healing ability, and conformal adaptability to irregular wound sites. Upon application, the platform delivers uniform ES to promote angiogenesis and re-epithelialization, achieving a 99.96% wound closure rate in vivo by day 14. Simultaneously, the system enables noninvasive clinical monitoring by capturing resistance signals that reflect healing status. Actively recovering wounds exhibited relative resistance changes of approximately 200% compared with the preoperative skin condition, while infected sites with subcutaneous abscesses showed reductions to less than 50% of the preoperative skin values. Fully healed tissues, measured 3 weeks post discharge, displayed resistance levels nearly identical to the preoperative skin condition. These findings validate the platform's dual therapeutic and sensing capabilities and demonstrate its translational potential for smart, data-driven postoperative wound care.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"40 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspergillus-Induced Cardiac Injury Modeling and Preventive Strategy Screening via a Universal Precise Cardiomyocyte-Based Electrophysiological Biosensing Platform. 基于通用精确的基于心肌细胞的电生理生物传感平台的曲霉诱导心脏损伤建模和预防策略筛选。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-09-24 DOI: 10.1021/acssensors.5c00997

Yumei Ge,Ling Zou,Jiajin Xue,Duote Cai,Yingwei Wang,Haote Han,Ning Hu

{"title":"Aspergillus-Induced Cardiac Injury Modeling and Preventive Strategy Screening via a Universal Precise Cardiomyocyte-Based Electrophysiological Biosensing Platform.","authors":"Yumei Ge,Ling Zou,Jiajin Xue,Duote Cai,Yingwei Wang,Haote Han,Ning Hu","doi":"10.1021/acssensors.5c00997","DOIUrl":"https://doi.org/10.1021/acssensors.5c00997","url":null,"abstract":"Aspergillus-induced cardiac injury represents a severe manifestation of invasive aspergillosis characterized by high mortality and diagnostic challenges. Current in vitro models fail to provide real-time monitoring of cardiac electrophysiological changes, which hinders the elucidation of the mechanisms underlying electrophysiological disturbances caused by fungal invasion and its associated metabolites. Hence, this study developed a universal precise electrophysiological biosensing platform to enable real-time, dynamic monitoring of cardiomyocyte electrophysiological fluctuations under exposure to gliotoxin (GT), a major virulence factor of Aspergillus fumigatus. Acute exposure to 250 nM GT significantly increased the firing rate of cardiomyocytes within 8 h, while prolonged exposure progressively reduced the signal amplitude. Skullcapflavone II (SF2) can effectively protect against GT-induced cardiomyocyte damage by maintaining the electrophysiological signal stability. This self-developed platform provides a universal and precise tool to investigate the pathophysiology of Aspergillus-induced cardiac injury and to assess protective strategies through real-time electrophysiological monitoring.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"86 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gas Sensor Selectivity Assessment Indicator of Fill Factor from Response Curve: A Case Study on WS2-Based Ammonia Gas Sensors 响应曲线中填充因子的气体传感器选择性评价指标——以ws2型氨气体传感器为例

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-09-23 DOI: 10.1021/acssensors.5c01453

Peng Wang, Ming Li, Zhiyuan Zhu, Chengli Tang

{"title":"Gas Sensor Selectivity Assessment Indicator of Fill Factor from Response Curve: A Case Study on WS2-Based Ammonia Gas Sensors","authors":"Peng Wang, Ming Li, Zhiyuan Zhu, Chengli Tang","doi":"10.1021/acssensors.5c01453","DOIUrl":"https://doi.org/10.1021/acssensors.5c01453","url":null,"abstract":"With the advancement of smart detection technologies, gas sensors have gained increasingly widespread applications in environmental monitoring, industrial safety, medical diagnostics, and intelligent agriculture. The response curve of a single gas sensor is conventionally used to calculate sensor performance evaluation parameters of response/recovery time and response value. The selectivity of a single sensor is currently evaluated by a selectivity coefficient based on the response value, which faces difficulty in distinguishing gases with different concentrations. In this study, a new metric of fill factor (FF) derived from response curve morphology features was introduced to offer a novel solution for single-sensor selectivity analysis. Three variants of the novel metrics, FFres (response phase fill factor), FFrec (recovery phase fill factor), and FF (total fill factor), can be calculated from the response curve. As a proof-of-concept, the FFs of WS2, WS2@PANI, and Au/PANI/WS2 sensors at different concentrations of ammonia, acetone, methanol, ethanol, and water vapor were calculated and used for gas selectivity analysis. Results demonstrated distinct FF ranges for ammonia and other gases, validating FF as a potential selectivity indicator. This approach provides a multidimensional analysis framework for enhanced single-sensor discrimination by constructing a parameter space incorporating curve morphology features.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"10 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated Fe Sites Mediated Construction of WO3 Homojunctions for Superior Electronic Sensors. 分离Fe位点介导的WO3同质结的构建

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-09-21 DOI: 10.1021/acssensors.5c01532

Jiangbin Guo,Xianghong Liu,Xiao Chang,Wei Zheng,Nicola Pinna,Jun Zhang

引用次数: 0

Hairpin DNA and Linear Single-Stranded DNA Synergy-Engineered Dual-Ratiometric Electrochemical Aptasensor for Simultaneous Malathion and Omethoate Detection with Enhanced Performance. 发夹DNA和线性单链DNA协同工程双比例电化学配体传感器用于同时检测马拉硫磷和乐果的增强性能。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-09-21 DOI: 10.1021/acssensors.5c03085

Ying Wang,Hao Tan,Cen Chen,Rui Liu,Jinxiu Wei,Yuye Li,Xiaohong Liu,Chengxi Zhu

{"title":"Hairpin DNA and Linear Single-Stranded DNA Synergy-Engineered Dual-Ratiometric Electrochemical Aptasensor for Simultaneous Malathion and Omethoate Detection with Enhanced Performance.","authors":"Ying Wang,Hao Tan,Cen Chen,Rui Liu,Jinxiu Wei,Yuye Li,Xiaohong Liu,Chengxi Zhu","doi":"10.1021/acssensors.5c03085","DOIUrl":"https://doi.org/10.1021/acssensors.5c03085","url":null,"abstract":"Simultaneously determining multiple pesticide residues in agricultural products is of great practical significance. This study presents a dual-ratiometric electrochemical aptasensor via the synergy of hairpin DNA and linear single-stranded DNA (ssDNA) for the simultaneous determination of two pesticides of malathion (MAL) and omethoate (OMT). MXene@AQ/AuNPs were prepared through a facile room-temperature self-assembly strategy, serving as a dual-functional platform to yield a stable reference signal (IAQ) and amplify response signals. Hairpin DNA and the methylene blue-labeled OMT aptamer (MB-OMT Apt1) were subsequently coimmobilized, with hairpin DNA providing binding sites for assembling the ferrocene-labeled MAL aptamer (Fc-MAL Apt1). In the presence of MAL and OMT, specific bindings triggered the detachment of Fc-MAL Apt1 (causing a decrease in IFc) and the approach of MB-OMT Apt1 toward the electrode (causing an increase in IMB), with ratios of IFc/IAQ and IMB/IAQ used for the quantification of MAL and OMT, respectively. Following this principle, two additional aptasensors based exclusively on hDNA or ssDNA were constructed for performance comparison. The findings indicate that hairpin DNA and linear ssDNA act synergistically through structural and characteristic complementarity, significantly enhancing the assembly and identification efficiency of the aptasensing platform, which endows the hDNA&ssDNA-based aptasensor with remarkable reliability and anti-interference performance for multipesticide analysis.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"16 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasensitive Electrochemical Detection of Amyloid-β Peptide Using a Homochiral Metal-Organic Framework Binding to the l-Diphenylalanine Targeting Site. 利用同手性金属-有机框架结合l-二苯丙氨酸靶向位点的超灵敏电化学检测淀粉样蛋白-β肽。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-09-20 DOI: 10.1021/acssensors.4c03425

Rui-Xuan Li,Xin Shang,Pei-Qi Shen,Yu-Feng Zhu,En-Qing Gao,Qi Yue

{"title":"Ultrasensitive Electrochemical Detection of Amyloid-β Peptide Using a Homochiral Metal-Organic Framework Binding to the l-Diphenylalanine Targeting Site.","authors":"Rui-Xuan Li,Xin Shang,Pei-Qi Shen,Yu-Feng Zhu,En-Qing Gao,Qi Yue","doi":"10.1021/acssensors.4c03425","DOIUrl":"https://doi.org/10.1021/acssensors.4c03425","url":null,"abstract":"The high sensitivity and accuracy of amyloid-β peptide (Aβ) detection could provide strong support for early diagnosis, monitoring of disease progression, and effective treatment of Alzheimer's disease (AD). Improving the specificity and affinity of sensing materials for Aβ is key to detecting Aβ. Herein, an electrochemical sensor based on an unmodified homochiral MOF, Zn-BPIleBp, was developed for the first time for the detection of Aβ1-40, with an ultralow detection limit of 1.7 pM (7.36 pg/mL). The Zn-BPIleBp sensor also displays high-efficiency enantioselectivity and ultrasensitivity in identifying diphenylalanine (PhePhe) corresponding to the core recognition motif of Aβ1-40, with a high peak current ratio (IL/ID) of 2.78, large potential difference (EL - ED) of 140 mV, and ultralow detection limit of 34 fM for l-PhePhe. The sensor has been successfully applied for the ultrasensitive quantification of l-PhePhe and Aβ1-40 in racemic mixtures, artificial cerebrospinal fluid (aCSF) and fetal bovine serum (FBS). According to structural and spectral analysis, the high sensitivity and affinity of homochiral MOF toward Aβ1-40, without the involvement of any biomolecular modifications such as antibodies or aptamers, stem from the structural, hydrophobic, and chiral matching between the framework and Aβ1-40. This sensor proffers a fast, highly stable, reproducible, ultrasensitive, and accurate detection method for Aβ1-40, demonstrating great potential in the clinical application of AD. This work also opens up new perspectives for designing sensing platforms using MOFs as sensing materials and expanding their functionality and applications to the fields of biological and medical analysis.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"121 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Signal to Significance: Why Sensors Need Culture 从信号到意义：为什么传感器需要培养

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-09-20 DOI: 10.1021/acssensors.5c02709

Andrey V. Kalinichev

{"title":"From Signal to Significance: Why Sensors Need Culture","authors":"Andrey V. Kalinichev","doi":"10.1021/acssensors.5c02709","DOIUrl":"https://doi.org/10.1021/acssensors.5c02709","url":null,"abstract":"Is it time for the sensor community to reconsider how we define success? Traditionally, sensors, including chemical and biochemical sensors, have been evaluated by precision, stability, selectivity, sensitivity, and response time. However, even the most accurate sensor can fail if users do not understand or trust it. As sensors become more common in healthcare, climate monitoring, and everyday devices, public acceptance and perception have become as critical as technical performance. Questions of trust, usability, and cultural meaning are often raised in social or behavioral science journals, but they deserve attention within the core sensor research community itself. This Perspective argues that collaborations with artists, designers, communities, and the public can help create sensors that are not only functional but also meaningful and trustworthy. Through case studies drawn from interactive art, design, citizen science, and community-focused initiatives, it explores how participatory and cultural approaches can enhance the credibility of sensors and facilitate their adoption. This piece encourages the sensor research community to reflect on how sensors are experienced and to consider whether the future of sensing relies as much on trust and communication as it does on technical performance. It concludes with a set of practical principles for researchers calling for a broader definition of success in sensing that balances accuracy with trust and usability.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"54 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Electrode Structure on Glucose Monitoring by Reverse Iontophoresis 电极结构对反向离子电泳监测葡萄糖的影响

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-09-19 DOI: 10.1021/acssensors.5c02487

Hao Zheng, Youhao Liu, Wenjun Li, Xingguo Zhang, Wangwang Zhu, Jialing Wang, Yuxuan Chen, Dachao Li, Zhihua Pu, Fei Xie

{"title":"Effect of Electrode Structure on Glucose Monitoring by Reverse Iontophoresis","authors":"Hao Zheng, Youhao Liu, Wenjun Li, Xingguo Zhang, Wangwang Zhu, Jialing Wang, Yuxuan Chen, Dachao Li, Zhihua Pu, Fei Xie","doi":"10.1021/acssensors.5c02487","DOIUrl":"https://doi.org/10.1021/acssensors.5c02487","url":null,"abstract":"Continuous glucose monitoring (CGM) based on reverse iontophoresis (RI) offers a promising noninvasive solution for diabetes management. However, in the application of this technology, there are two key issues that affect the glucose detection results: the sensor sensitivity is gradually reduced due to the influence of the extraction current; the insufficient glucose extraction flux affects the accuracy of glucose prediction. We found that the electrode structure has a regulatory effect on these two types of influences. However, to date, there was no comprehensive or systematic investigation into the role of electrode structure in influencing the efficiency and accuracy of reverse iontophoresis-based glucose monitoring. This study investigated the impact of electrode structure on RI through multiphysics simulation, in vitro experiments, and human trials. By optimizing the spatial arrangement, spacing, shape, and position of the electrodes, the sensor sensitivity decline was minimized and the glucose extraction flux was maximized. Human trials verified the optimized design, achieving 74% of data points within the clinically accurate Clarke error grid A zone, with a mean absolute relative difference (MARD) of 13.17%, compared to 62 and 21.06% for the previous structure. These findings highlight the crucial role of electrode geometry in enhancing the accuracy of RI-based CGM.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"53 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0