Arabian Journal of Chemistry最新文献

{"title":"Gallic acid-derived carbon dots intercalated 3D porous Ti₃C₂T_x MXene for high-capacity supercapacitors","authors":"Qiaonan Yu, Dongmei Yang, Zhongliang Liu, Qiang Liu, Bingke Li, Bingke Li, Niuniu Gu","doi":"10.25259/ajc_264_2024","DOIUrl":"https://doi.org/10.25259/ajc_264_2024","url":null,"abstract":"Ti 3 C 2 T x Mxene shows good promise as an energy storage material. However, two-dimensional MXene materials are easily stacked, which negatively affects the energy density and limits the application of MXene-based supercapacitors. In this paper, a strategy for embedding carbon dots is proposed to address this issue. A three-dimensional structure is formed by cross-linking Ti 3 C 2 T x MXene nanosheets with gallic acid (GA), and a subsequent carbonization process is then utilized to prepare a three-dimensional porous carbon dot intercalated Ti 3 C 2 T x MXene material. The hydroxyl structures in GA are cross-linked with the hydroxyl structures on the surface of Ti 3 C 2 T x under the action of Zn 2+ to form a three-dimensional structure. The carbon dots formed by carbonizing the GA are embedded within the Ti 3 C 2 T x nanosheets, which increases the Ti 3 C 2 T x nanosheet layer spacing. The increase of layer spacing of Ti 3 C 2 T x nanosheets is conducive to the diffusion and transport of electrolyte ions in Ti 3 C 2 T x MXene. Consequently, at a scan rate of 2 mV s -1 , a Ti 3 C 2 T x @Celectrode achieves a high electrochemical gravimetric pecific capacitance (C g ) of 393.7 F g -1 . At a higher scan rate of 200 mV s -1 , 83.7% capacitance retention is obtained. Moreover, this electrode also shows 90.3% performance retention after 5000 cycles, demonstrating its good cycle stability. Finally, a symmetric supercapacitor was built using carbon cloth and Ti 3 C 2 T x @C, and at a power density of 153.25Wkg -1 , a superb energy density of 21.28Whkg -1 is attained. This study offers a facile strategy for effectively preparing MXene electrodes with desirable electrochemical performance.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"2642024-2642024"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and characterization of antibacterial metal complexes in ZiHua DiDing (<i>Viola philippica</i>) aqueous extract","authors":"Jiang Chenxi, Liu Jiayi, Wenying Guo, Liao Xiangwen, Xiong Yanshi, Jingtao Wang, Zhimin Li, Lin Zhang, Liang Peng","doi":"10.25259/ajc_99_2024","DOIUrl":"https://doi.org/10.25259/ajc_99_2024","url":null,"abstract":"The excessive use of antibiotics leading to bacterial resistance poses a significant threat to global public health, particularly the serious problem of resistance in Staphylococcus aureus , which requires the development of new antibiotics. Metal complexes can combat bacterial resistance due to their unique mode of action and minimal tendency to induce resistance. Exploring new antibacterial agents from traditional Chinese medicine mainly focuses on organic components. We aimed to discover metal complexes with strong antibacterial activity and low drug resistance from ZiHua DiDing ( Viola philippica ) aqueous extract (ZDAE). We identified metal complexes in ZDAE and demonstrated that the addition of metal ions, particularly manganese (Mn 2+ ), significantly affects the antibacterial activity of the extract. We also detected the heptasaponin manganese complex (ESM) in ZDAE. Subsequent synthesis and characterization of ESM showed that it is a 2:1 complex of esculetin (ES) and Mn 2+ , with significantly higher antibacterial activity against various bacteria. Activity against S. aureus reduced four-fold from 4800 μmol/L to 1200 μmol/L. The antibacterial mechanism of ESM against S. aureus includes inhibition of biofilm formation and protein synthesis, reduction of energy production, and disruption of cell wall structure. In addition, the minimum inhibitory concentration of ESM in the drug-containing medium remained stable for 20 generations, indicating that the extract of V. philippica produced potent metal complexes with enhanced antibacterial properties and lower ability to induce bacterial resistance.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"992024-992024"},"PeriodicalIF":0.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147904669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation into the mechanistic action of zhuye shigao decoction in acute pneumonia treatment <i>via</i> liquid chromatography-mass spectrometry-based metabolomics combined with network pharmacology analysis","authors":"Zhi-Liang Sun, Haipeng Tang, Guangzhi Cai, Kejin Xu, Yang Wang, Jiyu Gong","doi":"10.25259/ajc_192_2024","DOIUrl":"https://doi.org/10.25259/ajc_192_2024","url":null,"abstract":"The traditional Chinese medicine (TCM) formulation Zhuye Shigao Decoction (ZSD) has demonstrated therapeutic efficacy in the treatment of acute pneumonia. Nevertheless, the precise mechanisms underlying its pharmacological action remain inadequately elucidated. This study aims to assess the therapeutic efficacy of ZSD in managing acute pneumonia and to elucidate the potential mechanisms driving its effects. A lipopolysaccharide (LPS)-induced murine model of acute pneumonia was established. Histopathological examination and serum biochemical assays were conducted to assess the therapeutic efficacy of ZSD for acute pneumonia. An LC-MS-based metabolomics strategy was employed to explore the impact of ZSD on the serum metabolome. To further elucidate the underlying mechanisms of ZSD’s therapeutic effects, a combined metabolomics and network pharmacology strategy was employed. Compared with the model group, ZSD demonstrated the ability to reduce serum levels of Tumor necrosis factor α (TNF-α), Interleukin-1β (IL-1β), and Interleukin-6 (IL-6), while simultaneously enhancing the expression of IgA and IgM. Histological analysis showed that ZSD could significantly improve lung tissue changes caused by LPS exposure. We selected 74 serum metabolites as metabolic biomarkers for acute pneumonia, of which 67 demonstrated significant recovery following treatment with ZSD, thereby highlighting its therapeutic potential in addressing LPS-induced pneumonia. Network pharmacology analysis identified potential targets, including AKT1, IL-6, IL-1β, TNF, Myc proto-oncogene protein (MYC), and Peroxisome proliferator-activated receptor gamma (PPARG). The joint analysis indicated that the potential therapeutic mechanism of ZSD might associated with sphingolipid metabolism, arachidonic acid metabolism, glycerophospholipid metabolism, PPAR signaling pathway, and Janus kinase-signal transducer and activator of transcription ((JAK-STAT) signaling pathway. This study illustrated the comprehensive regulatory role of ZSD in the treatment of acute pneumonia and, for the first time, elucidated the possible mechanisms of ZSD at both the protein and metabolic levels. Furthermore, it offers a new perspective on the pharmacological effects of Chinese materia medica (CMM) in acute pneumonia treatment, with a particular emphasis on metabolic regulation.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"1922024-1922024"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of intranasal mPEG-PLA modified nanoliposomes loaded with Gleditsiae Fructus Abnormalis volatile on cerebral ischemia-reperfusion injury <i>via</i> the HIF-1α/VEGF signaling pathway","authors":"Wenyuan Chen, Linli Jiang, Lei Chen, Na-Na Dong, Lan Qin, Yixue Lin, Yong Gao, Zhigang Ju, Yuxin Pang, Xiaolan Chen","doi":"10.25259/ajc_76_2024","DOIUrl":"https://doi.org/10.25259/ajc_76_2024","url":null,"abstract":"Sustained release of neuroprotective agents from polymeric nanocarriers offers a promising approach for ischemic stroke treatment. This study investigates the neuroprotective effects of methoxy poly(ethylene glycol)-poly(lactic acid) (mPEG-PLA) modified nanoliposomes (mLP) loaded with Gleditsiae Fructus Abnormalis volatile oil (VOGFA) on cerebral ischemia-reperfusion injury (CIRI) in rats. Five active components—paeonol, eugenol, methyl eugenol, linalool, and anethole—were identified and screened for their potential to mitigate ischemic damage. The five active components of VOGFA of mPEG-PLA modified nanoliposomes (FVOGFA-mLP) system was prepared using an optimized ethanol injection method and characterized using transmission electron microscopy (TEM) and laser granulometry to evaluate particle size distribution and encapsulation efficiency. In vitro studies on PC12 cells subjected to oxygen-glucose deprivation/reperfusion (OGD/R) demonstrated that FVOGFA-mLP significantly enhanced cell survival and migration. In vivo experiments further confirmed the improved brain targeting capability and bioavailability of FVOGFA-mLP, which significantly reduced inflammatory cytokine levels [tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β)] and upregulated VEGF expression in cortical regions of CIRI rats. Behavioral assessments and histological analysis showed that medium and high doses of FVOGFA-mLP notably improved neurological function and reduced infarct volume, outperforming nimodipine. This study highlights the therapeutic potential of FVOGFA-mLP for ischemic stroke, demonstrating enhanced brain targeting and neuroprotection through the regulation of hypoxia-inducible factor 1-alpha (HIF-α) and vascular endothelial growth factor (VEGF) signaling pathways.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"762024-762024"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous extraction and separation of corn silk bioactive substance and the prediction of partition efficiency","authors":"Jiawei Xu, Yang Lu","doi":"10.25259/ajc_308_2024","DOIUrl":"https://doi.org/10.25259/ajc_308_2024","url":null,"abstract":"Flavonoids and polysaccharides are useful components of corn silk. For synchronously extracting and separating the flavonoids and polysaccharides from corn silk, the method of ultrasonic cell disruption extraction was combined with an aqueous two-phase system (ATPS). The separation of flavonoids and solvents, and the recycling of solvents can be achieved by utilizing smart polymers for phase-forming in ATPS. This method presents better extraction efficiency and recycling ability compared to others. The average extraction efficiency for flavonoid and corn silk polysaccharides can reach 16.73 mg·g -1 and 75.82 mg·g -1 . The recycling experiment demonstrates the feasibility of using the smart polymer for recycling. The prediction of partition efficiency of the corn silk bioactive substance was implemented by an artificial neural network (ANN) and response surface methodology (RSM). The ANN model outperformed the RSM one in both prediction accuracy and generalization ability.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"3082024-3082024"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of shikonin and fisetin on dapsone metabolism <i>in vitro</i> and <i>in vivo</i>","authors":"Hualu Wu, Hongchang Fu, Jun Wu, Peiqi Wang, Yuxin Shen, Lu Shi, Ren-ai Xu","doi":"10.25259/ajc_34_2024","DOIUrl":"https://doi.org/10.25259/ajc_34_2024","url":null,"abstract":"Dapsone, a sulfonamide compound commonly used in the treatment of leprosy and herpes, is metabolized by cytochrome P450 to dapsone hydroxylamine, which in turn causes methemoglobinemia and hemolysis. Consequently, the interaction of dapsone with other pharmaceutical agents has been the subject of investigation for researchers. In the present study, we conducted a screening of 48 traditional Chinese medicines that may have the potential to exert inhibitory effects in conjunction with dapsone. We focused on the in vitro and in vivo drug-drug interactions of dapsone with shikonin or fisetin. In rat liver microsomes (RLM), the half-maximum inhibitory concentration (IC 50 ) values for shikonin and fisetin were 12.21 μM and 4.97 μM, respectively, and the types of inhibition of dapsone metabolism were non-competitive in both. In human liver microsomes (HLM), the IC 50 values of shikonin and fisetin were 31.39 μM with non-competitive inhibition and 15.00 μM with mixed-type inhibition, respectively. In the Sprague-Dawley (SD) rat pharmacokinetic assay, the plasma exposure of dapsone significantly increased after the co-administration of shikonin or fisetin. When shikonin and dapsone were co-administered, the AUC (0-t) and AUC (0-∞) of dapsone exhibited an increase of 0.37 and 0.36 times, respectively, while the CL z/F exhibited a significant 0.27-fold reduction. Moreover, in combination with fisetin, the AUC (0-t) and AUC (0-∞) exhibited an increase of 0.30-fold and 0.33-fold, respectively, with a near doubling of the C max and a notable decrease in the CL z/F by 0.23-fold. The metabolite dapsone hydroxylamine showed no statistically significant differences. It could be concluded that shikonin and fisetin inhibited dapsone metabolism in vitro and in vivo . Therefore, when used in clinical association, it is important to monitor the plasma concentration of dapsone and dapsone hydroxylamine and make appropriate adjustments to the dosage of dapsone to minimize the risk of adverse reactions and achieve personalized treatment.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"342024-342024"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical characterization and discovery of anti-inflammatory components and their mechanism from <i>Artemisia argyi</i> leaves by UPLC-Q/TOF-MS, spectrum-effect relationship analysis, and MAPK pathway","authors":"Yue Zhong, Yaqing Chang, Yifan Du, Yan‐Li Ji, Ziyu Gu, Yuguang Zheng, Dan Zhang, Long Guo","doi":"10.25259/ajc_229_2024","DOIUrl":"https://doi.org/10.25259/ajc_229_2024","url":null,"abstract":"Artemisia argyi is a high-value herbaceous plant in the Artemisia genus, and its leaves are commonly used in medicine and aromatic products. A. argyi leaves are a traditional herbal medicine used to treat inflammation, abdominal pain, hemorrhage, and dysmenorrhea. Several studies have reported that the A. argyi leaves extract exhibited significant anti-inflammatory activities, the components and mechanism of which remain uncovered. The study aimed to reveal these components and their mechanisms by ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS), chemical fingerprint, spectrum effect relationship, and mitogen-activated protein kinase (MAPK) pathway. Firstly, UPLC-Q/TOF-MS was employed to characterize secondary metabolites in A. argyi leaves, and fifty secondary metabolitesx, including 15 phenolic acids, 29 flavonoids, five coumarins, and one terpene were identified. The chemical fingerprint of A. argyi leaves was established using high performance liquid chromatography (HPLC), and 13 secondary metabolites were identified as common components. The contents of the 13 secondary metabolites in different batches of A. argyi leaves were simultaneously determined. The anti-inflammatory capacities of different batches of A. argyi leaves were evaluated using the lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage inflammation model. The spectrum-effect relationship analysis was applied to investigate correlation between main secondary metabolites and anti-inflammation, and five metabolites, including 3-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid, schaftoside, and rutin were explored as latent anti-inflammatory compounds. The five selected metabolites exhibited remarkable inhibition of NO, IL-6, IL-1β, and tumor necrosis factor-α (TNF-α), and 3,5-dicaffeoylquinic acid and schaftoside had relatively great anti-inflammatory capacities. The western blot results indicated that 3,5-dicaffeoylquinic acid and schaftoside could reduce inflammation by inhibiting phosphorylation levels of p38, extracellular signal regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in the MAPK pathway. This work provided a thorough understanding of anti-inflammatory components of A. argyi leaves and their mechanism and also provided evidence for the utilization of A. argyi leaves as anti-inflammatory ingredients in medicinal products.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"2292024-2292024"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147888684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the active components and molecular mechanism of <i>alpinia officinarum hance</i> therapy against depression by network pharmacology and molecular docking combined with neuroprotective effects in PC12 cells","authors":"Xiuling Sun, Zhiwei Jiang, Qihua Wang, Wenjie Hu, Litao Zhang","doi":"10.25259/ajc_27_2024","DOIUrl":"https://doi.org/10.25259/ajc_27_2024","url":null,"abstract":"Depression is a common chronic mood-related disorder characterized by depressed mood, loss of interest, and fatigue. Extract from alpinia officinarum hance (AOH) has shown anti-depressant properties in Bagg Albino/C (BALB/c) mice with depression induced by chronic unanticipated stress. However, the molecular mechanisms underlying the anti-depressant effects of AOH remained unclear. The active ingredients of AOH were acquired via the Traditional Chinese Medicine Systems Pharmacology database and analysis platform (TCMSP), and their corresponding targets were collected from the high-throughput experiment- and reference-guided database of traditional Chinese medicine (HERB). Moreover, the targets associated with depression were identified using the GeneCards database. Common targets between the databases were identified as the anti-depressant targets of AOH. The Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) was used to build the Protein-Protein Interaction (PPI) network. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) enrichment analyses were performed using Database for Annotation, Visualization, and Integrated Discovery (DAVID). Using AutoDock Vina and PyMOL software, molecular docking technology was employed to verify whether the main active components in AOH could bind to central targets. Finally, the CCK8 assay was used to analyze the activity of AOH extract on PC12 cells and depression model cells induced by corticosterone (CORT). The expression was checked via the Quantitative Real - Time Polymerase Chain Reaction (qRT-PCR) of key target molecules. After a successful screening of 10 active components in AOH, it was demonstrated that these compounds had strong relationships with 115 targets associated with depression, among which Interleukin - 6 (IL6), RAC - alpha serine/threonine - protein kinase (AKT1), Interleukin - 1 beta (IL1B), tumor necrosis factor (TNF), Epidermal Growth Factor Receptor (EGFR), and Tumor protein p53 (TP53) could be the potential targets for treating depression. GO and KEGG enrichment pathway analysis yielded 416 terms and 153 pathways, respectively. Quercetin, kaempferol, sitosterol, medicarpin, and galangin were the key active components of AOH involved in treating depression. Molecular docking indicated the screened target proteins had good binding activity with active components with affinity values &lt; 5 kcal/mol. AOH extract was non-cytotoxic to PC12 cells and had a good protective effect on the depression cell model. The qRT-PCR analysis showed that the AOH extract can restore EGFR, TP53, and IL1B levels in CORT-induced PC12 cells to normal. Totally Quercetin, kaempferol, sitosterol, medicarpin, and galangin were identified as possible active ingredients in AOH that could potentially treat depression. The antidepressant benefits of AOH may stem from its capacity to modulate neuroinflammation.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"0 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High activity Ni-MoS_2-x monolayer nano-sheets fabricated through photo-deposition for highly efficient HER in acid solution","authors":"Yongling Du, XuanYe Du, Yang Du, Xiaolong Li, Yuhao Li, Xuezhao Shi, Zhixiang Zheng","doi":"10.25259/ajc_283_2024","DOIUrl":"https://doi.org/10.25259/ajc_283_2024","url":null,"abstract":"A highly active and stable electro-catalyst for hydrogen evolution was developed by in-situ photo-deposition of Ni metal on MoS 2 nano-sheets with many sulfur vacancies. It was found that Ni metal deposition improved the electrical conductivity of MoS 2 and further enhanced the catalytic activity by synergistic effect with Ni metal with MoS 2 nano-sheets. During photochemical deposition, photo-corrosion moved some sulfur, leading to many sulfur vacancies. Sulfur vacancies further enhance the activity of MoS 2 nano-sheets. Electrochemical experiments demonstrate that the catalyst exhibited excellent hydrogen evolution reaction activity with a large cathode current and a Tafel slope as small as 81 per decade. The high hydrogen evolution activity of Ni-doped MoS 2 was attributed to synergistic electro-catalytic effects between MoS 2 nano-sheets and Ni ions.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"2832024-2832024"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147912621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel composite nano-frameworks for prostate cancer therapy <i>via</i> synergistic targeting of ribonucleotide reductase","authors":"Mingwei Xu, Jun Chen, Chengran Huang, Cheng Liu","doi":"10.25259/ajc_73_2025","DOIUrl":"https://doi.org/10.25259/ajc_73_2025","url":null,"abstract":"Prostate cancer, a common malignancy in men, poses significant clinical challenges, especially as it progresses to castration-resistant prostate cancer (CRPC). Conventional therapies become less effective due to acquired drug resistance, and even enzalutamide (ENZR), a cornerstone treatment for CRPC, eventually faces resistance. Understanding the clinical significance of ENZR resistance is crucial for improving prostate cancer treatment. To address this issue, we developed an innovative nanosystem: Deferasirox (DEF)-loaded self-etched platinum-cobalt nanodendrites encapsulated within a nanoframe (Pt/Co-ND@DEF). This system combines chemodynamic therapy (CDT) with DEF delivery. Pt/Co-ND@DEF demonstrates potent peroxidase-like activity, catalyzing hydrogen peroxide (H 2 O 2 ) decomposition and glutathione (GSH) depletion to generate reactive oxygen species (ROS). Additionally, DEF release reduces tumor iron ion (Fe 3+ ) content, disrupting ribonucleotide reductase activity essential for DNA synthesis and arresting the cell cycle. This dual-action mechanism enhances ROS-induced cytotoxicity and boosts ENZR’s efficacy against CRPC, offering a promising multi-target strategy. Our study represents a significant step forward in overcoming ENZR resistance and enhancing prostate cancer treatment, providing new therapeutic avenues for advanced cases.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"732025-732025"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147919657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}