Arabian Journal of Chemistry最新文献

{"title":"Synthesis, characterization and adsorption of Pb(Ⅱ), Cd(Ⅱ) and Cu(Ⅱ) by red mud/polyacrylic acid/sodium carboxymethyl cellulose hydrogel","authors":"Dong Zhao ,&nbsp;Hua Deng ,&nbsp;Wei Wang ,&nbsp;Lening Hu ,&nbsp;Shunyun Ye ,&nbsp;Jiahui Fu ,&nbsp;Shuyun Zhang","doi":"10.1016/j.arabjc.2024.106067","DOIUrl":"10.1016/j.arabjc.2024.106067","url":null,"abstract":"<div><div>Heavy metal pollution in water and pollution hazards caused by red mud disposal are urgent environmental problems to be solved. Red mud waste can be utilized as resources by preparing hydrogels. By employing free radical polymerization, a red mud/polyacrylate/sodium carboxymethyl cellulose hydrogel (RMAAC) was synthesized using red mud (RM) as the main component, sodium carboxymethyl cellulose (SCMC) as the grafting substrate, N, N’-methylene bisacrylamide (MBA) as the crosslinking agent, and potassium persulfate (KPS) as the initiator. The proportions of MBA, KPS, and SCMC were optimized using the response surface method. The adsorption kinetics and isothermal adsorption model were applied to analyze the adsorption characteristics, while XRD, FTIR, SEM-EDS, and XPS characterization methods were employed to study the adsorption mechanism. The results demonstrated that the optimal proportions of MBA, KPS, and SCMC in RMAAC were determined to be 0.15 %, 0.2 %, and 1.5 %, respectively, and the addition of 0.5 % RM to enhance the adsorption performance of the hydrogel. The adsorption processes of Pb(II), Cd(II), and Cu(II) by RMAAC followed the pseudo-second-order kinetic model and the Langmuir model, suggesting chemisorption through a single molecular layer as the main adsorption mechanism. The maximum theoretical adsorption capacities of the three heavy metal ions at 25°C were determined to be 730.16, 292.71, and 215.37 mg/g, respectively. It was found that RMAAC exhibited a higher affinity toward Pb(II) compared to Cu(II) and Cd(II). Characterization analyses revealed that ion exchange and coordination chelation were the predominant mechanisms involved in the adsorption of Pb(II), Cd(II), and Cu(II) by RMAAC.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106067"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of lanthanum-silane film by electrochemically assisted sol–gel method for enhanced corrosion resistance of sintered NdFeB","authors":"Zhu Tao ,&nbsp;Li Jiang ,&nbsp;Wentao Ju ,&nbsp;Yanxia Liang ,&nbsp;Yumeng Yang ,&nbsp;Guoying Wei ,&nbsp;Yu Chen ,&nbsp;Zhao Zhang","doi":"10.1016/j.arabjc.2024.106057","DOIUrl":"10.1016/j.arabjc.2024.106057","url":null,"abstract":"<div><div>The surface of sintered NdFeB was coated with a lanthanum-silane film using an electrochemically assisted sol–gel method to improve its protective performance. The electrochemically assisted deposition mechanism is localized alkali catalysis at the surface with an applied cathodic potential, which promotes the condensation reaction of hydrolyzed silanol groups on the sintered NdFeB substrate surface and the production of lanthanum oxide/hydroxide in the silane film as well. Contact angle test results indicated that the hydrophobicity of the lanthanum-silane film was considerably enhanced compared to the bare sintered NdFeB substrate, and the water contact angle was above 150°. Meanwhile, electrochemical measurements suggested that the lanthanum-doped silane film significantly reduced the corrosion rate of the sintered NdFeB magnet in a 3.5 wt% NaCl solution with an <em>I_corr</em> value of 5.26 × 10⁻⁷ A cm⁻², and the protection efficiency reached 92.5 %. Furthermore, the magnetic properties of the lanthanum-silane film-coated sintered NdFeB sample were also evaluated and the effect was negligible.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106057"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular pathways of generation and detoxification of reactive oxygen species and induction of apoptosis in yeasts","authors":"Sidra Gull ,&nbsp;Chaudhry Ahmed Shabbir ,&nbsp;Zaman Khan ,&nbsp;Dilara A. Bukhari ,&nbsp;Abdul Rehman","doi":"10.1016/j.arabjc.2024.106069","DOIUrl":"10.1016/j.arabjc.2024.106069","url":null,"abstract":"<div><div>Reactive oxygen species (ROS) can trigger cell death in <em>Saccharomyces cerevisiae</em> and other lower eukaryotic organisms. Protein structure and function may be altered by ROS produced by cellular metabolism or by exposure to environmental oxidants. This happens regardless of whether peroxidases, superoxide dismutases, or catalases are active. Depending on the redox state of cysteine residues, oxidative alteration of sulfhydryl groups in proteins may inhibit protein activity or begin alternative pathways that affect cell function. Redox control is made possible by conserved, interdependent thioredoxin and glutaredoxin systems, which may play a comparable function in metal homeostasis in eukaryotic organisms. In response to oxidative stress, gene expression in <em>S. cerevisiae</em> is regulated by several transcription factors, including Yap1, and Gpx3 peroxidase, and one function of Yap1 is to regulate gene expression. Notwithstanding this information, many issues about the link between ROS production and apoptosis remain unsolved. ROS may disrupt cells or activate certain molecular and cellular pathways during cell death, promoting apoptosis. This review aims to elucidate ROS’s essence, their harm to cells, how <em>S. cerevisiae</em> reacts to ROS, and how ROS might affect cell integrity and cause cell death.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106069"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced bioactivity, antimicrobial efficacy and biocompatibility of silver-doped larnite for orthopaedic applications","authors":"Naveensubramaniam Vijayakumar ,&nbsp;Senthil Kumar Venkatraman ,&nbsp;Krishnamurithy Genasen ,&nbsp;Peggy Kong ,&nbsp;K.M. Nimmi Maria ,&nbsp;Anushree Suresh ,&nbsp;Jayanthi Abraham ,&nbsp;Sasikumar Swamiappan","doi":"10.1016/j.arabjc.2024.106055","DOIUrl":"10.1016/j.arabjc.2024.106055","url":null,"abstract":"<div><div>Bone tissue engineering is an interdisciplinary field at the forefront of regenerative medicine, aiming to develop innovative strategies for repairing and regenerating bone tissue. Biomaterials play a crucial role as it provides a supportive environment that facilitates cell attachment, proliferation, and differentiation for bone formation. The current work investigates the influence of silver doping on the physicochemical and biological properties of larnite (Ca₂SiO₄) for the application of bone tissue regeneration. In the current work combustion assisted sol–gel method was implemented to synthesize silver doped larnite which offers phase formation at lower temperatures. <em>In-vitro</em> biomineralization studies revealed that silver addition significantly improved hydroxyapatite (HAp) nucleation on the scaffold surfaces when immersed in simulated body fluid. The antibacterial studies of Ag-doped larnite powders were performed using broth dilution assay which showed bacterial inhibition up to 87 % at higher addition of silver concentrations against the clinical pathogens. The biocompatibility of the materials on human adipose-derived mesenchymal stromal cells (hAMSC’s) exhibited significant proliferation (<em>p</em> &lt; 0.05) on Ca_1.90Ag_0.10SiO₄ as compared with Ca₂Ag₀SiO₄. The increased Ag concentration was found to have a significant influence on the antibacterial properties without affecting the biocompatibility of larnite. These findings highlight the potential of Ag-doped larnite, particularly Ca_1.90Ag_0.10SiO₄, as a promising biomaterial for bone tissue engineering. It demonstrates excellent antibacterial efficacy while maintaining biocompatibility, addressing the critical balance between these two aspects for an optimal bone tissue regeneration.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106055"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Discovering common pathogenetic processes between polycystic ovary syndrome and uterine corpus endometrial carcinoma by bioinformatics and experimental approach” [Arab. J. Chem. 17 (2024) 105548]","authors":"Mingming Wang ,&nbsp;Kangyang Diao ,&nbsp;Mprah Richard ,&nbsp;Lefan Dai ,&nbsp;Tao Hu ,&nbsp;Huanhuan Ding","doi":"10.1016/j.arabjc.2024.106016","DOIUrl":"10.1016/j.arabjc.2024.106016","url":null,"abstract":"","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106016"},"PeriodicalIF":5.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of xanthoxyletin with protein, molecular docking and antitumor activity in human chronic myeloid leukemia K562 cells","authors":"Chen Wang ,&nbsp;Zhijie You ,&nbsp;Yihui He ,&nbsp;Siqi Chen ,&nbsp;Xin Chen ,&nbsp;Shuang Qu ,&nbsp;Ning Zhao ,&nbsp;Xin Chen","doi":"10.1016/j.arabjc.2024.106015","DOIUrl":"10.1016/j.arabjc.2024.106015","url":null,"abstract":"<div><div>Xanthoxyletin (C₁₅H₁₄O₄), a natural linear pyranocoumarin, is known to trigger anti-cancer activities, although its anticancer mechanisms are largely unknown. Human hemoglobin (HHb) as a major plasma protein could play a key role in the transportation and biodistribution of therapeutic molecules In this study, the interaction of xanthoxyletin with HHb was measured under physiological conditions using multi-spectroscopic techniques along with molecular docking simulation. Also, the interaction of xanthoxyletin with human chronic myeloid leukemia K562 cells was assessed by cellular assays. It was deduced that each xanthoxyletin molecule shows a thermodynamically favorable interaction with one molecule of HHb with a binding constant (K_b) in the orders of 10^3-4 M⁻¹. These interactions did not significantly result in the loss of α-helical content of HHb. In silico studies supported the experimental findings and demonstrated that non-covalent forces including hydrogen bonds (Ala88 and Arg92), pi-pi stacking (Trp37), and hydrophobic interactions (and Pro95 and Pro36) are the main forces contributing to the xanthoxyletin-HHb complex formation. Cellular and molecular assays showed that xanthoxyletin mitigated the proliferation of K562 cells through apoptosis induction mediated by overexpression of p53, caspase-3, and PARP cleavage. This data may hold great promise for the development of anticancer compounds with potential blood protein binding stemming from xanthoxyletin derivatives/hybrids.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106015"},"PeriodicalIF":5.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bone-targeting delivery platform based on mesoporous silica loaded with piR7472 for the treatment of osteoporosis","authors":"Long Yubin ,&nbsp;Ma Yuan ,&nbsp;Yang Houzhi ,&nbsp;Wang Xiangbin ,&nbsp;Fan Jigeng ,&nbsp;Li Yong ,&nbsp;Tao Bo ,&nbsp;Sun Tianwei","doi":"10.1016/j.arabjc.2024.106040","DOIUrl":"10.1016/j.arabjc.2024.106040","url":null,"abstract":"<div><div>Promoting osteogenic differentiation and inhibiting osteoclast formation remain significant challenges in the treatment of osteoporosis. With the growing understanding of osteoporosis, increasing literature has highlighted the regulatory role of m6A methylation in this condition. However, there is currently no reliable method to stably regulate cellular m6A methylation levels. Here, we report a novel approach utilizing alendronate (aln)-modified mesoporous silica nanoparticles (MSNs) to deliver sodium bicarbonate and piR7472, modulating cellular behavior. Our experimental results demonstrate that Aln modification enables the nanoparticles to stably target hydroxyapatite, thereby accumulating in osteoporotic regions. Sodium bicarbonate suppresses osteoclastogenesis, while piR7472 enhances m6A methylation, promoting osteogenic differentiation of bone marrow stromal cells (BMSCs). Computed tomography (CT) and hematoxylin and eosin (HE) staining showed that after 2 weeks of treatment with MSNs-Na@piR7472, cortical bone thickened, trabecular bone density increased, collagen fiber thickness improved, and both the number and staining area of osteoclasts were significantly reduced. These findings indicate a marked improvement in osteoporosis.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106040"},"PeriodicalIF":5.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of micropatterning with nanowire-based microcavity array on bacterial enrichment and selective distribution","authors":"Yifan Wang ,&nbsp;Yuting Huang ,&nbsp;Hui Che ,&nbsp;Biaowen Wei ,&nbsp;Liyuan Zheng","doi":"10.1016/j.arabjc.2024.106013","DOIUrl":"10.1016/j.arabjc.2024.106013","url":null,"abstract":"<div><div>The micro-patterned topography can affect bacterial enrichment and selective distribution by modifying the characteristics of material surface. In this study, we fabricated microcavity patterned silicon surfaces, and quantitatively explored the amount and distribution of Escherichia coli (<em>E. coli</em>) cells attached on a series of defined topographies. The results showed that <em>E. coli</em> cells enrichment was significantly increased on silicon nanowires-based microcavity array when compared to nanowires patterned silicon wafer. Furthermore, the microcavity diameter can control bacterial distribution by changing hydrophilic performance of interface. With the microcavity diameter of 7 µm, the cells colonized into the microcavity almost in its entirety, whilst distributed around the microcavity completely with 10 µm diameter, regardless of centre distances. This phenomenon can be explained by the Cassie-Baxter model equation according to the wettability. The distribution of bacterial enrichment changed with the silicon surfaces turning from non-wetting status to wetting status when treated with oxygen plasma to modify the hydrophobicity. These results demonstrated that microcavity patterned surface could favor bacterial enrichment on silicon and strictly confined bacterial distribution inside/outside the microcavity. Moreover, the nanowires inside microcavity can also increase electron conductivity and reduce the internal resistance, thus providing scientific evidence for the design of wearable microbial fuel cell with rational optimization and integration of different components for electronic skin.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106013"},"PeriodicalIF":5.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bimetallic FeCo metal–organic framework based cascade reaction system: Enhanced peroxidase activity for antibacterial performance","authors":"Siyuan Zhang ,&nbsp;Wenbo Wu ,&nbsp;Ya Li ,&nbsp;Dongxin Wang ,&nbsp;Xiangjun Li ,&nbsp;Jisheng Nie ,&nbsp;Hong Cui","doi":"10.1016/j.arabjc.2024.106032","DOIUrl":"10.1016/j.arabjc.2024.106032","url":null,"abstract":"<div><div>Metal-organic frameworks (MOFs), as a peroxidase (POD), can catalyze the conversion of H₂O₂ to reactive oxygen species (ROS) for antibacterial application. To achieve strong antibacterial activity, it is necessary to improve the enzyme-like activity of MOFs. In this study, Fe_xCoMOF was synthesized by incorporating Co(II) to improve the electron transfer of Fe(III)/Fe(II), which enhanced its redox capacity as a nanozyme and further promoted the generation of hydroxyl radical (⋅OH), exhibiting higher POD activity. Doping with different amounts of Co(II) altered the particle size, specific surface area, and surface defects of Fe_xCoMOF, thus exhibiting differential enzyme-like activities. Additionally, a glucose-responsive enzyme cascade reaction system based on Fe₄CoMOF/glucose oxidase (GOx) was established. In the presence of glucose, the <em>in situ</em>-generated substrate H₂O₂ was in contact with the catalytic site and the generated gluconic acid enabled Fe₄CoMOF to maintain maximum enzyme activity under physiological pH conditions, avoiding damage caused by the use of exogenous high concentrations of H₂O₂. In the <em>in vitro</em> antibacterial experiment, the minimum inhibitory concentration (MIC) of Fe₄CoMOF/GOx was 10 μg mL⁻¹ for <em>Escherichia coli</em> (<em>E. coli</em>) and 5 μg mL⁻¹ for <em>Staphylococcus aureus</em> (<em>S. aureus</em>) (∼10⁸ CFU mL⁻¹). The increase in enzyme activity resulted in a considerable reduction in the dose of the antibacterial agent, which was conducive to improving bio-safety. The <em>in vivo</em> experiment in mice demonstrated that the glucose-responsive Fe₄CoMOF-based cascade reaction system had excellent antibacterial properties and remarkably promoted wound healing. The antibacterial agent based on bimetallic MOF developed in this work provides a new idea for cascade catalytic antibacterial therapy and will have remarkable application prospects in biomaterials and nanomedicine.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106032"},"PeriodicalIF":5.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conessine alleviates PTZ-induced epilepsy in rat model via attenuating neuroinflammation and oxidative stress","authors":"Fang Chen,&nbsp;Tingting Peng,&nbsp;Mengjiao Gou","doi":"10.1016/j.arabjc.2024.106009","DOIUrl":"10.1016/j.arabjc.2024.106009","url":null,"abstract":"<div><div>Epilepsy is a complex neurological disorder which affects the quality life of individual and also hinders the economic status of both the individuals and the country since it requires prolonged medications. The etiology of epilepsy is varied and the neuroinflammation has been considered to be the prime initiator and the stimulator of the disease progression. Therefore anti-inflammatory drugs are suggested to treat seizure and also to prevent epilepsy. The currently available antiepileptic drugs cause’s adverse effects which obstructs the usage of these drugs and also these drugs are not cost effective. Phytochemicals are effective alternative to these drugs and it is prescribed in the traditional medicine. Conessine, a steroidal alkaloid present in bark extracts of Holarrhena sps possess antibiotic, anti-diarrheal, antimalarial and anti-inflammatory properties. We evaluated the antiepileptic potency of conessine in PTZ challenged animal model treated with 10 and 20 mg/kg of conessine respectively. The seizure induction, severity and the behavioral changes were observed in the rats. The impact of conessine on neurochemical signaling in PTZ challenged rats were assessed via quantifying the neurotransmitter and ATPase levels in the brain tissue. Antioxidants and MDA levels were measured to evaluate the antioxidant potency of conessine in epilepsy induced rats. iNOS and nNOS which are inducers of NO during epileptic conditions were analyzed in the test rats. The stimulators and inflammatory cytokines levels were quantified in the brain to analyze the anti-neuroinflammatory efficacy of the conessine in PTZ challenged rats. AKT/mTOR prime signaling proteins in initiation and progression of epilepsy was quantified in the brain tissue of experimental animals. Neurodegeneration inducers cytochrome <em>c</em>, NF-κB, COX-2 and Caspase 3 were quantified to evaluate the ameliorative potency of conessine against PTZ induced neuronal damage. The neuroprotective and antiepileptic potency of conessine was confirmed with the histopathological scoring of brain tissue in PTZ challenged rats. Conessine treatment effectively inhibited the seizure induction and regulated the neurochemical signaling in epileptic induced rats. It also attenuated the neuroinflammation and oxidative stress induction induced by PTZ treatment. The prime signaling proteins nitric oxide synthatase and AKT/mTOR signaling proteins were effectively inhibited by the conessine treatment which eventually prevented the neurodegeneration inducers. Conessine treatment significantly enhanced the levels of Caspase 3. The histopathological analysis confirms the neuroprotective, anti-inflammatory and antiepileptic potency of conessine. Conessine treatment also doesn’t caused any behavioral alterations in the rats hence it is safe and potent alternative for currently available antiepileptic drugs.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106009"},"PeriodicalIF":5.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}