Arabian Journal of Chemistry最新文献

{"title":"Fabrication of Fe ₃ O ₄ /GO-based precious metal composite and research in comprehensive photocatalysis of organic pollutants with mechanism","authors":"Rui Wu, Xi Song, Junhong Wang","doi":"10.25259/ajc_135_2025","DOIUrl":"https://doi.org/10.25259/ajc_135_2025","url":null,"abstract":"As a common antibacterial drug and organic dye, ciprofloxacin (CIP) and acid orange (AO) residues have posed a serious threat to ecosystems and human health. To solve this problem, Fe 3 O 4 /GO-based precious metal composites (Fe 3 O 4 /GO/M: Fe 3 O 4 /GO/Au, Fe 3 O 4 /GO/Ag) were prepared as catalysts to photocatalyze pollutants. The Fe 3 O 4 /GO/Au and Fe 3 O 4 /GO/Ag) composites underwent comprehensive characterization, including X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscope (SEM), energy dispersive spectroscopy (EDS)- mapping, and X-ray photoelectron spectroscopy (XPS). Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and diffuse reflectance spectroscopy (DRS) were carried out. It was demonstrated that the Fe 3 O 4 /GO/M composite were successfully fabricated with excellent properties. The Fe 3 O 4 /GO and Fe 3 O 4 /GO/M composite performed adsorption and unique photocatalysis properties, respectively. The Fe 3 O 4 /GO/M composites were assessed through synergized adsorption-photocatalysis degradation of AO II and CIP. The pseudo-first-order and pseudo-second-order kinetic models, as well as Langmuir and Freundlich isotherms models were employed to evaluate the adsorption performance. The influence of various factors on photocatalysis were investigated in detail. The findings indicated that the composites demonstrated remarkable capabilities for pollutant removal, with the degradation rates of (84 ± 3.3) % for AO II by Fe 3 O 4 /GO/Au and (89 ± 3.9) % for CIP by Fe 3 O 4 /GO/Ag, respectively. The scavenger analysis and total organic carbon (TOC) was also conducted. The photocatalysis mechanisms was also highlighted in detail. It was primarily attributed to the surface plasmon resonance (SPR) of the precious metals and the charge transfer of graphene oxide (GO). Furthermore, the catalyst exhibited nice reusability in six consecutive cycle experiments. A preferable approach to fabrication of Fe 3 O 4 /GO/M composite and photocatalytic degradation of organic pollutants was established.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"1352025-1352025"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of biological activities and phytochemical constituents between <i>Pegaeophyton scapiflorum</i> and <i>Solms-laubachia eurycarpa</i> revealed by UPLC-Q-Orbitrap HRMS-based metabolomics","authors":"Si-Yan Yang, Shiqi He, Yuan Li, Jielin Zhang, Ying Chen, Cai-Ren Banma, Rui Gu","doi":"10.25259/ajc_475_2025","DOIUrl":"https://doi.org/10.25259/ajc_475_2025","url":null,"abstract":"Pegaeophyton scapiflorum (DHJ) and Solms-laubachia eurycarpa (KGCF) are perennial herbs from the cruciferous family. Historically, these two herbs have been documented to be effective in clearing lung heat and have been widely used clinically to treat symptoms such as pneumonia, colds, and fever. However, due to the scarcity of resources and the similarity of morphological features, the two are often confused in practical applications. In this study, ultra-performance liquid chromatography coupled with quadrupole-Orbitrap high-resolution mass spectrometry (UPLC-Q-Orbitrap HRMS) was employed to comprehensively identify the chemical components of DHJ and KGCF. Leveraging non-targeted metabolomics analysis, we systematically elucidated the compositional disparities between these two herbals and further evaluated their respective biological activities. The UPLC-Q-Orbitrap HRMS technique enabled the identification of 82 compounds. The differences in the chemical compositions of the two herbs could clearly be observed through the chromatographic base peaks and ion flow diagrams. Further screening revealed a total of 41 differential metabolites, including hispidulin, α-linolenic acid, and chlorogenic acid. Additionally, the aqueous extracts of both herbs exhibited good anti-inflammatory and antioxidant activities. Under high-concentration conditions, both extracts significantly alleviated lipopolysaccharide (LPS)-induced cellular inflammatory responses. Moreover, IC50 analysis quantitatively demonstrated that DHJ outperformed KGCF in terms of anti-inflammatory and antioxidant efficacy. However, these results have not yet been validated in vivo . In summary, the present study not only provides a scientific basis for the in-depth analysis of the compositional differences between the two herbs and their anti-inflammatory and antioxidant properties, but also lays a theoretical foundation for the establishment of their quality evaluation system.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"4752025-4752025"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorption of azithromycin pharmaceutical by polypyrrole and polypyrrole/zinc ferrite@magnetite (PPy/ZnFe₂O₄@Fe₃O₄) adsorbents synthesized from deep eutectic solvent: Kinetic, isothermic, and thermodynamic studies","authors":"Ahmad F. Hamasdiq, Hani K. Ismail, Rebaz Anwar Omer","doi":"10.25259/ajc_635_2025","DOIUrl":"https://doi.org/10.25259/ajc_635_2025","url":null,"abstract":"The aim of this study was to use novel polypyrrole (PPy)/zinc ferrite@magnetite (PPy/ZnFe 2 O 4 @Fe 3 O 4 ) and PPy compounds as adsorbents to remove azithromycin (AZM) from aqueous solutions. These adsorbents were made by chemical polymerization in a deep eutectic solvent (DES) known as oxaline. A range of techniques, such as Fourier transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), vibrating sample magnetometer (VSM), Brunauer-Emmett-Teller (BET), and zeta potential, were employed to comprehensively evaluate the synthesized adsorbents. Additionally, adsorption tests were conducted to examine the influences of AZM concentration, pH, contact duration, and adsorbent dose. The ideal results indicate that AZM removal effectiveness was 62.3% for PPy and 98.5% for PPy/ZnFe 2 O 4 @Fe 3 O 4 under the following conditions: pH 6, with 80 mg of PPy and 60 mg of PPy/ZnFe 2 O 4 @Fe 3 O 4 adsorbents, a drug concentration of 100 mg/L, and stirring for 180 min. The adsorption process was thoroughly investigated using the kinetic and isothermal models. The pseudo-second-order kinetic and Langmuir models were identified as the most accurate representations of AZM adsorption for both adsorbents at 298 K. Additionally, the data demonstrated that pure PPy had an adsorption capacity of 80.13 mg/g, but the PPy/ZnFe 2 O 4 @Fe 3 O 4 nanocomposite had a high adsorption capacity of 183.73 mg/g. Thermodynamic analysis revealed that the adsorption process was spontaneous and endothermic. The adsorbent exhibited exceptional regenerative properties, allowing for reuse throughout five cycles. The study also investigated the adsorption of AZM medicines from real tablet samples utilizing the PPy/ZnFe 2 O 4 @Fe 3 O 4 nanocomposite. These results showed the good absorbent capacity of PPy/ZnFe 2 O 4 @Fe 3 O 4 in the efficient removal of AZM from water sources.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"6352025-6352025"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tea waste-derived porous carbon: Electrochemical performance regulation and sensing applications","authors":"Qi Jia, Yicheng Yao, Liudi Ji, Xiaoming Zhu, Zeyu Li, Peng Hu","doi":"10.25259/ajc_195_2024","DOIUrl":"https://doi.org/10.25259/ajc_195_2024","url":null,"abstract":"In this study, three porous carbon materials were prepared by using Xinyang maojian tea (MJ), black tea (BLT), and brick tea (BRT) waste. The tea waste-derived porous carbons (MJ-PC, BLT-PC, BRT-PC) exhibited different morphology and pore structure. Loose porous structures were obtained from BRT waste, maybe due to their original structure. Moreover, MJ-PC, BLT-PC, and BRT-PC showed varied electrochemical active surface areas (ECSAs), electron transfer abilities, electrocatalytic activity, and electrochemical oxidation capacity for p-aminophenol (4-AP) and acetaminophen (AC). As a result, the BRT-PC was selected as the sensitive material due to its outstanding performance, and a sensitive, reproducible, and selective electrochemical sensing platform for the simultaneous determination of 4-AP and AC was developed. Their detection limits are as low as 7 nM and 0.09 nM. Moreover, it has a high recovery in the detection of 4-AP and AC in paracetamol tablets and river water. This study provides a new way to tune the electrochemistry of porous carbon materials and to design new applications.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"0 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147892038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the fluorescent chiral derivatization reagent DBMA for targeting amino functional groups: An application in the analysis of DL-amino acids in the saliva of patients with diabetes","authors":"Xiaoqing Cong, Xiaoxi Man, Xiao Shu-yun, Yuxuan Li, Xiling Li, Mingshan Zheng, Jun Zhe Min","doi":"10.25259/ajc_127_2025","DOIUrl":"https://doi.org/10.25259/ajc_127_2025","url":null,"abstract":"The study developed a novel chiral fluorescence (FL) derivatization reagent, ( R )-1-(7-( N,N -dimethylsulfamoyl)-benzo[ c ][1,2,5]oxadiazol-4-yl)-2-methylpyrrolidine-2-carboxylic acid (DBMA), targeting the amino functional group. Eighteen DL-amino acids were tested for chiral separation efficiency using ultra-performance liquid chromatography-FL (UPLC-FL). DBMA and DL-amino acids formed diastereomers following reaction conducted at 40°C for 30 min, employing 1-(3-dimethylaminopropyl)-3-ethylcarbohydrazide (EDC) and hydroxybenzotriazole (HOBt) condensation agents. The analysis was performed using a BEH C18 column (2.1 × 100 mm, 1.7 μm) with detection wavelengths set at 460 nm (excitation) and 550 nm (emission). The mobile phase consisted of two components: an aqueous phase containing 10 mM ammonium acetate with 0.05% formic acid (FA), and an organic phase comprising either 0.1% FA in acetonitrile or 0.1% FA in MeOH. The results demonstrated that the Rs was 1.51-4.40, indicating a favorable chiral separation effect. Furthermore, the method was extended to the simultaneous detection of four DL-amino acids (DL-Asp, DL-Thr, DL-Ile, and DL-Lys) from 31 healthy volunteers and 19 diabetic patients. The R 2 was ≥ 0.9991 in the 5-2000 μM concentration range, with a limit of detection ranging from 2.5 to 25 pmol. The intraday and interday precisions ranged from 1.13% to 9.25%. Diabetic patients exhibited notably elevated average concentrations of D-Asp, DL-Thr, L-Ile, and DL-Lys in their saliva, in contrast to healthy volunteers. The disparity was determined to have statistical significance ( p &lt; 0.01). Furthermore, the ratios of D/L-Asp, D/L-Thr, and D/L-Lys were statistically significant ( p &lt; 0.01). DBMA, a novel fluorescent chiral derivatizing agent, enables enantioselective detection of D/L-amino acid biomarkers in biological matrices. This introduces an innovative chiral derivatization agent for studying chiral metabolomics.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"1272025-1272025"},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://arabjchem.org/content/184/2025/18/9/pdf/AJC-18-1272025.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-component fluorescence composite strategy for constructing a mesh coating pattern: Design, synthesis, cell imaging, and bioactivity study of a visual antitumor fluorescent complex","authors":"Haixia Gu, Yuanye Wan, Zhipeng Xu, Jian‐Peng Hu, Guofan Jin","doi":"10.25259/ajc_108_2024","DOIUrl":"https://doi.org/10.25259/ajc_108_2024","url":null,"abstract":"A novel visualized anti-tumor complex was designed to accomplish the targeting and visualization of anti-tumor drugs, thereby reducing adverse drug reactions and achieving precision medicine. One-pot fluorescent complexes were created using isorhamnetin, nido -carborane, and rhodamine B as raw materials. By embedding these complexes in four medicinal acrylic resins, which are high molecular-weight polymers prepared by polymerization reactions of acrylic acid or methacrylic acid and their ester monomers, a series of fluorescent anti-tumor complexes Eudragit ® L 100-55@isorhamnetin/ nido -carborane/rhodamine B ( L-ICR ), Eudragit ® E PO@isorhamnetin/ nido -carborane/rhodamine B ( E-ICR ), Eudragit ® RS 100@isorhamnetin/ nido -carborane/rhodamine B ( S-ICR ), and Eudragit ® RL 100@isorhamnetin/ nido -carborane/rhodamine B ( R-ICR ) were created, which enhanced the bioavailability and stability of isorhamnetin and nido -carborane and made it possible to see the specific locations where medications were targeted. L-ICR was then screened using the cell proliferation toxicity test (CCK8), which had a greater anti-tumor effect. As the concentration of L-ICR reached 24 µg/mL, the inhibition rate of HeLa cells and PC3 cells was 67.66% and 48.25%, respectively. Using transmission electron microscopy (TEM), it was observed that the internal microstructure of L-ICR was tightly wrapped in an acrylic resin network. According to in vitro tumor cell imaging experiments, L-ICR exhibited good biocompatibility and selectivity, as most tumor cells were successfully entered into the nucleus. The complex in this study was a good fluorescent anti-tumor complex, with great imaging and targeting effect, and anti-tumor ability, which provided a new idea for the further development of anti-tumor drugs in the future.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"1082024-1082024"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of trifunctional magnetic ZnO-based biochar for pollutions removal from wastewater","authors":"Chao Lv, Haoyu Li, Xiaojing Qin","doi":"10.25259/ajc_345_2025","DOIUrl":"https://doi.org/10.25259/ajc_345_2025","url":null,"abstract":"The trifunctional magnetic Fe 3 O 4 /ZnO-based biochar (ZF-BC) was prepared for the removal of levofloxacin and Cr 6+ from wastewater in single and binary contaminant systems. The physical and chemical properties of the ZF-BC were characterized and analyzed. The adsorption amounts of levofloxacin and Cr 6+ for ZF-BC are 332.11 and 34.40 mg/g in a single contaminant system based on Hill model calculation, respectively. Levofloxacin slightly contributes to Cr 6+ , while levofloxacin adsorption on ZF-BC is restrained at high Cr 6+ concentration in the binary contaminant system. The levofloxacin and Cr 6+ adsorption mechanism were investigated and analyzed, combined with density functional theory calculations. ZF-BC also has excellent reusability and stability for levofloxacin and Cr 6+ adsorption. Using the photocatalytic degradation system, 97.60% of levofloxacin and 79.43% of Cr 6+ were removed. The photocatalytic degradation mechanism analysis indicates that levofloxacin is first adsorbed on ZF-BC and then used as the hole sacrificial agent to release more electrons/holes to participate in the Cr 6+ redox reaction.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"3452025-3452025"},"PeriodicalIF":0.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://arabjchem.org/content/184/2025/18/8/pdf/AJC-18-3452025.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of CuCl₂ modified biochar for levofloxacin removal from municipal wastewater","authors":"Lixiang Cui, Kejun Bi, Tianlun Cui, Shuqi Feng, Qi Wang, Shanshan Zhao","doi":"10.25259/ajc_438_2025","DOIUrl":"https://doi.org/10.25259/ajc_438_2025","url":null,"abstract":"The residual quantities of levofloxacin (LFX) in the ecology have caused extremely serious problems due to the misuse of LFX. Copper-modified biochar (Cu-BC) is prepared by co-pyrolysis of CuCl 2 with fir sawdust (FS) for LFX removal by adsorption, activation of peroxydisulfate (PDS) degradation and the photocatalytic degradation process. The physicochemical properties of the Cu-BC were investigated and analyzed, which include Cu, Cu 2 O, and CuO. Cu-BC can adsorb LFX with an adsorption amount of 97.35 mg/g, which is larger than that of the original biochar (BC). The π-π interactions, H-bonding, and surface functional groups are responsible for LFX adsorption, based on adsorption mechanism analysis. Cu-BC activation PDS can highly efficient realize LFX removal. The e - generated from the Cu + /Cu 2+ cycling are gathered around Cu to form the electron-rich center for achieving activation of PDS degradation of LFX, reducing its toxicity. While 1 O 2 and SO 4 • - significantly influence the LFX degradation process, based on degradation mechanism analysis. Besides, the Cu-BC can be used as the photocatalyst for LFX removal owing to the existence of Cu 2 O. The photocatalytic degradation mechanism of LFX is also put forward.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"4382025-4382025"},"PeriodicalIF":0.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://arabjchem.org/content/184/2025/18/8/pdf/AJC-18-4382025.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly performant biochar prepared <i>via</i> co-activation designed for the removal of antibiotics","authors":"Wanting Liu, Tao Yuan, Keke Zhang, Shanshan Tang, Yiping Jin, Siji Chen, Dadong Liang, Jian Li, Qi Sui, Lin Li","doi":"10.25259/ajc_199_2025","DOIUrl":"https://doi.org/10.25259/ajc_199_2025","url":null,"abstract":"Antibiotics in water bodies pose a serious threat to the ecosystem and human health, necessitating the development of environmentally friendly and sustainable adsorbents for water purification. This paper proposes a novel ratio of adsorbents K 2 FeO 4 , KHCO 3 , and rice straw (RS) in composites. The synergistic co-activation of K 2 FeO 4 and KHCO 3 significantly enhances the adsorption performance through surface modification and porosity development, which is 4.21 times that of the original biochar (BC). The adsorption behavior of the composites under different conditions was investigated by varying the adsorbent dosage, tetracycline hydrochloride (TH) concentration, and pH. The removal rate of TH in water by magnetic materials is 85.93%, an increase of 65.54% compared with the original BC. The removal performance of 1RS-2Fe-1K was better than most adsorbents, and its adsorption performance in real water was also satisfactory. The removal rate of TH in all water bodies was above 80%. A fixed bed column experiment revealed that 1RS-2Fe-1K was suitable for the continuous adsorption of TH in an aqueous medium, which was completed after 1,840 min. Washing with deionized water improves the protonation of functional groups and layer-by-layer exposure of the composite structure in 1RS-2Fe-1K. It also improves the reusability of the composite. Repeated use tests confirmed a retention rate of 50.81% after five cycles. From an economic perspective, using agricultural waste as a feedstock reduces raw material costs, while the co-activation process ensures high adsorption efficiency with minimal additional inputs. Environmentally, this approach minimizes waste and promotes sustainable water treatment. This study provides a new perspective on utilizing agricultural waste composites as sustainable adsorbents, offering a cost-effective and environmentally friendly solution for the removal of antibiotics from water.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"1992025-1992025"},"PeriodicalIF":0.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://arabjchem.org/content/184/2025/18/8/pdf/AJC-18-1992025.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147881999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual chemical-photothermal drug delivery platform inhibits LPS-induced oxidative damage by suppressing the p38 MAPK pathway in cardiomyocytes","authors":"Xi Han, Yue Li, Xuelian Zhu, Pengxia Zhang","doi":"10.25259/ajc_348_2025","DOIUrl":"https://doi.org/10.25259/ajc_348_2025","url":null,"abstract":"Heart failure (HF) is a complex clinical syndrome marked by impaired cardiac function, often driven by cardiomyocyte apoptosis. The latter is induced by myocardial infarction, atherosclerosis, or ischemia-reperfusion injury, with oxidative stress playing a central role in progression. In this study, a therapeutic molecule (compound I) targeting HF was synthesized and loaded into a zwitterionic amphiphilic polymer nanocarrier system (PSBMA-CP1@I), constructed via coordination between compound I and CP1. The structural and optical properties of PSBMA-CP1@I were systematically characterized. Fluorescence spectroscopy revealed that the introduction of compound I led to significant emission quenching of the PSBMA-CP1 scaffold under 365 nm excitation (from ∼432 nm), indicating successful drug loading. Fluorescence titration experiments conducted in the 0–2400 pM range showed a concentration-dependent response with a Stern–Volmer quenching constant (K SV ) of 1.63 × 10⁶ M⁻ 1 and good linearity in the low concentration region (0–750 pM, R 2 = 0.9930), demonstrating high detection sensitivity. pH-responsive release tests indicated enhanced release of compound I under acidic conditions (pH 5.0), with a cumulative release of up to 75% within 60 minutes, compared to a much slower release at pH 7.4. Moreover, in vitro studies in lipopolysaccharide (LPS)-stimulated H9C2 cells showed that PSBMA-CP1@I effectively attenuates oxidative damage and modulates p38-MAPK signaling, supporting its application in anti-inflammatory and cardioprotective therapies.","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"3482025-3482025"},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}