Journal of obesity and weight loss therapy最新文献

{"title":"Validity of newly developed BMI and waist cutoff values for Sri Lankan children.","authors":"P. Wickramasinghe","doi":"10.4172/2165-7904.1000282","DOIUrl":"https://doi.org/10.4172/2165-7904.1000282","url":null,"abstract":"","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117228811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Into Thinner Air: A Novel Strategy to Improve Clinical Outcomes and Support Weight Loss?","authors":"S. Carter","doi":"10.4172/2165-7904.1000E118","DOIUrl":"https://doi.org/10.4172/2165-7904.1000E118","url":null,"abstract":"Despite well-intentioned health policy and research efforts, the obesity crisis continues to plague modern society. While multiple factors have been implicated, the source of this problem remains hotly debated, and one which is likely to continue for the foreseeable future. According to the World Health Organization, the majority of annual deaths among the populous are attributable to non-communicable chronic diseases (e.g., type 2 diabetes, cancer) [1], known to be intimately linked to excess adiposity and poor cardiorespiratory fitness [2]. It is generally felt that an overabundant caloric load coupled with insufficient physical activity is responsible. To this end, energy restriction and increased physical activity are recommended to support weight loss; however, long-term adherence is difficult and often met with limited success. As many have discovered, feelings of hunger and lethargy commonly arise during dieting which in some cases are exacerbated with concurrent exercise. Excluding surgical techniques, the ideal strategy to promote expeditious weight loss is through the collective influence of appetite suppression and increased energy expenditure. In the absence of disease, appetite suppression and increased energy expenditure are natural, adaptive responses to higher altitude (i.e., hypoxia). As of late, there is a growing interest in the therapeutic utility of exercise in hypoxic conditions for the purpose of improving a variety of clinical outcomes [3-5].","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131547485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Image: Coronary Atherosclerosis","authors":"Brandon Micsh","doi":"10.4172/2165-7904.1000I002","DOIUrl":"https://doi.org/10.4172/2165-7904.1000I002","url":null,"abstract":"","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123560974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations of oxidized low density lipoprotein with insulin, leptin and risk of cardiovascular disease in a group of diabetic obese Tunisian women.","authors":"F. B. Slama, Wala Gaaloul Helali, F. Mami, M. C. B. Rayana, O. Belhadj, H. Skhiri","doi":"10.4172/2165-7904.1000279","DOIUrl":"https://doi.org/10.4172/2165-7904.1000279","url":null,"abstract":"At the obese diabetic ones, there’s a disturbance of lipid parameters from where the installation of an insulin resistance responsible for the development of non-insulin-dependent diabetes. \u0000Objectives: Our objectives were to evaluate the levels of insulin, leptin and oxidized LDL, and to search the link which could exist between these parameters and obesity represented by the body mass index (BMI >30 kg/m2). \u0000Methods: We proportioned the rate in total cholesterol, triglycerides, blood glucose, insulin, leptin, cholesterol LDL, cholesterol HDL and oxidized LDL at 53 obese women diabetic not carrying pathologies other than the diabetes type 2 and obesity compared to 21 witnesses who theirs are paired according to the age. \u0000Results: Our results shows that levels of total cholesterol, triglycerides, blood glucose, insulin, leptin, cholesterol LDL and oxidized LDL were higher in obese women with non-insulin-dependent diabetes mellitus compared with control group. Moreover a positive and significant correlation between body mass index and blood glucose (r=0.408, p=0.002), leptin (r=0.436, p=0.001), insulin (r=0.403, p=0.003), cholesterol LDL (r=0.365, p=0.007) and oxidized LDL (r=0.632, p<0.001) and a negative and significant correlation between body mass index and cholesterol HDL (r=-0.345, p=0.011) were observed. An analysis multivariate linear regression showed that leptin, cholesterol LDL and oxidized LDL were directly correlated with body mass index. Different biochemical parameters were correlated between each other and with body mass index. Leptin, cholesterol LDL and oxidized LDL were directly correlated to obesity. Body mass index is a strong predictor of leptin circulating levels, cholesterol LDL and oxidized LDL. \u0000Conclusion: Body mass index can predict leptin, cholesterol LDL and oxidized LDL circulating levels. So these parameters involved in diabetes mellitus and cardiovascular diseases can be controlling by regulation of body weight and prevention of obesity.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"8 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134393207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Does Bariatric Surgery Improve Type II Diabetes? The ''Neglected'' Importance of the Liver in Clearing Glucose and Insulin from the Portal Blood","authors":"S. Alwahsh, G. Ramadori","doi":"10.4172/2165-7904.1000280","DOIUrl":"https://doi.org/10.4172/2165-7904.1000280","url":null,"abstract":"The pandemic of obesity due to food “addiction” has led to a dramatic increase in rates of Type II Diabetes Mellitus (T2DM). T2DM is characterized by increased glucose and insulin (but not of the C-peptide) serum levels. Increase of insulin serum level without increase of insulin synthesis is supposed to be due to insulin resistance. Reduction of body weight (BW) through reduction of calories uptake is the most effective measure to treat T2DM and metabolic syndrome in obese patients. Appetite suppressant drugs which potentially reduce BW have several side effects, and as \"lifestyle modifiers\" are not approved of as potential antidiabetic drugs. In addition to the treatment of extreme (BMI ≥ 40) obesity, surgeons have expanded the offer of bariatric surgery as therapeutic option for diabetic, \"non-morbid\" (BMI ≤ 35) obesity. As a \"collateral effect\" of this surgical intervention, acute and long-term improvement of T2DM has been observed. Although several hypotheses to explain this improvement have been reported, the exact mechanism underlying the reduced hyperglycemia and hyperinsulinemia immediately after surgery is unclear. Though long-term effects of the different operations have not yet been studied thoroughly. Besides weight-loss, bariatric surgery may also reduce lipid accumulation in the liver. Reverse of the hepatic lipid deposition may improve clearance of glucose and insulin from the liver and consequently lead to reduction their concentrations in the peripheral blood. This mechanism has not, however, been considered when effects of bariatric surgery on glucose metabolism have been reported. In fact, a few reports on limited patients number already published have given information about changes of liver size and/or liver lipid content at different time points postoperation. Future prospective studies should focus on the changes in glucose and lipid metabolism induced in the liver by the various types of surgical interventions.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114254499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight Loss Pharmacotherapy of Obese Non-Diabetic and Type 2 Diabetic Patients","authors":"Fábryová Ľubomíra","doi":"10.4172/2165-7904.1000277","DOIUrl":"https://doi.org/10.4172/2165-7904.1000277","url":null,"abstract":"The first line in the treatment of obesity is a combination of a low calorie diet, increased physical activity and behavioural therapy. Unless these options fail, should be considered an effective and safe pharmacotherapy. The market situation in anti-obesity treatment will change in a relatively short time; the combination anti-obesity therapy is entering into clinical practice. Currently in Europe we have three drugs approved for long-term chronic treatment of obesity. In addition to the orlistat EMA approved a combination of naltrexon SR/bupropion SR and liraglutide 3.0 mg. A specific feature management of obese diabetic patients is the selection of weight neutral or weight-reducing anti-diabetic treatment (oral anti-diabetics, insulin), but also weight neutral treatment associated with co-morbidities.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116317499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics are Not Significant Predictors of Advanced Obstructive Sleep Apnea in the Severely Obese","authors":"L. Benoit, A. Malhotra, J. Sebastian, C. Agborsangaya, M. Bhutani, R. Padwal","doi":"10.4172/2165-7904.1000278","DOIUrl":"https://doi.org/10.4172/2165-7904.1000278","url":null,"abstract":"Introduction: Obstructive Sleep Apnea (OSA), present in 30-93% of bariatric patients, is an independent predictor of post-bariatric surgery complications. Universal screening with Polysomnography (PSG), the gold \u0000standard test for OSA, would be difficult to access and costly to perform. The purpose of this study was to identify clinically important, statistically significant predictors of moderate-to-severe OSA in a bariatric population that would enable providers to stratify or prioritize patients needing PSG. \u0000Methods: A cross-sectional study was performed in patients referred for clinical suspicion of OSA. All patients underwent PSG. From a list of potential covariates deemed clinically important, multivariable binary logistic regression was used to identify statistically significant predictors (p<0.05) of moderate-to-severe OSA. Subjects were recruited from a bariatric specialty program in Edmonton, Alberta, with a central, region-wide, single-point-ofaccess referral system. \u0000Results: Of 169 patients undergoing PSG, 161 (95.3%) had complete data. Mean age was 48.7 ± 9.1 years, \u000045(28%) were men, mean body mass index (BMI) was 49.5 ± 9.7 kg/m2. 96(60%) patients had moderate-to-severe OSA and the mean Apnea-Hypopnea Index (AHI) was 27.0 ± 27.3. The strongest predictors of OSA were neck circumference (OR 1.08; 95% CI 0.99-1.18) and hypertension (OR 1.95, 95% CI 0.93-4.09). However, no variable reached statistical significance. \u0000Conclusion: Despite a model adequately powered to identify 16-32 statistically significant predictors, none was found. Given the high prevalence of OSA in patients undergoing bariatric care, the lack of identifiable predictors mandates that objective sleep testing be performed in all patients clinically suspected to have OSA.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128111366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome: Risk factors and predictors among adults in Saudi Arabia","authors":"N. Aljohani","doi":"10.4172/2165-7904.C1.020","DOIUrl":"https://doi.org/10.4172/2165-7904.C1.020","url":null,"abstract":"Background: Metabolic Syndrome (MetS) is a cluster of established cardiovascular risk factors that collectively increase predisposition to major chronic diseases including heart diseases and diabetes mellitus. Citizens of developing countries such as Saudi Arabia are at risk for MetS secondary to industrialization and accessibility to fast foods. In this epidemiologic study, the kingdom-wide prevalence of MetS is determined.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116615617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gerontologic public health problem of obesity in early old age","authors":"Spomenka TomekRoks, ra JuliaLechner Stela Mravak, Marcel Leppe","doi":"10.4172/2165-7904.C1.021","DOIUrl":"https://doi.org/10.4172/2165-7904.C1.021","url":null,"abstract":"T present study investigated the effects of M. charantia on haematological changes of streptozotocin-induced diabetic Wistar rats. Forty healthy adult Wistar rats of both sexes were randomly assigned into five groups A, B, C, D and E of eight rats each. Group A were the control (normal rats); B were the experimentally-induced diabetic rats; C were diabetic rats treated with methanolic extracts of M. charantia for two weeks (withdrawal group); D were diabetic rats treated with methanolic extracts of M. charantia for four weeks. E was diabetic rats treated glimepiride for four weeks. Blood samples obtained by cardiac puncture were used for haematological studies. Results showed significant (p<0.05) increase in most RBC indices in groups D and E. Reduced WBC and NEUT count in diabetic group was significantly (p<0.05) increased in groups D and E. Lymphocyte count was not significantly affected. Platelet count, PDW and MPV were significantly (p<0.05) reduced in groups D and E following an increase in diabetic group. Thus M. charantia could restore some haematological changes in diabetic animals, and in a manner similar to glimepiride.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114635673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and Leanness Caused by Mutations in the Leptin Gene: Already 6 Pathogenic Mutations Reported in this Gene","authors":"M. Wasim","doi":"10.4172/2165-7904.1000276","DOIUrl":"https://doi.org/10.4172/2165-7904.1000276","url":null,"abstract":"Obesity and leanness are the medical conditions in which excess and deficient body fat present respectively. It may have an adverse effect on health, leading to reduced life expectancy and increased health problems. Environmental factors, especially increased consumption of high caloric diet, are considered responsible for the obesity epidemic, although genetic factors also contribute dysregulation of food consumption. Leptin gene may have an effect on the obesity and leanness because six pathogenic mutations already reported in leptin gene. Leptin gene mutations have a vital role to cause different types of cancers.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132467257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}