Journal of obesity and weight loss therapy最新文献_第5页

Leptin and Metabolic Syndrome in Obese Pediatric Population: A CrosssectionalStudy 肥胖儿童瘦素与代谢综合征:一项横断面研究

Journal of obesity and weight loss therapy Pub Date : 2016-04-21 DOI: 10.4172/2165-7904.1000305

T. Durá-Travé, F. Gallinas-Victoriano, L. LloredaMartín, Chueca Guindulain Mj, S. Berrade-Zubiri

{"title":"Leptin and Metabolic Syndrome in Obese Pediatric Population: A CrosssectionalStudy","authors":"T. Durá-Travé, F. Gallinas-Victoriano, L. LloredaMartín, Chueca Guindulain Mj, S. Berrade-Zubiri","doi":"10.4172/2165-7904.1000305","DOIUrl":"https://doi.org/10.4172/2165-7904.1000305","url":null,"abstract":"Background/Objectives: Childhood obesity represents the most relevant nutritional disorder in our environment. This study examines the prevalence of metabolic syndrome in an obese pediatric population and its relation to serum Leptin concentrations. Subjects/Methods: A cross-sectional clinical and metabolic study was accomplished in a group of 106 obese children (47 males and 59 females). Patients were classified in prepubertal group (Tanner stage I) and pubertal group (Tanner stages II–V). Results: Prevalence of insulin resistance (HOMA), hypertriglyceridemia, low high-density lipoprotein (HDL) and arterial hypertension (HTA) was 38.7, 45.3, 28.3 and 33.8% respectively. Metabolic syndrome prevalence (38%) was significantly higher in the pubertal group (38%) in relation to the prepubertal group (23.2%). There was a positive correlation between leptin and BMI (r=0.529), leptin and HOMA indexes (r=562) and Leptin and triglycerides (r=0,314). In addition, there was a positive correlation between HOMA indexes and triglycerides (r=596). Conclusions: Clinical and metabolic disorders associated to obesity and related to the so-called metabolic syndrome are already present in pediatric population. Leptin could play an important role in the etiopathogenesis of the metabolic syndrome.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123871228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of Borax and Sleeve Gastrectomy on mRNA Expression of Antioxidant Genes in Substantia Nigra Tissue of Obese Rats 硼砂和袖胃切除术对肥胖大鼠黑质抗氧化基因mRNA表达的影响

Journal of obesity and weight loss therapy Pub Date : 2016-02-29 DOI: 10.4172/2165-7904.1000302

İ. Gezgin, C. Ozic, A. M. Geyik, C. H. Yıldırım, Y. Ehi, Miktat Kaya, Filiz Susuz AlanyalÄ

{"title":"Effects of Borax and Sleeve Gastrectomy on mRNA Expression of Antioxidant Genes in Substantia Nigra Tissue of Obese Rats","authors":"İ. Gezgin, C. Ozic, A. M. Geyik, C. H. Yıldırım, Y. Ehi, Miktat Kaya, Filiz Susuz AlanyalÄ","doi":"10.4172/2165-7904.1000302","DOIUrl":"https://doi.org/10.4172/2165-7904.1000302","url":null,"abstract":"Aim: To evaluate the effects of borax and sleeve gastrectomy on mRNA expression of antioxidant genes in substantia nigra tissue of obese rats. Methods: Obese rats were fed with a high-fat diet containing 40% additional fat to the diet. Rats were allocated into four groups in random, which were normal rats (Group I) (n=14), obese rats subjected to SG (Group II) (n=14), obese rats subjected to borax (Group III) (n=14), and obese rats subjected to SG and borax (Group IV) (n=14). Catalase, superoxide dismutase (SOD) and glutathione S-transferase (GST) gene expressions were determined by polymerase chain reaction, real-time polymerase chain reaction (RT-qPCR) and western blotting. Results: When normal rats (Group I), and obese rats subjected to SG (Group II) were compared, a decrease in expressions of catalase, SOD and GST genes was observed in Group II. When obese rats subjected to borax (Group III) were compared with Group I and Group II, a decrease in expressions of catalase, SOD and GST genes was observed in Group III. This phenomenon demonstrates that borax and SG both decrease expressions of catalase, SOD and GST genes. Furthermore, the most significant decrease in expressions of catalase, SOD and GST genes was observed in obese rats subjected to SG and borax (Group IV) when compared to other three study groups. Conclusion: The borax decreases molecular obesity and consequently increases the expressions of Catalase, SOD and GST genes. These data show decrease of Catalase, SOD and GST genes in the substantia nigra tissue of obese rats, consistent with the possibility that these changes may contribute to disease pathogenesis.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"470 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115480982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gestational Weight Gain and Changes in Body Composition in PregnantWomen with BMI 25 Kg/m2 Undergoing a Healthy Lifestyle ProgramStarting Early in Pregnancy 体重指数为25kg /m2的孕妇在妊娠早期开始进行健康生活方式计划时，妊娠期体重增加和身体组成的变化

Journal of obesity and weight loss therapy Pub Date : 2016-02-21 DOI: 10.4172/2165-7904.1000300

M. Malavolti, E. Petrella, Valentina Bertarini, Dietitian, Cristina Cicchetti, I. Neri, F. Facchinetti

{"title":"Gestational Weight Gain and Changes in Body Composition in PregnantWomen with BMI 25 Kg/m2 Undergoing a Healthy Lifestyle ProgramStarting Early in Pregnancy","authors":"M. Malavolti, E. Petrella, Valentina Bertarini, Dietitian, Cristina Cicchetti, I. Neri, F. Facchinetti","doi":"10.4172/2165-7904.1000300","DOIUrl":"https://doi.org/10.4172/2165-7904.1000300","url":null,"abstract":"Introduction: we evaluated the utility of bioimpedance analysis and the SenseWear armband for monitoring gestational weight gain (GWG) in overweight/obese pregnant women. Materials and methods: Sixty overweight/obese pregnant women were recruited and advised to follow a physical activity (PA) program (sessions gradually increasing to 30 minutes of mild physical activity intensity per day at least 4-5 days a week) with caloric restriction (1500 kcal/day + 200 kcal/day for obese and 300 kcal/day for overweight women). Weight, GWG and body composition were measured at enrollment (within the 12th week of gestation), at the 16th, 20th, 32nd, and 36th week, at delivery and 12 weeks after delivery using BIA. The patients were also instructed to wear the SWA, for 5 consecutive days, at enrollment, and at the 20th and 36th weeks of gestation. Results: GWG at delivery was 12.6 ± 5.4 kg for overweight, 9.0 ± 8.0 kg for obese women and 3.3 ± 5.3 kg for morbidly obese women. Nine overweight (60.0%), 22 obese (66.7%) and 10 morbidly obese (90.9%) women remained within the Institute of Medicine recommended ranges at delivery. Overall percentual body composition changed significantly throughout pregnancy, (fat-free mass: 53.4 ± 6.1 to 56.9 ± 6.5; FM = 40.9 ± 12.8 to 44.1 ± 11.8, p < 0.05). Logistic regression analysis showed that women who adhered to the prescribed diet achieved a lower GWG (CI 95% = -1.65-0.54; r = -1.10, p = 0.001). Conclusion: The efficacy of the intervention depends directly on the adherence to the prescribed diet and PA program","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"105 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115784151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A Placebo-Controlled, Randomized Study on the Impact of Dietary Salmon Protein Hydrolysate Supplementation on Body Mass Index in Overweight Human Subjects 一项关于膳食中补充鲑鱼水解蛋白对超重人群体重指数影响的安慰剂对照、随机研究

Journal of obesity and weight loss therapy Pub Date : 2016-01-15 DOI: 10.4172/2165-7904.1000296

B. Framroze, Sanjay Vekariya, Dhruv Swaroop

引用次数: 6

The Necessity of Preoperative Pulmonary Function Screening in PatientsScheduled for Bariatric Surgery 减肥手术患者术前肺功能筛查的必要性

Journal of obesity and weight loss therapy Pub Date : 2016-01-08 DOI: 10.4172/2165-7904.1000295

S. Pouwels, M. Said, A. Celik

引用次数: 1

Parental Influences on Child Weight: Perception, Willingness to Change,and Barriers 父母对儿童体重的影响:感知、改变意愿和障碍

Journal of obesity and weight loss therapy Pub Date : 2016-01-07 DOI: 10.4172/2165-7904.1000293

D. White, Dana L. Rofey, A. Kriska, E. Venditti, B. Gibbs, J. Gallagher, J. Jakicic

{"title":"Parental Influences on Child Weight: Perception, Willingness to Change,and Barriers","authors":"D. White, Dana L. Rofey, A. Kriska, E. Venditti, B. Gibbs, J. Gallagher, J. Jakicic","doi":"10.4172/2165-7904.1000293","DOIUrl":"https://doi.org/10.4172/2165-7904.1000293","url":null,"abstract":"Background: Although parents are primary to development of obese genic behaviors, many parents do not perceive their child’s obesity as problematic and are not ready to make changes to address their child’s weight. The purpose of the study is to examine relationships between parental perception of child weight, parental readiness to change behaviors, and barriers to behavior change. Methods: A sample of low-socioeconomic and minority parents of 6-12 year old children who are overweight or obese completed questionnaires on perception of their child’s weight, stage of readiness to change behaviors for their child’s weight (SOC), and barriers to changing child weight control behaviors. Parents were blinded to the purpose of the study. Child weight status was categorized ‘overweight’ (BMI ≤85th-95th percentile) or ‘obese’ (BMI ≥95th percentile). Results: Of the 48 parent-child dyads, 77.1% of parents underestimated their child’s weight status and 54.2% perceived their child as normal weight. Older (p=0.045) and married parents (p=0.025) were more likely to perceive their child as overweight. Accurate parental perception was significantly associated with advanced stage of change (SOC; r=0.358, p=0.012). Conclusions: Parents of overweight or obese children underestimated their child’s weight status. Parental perception of child weight was associated with the parent’s SOC for their child’s weight.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122309610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of a High Carbohydrate and High Protein Formula Diet On Body Composition and Metabolic Risk Parameters in Obese Subjects 高碳水化合物和高蛋白配方饮食对肥胖受试者身体组成和代谢危险参数的影响

Journal of obesity and weight loss therapy Pub Date : 2015-12-31 DOI: 10.4172/2165-7904.1000291

Katharina Möller, Inga Schneider, J. Willers, A. Hahn

{"title":"Effects of a High Carbohydrate and High Protein Formula Diet On Body Composition and Metabolic Risk Parameters in Obese Subjects","authors":"Katharina Möller, Inga Schneider, J. Willers, A. Hahn","doi":"10.4172/2165-7904.1000291","DOIUrl":"https://doi.org/10.4172/2165-7904.1000291","url":null,"abstract":"Background: In obese subject’s weight loss is known to improve blood lipid profiles, glycemic control and other conditions that may contribute to the development of metabolic syndrome or cardiovascular diseases. However, the optimal dietary carbohydrate and protein composition to facilitate weight loss and improving potential adverse effects is still in debate. Therefore, the aim of this study was to compare the effect of two low-fat formula diets either high in carbohydrate or high in protein, on body composition and metabolic risk factors. Methods: 154 obese (BMI 32.5 ± 0.14 kg/m2) men and women were included in this randomized clinical trial and classified in two groups (highcarbohydrateformula diet (HC) and high protein formula diet (HP)) of 80 matched subjects. They underwent an intervention for eight weeks, which consisted of two phases: (1) week 1 and 2: total replacement of three meals by a formula diet and (2) six week partial formula diet (replacement of 1-2 meals). Measurements were taken prior and post intervention for analysis of body composition and parameters of lipid and glucose metabolism. Results: After eight weeks both groups lost significantly body fat mass (HC: -5.11 ± 0.51 kg, p<0.001; HP: -5.81 ± 0.54 kg, p<0.001), while only for subjects of HP group no change of lean body mass and body cell mass was observed. Metabolic risk parameters were reduced in both the HC and HP group; however, subjects in the HC group showed a higher reduction in triacylglycerol concentration (-29.1 mg/dl vs. -14.0 mg/dl, p<0.04). Further, the prevalence of the metabolic syndrome was reduced in both groups without difference (HC: -17.9%, p=0.004; HP: -18.4%, p=0.003). Conclusion: Our data demonstrate, that even in a short period of time, a low-fat meal replacement diet high in carbohydrate or high in protein is effective in improving body composition and reducing metabolic risk parameters.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124879013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Social-Demographic and Behavioural Characteristics of a Morbid ObesePopulation Seeking Bariatric Surgery 寻求减肥手术的病态肥胖人群的社会人口统计学和行为特征

Journal of obesity and weight loss therapy Pub Date : 2015-12-31 DOI: 10.4172/2165-7904.1000290

Boesten Rhm, L. Re, van Hout Gcm, Nienhuijs Sw

{"title":"Social-Demographic and Behavioural Characteristics of a Morbid ObesePopulation Seeking Bariatric Surgery","authors":"Boesten Rhm, L. Re, van Hout Gcm, Nienhuijs Sw","doi":"10.4172/2165-7904.1000290","DOIUrl":"https://doi.org/10.4172/2165-7904.1000290","url":null,"abstract":"Introduction: Bariatric surgery is proven to be the only successful and sustainable treatment of morbid obesity. Unfortunately there is a fair amount of patients that encounter a regain of weight after years. This is probably highly associated with psychological and behavioural aspects making them substantial factors in the decision making process to diminish the risk of weight regain after bariatric surgery. Method: The purpose of this research was to describe the characteristics of morbid obese patients undergoing a preoperative screening for potential bariatric surgery, in order to improve information, pre-care, treatment and followup given to obese patients. In the Catharina Hospital in Eindhoven, the Netherlands, the self-reported screening questionnaires of 345 bariatric patients were reviewed. Results: The results provided information about the patients’ support system, the educational level, work situation, eating habits, eating disorders among others binge eating disorder, coping, the high prevalence of psychical disorders and limited substance abuse. Conclusion: Further research is needed to investigate a possible gender difference. The factors relationships, family, work and coping styles in the bariatric population should be investigated more in depth, to obtain greater insight into the influence and to further personalize pre- and postoperative support of the bariatric surgery","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114499944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Outcome Analysis of Obesity in Trauma Surgery Related to Closed Injuries of Lower Limb in Orthopedic Surgery 骨科闭合性下肢损伤创伤手术中肥胖的结局分析

Journal of obesity and weight loss therapy Pub Date : 2015-12-11 DOI: 10.4172/2165-7904.1000287

S. Nikose, Mahendra Gudhe, P. Singh, Sohael M. Khan, Devashree Nikose, M. Arora, M. Mehmood

{"title":"Outcome Analysis of Obesity in Trauma Surgery Related to Closed Injuries of Lower Limb in Orthopedic Surgery","authors":"S. Nikose, Mahendra Gudhe, P. Singh, Sohael M. Khan, Devashree Nikose, M. Arora, M. Mehmood","doi":"10.4172/2165-7904.1000287","DOIUrl":"https://doi.org/10.4172/2165-7904.1000287","url":null,"abstract":"Background: Obesity is fast becoming a global epidemic and has profound effect on lower limb trauma surgeries is not well defined. This study aimed to evaluate and investigate the influence of obesity on health related quality of life (HRQL), patient reported outcome, incidence of postoperative surgical site infection (SSI), perioperative and postoperative complications. The specific association of obesity and outcome is not examined and measured previously in trauma surgery of lower limbs. Methods and Materials: During 2005 to 2014, a total of 12853 patients underwent different lower limb trauma surgeries and outcome measurement was based according to Body Mass Index (BMI). 10885 Patients with BMI of < 30kg/m2 were classified as non-obese and used as control groups. 1968 Patients with BMI of ≥ 30 kg/m2 were classified as obese and data analyzed in terms of outcome, adverse effects, complications and health related quality of life (HRQL) Results: The Increase in BMI leads to increased perioperative complications in terms of Intubation difficulty, blood loss, and duration of surgery. The post-operative adverse incidences in early period like deep venous thrombosis (DVT), surgical site infections (SSI), cardiac and renal events, superficial and deep infections were significant statistically. The delayed adverse effects relate to complications like late development of surgical site infection (SSI), implant loosening and orthopedic implant failure, re-operation rates for different complications. The improvement in health related quality (HQRL) is low among obese patients. Conclusions: Obesity has an inverse influence on patient outcome as compared to non obese patients. However, despite these increased obese patients do benefit from trauma surgeries of lower limb and patient reported outcome was found to be slightly lower among obese patients","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127223398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Weight Loss Following Left Gastric Artery Embolization in a Human Population without Malignancy: A Retrospective Review 无恶性肿瘤人群胃左动脉栓塞后体重减轻:回顾性回顾

Journal of obesity and weight loss therapy Pub Date : 2015-12-03 DOI: 10.4172/2165-7904.1000285

K. Anton, Tariq Rahman, A. Bhanushali, Luis L. Nadal, G. Pierce, Aalpen A. Patel

{"title":"Weight Loss Following Left Gastric Artery Embolization in a Human Population without Malignancy: A Retrospective Review","authors":"K. Anton, Tariq Rahman, A. Bhanushali, Luis L. Nadal, G. Pierce, Aalpen A. Patel","doi":"10.4172/2165-7904.1000285","DOIUrl":"https://doi.org/10.4172/2165-7904.1000285","url":null,"abstract":"Objective: Recent evidence suggests embolization of the left gastric artery, which provides the predominant arterial supply to the gastric fundus, may affect energy homeostasis through alterations in ghrelin production. The purpose of this study is to evaluate post-procedural weight loss following left gastric artery embolization (performed for reasons other than for weight loss) in patients without malignancy. Materials and Methods: A retrospective review of patients who underwent arterial embolization for acute upper gastrointestinal hemorrhage between January 2002 and January 2014 was conducted. A study group of 10 patients who underwent left gastric artery embolization and control group of 22 patients who underwent embolization of a different mesenteric or visceral arterial branch for non-tumoral acute gastrointestinal bleeding were collected. Their electronic medical records were reviewed and data points for height, weight, and body mass index were collected at 1-, 4-, 8-, and 12-month post-procedural time points. Exclusion criteria included age less than 18 years and documented history of malignancy. Results: The left gastric artery embolization group had a significantly greater reduction in body mass index compared with the control group at 1 month (-9.8% vs. -4.0%, p=0.042) and 4 months (-11.7% vs. +0.1%, p=0.033). No significant change was demonstrated at 8 months (-8.6% vs. -1.7%, p=0.32) and 1 year (-5% vs. +2.6%, p=0.42) compared with controls. Conclusion: Left gastric artery embolization provides early post-procedural weight loss that may persist for at least 1 year. Further studies will better elucidate the role of gastric artery embolization in the management of bariatric patients.","PeriodicalId":243288,"journal":{"name":"Journal of obesity and weight loss therapy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129718329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14