Analytica Chimica Acta最新文献

{"title":"In-situ laser-induced metal (M = Fe, Co, Ni, Cu)-doped graphene electrode for sensitive uric acid sensing in sweat","authors":"Nannan Ma ,&nbsp;Qilin Liu ,&nbsp;Nianyang Cai ,&nbsp;Fangfang Zhu ,&nbsp;Ning Gan ,&nbsp;Zhenzhong Yu","doi":"10.1016/j.aca.2026.345130","DOIUrl":"10.1016/j.aca.2026.345130","url":null,"abstract":"<div><h3>Background</h3><div>Laser-induced graphene (LIG) technology has demonstrated considerable promise for the fabrication of wearable electrochemical sensing devices. However, the pristine LIG typically exhibits suboptimal electrochemical performance, often necessitating heteroatom doping to enhance its functionality. Among these strategies, metal doping has proven particularly effective in significantly boosting sensing capabilities. Conventional doping approaches, however, are frequently hampered by cumbersome pretreatment procedures or weak metal-graphene interfacial interaction, thereby restricting their practical efficacy. Therefore, novel synthetic methodologies are urgently needed for efficient metal-doped LIG fabrication.</div></div><div><h3>Results</h3><div>This study developed an <em>in-situ</em> laser-induced metal-doped graphene (M-LIG, M = Fe, Co, Ni, Cu) fabrication method. It involved plasma-treating polyimide films to introduce hydrophilic groups for metal ion adsorption, followed by CO₂ laser irradiation that achieved atomic-scale metal doping during graphene formation. A systematic investigation of preparation parameters and metal dopant types revealed their significant effects on the morphology, structure, and electrochemical performance of the resulting LIG. These materials were used to construct a portable electrochemical detection system for highly sensitive uric acid monitoring in sweat. Results showed that M-LIG sensors outperformed pristine LIG, with Ni-LIG exhibiting optimal performance of a 10.6-fold reduction in detection limit and a 5-fold enhancement in the upper linear detection range. Density functional theory calculations indicated that Ni active sites played a crucial role in enhancing sensing performance by facilitating analyte adsorption and electron transfer.</div></div><div><h3>Significance</h3><div>This study presents a universal fabrication strategy for M-LIG, which significantly streamlines the preparation process of LIG and enhances its sensing performance. Demonstrating broad application prospects in electrode surface engineering for wearable electrochemical biosensors, this approach paves a new avenue for the development of advanced devices aimed at precise personalized health monitoring.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1390 ","pages":"Article 345130"},"PeriodicalIF":6.0,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tutorial on developing metric tools for sample preparation: from green towards sustainable","authors":"Lorenzo Sanjuan-Navarro ,&nbsp;Juan Luís Benedé ,&nbsp;Soledad Rubio ,&nbsp;Carlos Moreno ,&nbsp;Verónica Pino ,&nbsp;Francisco Javier Pena-Pereira ,&nbsp;Yolanda Moliner-Martínez","doi":"10.1016/j.aca.2025.345044","DOIUrl":"10.1016/j.aca.2025.345044","url":null,"abstract":"<div><h3>Background</h3><div>The use of current metric tools for sample preparation has proven highly valuable in identifying the strengths and weaknesses of various analytical approaches. However, as Analytical Sciences increasingly move towards sustainability, it becomes evident that existing metrics may not fully cover all the dimensions required for a comprehensive assessment.</div></div><div><h3>Results</h3><div>An overview to encourage the evolution towards more advanced metric tools for sample preparation by reflecting on which parameters should be evaluated and on the principles that ought to guide their design. The tutorial highlights the need for new or improved metrics capable and identify the most relevant criteria and how they can be integrated.</div><div>The discussion is particularly focused in the context of miniaturization and the development of new extractive materials. Through case studies, solvents and sorbents are examined using analytical performance, green, and market-related criteria, emphasizing the importance of integrating these perspectives into future tools. Solid-phase (SPME) and liquid-phase microextraction (LPME) are evaluated using the metric tools currently available, pointing out the challenges associated with the application. The results reveal the need to advance towards more advanced metric tools contextualizing the outcomes within the complexity of the analytical problem.</div></div><div><h3>Significance and novelty</h3><div>This manuscript highlight the need to advance metric tools towards models capable of integrating environmental, analytical, and practical dimensions within a coherent sustainability-oriented framework. The tutorial offers guidance for researchers and developers aiming to create more effective tools for the design and evaluation of sample preparation methods, tools that not only address greenness but also deliver greater robustness, relevance, and applicability in real analytical scenarios.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1390 ","pages":"Article 345044"},"PeriodicalIF":6.0,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Antioxidant 3-hydroxyflavone analogues: Integrated experimental and theoretical insights into lead fluoro-sensing and toxicity mitigation in living systems” [Analyt. Chim. Acta 1385 (2026) 344996]","authors":"Trisha Samanta ,&nbsp;Partha Chakrobarty ,&nbsp;Suktara Guria ,&nbsp;Soumyadeep Basu ,&nbsp;Abhijit Karmakar ,&nbsp;Anup Pramanik ,&nbsp;Sutapa Mukherjee ,&nbsp;Naznin Ara Begum","doi":"10.1016/j.aca.2026.345134","DOIUrl":"10.1016/j.aca.2026.345134","url":null,"abstract":"","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1390 ","pages":"Article 345134"},"PeriodicalIF":6.0,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical and spectrophotometric investigation of DNA interactions with TURKOVAC and Pfizer-BioNTech vaccines: Implications for biosensor sensitivity","authors":"Mehmet Aslan ,&nbsp;Abdulkadir Levent","doi":"10.1016/j.aca.2026.345060","DOIUrl":"10.1016/j.aca.2026.345060","url":null,"abstract":"<div><h3>Background</h3><div>The novel coronavirus disease (COVID-19), caused by the SARS-CoV-2 virus, has led to the rapid development of several vaccines, including TURKOVAC and Pfizer-BioNTech. Understanding their electrochemical behavior and interactions with biological macromolecules is crucial for vaccine safety and efficacy evaluation. In this context, a simple, cost-effective, and sensitive electrochemical bio sensing platform was designed using differential pulse voltammetry (DPV) on a disposable pencil graphite electrode. The proposed sensor enables rapid electroanalytical characterization of vaccine formulations and provides a green analytical approach suitable for biological and pharmaceutical investigations.</div></div><div><h3>Results</h3><div>The disposable pencil graphite electrode demonstrated distinct anodic oxidation peaks at +0.90 V and +0.92 V for TURKOVAC and Pfizer-BioNTech vaccines, respectively, in Britton–Robinson buffer at pH 4.0. Surface characterization was carried out using cyclic voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy, confirming successful sensor performance and reproducibility. Under optimized experimental conditions, DNA interaction studies were performed by DPV, revealing marked shifts in oxidation signals upon complex formation with both vaccines. Complementary UV–Visible spectrophotometric analyses confirmed these findings, indicating consistent and thermodynamically stable vaccine–DNA binding. The combined results validated the sensor's high sensitivity, reliability, and applicability in real biological samples.</div></div><div><h3>Significance</h3><div>This study demonstrates the first use of a disposable pencil graphite electrode for simultaneous electrochemical and spectrophotometric investigation of SARS-CoV-2 vaccines and their DNA interactions. The developed platform offers a green, sustainable, and disposable analytical approach with potential applications in vaccine quality control, biosensor development, and molecular-level understanding of vaccine–biomolecule interactions essential for future vaccine design strategies.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1389 ","pages":"Article 345060"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145962777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible hydrophilic-hydrophobic array detection patch integrated with Au NPs/Cu-TCPP(Fe) biomimetic cascade catalysis reactions for enzyme-free sweat glucose monitoring","authors":"Chen Yang,&nbsp;Limin Zhang,&nbsp;Zijun Ma,&nbsp;Junhao Gao,&nbsp;Yang Zhou,&nbsp;Bing Li,&nbsp;Jianbo He,&nbsp;Fang Li","doi":"10.1016/j.aca.2026.345105","DOIUrl":"10.1016/j.aca.2026.345105","url":null,"abstract":"<div><h3>Background</h3><div>The detection and quantification of glucose in human biofluids are critical for the early diagnosis and management of metabolic disorders such as hypoglycemia and diabetes. Non-invasive wearable sensors for sweat glucose monitoring have emerged as promising alternatives to traditional blood glucose testing due to their ease of use, rapid response, and portability. However, the development of stable, cost-effective, and enzyme-free wearable platforms capable of reliable sweat glucose detection remains a significant challenge. Current enzyme-based sensors often suffer from poor stability under ambient conditions, complex fabrication processes, and high costs, limiting their widespread applicability in resource-constrained settings.</div></div><div><h3>Results</h3><div>Au NPs/Cu-TCPP(Fe) nanozymes exhibiting dual peroxidase-like and glucose oxidase-like catalytic activities were synthesized and characterized. These nanozymes catalyze a cascade reaction: glucose oxidation generates H₂O₂, which is then decomposed to produce hydroxyl radicals that oxidize 3,3′,5,5′-tetramethylbenzidine (TMB), yielding a blue-colored product for colorimetric detection. A flexible, multi-layer hydrophilic-hydrophobic array patch was fabricated by integrating the nanozymes and TMB into a paper-based matrix. This design enables efficient in situ sweat collection, concentration, and colorimetric analysis. The patch exhibits a linear detection range of 20–200 μM with a detection limit of 12.72 μM, suitable for physiological sweat glucose levels. Selectivity tests confirmed negligible interference from common sweat components. A smartphone application was developed to enable real-time, quantitative analysis of colorimetric signals. Clinical validation on multiple volunteers across different skin locations (chest, back, forearm, forehead) showed strong correlation with reference methods (HPLC-MS, commercial glucose detection kit), with relative errors &lt;10 %.</div></div><div><h3>Significance</h3><div>This study presents a low-cost and enzyme-free sweat glucose detection platform based on Au NPs/Cu-TCPP(Fe) nanozymes. The integration of smartphone technology enables point-of-care testing, making the platform particularly suitable for personalized health monitoring. The successful validation in human subjects demonstrates its potential for real-world applications in diabetes management and early disease detection. This work bridges the gap between nanozyme catalysis and wearable sensor technology, providing a versatile platform for non-invasive biomarker detection.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1389 ","pages":"Article 345105"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145995956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid detection of measles virus RNA from clinical specimens by using RT-LAMP coupled with CRISPR/Cas12b via fluorescence and lateral flow biosensor readouts: A proof-of-concept study","authors":"Shivani Sharma ,&nbsp;Shibendra Kumar Lal Karna ,&nbsp;Sudhir Khanal ,&nbsp;Yuba Raj Pokharel","doi":"10.1016/j.aca.2026.345081","DOIUrl":"10.1016/j.aca.2026.345081","url":null,"abstract":"<div><h3>Background</h3><div>Rapid laboratory confirmation of suspected cases is essential for measles control, but current methods require a complex laboratory infrastructure. We developed loop-mediated isothermal amplification coupled with CRISPR-Cas-mediated diagnostic (LAmCaD), a novel two-pot diagnostic platform that integrates rapid nucleic acid extraction, RT-LAMP amplification, and in-house purified AapCas12b as a rapid test to detect measles RNA that could be used in settings lacking laboratory infrastructure.</div></div><div><h3>Methods</h3><div>LAmCaD is based on dual detection modalities, fluorescence and lateral flow biosensor readouts. The LAmCaD assay was evaluated for analytical sensitivity and specificity using RNA from Vero/hSLAM-grown measles virus, and diagnostic evaluation was performed using patient samples, compared with standard RT-PCR. The cross-genotype detection capability was assessed across epidemiologically relevant measles genotypes D8, D4, and B3.</div></div><div><h3>Results</h3><div>The in-house purified protein AapCas12b from <em>Alicyclobacillus acidiphilus</em> exhibited strong <em>cis</em> and <em>trans</em> cleavage activities, eliminating dependence on commercial enzyme preparations. The platform enables the use of clinical samples from patients through rapid nucleic acid extraction that eliminates the need for RNA purification steps, allowing direct use of extracted material in RT-LAMP reactions. RT-LAMP alone achieved analytical sensitivity of ∼10³ copies, while the complete protocol detected measles virus at ∼10⁵ copies by fluorescence and ∼10⁴ copies by lateral flow detection. Diagnostic evaluation demonstrated sensitivity of 64.00 %, specificity of 92.59 %, and negative predictive value of 99.95 % with an overall accuracy of 92.56 %. ROC curve analysis revealed an AUC of 0.717, indicating fair discriminatory performance. The assay demonstrated moderate agreement with RT-PCR (κ = 0.6) and successfully identified genotypes D8, D4, and B3. The entire testing process took 90 min to complete.</div></div><div><h3>Conclusions</h3><div>This proof-of-concept LAmCaD platform establishes the foundation for a cost-effective, field-deployable diagnostic test without relying on commercial enzymes or complex sample processing. The platform could facilitate the rapid confirmation of measles cases in resource-limited and/or remote settings, thereby contributing to global measles elimination goals. Conducted within the WHO South-East Asia Region, this study is particularly relevant to the region's 2023 elimination target, addressing current surveillance gaps and specimen transport challenges that hinder efforts to eliminate the disease.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1389 ","pages":"Article 345081"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization techniques in microfluidic impedance cytometry toward bacteria and submicron particles analysis-A review","authors":"Guangzu Wu ,&nbsp;Zhiwei Zhang ,&nbsp;Manman Du ,&nbsp;Dan Wu ,&nbsp;Junting Zhou ,&nbsp;Xinwu Xie ,&nbsp;Feng Tian","doi":"10.1016/j.aca.2025.345004","DOIUrl":"10.1016/j.aca.2025.345004","url":null,"abstract":"<div><h3>Background</h3><div>Single-cell analysis has been widely used in biomedical researches as cellular heterogeneity reveals many physiological characteristics and processes. In recent years, microfluidic impedance cytometry (MIC) has demonstrated tremendous potential in single-cell analysis, clinical medicine, and at-home diagnostics. Currently, this technique is adopted in laboratory for detecting routine cancer cells, abnormal blood cells, rare cells, bacteria, etc. However, MIC-based detection of submicron-sized biological particles, such as bacteria, remains challenging and needs further optimization.</div></div><div><h3>Result</h3><div>In this review, we introduce and examine the current status of the optimization techniques for MIC systems, covering the aspects such as electrode layout, channel design, data processing algorithms, excitation signals. By summarizing and comparing between the advantages and limitations of various methods, we provide feasible strategies of bacteria and submicron particle detection and classification with MIC for its future development.</div></div><div><h3>Significance</h3><div>This review provides a comprehensive insight for researchers working on single-cell analysis, facilitating their work on developing and optimizing the strategies for bacterial/submicron particles detection and classification with MIC. This might also promote the development of MIC-based systems and their analytical capabilities on submicron/nano-particles, providing valuable information of bacteria, virus, subcellular structures (such as exosomes) or even biological macromolecules for researchers engaged in biophysical analysis.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1389 ","pages":"Article 345004"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipase-based HKUST-1 (Cu) biocomposites as chiral stationary phase for enantiomer separation in capillary electrochromatography","authors":"Mengxue Tang ,&nbsp;Jiale Zhang ,&nbsp;Qixuan Mu ,&nbsp;Keyan Chen ,&nbsp;Yibing Ji","doi":"10.1016/j.aca.2026.345102","DOIUrl":"10.1016/j.aca.2026.345102","url":null,"abstract":"<div><h3>Background</h3><div>Enantiomers may have differences in biological effects, pharmacological activity, and toxicity. Currently, global regulatory authorities are imposing increasingly stringent approval requirements for single-enantiomer drugs. Coupled with the continued growth of the chiral pharmaceutical market, this makes the development of chiral separation technology an urgent scientific task. Therefore, the separation and analysis of chiral drug enantiomers are directly related to human health. Enzyme-based chiral stationary phase (CSP) is a promising platform. Unfortunately, the fragility of natural enzymes, as well as the complexity and low efficiency of the preparation process, hinder their practical application in chiral separation.</div></div><div><h3>Results</h3><div>Metal organic frameworks (MOFs), which have enormous potential in the fields of enzyme immobilization and capillary electrochromatography (CEC) separation, were explored as support materials with good enzyme immobilization performance and CSP with separation abilities. Lipase (from porcine pancreatic) was encapsulated into a metal organic framework (MOF) under the concept of “in situ”. Effective enzyme loading capacity enables composite materials (Lipase@HKUST-1) to inherit lipase's natural chiral recognition ability. On this basis, inspired by the same concept, Lipase@HKUST-1 was directly grown in the open column for capillary electrochromatography (CEC). By optimizing the interface combination method and simplifying the column preparation steps, the efficiency and performance of capillary column preparation have been effectively improved. Enantiomer separation of multi-chiral drugs such as naproxen and chlorpheniramine has been achieved. Theoretical calculations further explore potential chiral recognition mechanisms.</div></div><div><h3>Significance</h3><div>The effective combination of cost-effective lipase (from porcine pancreatic) and MOF materials enriches the library of chiral materials for enantioseparation. The understanding of the chiral recognition mechanism inspires the design of ideal performance materials. The highly stable MOF separation platform for biological functions has introduced a pioneering research paradigm for the CSP development of OT-CEC.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1389 ","pages":"Article 345102"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of branched and linear polyethyleneimine by trapped ion mobility-time of flight-mass spectrometry","authors":"Faraz Mohammad Valipour ,&nbsp;Mehmet Atakay ,&nbsp;Sahin Demirci ,&nbsp;Nurettin Sahiner ,&nbsp;Bekir Salih","doi":"10.1016/j.aca.2026.345107","DOIUrl":"10.1016/j.aca.2026.345107","url":null,"abstract":"<div><h3>Background</h3><div>Polyethyleneimine (PEI) is a common polyelectrolyte that is used in many areas, such as drug delivery, gene therapy, and water treatment. This is because it has a highly branched structure, functional amine groups in its repeating unit, and a high cationic charge density. To understand the behavior and function of PEI, it is important to accurately describe its structure. The ion mobility-mass spectrometry method is expected to yield structural insights into PEI's molecular architecture, encompassing variations in branching patterns, chain conformations, and the potential presence of isomeric forms.</div></div><div><h3>Results</h3><div>The difference in zeta potential values between B-PEI and L-PEI can be attributed to the distinct types of functional amine groups present in their structures. The trapped ion mobility-time of flight-mass spectrometry (TIMS-ToF-MS) technique was used in this study to elucidate the molecular architecture of linear and branched PEI with varying polymeric distributions of ion series and end groups, concentrating on its dimensions, morphology, conformational variations, variable cationic adducts (Na⁺, K⁺, Li⁺, and Ag⁺), and charge states (+1 and + 2). The singly charged ions, like those in the main series and fragment series of PEI, are more compact than doubly charged ions because of the change in charge repulsion. TIMS, in conjunction with mass spectrometry, facilitated high-resolution separation of PEI conformers according to their collision cross-section (CCS) values and charge states.</div></div><div><h3>Significance</h3><div>The findings indicated that PEI displays a wide range of both compact and extended molecular conformations at various <em>m/z</em> ratios, with specific populations associated with varying branching levels, cationic adducts, and charge distribution. The influence of various metal ions on PEI conformation was examined, indicating substantial alterations in CCS values under diverse conditions of analysis. Hyphenated TIMS and MS technologies make a strong analytical platform for studying polymer structures in depth.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1389 ","pages":"Article 345107"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive soil pollution monitoring system based on convolutional recursive sequence network and terahertz spectroscopy","authors":"Ao Feng ,&nbsp;Lijia Xu ,&nbsp;Yuchao Wang,&nbsp;Zhijun Wu","doi":"10.1016/j.aca.2026.345117","DOIUrl":"10.1016/j.aca.2026.345117","url":null,"abstract":"<div><h3>Background</h3><div>Accurate analysis of the total amount of heavy metals and their distribution patterns in soil can aid in determining the extent of soil pollution and iake appropriate remediation measures.Traditional detection methods are inefficient, and standard machine learning approaches are insufficiently sensitive in detecting the range when dealing with several contaminants of heavy metals. In this study, the contents of three heavy metals, cadmium (Cd), nickel (Ni), and zinc (Zn), in soils of different pollution types and concentrations were detected through terahertz spectral curve analysis.</div></div><div><h3>Results</h3><div>A convolutional recursive sequence network (CRST) with cascaded convolutional kernel and cyclic sequence structure was designed to further improve the soil heavy metal detection accuracy by capturing and integrating the sequence dependencies in the continuous terahertz bands. We compared common machine learning models with feature extraction algorithms, and the experimental results show that the CRST method can accurately identify soil heavy metal contamination species under the combined model of all data. The CARS-CRST combination achieved a classification accuracy of 99.54 % when the soil was contaminated with a single heavy metal. The CARS-CRST combination achieved a classification accuracy of 95.26 % when the soil was contaminated with a mixture of heavy metals. The CRST method can also accurately determine the heavy metal content in soil for Cd, Ni, and Zn, achieving optimal R² and RMSE values when the prediction model is constructed for these elements.</div></div><div><h3>Significance</h3><div>Based on terahertz spectroscopy and machine learning technology, this study conducted both qualitative and quantitative research on soil heavy metals, providing robust technical support for the scientific management and precise monitoring of soil.The results show that terahertz technology and machine learning technology can bring new ideas and prospects for soil pollution detection.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1389 ","pages":"Article 345117"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145993140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}