Zoonoses and Public Health最新文献

{"title":"Zoonotic Tick-Borne Pathogens in Ixodes ricinus Complex (Acari: Ixodidae) From Urban and Peri-Urban Areas of Kosovo.","authors":"Ina Hoxha, Betim Xhekaj, Genc Halimi, Michiel Wijnveld, Margarida Ruivo, Driton Çaushi, Albana Matoshi, Adelheid G Obwaller, Bernhard Jäger, Martin Weiler, Julia Walochnik, Kurtesh Sherifi, Edwin Kniha","doi":"10.1111/zph.13197","DOIUrl":"10.1111/zph.13197","url":null,"abstract":"<p><strong>Introduction: </strong>Ixodes ricinus, the castor bean tick, is the most prevalent tick species in Europe. It favours habitats such as shrubs, deciduous and mixed forests, but can also be found in urban environments. Due to its high vector competence, it is of enormous veterinary as well as medical importance, transmitting tick-borne encephalitis (TBE) virus, Borrelia burgdorferi s. l., the causative agent of lyme borreliosis, Rickettsia spp. and Anaplasma phagocytophilum amongst many other pathogens. In Kosovo, I. ricinus is the predominant species and a few studies, mostly based on human and animal seroprevalences, indicate the circulation of tick-borne pathogens. However, data on pathogens in I. ricinus are scarce in Kosovo, particularly in urban settings. This study aimed to provide first insights into the circulation of tic-kborne pathogens in I. ricinus from urban and peri-urban areas in Kosovo.</p><p><strong>Methods: </strong>Urban and peri-urban areas were sampled by flagging 150 m transects. In total, 197 ticks were morphologicaly identified as I. ricinus, and consequently DNA and RNA were isolated. All individuals were screened for the presence of tick-borne pathogens by using reverse line blotting (RLB) hybridisation.</p><p><strong>Results: </strong>DNA of nine different pathogens from four genera including Borrelia spp., Rickettsia spp., Anaplasma spp. and Babesia spp. was detected in 60 (33.5%) specimens. The most frequently detected pathogens were Rickettsia spp. (16.2%), followed by Borrelia spp. (11.7%). Altogether, 54 single infections, 11 double infections and 1 triple infection were observed.</p><p><strong>Conclusions: </strong>We provide first data on genotyping of B. burgdorferi sensu lato as well as the detection of Anaplasma, Babesia and Rickettsia from I. ricinus in this country. The data underline that particularly recreational (peri-)urban areas could facilitate the spillover of zoonotic tick-borne pathogens to humans in Kosovo and provide baseline data for future surveys.</p>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":" ","pages":"174-183"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Occurrence of ST131 Among Extraintestinal Pathogenic Escherichia coli in Humans and Dogs in Sri Lanka.","authors":"W A Pamudi Maldam Dewasmika, D R Anuruddhika Dissanayake, N G Dulanjalee Anuruddhika Kumari Neelawala, B G Nilanthi Dissanayake, D V Pahan Prasada, Veithehi Rajeevan Francis, Sophie Octavia, Ruiting Lan","doi":"10.1111/zph.13199","DOIUrl":"10.1111/zph.13199","url":null,"abstract":"<p><strong>Aims: </strong>Extraintestinal pathogenic Escherichia coli (ExPEC) is an important human and animal pathogen. In particular, the ST131 of ExPEC is a widely distributed clone, resistant to extended-spectrum cephalosporins and fluoroquinolones. We investigated the occurrence of ST131 among ExPEC from humans and dogs in Sri Lanka and determined its antimicrobial resistance.</p><p><strong>Methods: </strong>A total of 215 ExPEC isolates were collected from humans (n = 179) and dogs (n = 36) from two different cities in Sri Lanka. Antimicrobial resistance was tested by the disk diffusion method, and the presence of resistance-encoding genes (bla_TEM, bla_SHV and bla_CTX-M) and ST131 clades/subclades was tested by PCR.</p><p><strong>Results: </strong>The majority of the isolates were (61.8%) ST131, with 55.8% in ST131-clade C. Of the clade C isolates, 44.3%, 27.8%, 15.7% and 6.7% were in clades C2, C other, C1-non-M27 and C1-M27, respectively. Approximately 11% of the ST131 isolates were carbapenem resistant. ExPEC from dogs showed comparable resistance rates to human isolates except for resistance to amoxicillin-clavulanate and amikacin.</p><p><strong>Conclusion: </strong>We observed a high occurrence of ST131 and its clade C, with more than 11% exhibiting resistance to carbapenems in Sri Lanka. Furthermore, ST131-C1-M27, with high resistance to both quinolones and extended-spectrum cephalosporins, was also present. Our results emphasise the importance of the One Health approach in the monitoring of antimicrobial-resistant E. coli in different regions of Sri Lanka to gain a better understanding of their prevalence over time, contributing to effective antimicrobial stewardship.</p>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":" ","pages":"200-206"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brucella microti and Rodent-Borne Brucellosis: A Neglected Public Health Threat.","authors":"Ivo Rudolf, Romana Kejíková, Michael Kosoy, Zdeněk Hubálek, Kristína Mravcová, Silvie Šikutová, Adrian M Whatmore, Sascha Al Dahouk","doi":"10.1111/zph.13188","DOIUrl":"10.1111/zph.13188","url":null,"abstract":"<p><p>Brucellosis is one of the most important zoonoses worldwide, primarily affecting livestock but also posing a serious threat to public health. The major Brucella species are known to cause a feverish disease in humans with various clinical signs. These classical Brucella species are (re-)emerging, but also novel strains and species, some of them transmitted from rodents, can be associated with human infections. As a result of our review on rodent-borne brucellosis, we emphasise the need for more comprehensive surveillance of Brucella and especially Brucella microti in rodent populations and call for further research targeting the ecological persistence of rodent-associated Brucella species in the environment, their epizootic role in wild rodents and their virulence and pathogenicity for wildlife.</p>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":" ","pages":"1-8"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excess Healthcare Costs and Resource Utilisation of Lyme Borreliosis in Germany: A Propensity Score-Matched Cohort Study.","authors":"Gordon Brestrich, Joanna Diesing, Nils Kossack, James H Stark, Andreas Pilz, Holly Yu, Jochen Suess","doi":"10.1111/zph.13180","DOIUrl":"10.1111/zph.13180","url":null,"abstract":"<p><strong>Aim: </strong>Lyme borreliosis (LB) is the most common tick-borne disease in Germany; however, data on the economic burden of LB are limited. In this study, we aim to report healthcare costs, healthcare resource utilisation (HCRU) and diagnostic consumption associated with LB by clinical manifestation.</p><p><strong>Method: </strong>Using specific case definitions, patients with localised disease (erythema migrans [EM]) or disseminated disease (Lyme arthritis [LA], Lyme neuroborreliosis [LNB] and other rarer manifestations [OTH]) were identified from a claims database in 2016 and followed up for 3 years (2016-2019). After propensity score matching, excess costs and HCRU were calculated as the differences between each LB cohort and the matched control cohort.</p><p><strong>Results: </strong>On a per-patient basis, the excess all-cause healthcare cost was €130 for EM during Quarter 1 of Year 1, and €1539 for LA, €3248 for LNB and €4137 for OTH during Year 1. Only for OTH, additional €1860 was observed in Year 2. No increase in costs was observed in Year 3. When extrapolated to all German patients with statutory health insurance, LB was associated with €64.5 million in excess costs. Although disseminated manifestations only accounted for 7.8% of all LB cases, they were responsible for 66% of overall costs. In addition, LB patients consumed healthcare resources of 1.4 million excess outpatient visits, 13,000 excess hospitalisations, 96,000 ELISAs and 65,000 Western blots.</p><p><strong>Conclusion: </strong>This study shows the substantial economic burden of LB to the German healthcare system.</p>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":" ","pages":"23-31"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of Feline Sporotrichosis in Espírito Santo, Brazil: Impact of Urbanisation.","authors":"Angelita Reis Gomes, Luisa Frasson Vieira, Oscar Giovanny Enriquez-Martinez, Fernanda Cristina de Abreu Quintela Castro, Sarah Fernandes Teixeira, Roberta Passamani Ambrósio, Bruno Carneiro Rediguieri, Sarah Santos Gonçalves, Renata Osorio Faria, Ágata Fernandes Romero, Clairton Marcolongo Pereira","doi":"10.1111/zph.13185","DOIUrl":"10.1111/zph.13185","url":null,"abstract":"<p><strong>Introduction: </strong>Sporotrichosis is a chronic infectious mycosis caused by traumatic implantation of Sporothrix spp., which poses a significant challenge to public health because of its zoonotic nature. It affects humans and other animals, particularly cats. This study investigated epidemiological trends and spatial distribution of feline sporotrichosis in Espírito Santo between 2017 and 2022.</p><p><strong>Methods: </strong>This study collected diagnostic data on sporotrichosis from the Veterinary Pathology Laboratory and Center for Infectious Diseases in Espírito Santo from 2017 to 2022. Statistical analyses were performed using STATA and spatial analyses were performed using ArcGIS software to create maps and identify hotspots. Kernel density estimation and directional mean statistics were applied to visualise the disease concentration and transmission trends.</p><p><strong>Results: </strong>The results showed a significant increase in feline sporotrichosis cases in Espírito Santo from 2017 to 2022, with hotspots identified in urban and densely populated areas. Anchieta, Aracruz and Vila Velha reported the highest numbers of cases. Spatial analysis indicated a spread towards the central and northern coastal regions.</p><p><strong>Conclusion: </strong>This study highlights the growing threat of feline sporotrichosis in Espírito Santo, Brazil, particularly in densely populated urban areas. This underscores the urgent need for comprehensive public health strategies that address urbanisation, human-animal interactions and managing stray cat populations. Effective control measures and enhanced surveillance are crucial to mitigate the spread of this zoonotic disease. Importantly, this study provides valuable insights into the epidemiology of sporotrichosis in Brazil and offers a framework for other regions identified as emerging hotspots that face similar challenges.</p>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":" ","pages":"65-74"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Mycobacterium bovis in Free-Ranging Sapajus nigritus, Argentina.","authors":"Daniela Lamattina, Mariela Florencia Martinez, Esteban Manuel Couto, Clara Scarry, María Paula Tujague, Juan Pablo Arrabal, Dante Luis Di Nucci, Eduardo Ariel Lestani, Diego Bombelli, Marcela Andrea López, Natalia Sasoni, Rossana Piloni, Angélica Kim, Carlos Zenobi, María Jimena Marfil, Roberto Trigo, Néstor Eduardo Pérez, María Gabriela Cáceres, Oscar Daniel Salomón","doi":"10.1111/zph.13189","DOIUrl":"10.1111/zph.13189","url":null,"abstract":"<p><p>Mycobacterium bovis and Mycobacterium tuberculosis are the most relevant among pathogenic mycobacteria, both belonging to the M. tuberculosis complex (MTC). Samples of blood, liver, spleen, kidneys, lungs and caseous tubercles were collected from a free-ranging juvenile black capuchin monkey (Sapajus nigritus) showing non-specific signs of illness. Macroscopic findings included emaciation, a caseous lesion in a tooth and gingiva, disseminated nodules in both lungs and left kidney parenchyma and caseous nodules on the pleura and mesentery. The lesions suggested MTC infection, a diagnosis subsequently supported in the lung by bacilloscopy, immunochromatography and PCR. A multiplex PCR further validated the presence of M. bovis genes. Cases of tuberculosis in platyrrhine primates have only been reported in animals maintained in captivity. We describe for the first time the pathological and molecular findings of M. bovis infection in a free-ranging platyrrhine monkey within an area of intense human-wildlife interaction, which has important implications from a One Health perspective.</p>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":" ","pages":"95-99"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Campylobacter Diversity Along the Farm-to-Fork Continuum of Pastured Poultry Flocks in the Southeastern United States.","authors":"Walid G Al Hakeem, Adelumola Oladeinde, Xiang Li, Sohyun Cho, Issmat I Kassem, Michael J Rothrock","doi":"10.1111/zph.13184","DOIUrl":"10.1111/zph.13184","url":null,"abstract":"<p><strong>Introduction: </strong>Consumer demand for pasture raised, antibiotic-free poultry products has led to an increase in pastured poultry operations within the United States. Given the level of environmental interaction and the potential increase in exposure to foodborne pathogens in these settings, a greater understanding of the prevalence and diversity of Campylobacter populations inherent within pastured poultry flocks is needed.</p><p><strong>Methods: </strong>To achieve this, 40 pastured poultry flocks from nine farms were sampled using a farm-to-fork strategy, and Campylobacter was isolated and characterised from preharvest (faeces, soil) through postharvest (caeca, whole carcass rinse) to the final product the consumer would purchase (whole carcass rinse).</p><p><strong>Results: </strong>Campylobacter was isolated from 872 of 1820 samples, showing an overall prevalence of 47.91%. The caeca showed the highest (p < 0.05) Campylobacter load (4.64 log₁₀ CFU/mL) and prevalence (95.5%), while the final product whole carcass rinses had the lowest (p < 0.05) Campylobacter load (0.32 log₁₀ CFU/mL) and prevalence (15.45%), suggesting that the Campylobacter load in the caeca may not be indicative of the Campylobacter load on the final product. Of the 872 positive samples, 337 Campylobacter isolates were selected for further characterisation. Campylobacter jejuni and Campylobacter coli comprised 74.18% (250/337) and 21.95% (74/337) of the selected isolates respectively. While the Campylobacter isolates displayed resistance to several antibiotics, the most common resistance for both C. jejuni and C. coli was against tetracycline (55.86% and 70.31% respectively). Multidrug resistance phenotypes (≥ 3 antibiotic classes) were relatively low for both C. jejuni (2.80%) and C. coli (9.45%).</p><p><strong>Conclusions: </strong>Campylobacter load, prevalence and diversity were more affected by farm location than by the type of sample from which the Campylobacter was isolated. Overall, these results indicated a need for farm-specific Campylobacter mitigation strategies to ensure the safety of these increasingly in-demand poultry products.</p>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":" ","pages":"55-64"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Historical Summary of Tick and Animal Surveillance Studies for Lyme Disease in Canada, 1975-2023: A Scoping Review.","authors":"Alexander Davidson, Patrick H Kelly, Julie Davis, Maria Major, Jennifer C Moïsi, James H Stark","doi":"10.1111/zph.13191","DOIUrl":"10.1111/zph.13191","url":null,"abstract":"<p><strong>Introduction: </strong>Lyme disease (LD) is caused by infection with the bacteria Borrelia burgdorferi sensu lato (Bb) through the bite of an infected Ixodes spp. tick. LD has emerged as a public and animal health issue in Canada, with human incidence increasing in part due to the expansion of Ixodes scapularis ticks and their vertebrate hosts. We sought to provide the first comprehensive summary of published tick and animal surveillance literature regarding LD in Canada to describe changes in LD over time.</p><p><strong>Methods: </strong>We conducted a review to identify peer-reviewed LD-focused tick, mammal, and bird surveillance articles in three online databases between 1975 and 2023. Data on study characteristics, data collection years, and surveillance methods and findings were extracted. Descriptive statistics were reported.</p><p><strong>Results: </strong>In total, 115 studies were included for review. Results showed an increase in published surveillance literature and changes in study approaches and their provincial distribution over time, coinciding with increased LD cases in Canada. Seventy-four studies were published after 2014 when Canada's Federal Framework on Lyme Disease Act was introduced, and two-thirds of these studies focused on tick surveillance only. Overall, 58% of studies involved surveillance in Ontario but increases in all other provinces were observed after 2009.</p><p><strong>Conclusions: </strong>Observed changes in five decades of LD-related tick and animal surveillance literature helps document the historical rapid spread of Ixodes and Bb across provinces. This can provide lessons for other regions that may transition from emerging to endemic status for LD in the coming years.</p>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":" ","pages":"9-22"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of Antimicrobial Resistance in Special-Fed Veal Production Environments.","authors":"Alexander Dunmyre, Poonam Vinayamohan, Samantha R Locke, Ting-Yu Cheng, Victoria Schaffner, Greg Habing","doi":"10.1111/zph.13186","DOIUrl":"10.1111/zph.13186","url":null,"abstract":"<p><strong>Introduction: </strong>Antimicrobial resistance (AMR) is one of the leading public health threats globally. AMR genes can be transferred between bacteria through lateral gene transfer, and AMR organisms can spread through environments by contaminated water, agriculture and animals. Thus, widespread environmental dissemination of bacteria and lateral gene transfer facilitate AMR transmission pathways. Farm environments in dairy and calf production are known to harbour AMR bacteria that pose a risk for food contamination and to workers in direct or indirect contact with animals. Escherichia coli is present in farm environments and is known to participate in lateral gene transfer, providing a good marker of resistance genes in each environment.</p><p><strong>Methods: </strong>In this study, E. coli from nine cohorts of calves was isolated at different time points from nine barns, nine trailers and one slaughterhouse environment in a single special-fed veal calf production facility. The antimicrobial susceptibility to 15 antimicrobials, classified as highly or critically important by the World Health Organization, was characterised for E. coli isolates using Kirby-Bauer disk diffusion.</p><p><strong>Results: </strong>The highest proportion of isolates showing multidrug resistance was present in barn environments (51.7%), where calves were housed from their arrival at < 2 weeks of age until they were transported to slaughter. Additionally, 15 E. coli isolates were resistant to 11 of the 15 antimicrobials tested. Trailer and slaughterhouse environments had greater prevalence of resistance after accommodating calves, including resistance to third-generation cephalosporins.</p><p><strong>Conclusion: </strong>These data highlight the importance of calf environments in the dissemination of resistant bacteria and gives insight into where interventions could be most effective in combatting antimicrobial-resistant bacteria that could infect humans and livestock.</p>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":" ","pages":"75-83"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance and Zoonotic Potential of Nontyphoidal Salmonella From Household Dogs.","authors":"Sophia M Kenney, Nkuchia M M'ikanatha, Erika Ganda","doi":"10.1111/zph.13174","DOIUrl":"10.1111/zph.13174","url":null,"abstract":"<p><strong>Background: </strong>Companion animals, like household dogs, are an overlooked transmission point for zoonotic pathogens such as nontyphoidal Salmonella (NTS). Given the proximity of dogs to humans and the use of critically important antibiotics in companion animal medicine, household dogs represent a risk for the spread of antimicrobial-resistant (AMR) Salmonella.</p><p><strong>Methods and results: </strong>To this end, we aimed to leverage existing biosurveillance infrastructure to investigate AMR and the zoonotic potential of NTS isolated from dogs and humans. We identified all NTS strains isolated from domestic dogs via the Veterinary Laboratory Investigation and Response Network between May 2017 and March 2023 (N = 87), and spatiotemporally matched strains isolated from humans in the NCBI Pathogen Isolate Browser (N = 77). These 164 strains, collected from 17 states in the United States, formed the basis of our analysis. Strains isolated from dogs comprised diverse serovars, with most being clinically relevant to human health. All strains possessed AMR determinants for drug classes deemed critically or highly important by the World Health Organization. We identified sixteen NTS isolates from humans closely related to ≥1 of six dog-associated strains.</p><p><strong>Conclusions: </strong>Collectively, our data emphasize the importance of antimicrobial stewardship and sustained biosurveillance beyond human- and agriculture-associated veterinary medicine, using a One-Health framework that accounts for all transmission points including companion animals.</p>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":" ","pages":"84-94"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}