Zhonghua yi xue za zhi最新文献

{"title":"[Clinical characteristics of whooping cough pneumonia in adults].","authors":"Z R Liu, J W Ge, K Kong, G C Lyu, S H Jiang","doi":"10.3760/cma.j.cn112137-20250117-00147","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250117-00147","url":null,"abstract":"<p><p>The data of adult whooping cough pneumonia patients admitted to the Affiliated Hospital of Jining Medical College from January 2023 to December 2024 were retrospectively analyzed, and the Leicester Cough Questionnaire (LCQ) was used to analyze the severity of the patients' cough and the decline of their quality of life, and to summarize the clinical manifestation, imaging feature, and bronchoscopic manifestation. A total of 24 adult patients with whooping cough, 13 males and 11 females, aged (56.0±15.9) years, were included, and all of them had cough as the cheif complaint. Using fractional exhaled nitric oxide (FeNO) levels, they were divided into the elevated FeNO group [>25 ppb (1 ppb=1×10^-9)) and the normal FeNO group (5-25 ppb).The total LCQ score of the 24 patients was (10.6±3.1) points. The total LCQ score [(8.9±2.8) vs (12.1±2.5) points] and psychological score [(2.8±1.5) vs (4.5±1.7) points] of females were lower than those of males (all <i>P</i><0.05); the total LCQ score [(8.7±2.3) vs (11.2±3.1) points] and psychological score [(2.6±0.8) vs (4.6±1.6) points] of the FeNO elevation group were lower than those of the FeNO normal group (all <i>P</i><0.05).Chest CT in the 24 patients showed bronchial wall thickening (79.1%, 19/24), patchy infiltrating shadow (54.2%, 13/24), solid lung shadow (45.8%, 11/24), intrapulmonary striated shadow (29.2%, 7/24), and dendritic sign (16.7%, 4/24) and ground glass density shadow (12.5%, 3/24). Bronchoscopy showed mucosal congestion and edema in all cases (100%, 24/24), and in some cases, purulent secretion (66.7%, 16/24), mucus plug (20.8%, 5/24), inflammatory stenosis of the lumen (8.3%, 2/24), mucosal erosions (4.2%, 1/24), and mucosal leukoplakia (4.2%, 1/24). Whooping cough in adults was characterized by cough as the cheif complaint, decreased LCQ score, lower LCQ score in the elevated FeNO group compared to the normal FeNO group, and imaging manifestations of bronchiolitis, pneumonia, and bronchoscopic lesions of varying severity. Adult patients with cough who do not respond well to conventional treatment need to be alerted to pertussis infection.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 30","pages":"2573-2576"},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Incidence and risk factors of acute kidney injury after aortic dissection surgery].","authors":"X Y Lu, B Y Wu, B Q Ni, H J Mao","doi":"10.3760/cma.j.cn112137-20250314-00628","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250314-00628","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the incidence and risk factors of acute kidney injury (AKI) after aortic dissection surgery. <b>Methods:</b> The data of patients who underwent aortic dissection surgery in the Department of Cardiovascular Surgery of Jiangsu Provincial People's Hospital from January 2020 to June 2024 were retrospectively collected. The primary endpoint was the incidence of AKI within 7 days postoperatively, and the secondary endpoint was the occurrence of AKI combined with dialysis (AKI-D). Logistic regression was used to analyze the influencing factors of AKI and AKI-D. The Shapley additive explanation (SHAP) method was employed to interpret the results of the multivariate logistic regression analysis and quantify the contribution of each factor. <b>Results:</b> A total of 850 patients aged [<i>M</i> (<i>Q</i>₁, <i>Q</i>₃)] 56 (48, 66) years were included, with 679 males (79.9%) and 171 females (20.1%). The study identified 490 cases (57.6%) with Stanford type A aortic dissection and 360 cases (42.4%) with type B. The incidence of AKI within 7 days postoperatively was 40.1% (341/850), with the incidence of AKI in type A dissection significantly higher than that in type B dissection [60.8% (298/490) vs 11.9% (43/360), <i>P</i><0.001]. AKI-D occurred in 19.5% (166/850) of patients, and the in-hospital mortality rate was 8.8% (75/850). The independent risk factors for postoperative AKI, ranked by contribution, were emergency surgery (<i>OR</i>=2.38, 95%<i>CI</i>: 1.39-4.06; SHAP=0.085), surgery duration (per 1-hour increase, <i>OR</i>=1.18, 95%<i>CI</i>: 1.09-1.29; SHAP=0.084), Stanford type A (<i>OR</i>=2.04, 95%<i>CI</i>: 1.09-3.81; SHAP=0.062), baseline serum creatinine (per 10 μmol/L increase, <i>OR</i>=1.12, 95%<i>CI</i>: 1.06-1.18; SHAP=0.058), intraoperative erythrocyte transfusion (for each additional U, <i>OR</i>=1.09, 95%<i>CI</i>: 1.02-1.15; SHAP=0.037), D-dimer (per 1 mg/L increase, <i>OR</i>=1.03, 95%<i>CI</i>: 1.01-1.06; SHAP=0.036). The independent risk factors for AKI-D, ranked by contribution, were surgical duration (per 1-hour increase, <i>OR</i>=1.31, 95%<i>CI</i>: 1.19-1.45; SHAP=0.083), baseline serum creatinine (per 10 μmol/L increase, <i>OR</i>=1.16, 95%<i>CI</i>: 1.09-1.24; SHAP=0.053), emergency surgery (<i>OR</i>=2.60, 95%<i>CI</i>: 1.34-5.01; SHAP=0.045), female gender (<i>OR</i>=2.73,95%<i>CI</i>: 1.57-4.76; SHAP=0.040), D-dimer (per 1 mg/L increase, <i>OR</i>=1.05, 95%<i>CI</i>: 1.02-1.07; SHAP=0.033), poor renal perfusion classification (missing, <i>OR</i>=2.34, 95%<i>CI</i>: 1.34-4.09; SHAP=0.032), intraoperative erythrocyte transfusion (per 1 U increase, <i>OR</i>=1.07, 95%<i>CI</i>: 1.01-1.14; SHAP=0.021). <b>Conclusions:</b> The incidence of AKI after aortic dissection surgery is high, particularly in patients with type A dissection. Prolonged operation time and elevated preoperative serum creatinine are common risk factors for both AKI and AKI-D.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 30","pages":"2558-2566"},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Development of a machine learning-based diagnostic model for T-shaped uterus using transvaginal 3D ultrasound quantitative parameters].","authors":"S J Li, Y Wang, R Huang, L M Yang, X D Lyu, X W Huang, X B Peng, D M Song, N Ma, Y Xiao, Q Y Zhou, Y Guo, N Liang, S Liu, K Gao, Y N Yan, E L Xia","doi":"10.3760/cma.j.cn112137-20250302-00493","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250302-00493","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To develop a machine learning diagnostic model for T-shaped uterus based on quantitative parameters from 3D transvaginal ultrasound. &lt;b&gt;Methods:&lt;/b&gt; A retrospective cross-sectional study was conducted, recruiting 304 patients who visited the hysteroscopy centre of Fuxing Hospital, Beijing, China, between July 2021 and June 2024 for reasons such as \"infertility or recurrent pregnancy loss\" and other adverse obstetric histories. Twelve experts, including seven clinicians and five sonographers, from Fuxing Hospital and Beijing Obstetrics and Gynecology Hospital of Capital Medical University, Peking University People's Hospital, and Beijing Hospital, independently and anonymously assessed the diagnosis of T-shaped uterus using a modified Delphi method. Based on the consensus results, 56 cases were classified into the T-shaped uterus group and 248 cases into the non-T-shaped uterus group. A total of 7 clinical features and 14 sonographic features were initially included. Features demonstrating significant diagnostic impact were selected using 10-fold cross-validated LASSO (Least Absolute Shrinkage and Selection Operator) regression. Four machine learning algorithms [logistic regression (LR), decision tree (DT), random forest (RF), and support vector machine (SVM)] were subsequently implemented to develop T-shaped uterus diagnostic models. Using the Python random module, the patient dataset was randomly divided into five subsets, each maintaining the original class distribution (T-shaped uterus: non-T-shaped uterus ≈ 1∶4) and a balanced number of samples between the two categories. Five-fold cross-validation was performed, with four subsets used for training and one for validation in each round, to enhance the reliability of model evaluation. Model performance was rigorously assessed using established metrics: area under the curve (AUC) of receiver operator characteristic (ROC) curve, sensitivity, specificity, precision, and F1-score. In the RF model, feature importance was assessed by the mean decrease in Gini impurity attributed to each variable. &lt;b&gt;Results:&lt;/b&gt; A total of 304 patients had a mean age of (35±4) years, and the age of the T-shaped uterus group was (35±5) years; the age of the non-T-shaped uterus group was (34±4) years.. Eight features with non-zero coefficients were selected by LASSO regression, including average lateral wall indentation width, average lateral wall indentation angle, upper cavity depth, endometrial thickness, uterine cavity area, cavity width at level of lateral wall indentation, angle formed by the bilateral lateral walls, and average cornual angle (coefficient: 0.125, -0.064,-0.037,-0.030,-0.026,-0.025,-0.025 and -0.024, respectively). The RF model showed the best diagnostic performance: in training set, AUC was 0.986 (95%&lt;i&gt;CI&lt;/i&gt;: 0.980-0.992), sensitivity was 0.978, specificity 0.946, precision 0.802, and F1-score 0.881; in testing set, AUC was 0.948 (95%&lt;i&gt;CI&lt;/i&gt;: 0.911-0.985), sensitivity ","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 30","pages":"2551-2557"},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidemiological characteristics and clinical manifestations of adult pertussis in Zhejiang Province, 2024].","authors":"Y Zhu, Y Zhou, X H Qi, L L Ding, X W Tang, K Gao, Y X Liang, H Q He","doi":"10.3760/cma.j.cn112137-20250401-00783","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250401-00783","url":null,"abstract":"<p><p><b>Objective:</b> To systematically describe and analyze the epidemiological characteristics and clinical manifestations of adult pertussis in Zhejiang Province in 2024. <b>Methods:</b> Data on pertussis cases reported in 2024 among individuals aged≥18 years residing in Zhejiang Province were collected from the China Disease Control and Prevention Information System. Additional clinical and hospitalization information was obtained through a specialized survey. Descriptive analysis was conducted on epidemiological and clinical characteristics. <b>Results:</b> In 2024, a total of 3 994 adult pertussis cases were reported in Zhejiang Province, accounting for 6.67% of all pertussis cases (59 917), with a reported incidence rate of 7.14 per 100 000. Female cases (2 541, 63.62%) outnumbered male cases (1 453, 36.38%). The majority of cases were aged 30-39 years (1 598, 40.01%) and 40-49 years (885, 22.16%). The reported incidence rate varied across different cities, ranging from 3.38 per 100 000 to 14.42 per 100 000. The proportion of adult cases among total cases showed a monthly increasing trend from 1.02% in January to 16.43% in December (<i>P</i><0.001). The main clinical symptoms included nocturnal cough exacerbation (1 765, 45.42%) and paroxysmal spasmodic cough (1 253, 32.24%). Cases aged≥60 years had higher rates of complications [13.48% (81) vs 8.28% (272), <i>P</i><0.001] and hospitalizations [20.47% (123) vs 6.06% (199), <i>P</i><0.001] compared to those aged<60 years. <b>Conclusions:</b> The incidence of pertussis among adults in Zhejiang Province was significantly increasing in 2024, with the proportion of adult cases rising month by month. Women aged 30 to 49 were the high-risk group, and the elderly bore a relatively heavy disease burden. The clinical manifestations were mainly atypical symptoms such as exacerbated nocturnal coughing.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 30","pages":"2567-2572"},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Outcomes of excisional goniotomy using the Kahook Dual Blade in refractory glaucoma].","authors":"Y Xie, S M Lin, J Han, Q Guo, C Y Guo, J Y Fan, S Y Wang, Y Y Li, C Y Qiao","doi":"10.3760/cma.j.cn112137-20241210-02793","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20241210-02793","url":null,"abstract":"<p><p>The current study aimed to explore the efficacy and safety of excisional goniotomy using the Kahook Dual Blade (KDB-GTE) in refractory glaucoma. A total of 20 eyes from 19 subjects with mild to late-stage refractory glaucoma who underwent standalone KDB goniotomyor combined phacoemulsification plusintraocular lens (IOL) implantation (partially combined withgoniosynechialysis) in Beijing Tongren Hospital from August 2021 to April 2023 were included. There were 9 males and 10 females, with a mean age of (57±17) years and a follow-up time of (19.8±6.4) months.The preoperative intraocular pressure (IOP) decreased from (29.4±11.8) mmHg (1 mmHg=0.133 kPa) to (15.7±2.6) mmHg (<i>P</i><0.001). The types of preoperativeanti-glaucoma medications were reduced from 4 (3, 4) to 2 (1, 3) (<i>P</i><0.001). At 12-month follow-up, 70% (14/20) achieved a IOP of≤18 mmHg after medication. No severe complications were reported. This study suggests that KDB-GTE is an effective and minimally invasive surgery for refractory glaucoma, demonstrating significant reductions in both IOP and medication burden, with a favorable safety profile.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 30","pages":"2577-2580"},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Introduction of WHO position paper on immunization to protect infants against respiratory syncytial virus disease, May 2025].","authors":"M Y Jiang, Y P Duan, W Z Yang, L Z Feng","doi":"10.3760/cma.j.cn112137-20250624-01544","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250624-01544","url":null,"abstract":"<p><p>On May 30, 2025, World Health Organization (WHO) position paper on immunization to protect infants against respiratory syncytial virus (RSV) disease, May 2025 was published (hereinafter referred to as the position paper). The WHO recommends that countries use RSV vaccines or long-acting monoclonal antibodies to prevent severe RSV-related diseases. It provides guidance on immunization schedules and timing, safety and contraindications, product choice, health system integration, surveillance, vaccination of special-population, and research priorities. This paper analyzes the position paper's implications for RSV immunization in China: (1) expanding the application of approved monoclonal antibodies; (2) speeding up the research, development, and introduction of immune products; (3) clarifying vaccination strategies and implementation paths; (4) improving monitoring and evaluation;(5) strengthening professional training and public education; (6) optimizing inter-departmental cooperation.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Differences in psychological states among patients with chronic pain in different lower limb joints].","authors":"Z Y Zhao, Q Jia, K K Yu, Y He, M Y An, Y T Wang, L Wang, M X Wang, X Q Kang, C B Li","doi":"10.3760/cma.j.cn112137-20250101-00006","DOIUrl":"10.3760/cma.j.cn112137-20250101-00006","url":null,"abstract":"<p><p>This study intends to compare the differences in psychological status of patients with chronic pain in different lower extremity joints. A retrospective cross-sectional study was used to assess patients with chronic hip, knee, and ankle pain hospitalized from June to December 2024 in the Sports Medicine Ward of the Department of Orthopaedic Medicine, General Hospital of the People's Liberation Army. A total of 75 patients with chronic pain in the joints, 36 males and 39 females, aged (31.6±9.5) years, were included. General information such as age, gender, and body mass index (BMI) were recorded, and the psychological status of patients was assessed by the Zong-type Anxiety Scale (SAS) and Beck Depression Inventory (BDI). A total of 25 patients each with chronic hip, knee, and ankle pain were included, and the differences in baseline data among the three groups were not statistically significant and were comparable. The results showed that the SAS scores in the hip group were higher than those in the ankle group (mean difference=0.101, 95<i>%CI</i>: 0.029-0.174) and the knee group (mean difference=0.164, 95<i>%CI</i>: 0.094-0.235); the BDI scores in the hip group were higher than those in the ankle group (mean difference=2.081, 95<i>%CI</i>: 0.848-3.314) and knee group (mean difference=2.044, 95<i>%CI</i>: 0.866-3.222). This study suggests that psychological disorders in patients with chronic hip pain are more significant compared to other lower extremity arthralgia patients, and psychological intervention support should be strengthened in this group of patients.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 ","pages":"2511-2514"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Targeting neonatal Fc receptor blockade: reshaping the treatment landscape for IgG-mediated autoimmune diseases].","authors":"J Wu, L N Zhu, X Y Liu","doi":"10.3760/cma.j.cn112137-20250308-00560","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250308-00560","url":null,"abstract":"<p><p>Autoimmune diseases are conditions in which the immune system mistakenly recognizes and attacks its own tissues, triggering a series of inflammatory responses and tissue damage. Pathogenic IgG plays a pivotal role in the pathogenesis and progression of these diseases. Traditional therapeutic agents often yield limited efficacy and are frequently associated with significant adverse effects. The advent of novel biologics, particularly neonatal Fc receptor (FcRn) inhibitors, represents a breakthrough in the treatment of autoimmune diseases. FcRn inhibitors specifically block the interaction between FcRn and IgG, thereby accelerating the degradation of pathogenic IgG and alleviating damage to target organs. Multiple high-quality clinical studies have demonstrated that FcRn inhibitors exhibit remarkable efficacy and favorable safety in various IgG-mediated autoimmune diseases. However, several challenges remain, including variability in individual therapeutic responses, and the need for optimization of dosing regimens. Future research should prioritize the following areas: structural optimization of FcRn inhibitors, expansion of the therapeutic indications, exploration of combination therapy strategies, and the development of personalized dosing regimens. With the improvement in drug structure, accumulation of clinical evidence, and refinement of treatment approaches, FcRn inhibitors hold considerable promise as a major therapeutic option in the field of autoimmune disease treatment, offering more profound clinical benefits for patients.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 29","pages":"2440-2448"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[From the integration of the internet and medicine to the synergy of artificial intelligence and medicine: my perspective on \"future medicine\" and the development of medical education].","authors":"D N Ba","doi":"10.3760/cma.j.cn112137-20250417-00956","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250417-00956","url":null,"abstract":"<p><p>On the occasion of the 110th anniversary of the Chinese Medical Association, this article reflects on the author's over six decades of experience in medical education, including leadership roles as president and dean at multiple medical schools, sharing insights into advancing medical science and improving medical education. This article details the author's journey and achievements in publishing medical journals and book series, introducing foreign scientific literature, reforming medical education and residency training systems, and facilitating the translation of research into clinical practice. Furthermore, this article calls upon healthcare professionals to embrace artificial intelligence (AI) in medical education, research, and patient care, advocating for its integration to propel China's medical progress and contribute to the nation's Healthy China initiative and rejuvenation.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 29","pages":"2437-2439"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Guidelines for diagnosis and treatment of intracranial atherosclerotic stenosis (2025 edition)].","authors":"","doi":"10.3760/cma.j.cn112137-20250401-00785","DOIUrl":"10.3760/cma.j.cn112137-20250401-00785","url":null,"abstract":"<p><p>Intracranial atherosclerotic stenosis (ICAS) is an important cause of ischemic stroke and transient ischemic attack (TIA), which can also lead to cognitive impairment and dementia. Overall, the prevalence of ICAS is significantly higher in Asian than in Western countries/regions. In recent years, new evidence has emerged regarding the epidemiology, diagnosis, assessment, prognosis and treatment of ICAS, hence there have been guidelines or consensus statements published on the topic in other countries/regions. To better guide the screening, diagnosis and treatment of ICAS in China, the Chinese Research Hospital Association, the Neurointerventional Professional Committee of Chinese Medical Doctor Association, and the Branch of Cerebrovascular Function & Disease convened an expert panel to develop the'Guidelines for Diagnosis and Treatment of Intracranial Atherosclerotic Stenosis (2025 edition). The guidelines are developed based on published research evidence and in reference to relevant domestic and international guidelines or expert consensus, aiming to further clarify the definition, epidemiology and prognosis of ICAS and profiles of high-risk ICAS patients, and provide 30 recommendations on screening, diagnosis, assessment and treatment strategies based on current evidence. We also aim to enhance awareness and understanding of ICAS among clinical and research professionals, promote standardized patient management, and ultimately reduce the prevalence of ICAS and the subsequent risks of stroke, cognitive impairment and other clinical events, thereby improving patient outcomes.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 29","pages":"2449-2468"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}