中华肝脏病杂志最新文献

{"title":"[Clinical cure and safe drug withdrawal in chronic hepatitis B].","authors":"J L Hu, Y W Ji, P Peng, H Fan, L Y Zhao, H J Deng, N Tang, A L Huang","doi":"10.3760/cma.j.cn501113-20250106-00008","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20250106-00008","url":null,"abstract":"<p><p>With the widespread implementation of immunoprophylaxis strategies, the primary challenge in HBV infection prevention and control in China has shifted to reducing the burden of existing infections. A crucial approach to decreasing the burden of existing infections is to develop the effective treatment methods to achieve clinical or functional cures within a limited treatment duration for infected patients. The existing infections can be divided into two parts: those that are easy to cure and those that are difficult to treat. Patients who meet the current drug withdrawal criteria and at the same time have HBsAg<100 IU/mL following treatment with nucelos(t)ide analogue therapy are the easier one to treat, accounting for about 12% of the total infections, and the remaining 88% are difficult to cure. A necessary step toward clinical cure is pushing the HBsAg levels of patients to<100 IU/mL, but this driving effect must stem from effective immune reconstitution against HBV. Recent prevention and control, certain characteristics and implementation of clinical cure, and the safe drug withdrawal are discussed here to offer new perspectives on issues related to hepatitis B.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"33 ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Are antibiotics immunomodulators? An attempt to use vancomycin in the treatment of primary sclerosing cholangitis].","authors":"L P Guo, W R Wang, B M Wang, L Zhou","doi":"10.3760/cma.j.cn501113-20240424-00225","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240424-00225","url":null,"abstract":"<p><p>Primary sclerosing cholangitis (PSC) is a type of chronic idiopathic liver disease characterized by bile duct inflammation and concentric fibrosis. Currently, no drug therapy can change the natural progression of PSC. The mechanism by which PSC is accompanied by the occurrence of inflammatory bowel disease (IBD) is still unclear. Oral antibiotic therapy with vancomycin being the most widely used has been shown to be effective for PSC combined with IBD. This paper analyzes case reports and clinical studies on the use of vancomycin in PSC, with the aim of providing a reference for clinical therapy and in-depth exploration of novel therapeutic directions.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"33 3","pages":"287-292"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Etiological characteristics and drug resistance in patients with hepatitis B virus-associated acute-on-chronic liver failure combined with intra-abdominal infection].","authors":"X L Yu, H B Xie, Y Q Luo, Y Y Zeng","doi":"10.3760/cma.j.cn501113-20240804-00359","DOIUrl":"10.3760/cma.j.cn501113-20240804-00359","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To analyze the distribution, drug resistance, and factors influencing pathogenic microorganisms in patients with hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) combined with intra-abdominal infection (IAI). &lt;b&gt;Methods:&lt;/b&gt; A retrospective analysis was conducted on 282 cases with HBV-ACLF admitted to the Hepatobiliary Internal Medicine Department of Mengchao Hepatobiliary Hospital of Fujian Medical University from May 2019 to December 2022. Patients combined with IAI and positive pathogen culture were enrolled in the infection group (141 cases), and patients combined without IAI admitted during the same period were included in the non-infection group (141 cases). Patient's general clinical data, laboratory examination indicators, pathogen types, and drug sensitivity test results were collected. Logistic regression analysis was used for IAI occurrence risk factors in patients with HBV-ACLF. &lt;b&gt;Results:&lt;/b&gt; A total of 204 pathogenic bacteria were detected in the infection group, including 115 strains of Gram-negative bacteria (56.37%), 74 strains of Gram-positive bacteria (36.28%), and 15 strains of fungi (7.35%). The most frequently detected bacterial genera were Escherichia coli (21.57%, 44/204), &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt; (12.25%, 25/204), &lt;i&gt;Enterococcus faecium&lt;/i&gt; (6.37%, 13/204), &lt;i&gt;Staphylococcus aureus&lt;/i&gt; (5.39%, 11/204), and &lt;i&gt;Staphylococcus epidermidis&lt;/i&gt; (4.90%, 10/204). The results of drug sensitivity tests showed that the resistance rates of &lt;i&gt;Escherichia coli&lt;/i&gt; and &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt; to &lt;i&gt;levofloxacin&lt;/i&gt; and &lt;i&gt;ciprofloxacin&lt;/i&gt; were over 50% (66.67%,26/39;61.54%,24/39)and 30% (34.79%,8/23;39.13%,9/23)respectively. The resistance rate of &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; to carbapenems (&lt;i&gt;meropenem&lt;/i&gt; and &lt;i&gt;imipenem&lt;/i&gt;) was 60.00%. The resistance rates of &lt;i&gt;Acinetobacter baumannii&lt;/i&gt; to &lt;i&gt;meropenem&lt;/i&gt; and &lt;i&gt;imipenem&lt;/i&gt; were 100% (4/4) and 50.00% (2/4) respectively. The resistance rates of &lt;i&gt;Enterococcus faecium&lt;/i&gt; and &lt;i&gt;Enterococcus faecalis&lt;/i&gt; to &lt;i&gt;penicillin&lt;/i&gt; were 100% (13/13) and 33.33% (1/3) respectively. The resistance rates of &lt;i&gt;Staphylococcus aureus&lt;/i&gt; to &lt;i&gt;penicillin&lt;/i&gt; (77.78%,7/9) and &lt;i&gt;oxacillin&lt;/i&gt; (33.33%, 3/9) were relatively high. The results of the multivariate unconditional logistic regression analysis showed that puncture and drainage (&lt;i&gt;OR&lt;/i&gt;=17.90, 95%&lt;i&gt;CI&lt;/i&gt;: 7.94-43.42, &lt;i&gt;P&lt;/i&gt;&lt;0.001), procalcitonin (&lt;i&gt;OR&lt;/i&gt;=3.23, 95%&lt;i&gt;CI&lt;/i&gt;: 1.56-8.98, &lt;i&gt;P&lt;/i&gt;=0.012), C-reactive protein (&lt;i&gt;OR&lt;/i&gt;=1.05, 95%&lt;i&gt;CI&lt;/i&gt;: 1.02-1.00, &lt;i&gt;P&lt;/i&gt;=0.003), and age (&lt;i&gt;OR&lt;/i&gt;=1.06, 95%&lt;i&gt;CI&lt;/i&gt;: 1.02-1.10, &lt;i&gt;P&lt;/i&gt;=0.001) were independent risk factors for IAI in patients with HBV-ACLF. &lt;b&gt;Conclusions:&lt;/b&gt; The pathogenic microorganisms were mainly enterobacteriaceae and enterococci with varying degrees of drug resistance in HBV-ACLF patients combined with IAI. Early-stage intervention is an effective measure to prevent the occurrence of increase o","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"33 ","pages":"205-210"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of portal vein thrombosis on the long-term prognosis of patients with hepatitis B cirrhosis].","authors":"K K Jin, Y Han, Y J Yan, L N Lyu, Y N Liu, Y L He, H G Ding","doi":"10.3760/cma.j.cn501113-20240618-00296","DOIUrl":"10.3760/cma.j.cn501113-20240618-00296","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To explore the characteristics of portal vein thrombosis (PVT) formation in patients with hepatitis B cirrhosis and its effect on long-term prognosis. &lt;b&gt;Methods:&lt;/b&gt; The clinical data of a cohort of patients with hepatitis B cirrhosis who visited Beijing Youan Hospital from May 2009 to August 2020 were retrospectively analyzed. Enhanced CT examination was used as the standard for diagnosing PVT and its classification. Patients with hepatitis B cirrhosis without PVT at baseline were selected as the research subjects. According to whether PVT was formed during the follow-up period, they were divided into the PVT and control groups including 99 and 168 patients in the PVT and control groups with a follow-up time of 52.0 (46.7, 57.3) months. The changes in baseline and endpoint clinical indicators of the two groups were compared. Kaplan-Meier survival curve, log-rank test, and Cox regression were used to analyze the effect of PVT on prognosis. &lt;b&gt;Results:&lt;/b&gt; In the PVT group, 28.28% (28/99) of patients underwent splenectomy, and 74.75% (74/99) did not receive anticoagulation therapy. The main portal vein thrombosis, portal vein branch thrombosis, and thrombosis in both groups accounted for 34.34% (34/99), 23.23% (23/99), and 15.15% (15/99), respectively. The splenic vein or superior mesenteric vein accounted for 27.27% (27/99). PVT was stable in 63.27% (63/99), progressed in 31.31% (31/99), and relieved in 5.05% (5/99) during the follow-up period. The white blood cell, hemoglobin, and platelet counts were all decreased in the PVT group compared with the baseline (&lt;i&gt;P&lt;/i&gt;&lt;0.05). The international normalized ratio (INR) [1.28 (1.14, 1.39) &lt;i&gt;vs&lt;/i&gt;. 1.33 (1.19, 1.46), &lt;i&gt;P&lt;/i&gt;=0.041] and spleen length [(163.84±30.68) mm &lt;i&gt;vs&lt;/i&gt;. (177.26±32.61) mm, &lt;i&gt;P&lt;/i&gt;&lt;0.001] was increased compared with the baseline. The proportion of gastroesophageal variceal bleeding was higher in the PVT group than in the control group (57.0% &lt;i&gt;vs&lt;/i&gt;. 28.7%, &lt;i&gt;P&lt;/i&gt;&lt;0.001), and the constituent ratio of hepatic encephalopathy was not statistically significantly different (&lt;i&gt;P&lt;/i&gt;&gt;0.05). The proportion of patients with ascites in the control group decreased (63.1% &lt;i&gt;vs&lt;/i&gt;. 41.7%, &lt;i&gt;P&lt;/i&gt;&lt;0.001), while the proportion of patients with ascites in the PVT group was not statistically significantly different (&lt;i&gt;P&lt;/i&gt;&gt;0.05). The incidence of composite clinical endpoint events in the PVT and the control group was 21.21% (21/99) and 4.17% (7/168), respectively (&lt;i&gt;P&lt;/i&gt;＜0.05). The incidence of composite clinical endpoint events in PVT patients without anticoagulation and anticoagulation treatment was 25.68% (19/74) and 8.00% (2/25), respectively (&lt;i&gt;P&lt;/i&gt;=0.062). Cox regression analysis found that PVT formation was an independent risk factor for liver-related adverse events in patients with hepatitis B cirrhosis (&lt;i&gt;HR&lt;/i&gt;=9.36, 95%&lt;i&gt;CI:&lt;/i&gt; 3.65～24.02, &lt;i&gt;P&lt;/i&gt;=0.001). &lt;b&gt;Conclusions:&lt;/b&gt; The presence of PVT in patients with hepatitis B cirrhosis is a","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"33 ","pages":"217-226"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of cirrhosis combined with myeloproliferative neoplasms].","authors":"W C Li, S X Zhao, S H Liu, F Han, Y M Nan","doi":"10.3760/cma.j.cn501113-20240409-00187","DOIUrl":"10.3760/cma.j.cn501113-20240409-00187","url":null,"abstract":"","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"32 ","pages":"266-269"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of drug-induced hypersensitivity syndrome combined with acute hepatitis E].","authors":"T T Ji, T L Wang, H C Xing, Y Y Ren, Y Y Yu, T T Yao, S Wang, J H Xu","doi":"10.3760/cma.j.cn501113-20240531-00277","DOIUrl":"10.3760/cma.j.cn501113-20240531-00277","url":null,"abstract":"","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"33 3","pages":"270-272"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on the correlation between high expression of GIT1 and M2 macrophage infiltration and prognosis in hepatocellular carcinoma].","authors":"B B Su, C Zhang, B S Wei, J Cao, R Peng, D Y Tu, G Q Jiang, S J Jin, D S Bai","doi":"10.3760/cma.j.cn501113-20240827-00396","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240827-00396","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the expression, prognosis, and role of G protein-coupled receptor kinase-interacting protein 1 (GIT1) in patients with hepatocellular carcinoma (HCC) tumor micro environments. <b>Methods:</b> Clinical data of 140 cases who underwent complete HCC surgical resection from January 2015 to December 2021 in Subei People's Hospital affiliated to Yangzhou University, Jiangsu Province, were included. Tumor tissue and adjacent tissue samples were collected for immunohistochemical analysis. The patients were divided into a high expression group and a low expression group according to the expression of GIT1. Cox regression was used to analyze the risk factors for prognosis in patients with HCC. Fifteen pairs of cancer tissues and adjacent tissues were randomly matched for quantitative polymerase chain reaction (RT-PCR), western blot (WB), and immunohistochemical analysis. GITI knockout or overexpression cell lines of human hepatoma cell lines HepG2, HuH7 and MHCC97-H, and mouse hepatoma cell line Hepa 1-6 were constructed. The effects on M2 macrophage polarization were analyzed by flow cytometry. A mice tumor model was constructed. The growth curve of tumor tissue overexpressing GIT1 was plotted. Bioinformatics analysis of the Cancer Genome Atlas (TCGA) data was performed using OncoLnc, Kaplan-Meier Plotter, UALCAN, and GEPIA databases to explore the differential expression of GIT1 in HCC patients and its effect on prognosis. <b>Results:</b> Bioinformatics analysis showed that the expression level of GIT1 was significantly higher in HCC tissues than in normal liver tissues (<i>P</i><0.05). RT-PCR and WB experiments showed that GIT1 was highly expressed in HCC. The follow-up results showed that high expression of GIT1 was associated with poor prognosis in patients with HCC. The high expression of GIT1 was an independent risk factor for the prognosis in patients with HCC (<i>HR</i>=2.562, 95%<i>CI</i>: 0.231-0.704, <i>P</i><0.05). Functional enrichment analysis combined with TIMER database analysis found that GIT1 expression level was associated with multiple immune cell infiltrations in HCC, but the correlation coefficient with macrophage infiltration was the highest (<i>r</i>=0.545, <i>P</i><0.001). Mice tumorigenesis experiments showed that the tumor volume of GIT1-overexpressing mice was significantly increased (<i>P</i><0.05). Additionally, flow cytometry indicated that after GIT1 overexpression, there was a low degree of M1 infiltration/polarization (wild type: 5.06%±0.11%, overexpression type: 4.09%±0.04%; <i>P</i><0.05) and a high degree of M2 infiltration/polarization (wild type: 10.20%±0.33%, overexpression type: 14.7%±0.12%; <i>P</i><0.05). <b>Conclusion:</b> GIT1 serves as a prognostic biomarker in HCC, promoting tumor progression through its high expression and enhances M2 macrophage infiltration.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"33 3","pages":"237-247"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current status of research on the impairment of natural killer cell function caused by hepatitis B virus infection].","authors":"X Y Zhu, Y F Zhou, S G Zhu","doi":"10.3760/cma.j.cn501113-20240226-00094","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240226-00094","url":null,"abstract":"<p><p>Hepatitis B is a global health problem caused by hepatitis B virus (HBV) infection, with approximately 240 million people worldwide being hepatitis B surface antigen positive. However, existing antiviral therapies can only control HBV replication and cannot eliminate it, thereby seriously affecting the disease's prognosis. Immunotherapy has received widespread attention in recent years due to its long-lasting effects and safety profile. As one of the innate immune cells, natural killer cells play an important role in targeting HBV-infected cells and completely eliminating HBV infection. Natural killer cells can not only directly recognize and kill virus-infected cells but also regulate adaptive immune responses by secreting the cytokine interferon gamma. This article aims to review the regulatory relationship between natural killer cells and HBV-infected cells, research progress of natural killer cell-based immunotherapy targeting HBV infection, and explore the impact of natural killer cells on the occurrence and development of hepatocellular carcinoma in order to provide some enlightenment for improved treatment of HBV infection.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"33 3","pages":"300-306"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Factors affecting tumorigenicity in liver cancer xenografts].","authors":"M Y Chai, S S Dou, B X Kou, Y F Huo, M H Gao, Q W Li, X N Liu","doi":"10.3760/cma.j.cn501113-20241119-00587","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20241119-00587","url":null,"abstract":"<p><p><b>Objective:</b> To establish a tumor tissue xenograft (PDX) model derived from liver cancer patients and explore the factors affecting tumorigenicity of liver cancer in the PDX model. <b>Methods:</b> The hepatocellular carcinoma tissues were inoculated subcutaneously in the axilla of NPG mice using the tissue block method to establish a PDX model. The demographic characteristics and related clinical examination data of 60 hepatocellular carcinoma patients were collected using the electronic medical record system and comprehensive medical information system of Beijing You'an Hospital, affiliated to Capital Medical University. The hepatocellular carcinoma samples of 24 cases were sequenced using the Oak Wing TM-808 gene detection reagent and high-throughput sequencing technology. SPSS 17.0 statistical software was used for statistical analysis, and the count data were analyzed using the <i>χ</i>² test. <b>Results:</b> The tumorigenicity rate of PDX samples from 60 patients with liver cancer was 35% (21/60). The average tumorigenic duration in the PDX-P0 generation was 110.71±50.45 days. There were statistically significant differences (<i>P</i><0.05) corresponding to Edmondson grade (<i>χ</i>²=5.910, <i>P</i>=0.015) and Ki67 expression (<i>χ</i>²=4.615, <i>P</i>=0.032) among PDX with tumorigenicity and without tumorigenicity between the liver cancer samples. There was no statistically significant difference in gene mutation (TOP25) among PDX with tumorigenicity and without tumorigenicity between liver cancer samples. <b>Conclusion:</b> The factors affecting the tumorigenicity of liver cancer in PDX models are complex. The high pathological grade and strong Ki67 expression may be the key factors for the completion of liver cancer in PDX models.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"33 3","pages":"248-254"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the role of invariant natural killer T cells in immune-mediated liver injury].","authors":"L X Bai, W K Hao, J R Li, S F Li, L T Zhang, J F Li","doi":"10.3760/cma.j.cn501113-20240429-00235","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240429-00235","url":null,"abstract":"<p><p>The pathogenesis of immune-mediated liver injury is related to immune regulation disorders. In recent years, researchers have focused on the unique role of invariant natural killer T cells (iNKT cells) in immune-mediated liver injury. iNKT cells, a special subset of lymphocytes, are crucial for immune regulation by bridging innate and adaptive immunity. iNKT cells interact with various immune cells and possess strong immune regulatory capabilities, but their role is complex, potentially promoting liver injury or protecting the liver from damage. This article reviews the latest research progress on iNKT cells in immune-mediated liver injury and describes some factors that regulate immune liver injury by altering the expression of glycosphingolipids, such as liver X receptor and tumor progression site2. In addition, the research results are explored to assist in deepening the understanding of the mechanism of immune-mediated liver injury so as to provide new directions for the development of related treatment strategies.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"33 3","pages":"273-279"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}