中华肝脏病杂志最新文献

{"title":"[The nomogram model and its value study of Gd-EOB-DTPA enhanced MRI for preoperative diagnosis of proliferative hepatocellular carcinoma].","authors":"F X Chen, D J Guo, Y Xu, J Cheng, Y M Li, G L Chen, X M Li","doi":"10.3760/cma.j.cn501113-20240509-00246","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240509-00246","url":null,"abstract":"<p><p><b>Objective:</b> To develop a nomogram model for preoperative diagnosis of proliferative hepatocellular carcinoma(HCC) based on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced magnetic resonance imaging (MRI), and to explore its clinical value. <b>Methods:</b> MRI and clinical pathological data of patients confirmed by pathology as proliferative HCC (178 cases) and non-proliferative HCC (378 cases) between September 2017 and November 2022 who underwent preoperative Gd-EOB-DTPA enhanced MRI scans were retrospectively collected. The MRI features and clinical pathological characteristics of proliferative and non-proliferative HCC were evaluated. Multivariable logistic regression analysis was utilized to identify independent predictive factors for proliferative HCC, the R software was used to construct the nomogram prediction model, and its diagnostic performance was evaluated through receiver operating characteristic (ROC) curve. The calibration curve and decision curve analysis (DCA) were drawn to evaluate the calibration performance and clinical application value of the nomogram model. The optimal cut-off value was selected by calculating the Youden index to distinguish high risk and low risk. Kaplan-Meier survival curve was used to analyze the survival prognosis of proliferative and non-proliferative HCC, and log-rank test was used for comparison. <b>Results:</b> There were significant differences in AFP level(<i>χ</i><sup>2</sup>=17.244, <i>P</i><0.001), morphology of tumor(<i>χ</i><sup>2</sup>=13.669, <i>P</i><0.001), intertumoral fat(<i>χ</i><sup>2</sup>=10.495, <i>P</i>=0.001), arterial phase peritumoral enhancement(<i>χ</i><sup>2</sup>=37.662, <i>P</i><0.001), tumor capsule(<i>χ</i><sup>2</sup>=23.961, <i>P</i><0.001), substantial intratumoral necrosis(<i>χ</i><sup>2</sup>=77.184, <i>P</i><0.001), intratumoral hemorrhage(<i>χ</i><sup>2</sup>=4.892, <i>P</i>=0.027), peritumoral hypointense in hepatobiliary phase(<i>χ</i><sup>2</sup>=47.675, <i>P</i><0.001), rim arterial phase hyperenhancement(<i>χ</i><sup>2</sup>=115.976, <i>P</i><0.001), intratumoral artery(<i>χ</i><sup>2</sup>=15.528, <i>P</i><0.001) and venous tumor thrombus(<i>χ</i><sup>2</sup>=10.532, <i>P</i>=0.001) between proliferative and non-proliferative HCC groups. Multivariate Logistic regression analysis showed that AFP>200 ng/ml(<i>OR</i>=0.640, <i>P</i>=0.044), no intertumoral fat(<i>OR</i>=1.947, <i>P</i>=0.033), substantial intratumoral necrosis(<i>OR</i>=0.480, <i>P</i>=0.003), peritumoral hypointense in hepatobiliary phase(<i>OR</i>=0.432, <i>P</i>=0.001), and rim arterial phase hyperenhancement(<i>OR</i>=0.180, <i>P</i><0.001) were independent predictors of preoperative diagnosis of proliferative HCC. Based on the independent predictors, a nomogram model for preoperative prediction of proliferative HCC was established. The area under the ROC curve of the model for predicting proliferative HCC was 0.772 (95%<i>CI</i>: 0.735～0.807),","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"32 ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The Research and Application Progress of Heterologous Liver Transplantation].","authors":"Y Xie, D Wang, W T Jiang","doi":"10.3760/cma.j.cn501113-20240528-00270","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240528-00270","url":null,"abstract":"<p><p>Liver transplantation is an effective treatment for various end-stage liver diseases, and the shortage of donor livers is one of the main obstacles affecting the development of liver transplantation. Xenotransplantation holds promise as a potential solution to the organ shortage. By using gene-editing technology to modify animal genes, their physiological compatibility with humans can be improved. Combining this with new immunosuppressive drugs can reduce the occurrence of rejection, thereby increasing the survival time of the graft. Due to the more complex structure and physiological functions of the liver, inter-species incompatibility is more pronounced in liver xenotransplantation compared to heart or kidney. The molecular mechanisms related to xenograft rejection and coagulation disorders post-operation require further research. This article reviews the latest research progress domestically and internationally, the historical development of liver xenotransplantation, the main current challenges, and clinical applications, aiming to enhance clinicians' understanding of liver xenotransplantation.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"32 ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Excerpt from the 2023 European Association for the Study of the Liver practice guidelines: prevention, diagnosis, and treatment of intrahepatic cholangiocarcinoma].","authors":"Y W Shang, G H Han","doi":"10.3760/cma.j.cn501113-20240422-00221","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240422-00221","url":null,"abstract":"<p><p>Intrahepatic cholangiocarcinoma (iCCA) occurs within the liver, between the bile duct and the secondary bile duct. It is the second most common primary liver cancer after hepatocellular carcinoma, and its incidence rate is increasing worldwide. The mortality rate is alarming because of its clinical asymptomatic features (often leading to delayed diagnosis), high invasiveness, and treatment resistance. Early diagnosis, molecular pathological biology, accurate staging, and personalized multidisciplinary treatment are current challenges for researchers and physicians. Furthermore, iCCA is difficult to treat due to its high heterogeneity at the clinical, genomic, epigenetic, and molecular levels. However, recent advances in molecular, surgical, and targeted therapies, along with the recognition that the etiology, risk factors, pathophysiology, molecular biology, and clinical management of iCCA differ completely from those of hilar cholangiocarcinoma (pCCA) and distal cholangiocarcinoma (dCCA), have prompted the International Liver Cancer Association and the European Association for the Study of the Liver to commission international specialized experts to draft evidence-based guidelines for physicians involved in the diagnosis, treatment, and prognosis. Herein, the key points of the guidelines are excerpted.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"32 ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Rifaximin curative effect and mechanism on monocrotaline-induced hepatic sinusoidal obstruction syndrome in mice].","authors":"S Zhao, J Q Xiao, H Zhang, J J Tu, Q Yin, Y Z Zhuge","doi":"10.3760/cma.j.cn501113-20240118-00035","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240118-00035","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the curative effect and possible mechanism of rifaximin treatment on monocrotaline-induced hepatic sinusoidal obstruction syndrome (HSOS) in mice. <b>Methods:</b> Twenty-four male C57BL/6J mice were divided into three groups and treated with solvent control, monocrotaline, and rifaximin, respectively. The histopathological changes of the liver and intestine were observed by hematoxylin-eosin staining. The differences were compared in liver parameters, serum liver enzymes, inflammatory factors, apoptotic factors, gut microbiota, and gut tight junction proteins among three groups of mice. The inter-group comparison was conducted using a t-test and one-way analysis of variance. <b>Results:</b> The rifaximin-treated group had significantly improved liver histopathology. The serological levels of alanine aminotransferase and aspartate aminotransferase were (559.04±89.42) U/L and (676.90±106.25) U/L, respectively, which were significantly lower than those in the PA-HSOS model group [(846.05±148.46) U/L and (953.87±58.10) U/L, <i>P</i><0.05], and were accompanied by lower levels of apoptotic cells and inflammatory factors. Additionally, the rifaximin-treated mice group gut microbiota had higher diversity compared with the PA-HSOS group (<i>P</i><0.05), and the Shannon index was 7.77±0.10 and 7.16±0.07, respectively, indicating apparent differences in microbiota among different groups. The abundance of Firmicutes in the rifaximin group was 39.58%±0.56%, which was significantly higher than that in the model group (24.25%±0.64%, <i>P</i><0.05), while the abundance of Bacteroidetes was 54.7%±0.41%, which was significantly lower than that in the model group (70.92%±0.49%, <i>P</i><0.05). Simultaneously, the expressions of gut tight junction proteins ZO-1 and Occludin showed an upward trend and validated transcription levels compared to the model group following rifaximin intervention (<i>P</i><0.05). <b>Conclusion:</b> Rifaximin can alleviate monocrotaline-induced hepatic sinusoidal obstruction syndrome in mice, and its mechanism may be via gut microbiota regulation, which in turn plays a role in improving intestinal barrier function.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"32 ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Liver cirrhosis combined with Myeloproliferative neoplasms: A case report].","authors":"W C Li, S X Zhao, S H Liu, F Han, Y M Nan","doi":"10.3760/cma.j.cn501113-20240409-00187","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240409-00187","url":null,"abstract":"","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"32 ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Vancomycin may be an effective attempt in primary sclerosing cholangitis: antibiotic or immunomodulator].","authors":"L P Guo, W R Wang, B M Wang, L Zhou","doi":"10.3760/cma.j.cn501113-20240424-00225","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240424-00225","url":null,"abstract":"<p><p>Primary Sclerosing Cholangitis(PSC) is a rare, chronic liver disease characterized by bile duct inflammation and concentric fibrogenesis. To date, there has been no evidence that any drug therapy can alter the natural course of this disease. PSC is often concomitant with inflammatory bowel disease(IBD), but the pathogenesis remains unclear. Oral antibiotics have been shown to improve PSC and concomitant IBD, and vancomycin is the most widely used. Therefore, this paper reviews literatures on the application of vancomycin in PSC, aiming to explore therapeutic approaches for PSC that target other pathophysiological pathways.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"32 ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expression and clinical significance of PIKFYVE gene in hepatocellular carcinoma analyzed based on TCGA database and experimental validation].","authors":"L M Wen, Y L Guo, D X Zheng, Q Hou, W Dai, X Gao, J H Yang","doi":"10.3760/cma.j.cn501113-20240402-00168","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240402-00168","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the expression and clinical significance of human FYVE finger-containing phosphoinositide kinase (PIKFYVE) in hepatocellular carcinoma (HCC) on the basis of cancer genome atlas (The cancer genome atlas, TCGA) database analysis and clinical samples experimental validation. &lt;b&gt;Methods:&lt;/b&gt; Based on the data information of 424 clinical samples (including 374 cases of HCC tissues and 50 cases of nontumorous liver tissues) in the TCGA database, Cox regression analysis and Kaplan-Meier method were used to analyse the relationship between the PIKFYVE mRNA expression and the clinical characteristics, prognosis for survival of HCC patients. The relationship between the PIKFYVE gene and immune cell infiltration was examined by correlation analysis between the PIKFYVE gene and 24 immune cells. In addition, we analysed the correlation between the mRNA expression of PIKFYVE gene and RAC-alpha serine/threonine-protein kinase (AKT1), phosphatase and tensin homolog (PTEN), protein kinase C, alpha (PRKCA), inositol polyphosphate-5-phosphatase (INPP5D), phosphoinositide-3-kinase regulatory subunit 1(PIK3R1), Inositol Polyphosphate 4-phosphatase Type II (INPP4B) and phospholipase-C4 gene (PLCB4) in HCC tissues. Meanwhile, paraffin sections of highly differentiated, moderately differentiated, poorly differentiated, and nontumorous liver tissue in the Department of Pathology of the First Affiliated Hospital of Xinjiang Medical University were collected, each of which was 30 cases, and the histopathological observation was carried out by HE staining, and the expression levels of PIKFYVE and Ki67 proteins were verified by immunohistochemistry in each clinical sample. &lt;b&gt;Results:&lt;/b&gt; The expression level of PIKFYVE gene in HCC tumours was significantly higher than that in normal liver tissues (&lt;i&gt;P=&lt;/i&gt;0.000 2, &lt;i&gt;P&lt;/i&gt;&lt;0.01), and the overall survival of patients in the low PIKFYVE expression group was significantly longer than that in the high expression group (&lt;i&gt;HR&lt;/i&gt;=1.57, 95%&lt;i&gt;CI&lt;/i&gt;: 1.10～2.25, &lt;i&gt;P&lt;/i&gt;=0.014). The results of Univariate Cox regression analysis showed that there was an effect of TNM stage, pathological stage, tumour status and residual tumour on Overall survival (OS) (&lt;i&gt;P&lt;/i&gt;&lt;0.05), and the expression level of PIKFYVE had an effect on OS survival (&lt;i&gt;P&lt;/i&gt;&lt;0.05); the PIKFYVE prognostic risk model score ratio was &lt;i&gt;HR&lt;/i&gt;=1.533 (1.077-2.181, &lt;i&gt;P&lt;/i&gt;=0.018). Multivariate Cox regression analysis showed a PIKFYVE prognostic risk model score ratio &lt;i&gt;HR&lt;/i&gt;=1.481 (0.886-2.476, &lt;i&gt;P&lt;/i&gt;=0.134) and an area under the Receiver Operating Characteristic curve of 0.640, which was greater than 0.5, suggesting that the PIKFYVE prognostic risk model has a predictive value in survival prediction. Correlation analysis showed that the expression level of PIKFYVE was highly correlated with immune cell infiltration and &lt;i&gt;TP53&lt;/i&gt; (&lt;i&gt;P&lt;/i&gt;&lt;0.01). The immunohistochemistry staining results showed that the expression of PIKFYV","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"32 ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[CK19 is associated with poor survival in patients with dual-phenotype hepatocellular carcinoma].","authors":"Y Q Yan, L J Qu, X Z Ye, M Li, X J Ouyang","doi":"10.3760/cma.j.cn501113-20240307-00118","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240307-00118","url":null,"abstract":"<p><p><b>Objective:</b> To study the role of CK19 in the survival of patients diagnosed with DPHCC in Fujian, China, which has a high incidence of hepatocellular carcinoma (HCC). <b>Methods:</b> Patients with DPHCC (<i>n</i>=84) who had undergone surgical interventions at the 900th Hospital of Joint Logistic Support Force between 2013 and 2019 were retrospectively analyzed using the log-rank test and Kaplan-Meier method. Univariate and multivariate Cox model analyses were also conducted to further understand the correlation between CK19 and patient survival. <b>Results:</b> (1)Tumor size, differentiation, peripheral hepatic fibrosis, liver capsule invasion, microvascular invasion (MVI) and serum CA-199 level showed a correlation with CK19, as per the outcomes of Chi-squared tests. (2)According to the univariate analysis, the expression of CK19, MVI, the number of tumor lesions, necrosis, differentiation, peripheral hepatic fibrosis, and serum levels of both alpha-fetoprotein (AFP) and CA-199 showed a strong correlation with overall survival. (3)Necrosis and serum AFP levels were strongly related to an increased risk of death, according to the multivariate analysis. <b>Conclusions:</b> The expression of CK19 may correlate with the survival of patients with DPHCC and could potentially serve as a prognostic predictor of survival.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"32 ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Impact of ascites grading and non-selective β-blockers on 1-year prognosis of Acute-on-chronic liver failure].","authors":"W S Liu, L J Shen, X He, H Tian, Q H Zhai, D Z Li, S J Xin, S L You","doi":"10.3760/cma.j.cn501113-20240130-00067","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240130-00067","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the influence of ascites grading and non-selective β- blockers (NSBBs) on the 1-year prognosis of patients with acute-on-chronic liver failure (ACLF). <b>Methods:</b> A total of 1 386 patients with ACLF were graded for ascites and followed up for one year. Kaplan-Meier Log-rank test and Cox regression were used for multivariate regression to analyze the effects of ascites grading and NSBBs on the 1-year prognosis of ACLF. <b>Results:</b> The incidence of ascites in 1 836 patients with ACLF was 77.56% on admission. Ascites grade was related to the 1-year prognosis of ACLF [log rank (Mantel-Cox) <i>χ</i>²=21.384, <i>p</i>=0.000]. Cox stepwise regression analysis showed that ascites grade, age, gastrointestinal bleeding, pulmonary infection, acute kidney injury, prothrombin time activity(PTA), urea, MELD-Na score, and application of NSBBs were closely related to the 1-year prognosis of ACLF. The result of Kaplan-Meier Log-rank test for patients treated with NSBBs in the grade 2/3 ascites group suggest that NSBBs can improve the 1-year survival rate of ACLF patients with grade 2 and grade 3 ascites ( log rank (Mantel-Cox) <i>χ</i>²=6.113, <i>p</i>=0.013). <b>Conclusions:</b> Ascites grading and application of NSBBs can affect the 1-year prognosis of ACLF. NSBBs may be beneficial to the long-term prognosis of ACLF. Patients treated with NSBBs before the onset of ACLF should continue NSBBs treatment.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"32 ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of Wilson's disease misdiagnosed as autoimmune hepatitis and literature review].","authors":"L F Chen, Y P Wan, L M Xiao, D Li, Z L Wen, L L Yang","doi":"10.3760/cma.j.cn501113-20240411-00193","DOIUrl":"https://doi.org/10.3760/cma.j.cn501113-20240411-00193","url":null,"abstract":"","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"32 ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}