【凝血酶原异常在hbv相关肝癌诊断中的价值研究】。

Q3 Medicine
J M Zhang, S X Zhao, L D Liu, F Han, W G Ren, X Q Wu, M J Sun, J J Song, Y M Nan
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引用次数: 0

摘要

目的:建立并探讨基于异常脱氧-羧基凝血酶原(DCP)早期诊断乙型肝炎病毒(HBV)相关肝细胞癌(HCC)的新模型及其临床应用价值。方法:回顾性选择2021年1月至2024年6月河北医科大学第三医院影像学检查的420例慢性HBV感染伴肝结节性病变患者。按照现行HCC诊断标准分为HBV-HCC组(182例)和对照组(238例)。收集并分析患者基本信息、肝脏相关生化指标、血清DCP、甲胎蛋白(AFP)水平及联合检测对早期HCC的诊断效果。构建以DCP (D)为自变量,以性别(S)、γ-谷氨酰转移酶(GGT, G)、AFP (A)、年龄(A)为自变量的DSGAA模型。通过图形可视化输出和标定曲线,比较了新模型与传统模型的诊断性能。结果:HCC患者的年龄、性别、血红蛋白、白蛋白、丙氨酸转氨酶、碱性磷酸酶、GGT水平均显著高于对照组(p < 59.89%, p < 0.05)。结论:DCP对hbv相关HCC具有优越的诊断效果,DSGAA模型有望成为筛查和诊断早期hbv相关HCC的新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Study on the value of abnormal prothrombin in the diagnosis of HBV-related hepatocellular carcinoma].

Objective: To establish and explore a novel model and its clinical application value based on abnormal des-gamma-carboxy prothrombin (DCP) for the early-stage diagnosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods: A total of 420 cases with chronic HBV infection with nodular liver lesions examined by imaging at the Third Hospital of Hebei Medical University from January 2021 to June 2024 were retrospectively selected. They were divided into the HBV-HCC group (182 cases) and the control group (238 cases) according to the current HCC diagnostic criteria. The basic information of patients, liver-related biochemical indicators, serum DCP, alpha-fetoprotein (AFP) levels, and the efficacy of combined detection in diagnosing early-stage HCC were collected and analyzed. A DSGAA model based on DCP (D) combined with gender (S), γ-glutamyl transferase (GGT, G), AFP (A) and age (A) as independent variables was constructed. The diagnostic performance of the novel model was compared with that of the traditional model through nomogram visualization output and calibration curve. Results: The age, sex, hemoglobin, albumin, alanine aminotransferase, alkaline phosphatase, and GGT levels were significantly higher in patients with HCC than those of the control group (P<0.05). The positivity detection rate in patients with HBV-HCC was significantly higher in DCP than that of AFP (85.71% vs. 59.89%,P<0.05). The abnormal detection rate of DCP in patients with AFP-negative was 76.7%. The sensitivity for diagnosing HCC was significantly higher in DCP than AFP (73.63% vs. 64.29%,P<0.05), with specificity of 83.6% in all. The specificity for diagnosing early-stage HCC was 89.09%, surpassing that of AFP at 68.06% (P<0.05). The area under the receiver operating characteristic curve (AUC) for the constructed DSGAA diagnostic model was 0.8841, with an optimal cutoff value of 0.377, a sensitivity of 80.22%, and a specificity of 86.13%. The AUC for diagnosing early-stage HCC was 0.8122, with a sensitivity of 66.18%, and a specificity of 86.13%, and the diagnostic efficacy was higher than other models (P<0.05). Conclusion: DCP has superior diagnostic efficacy for HBV-related HCC, and the DSGAA model is expected to be used as a new method for screening and diagnosing early-stage HBV-related HCC.

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来源期刊
中华肝脏病杂志
中华肝脏病杂志 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
7574
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