【胆汁酸代谢与原发性肝癌的发生发展】。

Q3 Medicine
J Han, Y Y Lu
{"title":"【胆汁酸代谢与原发性肝癌的发生发展】。","authors":"J Han, Y Y Lu","doi":"10.3760/cma.j.cn501113-20250318-00098","DOIUrl":null,"url":null,"abstract":"<p><p>Primary liver cancer is a common malignant tumor with a high mortality rate. Therefore, early-stage diagnosis and screening are of enormous significance. In recent years, studies have found that bile acids play a key role in the occurrence and development of liver cancer and are expected to become novel diagnostic markers and intervention targets. This article reviews the abnormal changes in bile acid metabolism during the occurrence and development of liver cancer, including the changes in bile acid composition and levels in liver tissue, plasma, feces, and urine, as well as the changes in enzymes related to bile acid metabolism. Furthermore, it expounds the mechanism by which bile acids affect the occurrence of liver cancer, such as participating in multiple signaling pathways to initiate the occurrence and affecting the immune microenvironment, and discusses the potential of bile acids as diagnostic markers for prevention and treatment strategies targeting bile acid metabolism. Bile acids have potential value in the diagnosis and prevention of liver cancer; yet, there are still challenges. In the future, it is necessary to build a large-scale follow-up cohort and biobank, innovate technology for detecting bile acids, and integrate it with multi-omics so as to improve the accuracy of early-stage diagnosis and prevention and treatment of liver cancer.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"33 4","pages":"317-322"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Bile acid metabolism and the occurrence and development of primary liver cancer].\",\"authors\":\"J Han, Y Y Lu\",\"doi\":\"10.3760/cma.j.cn501113-20250318-00098\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Primary liver cancer is a common malignant tumor with a high mortality rate. Therefore, early-stage diagnosis and screening are of enormous significance. In recent years, studies have found that bile acids play a key role in the occurrence and development of liver cancer and are expected to become novel diagnostic markers and intervention targets. This article reviews the abnormal changes in bile acid metabolism during the occurrence and development of liver cancer, including the changes in bile acid composition and levels in liver tissue, plasma, feces, and urine, as well as the changes in enzymes related to bile acid metabolism. Furthermore, it expounds the mechanism by which bile acids affect the occurrence of liver cancer, such as participating in multiple signaling pathways to initiate the occurrence and affecting the immune microenvironment, and discusses the potential of bile acids as diagnostic markers for prevention and treatment strategies targeting bile acid metabolism. Bile acids have potential value in the diagnosis and prevention of liver cancer; yet, there are still challenges. In the future, it is necessary to build a large-scale follow-up cohort and biobank, innovate technology for detecting bile acids, and integrate it with multi-omics so as to improve the accuracy of early-stage diagnosis and prevention and treatment of liver cancer.</p>\",\"PeriodicalId\":24006,\"journal\":{\"name\":\"中华肝脏病杂志\",\"volume\":\"33 4\",\"pages\":\"317-322\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华肝脏病杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/cma.j.cn501113-20250318-00098\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华肝脏病杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/cma.j.cn501113-20250318-00098","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

原发性肝癌是一种常见的恶性肿瘤,死亡率高。因此,早期诊断和筛查具有重要意义。近年来,研究发现胆汁酸在肝癌的发生发展中起着关键作用,有望成为新的诊断标志物和干预靶点。本文综述了肝癌发生发展过程中胆汁酸代谢的异常变化,包括肝组织、血浆、粪便和尿液中胆汁酸组成和水平的变化,以及胆汁酸代谢相关酶的变化。进一步阐述了胆汁酸影响肝癌发生的机制,如参与多种信号通路启动肝癌发生、影响免疫微环境等,并探讨了胆汁酸作为诊断标志物的潜力,为针对胆汁酸代谢的防治策略提供依据。胆汁酸在肝癌的诊断和预防中具有潜在价值;然而,挑战依然存在。未来需要建立大规模的随访队列和生物库,创新胆汁酸检测技术,并与多组学相结合,以提高肝癌早期诊断和防治的准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Bile acid metabolism and the occurrence and development of primary liver cancer].

Primary liver cancer is a common malignant tumor with a high mortality rate. Therefore, early-stage diagnosis and screening are of enormous significance. In recent years, studies have found that bile acids play a key role in the occurrence and development of liver cancer and are expected to become novel diagnostic markers and intervention targets. This article reviews the abnormal changes in bile acid metabolism during the occurrence and development of liver cancer, including the changes in bile acid composition and levels in liver tissue, plasma, feces, and urine, as well as the changes in enzymes related to bile acid metabolism. Furthermore, it expounds the mechanism by which bile acids affect the occurrence of liver cancer, such as participating in multiple signaling pathways to initiate the occurrence and affecting the immune microenvironment, and discusses the potential of bile acids as diagnostic markers for prevention and treatment strategies targeting bile acid metabolism. Bile acids have potential value in the diagnosis and prevention of liver cancer; yet, there are still challenges. In the future, it is necessary to build a large-scale follow-up cohort and biobank, innovate technology for detecting bile acids, and integrate it with multi-omics so as to improve the accuracy of early-stage diagnosis and prevention and treatment of liver cancer.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
中华肝脏病杂志
中华肝脏病杂志 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
7574
期刊介绍:
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信