Chinese journal of otorhinolaryngology head and neck surgery最新文献

{"title":"[Surgery-based multimodal therapy for cervical esophageal squamous cell carcinoma: a retrospective analysis of 117 cases].","authors":"Z H Lyu, P H Jing, Y M Wei, J K Ma, X L Liu, C Zhou, W Xu","doi":"10.3760/cma.j.cn115330-20250720-00381","DOIUrl":"10.3760/cma.j.cn115330-20250720-00381","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the efficacy of a surgery based multimodal therapy for locally advanced resectable cervical esophageal squamous cell carcinoma, focusing on surgical indications, selection of resection and reconstruction methods, and factors influencing prognosis. <b>Methods:</b> A retrospective analysis was conducted on the clinical data of 117 patients with primary cervical esophageal squamous cell carcinoma treated at Department of Head and Neck Surgery, Shandong Ear-Nose-Throat Hospital from September 2014 to October 2023. The cohort consisted of 93 males and 24 females, aged from 45 to 77 years. There were 35 cases with T1-T2 stage and 82 cases with T3-T4 stage. Gastroscopy screening upon admission identified synchronous middle-inferior esophageal carcinoma in 11 cases and synchronous hypopharyngeal cancer in 4 cases. Treatment regimens were as follows: surgery with postoperative adjuvant radiotherapy in 72 cases; surgery with adjuvant concurrent chemoradiotherapy/radiotherapy plus targeted therapy in 7 cases; neoadjuvant chemotherapy (or with immunotherapy) followed by surgery and postoperative radiotherapy in 7 cases; neoadjuvant concurrent chemoradiotherapy or planned preoperative radiotherapy followed by surgery in 6 cases; and surgery alone or incomplete postoperative radiotherapy in 25 cases. Total laryngectomy was performed in 112 patients, while, 5 patients retained laryngeal function. The main reconstruction methods included free jejunal graft in 26 cases and gastric pull-up with pharyngogastric anastomosis in 91 cases. Among these, one patients underwent free jejunal graft combined with middle and lower esophageal resection, while two patients with gastric pull-up combined with free skin grafts, one patient combined with pectoralis major myocutaneous flaps, and one patient combined with free jejunal grafts reconstruction. Clinical data were analyzed using SPSS 25.0 software. <b>Results:</b> Follow-up was completed until Feb 2025. Eighty seven patients competed 3-year follow-up. Sixty one patients completed 5-year follow-up. The 3-year and 5-year overall survival rates were 65.0% and 50.5% calculated by the Kaplan-Meier method. Fifty patients died during follow-up, among whom 28 (56.0%) patients died from distant metastases. One patient died perioperatively. Major complications included partial gastric necrosis (<i>n</i>=1), vascular thrombosis of the jejunum graft requiring a second jejunal graft reconstruction (<i>n</i>=1) or salvageable gastric pull-up (<i>n</i>=1), pharyngeal fistula (<i>n</i>=10), severe pulmonary infection (<i>n</i>=3), cervical hemorrhage (<i>n</i>=2), pharyngeal fistula leading to pharyngogastric anastomotic stricture (<i>n</i>=2), and pleural effusion (<i>n</i>=5). Multivariate analysis revealed that T3-T4 stage,N2-N3 stage and stage Ⅲ-Ⅳ diseases were independent prognostic factors (all <i>P</i><0.05). <b>Conclusions:</b> Surgery-based multimodal therapy for cervical esophageal squamous c","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 ","pages":"410-416"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Management strategies for internal carotid artery rupture following radiotherapy for nasopharyngeal carcinoma].","authors":"Z X Wang, Z L Wang, X H Zeng, Q H Zhang","doi":"10.3760/cma.j.cn115330-20250716-00377","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250716-00377","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 4","pages":"474-480"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Multidimensional advances in in <i>vivo</i> cochlear imaging techniques in small rodents: from methodological innovations to translational applications].","authors":"R F Lin, Y Y Yuan","doi":"10.3760/cma.j.cn115330-20250811-00418","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250811-00418","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 4","pages":"493-498"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Genetic hearing loss <i>GJB2</i> c.109G>A (p.Val37Ile) consultation key points and clinical significance].","authors":"Q J Wang, H Wu, Y Sun, Y Chen, J Zhang, H W Li, H J Yuan, Y H Liu, T Yang, R J Chai, D Y Wang, S Sun, L H Huang, Y Li, H H Liu, H T Li, Y Gao, H Yao, B S Zhu, J Gao, J Guan, Y Y Yuan, D Bing, L M Suo, H B Shi, K Zhang, D J Zha","doi":"10.3760/cma.j.cn115330-20250717-00378","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250717-00378","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"191-206"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of ¹³¹iodine therapy on parathyroid function in postoperative patients with papillary thyroid carcinoma].","authors":"G X Wu, L Cai, G B Hu, L L Lan, J H Ge, Y Zhang, R L Zhao","doi":"10.3760/cma.j.cn115330-20250625-00333","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250625-00333","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the impact of postoperative iodine-131 (¹³¹I) therapy on parathyroid function in patients with papillary thyroid cancer (PTC) who did not develop hypoparathyroidism after total thyroidectomy. <b>Methods:</b> A retrospective analysis was conducted on patients with PTC who underwent total thyroidectomy followed by ¹³¹I therapy at the Fourth Hospital of Hebei Medical University between March 2016 and December 2023. Enrolled patients had no postoperative hypoparathyroidism and all received a fixed dose of ¹³¹I therapy. Changes in parathyroid hormone (PTH) and serum calcium levels were analyzed before ¹³¹I therapy and at 1, 3, 6, and 12 months after therapy in the overall population and in subgroups stratified by ¹³¹I dose (100 mCi and 150 mCi groups), sex, age, extent of central lymph node dissection, T stage, N stage, and clinical stage. Statistical analysis was performed using SPSS 25.0 software. <b>Results:</b> A total of 124 patients were enrolled, including 44 males and 80 females, with a mean age of 44.3±11.3 years. No patient developed symptomatic hypocalcemia or hypercalcemia within one year after ¹³¹I therapy. Pairwise comparisons of PTH and calcium levels before and at various time points after treatment in the overall population and all subgroups showed no statistically significant differences (all <i>P</i>>0.05). One patient (1/124, 0.81%) had a serum calcium level of 1.80 mmol/L and PTH of 33.0 ng/L at 12 months and received calcium supplementation. <b>Conclusion:</b> Conventional fixed-dose ¹³¹I therapy after total thyroidectomy does not result in long-term impairment of parathyroid function in PTC patients without baseline hypoparathyroidism. The incidence of hypocalcemia is low, and cases requiring calcium intervention are rare. Parathyroid function is not influenced by ¹³¹I dose, gender, age, extent of central lymph node dissection, T stage, N stage, or clinical stage.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"253-257"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on mechanism underlying the role of <i>HLA-DRA</i> in promoting radiation-induced sinusitis].","authors":"J Peng, X T Qiu, H Y Wang, Y J Yan, X Zou, S L Wang","doi":"10.3760/cma.j.cn115330-20250927-00515","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250927-00515","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To verify whether the &lt;i&gt;HLA-DRA&lt;/i&gt; gene regulates the radiosensitivity of nasal mucosal epithelial cells and to elucidate its underlying mechanism in the pathogenesis of radiation-induced sinusitis (RNS). &lt;b&gt;Methods:&lt;/b&gt; Sinonasal mucosal specimens were collected from five patients with RNS following radiotherapy and five without RNS (control group). HLA-DRA expression levels were assessed by real-time reverse transcription quantitative PCR (RT-qPCR), western blotting (WB), and immunohistochemistry (IHC). &lt;i&gt;HLA-DRA&lt;/i&gt; knockout (KO) and overexpression (OE) nasal mucosal epithelial cell models were generated using CRISPR/Cas9 technology. Cells were divided into three groups: control (wild-type), &lt;i&gt;HLA-DRA&lt;/i&gt; KO, and &lt;i&gt;HLA-DRA&lt;/i&gt; OE (overexpression/rescue). Cells in all groups were subjected to X-ray irradiation at identical doses. Cell proliferation and apoptosis following irradiation were assessed using colony formation assay, CCK-8 assay, and flow cytometry. The expression of inflammatory factors and the activation of the JAK-STAT signaling pathway were analyzed by RT-qPCR, enzyme-linked immunosorbent assay (ELISA), and WB. Statistical analysis was conducted using SPSS 23.0 software. &lt;b&gt;Results:&lt;/b&gt; Both RT-qPCR and WB revealed significantly elevated HLA-DRA expression at both mRNA and protein levels in sinonasal mucosal tissues from patients with RNS compared to non-RNS controls. Immunohistochemistry demonstrated diffuse HLA-DRA immunoreactivity throughout the full thickness of the epithelium, accompanied by marked inflammatory cell infiltration. &lt;i&gt;HLA-DRA&lt;/i&gt; knockout and overexpression nasal mucosal epithelial cell models were successfully established. Colony formation assay revealed significantly suppressed clonogenic survival in the OE group compared to the KO group (130.46±3.74 &lt;i&gt;vs&lt;/i&gt; 393.18±10.13, &lt;i&gt;P&lt;/i&gt;&lt;0.01), with the OE group showing the lowest colony counts overall. CCK-8 assay demonstrated significantly enhanced proliferative capacity in &lt;i&gt;HLA-DRA&lt;/i&gt; KO cells following irradiation compared to control cells, whereas, OE cells exhibited markedly suppressed proliferation. Flow cytometric analysis revealed a significantly higher apoptotic rate in the OE group compared to controls (80.41% &lt;i&gt;vs&lt;/i&gt; 77.82%, &lt;i&gt;P&lt;/i&gt;&lt;0.05), whereas, the KO group exhibited a dramatic reduction in the apoptotic rate (0.49% &lt;i&gt;vs&lt;/i&gt; 77.82%, &lt;i&gt;P&lt;/i&gt;&lt;0.001). RT-qPCR analysis demonstrated significantly decreased mRNA expression of interferon-γ (IFN-γ) and interleukin-6 (IL-6) in the KO group compared to controls (IFN-γ: 0.25±0.06 &lt;i&gt;vs&lt;/i&gt; 0.54±0.07; IL-6: 0.13±0.05 &lt;i&gt;vs&lt;/i&gt; 0.31±0.06; both &lt;i&gt;P&lt;/i&gt;&lt;0.01). Conversely, the OE group exhibited upregulated expression of both cytokines (IFN-γ: 0.48±0.08 &lt;i&gt;vs&lt;/i&gt; 0.25±0.06; IL-6: 0.39±0.05 &lt;i&gt;vs&lt;/i&gt; 0.13±0.05; both &lt;i&gt;P&lt;/i&gt;&lt;0.05). ELISA confirmed significantly reduced secretion of IFN-γ and IL-6 in the culture supernatant of KO cells compared to controls (IFN-γ: 12.53±1.04 &lt;i&gt;","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"272-279"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Comprehensive treatment strategies for pediatric head and neck parameningeal rhabdomyosarcoma: a single-center retrospective analysis of 53 cases].","authors":"Z S Huang, X J Chen, W L Zhang, Y Z Wang, Y H Yin, Z S Zhang, J G Fang, Z G Huang, Y Zhang","doi":"10.3760/cma.j.cn115330-20250924-00510","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250924-00510","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinical characteristics and treatment outcomes of parameningeal rhabdomyosarcoma (PM-RMS) of the head and neck in children, and to analyze the risk factors influencing prognosis. <b>Methods:</b> Clinical data of children with PM-RMS admitted to Beijing Tongren Hospital of Capital Medical University between September 2009 and September 2023 were collected. The cohort included 27 males and 26 females, aged from 4 to 191 months. Overall survival and event-free survival rates were calculated using the Kaplan-Meier method. Log-rank test was used for univariate analysis and Cox regression model for multivariate analysis. <b>Results:</b> The predominant pathological subtypes were embryonal (30 cases, 56.6%) and alveolar (21 cases, 39.6%). There were 23 cases in stage Ⅱ, 16 cases in stage Ⅲ, and 14 cases in stage Ⅳ. According to risk stratification, there were 9 cases with low-risk, 24 with intermediate-risk, 8 with high-risk, and 12 with the invasion of central nervous system. The median follow-up time was 36 months (range: 4-152 months). The overall survival rate was 67.9% (36/53) and the 5-year overall survival rate was 53.6%. All patients received chemotherapy and 43 patients received radiotherapy. Univariate analysis revealed that lymph node metastasis (χ²=4.82, <i>P</i>=0.028), distant metastasis (χ²=8.63, <i>P</i>=0.003), and absent of radiotherapy (χ²=4.18, <i>P</i>=0.041) were significantly associated with poor prognosis. Multivariate analysis identified distant metastasis (<i>HR</i>=4.888, 95%<i>CI</i>: 1.345-17.769, <i>P</i>=0.016) and absent of radiotherapy (<i>HR</i>=5.155, 95%<i>CI</i>: 1.637-16.130, <i>P</i>=0.005) as independent risk factors for prognosis<b>.</b> <b>Conclusion:</b> Pediatric PM-RMS of the head and neck is highly malignant, prone to distant metastasis, and associated with a poor prognosis. Radiotherapy can improve local control rates in affected children.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"265-271"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of nasopharyngeal tuberculosis misdiagnosed as chronic sinusitis].","authors":"J Y Lin, L C Zhang, D D Zhu, C D Meng","doi":"10.3760/cma.j.cn115330-20250722-00385","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250722-00385","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"290-291"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Variant frequency of <i>GJB2</i> c.109G>A (p.Val37Ile) in Chinese patients with hearing loss: a systematic review and Meta-analysis].","authors":"J Zhang, W J Wang, C Y Liu, X N Wu, J Guan, Q J Wang","doi":"10.3760/cma.j.cn115330-20250718-00380","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250718-00380","url":null,"abstract":"<p><p><b>Objective:</b> This study aims to systematically evaluate the frequency and geographic distribution of the <i>GJB2</i> c.109G>A (p.Val37Ile) variant in the Chinese patients with hearing loss, providing a data-driven basis for hereditary hearing loss prevention and control. <b>Methods:</b> A comprehensive literature search was conducted across seven databases-PubMed, Embase, Science Direct, Cochrane Library, Chinese Biomedical Literature Database, China National Knowledge Infrastructure and Wanfang Data System-from their inception to May 31, 2025. Studies were screened based on predefined inclusion and exclusion criteria. Data analysis was performed using R 4.4.2. Meta-analysis was applied to calculate the variant carrier rate, allele frequency, and corresponding 95% confidence intervals of <i>GJB2</i> c.109G>A (p.Val37Ile). Funnel plots and Egger's test were employed to assess publication bias. <b>Results:</b> A total of 53 studies were included, covering 28 430 individuals with hearing loss across 17 provinces in China. Meta-analysis showed that the overall carrier rate of the <i>GJB2</i> c.109G>A (p.Val37Ile) variant was 11.2% (95%<i>CI</i>: 8.8%-13.7%), and the allele frequency was 6.7% (95%<i>CI:</i> 5.0%-8.3%) in the Chinese patients with hearing loss. Subgroup analysis found that the variant frequency in southern China was significantly higher than in northern China (<i>P</i><0.05). The carrier rate in southern Chinese was 16.0% (95%<i>CI</i>: 12.3%-19.8%),that with an allele frequency of 10.5% (95%<i>CI</i>: 7.5%-13.4%). In northern China, the carrier rate was 3.4% (95%<i>CI</i>: 2.5%-4.3%), with an allele frequency of 2.0% (95%<i>CI</i>: 1.5%-2.6%). <b>Conclusions:</b> The <i>GJB2</i> c.109G>A (p.Val37Ile) variant exhibits a relatively high carrier rate and allele frequency among the Chinese patients with hearing loss, with a significant regional distribution pattern from south to north. This finding not only provides an important reference for genetic screening and counseling of hearing loss, but also offers evidence-based support for developing regional hearing health strategies.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"207-216"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[One case of CHARGE syndrome].","authors":"R L Wang, Y N Sun","doi":"10.3760/cma.j.cn115330-20250407-00209","DOIUrl":"10.3760/cma.j.cn115330-20250407-00209","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"294-295"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}