Chinese journal of otorhinolaryngology head and neck surgery最新文献

{"title":"[Pharmacoeconomic evaluation of preseasonal treatment of omalizumab in seasonal allergic rhinitis].","authors":"S J Li, Y B Gao, Y Zhang, L Zhang","doi":"10.3760/cma.j.cn115330-20240612-00346","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240612-00346","url":null,"abstract":"<p><p><b>Objective:</b> To assess the pharmacoeconomic benefits of using omalizumab in the treatment of seasonal allergic rhinitis (SAR) before the pollen season. <b>Methods:</b> This economic evaluation, which based on a prospective, randomized, controlled, open label, single center trial conducted in 2020, compared omalizumab treatment with standard medicine treatment in controlling SAR symptoms two weeks before autumn pollen season. Total nasal symptom scores (TNSS) were used as the effect index for cost-effectiveness analysis (CEA), with incremental cost-effectiveness ratio (ICER) calculated. Cost-utility analysis (CUA) was used to compare incremental cost-utility ratios (ICUR) between groups using 1.76 times of the national and Beijing per capita GDP as willingness-to-pay thresholds. The experimental group was divided into mild and moderate-severe groups for cost-effectiveness analysis. <b>Results:</b> CEA showed an ICER of 3 084.76 yuan/point. CUA revealed an ICUR of 554 288.39 yuan, exceeding 1.76 times of the 2020 national (126 417.28 yuan) and Beijing (288 918.08 yuan) per capita GDP. Therefore, omalizumab currently lacked economic advantage in both Beijing and nationwide. The moderate-severe subgroup had a lower ICUR (371 041.07 yuan/year) than the mild subgroup (1 436, 823.35 yuan/year). Omalizumab would gain economic advantage in Beijing if its cost dropped below 723.02 yuan/dose, and nationwide below 312.72 yuan/dose. For moderate-severe patients, the cost threshold for Beijing was 1 104.95 yuan/dose, and 482.45 yuan/dose nationwide. <b>Conclusions:</b> At its current price, a single pre-pollen season omalizumab injection (300 mg) offers no pharmacoeconomic advantage over conventional medication in improving SAR patients' quality of life in Beijing and nationwide. However, omalizumab shows lower ICUR in moderate-severe SAR patients compared to mild cases.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 4","pages":"427-434"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Attention network function and its influencing factors in patients with sensorineural hearing loss].","authors":"L L Wang, B X Zhang, Q Z Sun","doi":"10.3760/cma.j.cn115330-20240703-00401","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240703-00401","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the characteristics of attention network function and its related factors in sensorineural hearing loss (SNHL) patients. <b>Methods:</b> This study was a cross-sectional study. 116 patients with binaural severe or higher SNHL who were hospitalized in the Department of Otolaryngology, Head and Neck Surgery, the First Affiliated Hospital of Anhui Medical University from January to July 2023 were selected by the objective sampling method, including 54 males and 62 females, aged from 4 to 56 years old. Demographic data such as patient gender, age, education level, place of residence, per capita monthly family income, caregiver's education level and audiological and clinical data such as air conduction pure tone hearing threshold, age when hearing loss was first detected, whether hearing loss was gradually aggravated, hearing compensation mode, hearing compensation time, whether to participate in rehabilitation training, and rehabilitation time were collected through the general data questionnaire. The Attention Network Test was used to investigate three attention network functions in SNHL patients: alertness, orientation and executive control. SPSS 22.0 software was used for statistical analysis. <b>Results:</b> Univariate analysis showed that patients with postlingual deafness had lower executive control network score, patients with postlingual deafness, hearing loss gradually aggravated, hearing aid compensation, compensation time >5 years, and no rehabilitation learning had faster average response time, and patients with postlingual deafness, compensation time >5 years, and no rehabilitation learning had higher average accuracy (<i>P</i><0.05 for all). The results of multivariate analysis showed that patients aged 13-18 years, postlingual deafness and compensation time >5 years had faster average response time, and patients with compensation time >5 years and no rehabilitation learning had higher average accuracy (<i>P</i><0.05 for all). <b>Conclusions:</b> There is a general decline in attentional function and delayed development in patients with severe and above SNHL. No matter what mode of hearing compensation, timely and long-term hearing compensation intervention after hearing loss can effectively improve the attention network function, while the patients who do not participate in rehabilitation learning may improve their response accuracy by inhibiting interference and enhancing audio-visual interaction.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 4","pages":"412-419"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Experts consensus on sensitized airborne pollen monitoring].","authors":"Y H Ouyang, H Y Ning, J G Chen, E Z Fan, W X Fei, Y J Feng, Y Jin, F F Jiang, J Li, Y Li, Y Li, W W Liu, X Y Liu, X L Liu, X M Ren, H T Wang, Y L Xie, Y J Xu, Y Xu, Z D Xu, J M Xue, Q T Yang, Y C Yang, Y Zhang, Y Zhang, X Y Wang, L Zhang","doi":"10.3760/cma.j.cn115330-20241101-00610","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20241101-00610","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 4","pages":"387-393"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in local treatment of chronic sinusitis and clinical evaluation].","authors":"R R Ge, J H Lao, F T Jian, Z H Shi, Q T Yang, S Wu","doi":"10.3760/cma.j.cn115330-20240701-00396","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240701-00396","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 4","pages":"478-484"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of TNF-α on cisplatin-induced permeability change of blood labyrinth barrier in cochlea of C57BL/6J mice].","authors":"M Yu, M L Xia, M Yu, W J Jiang, Z Zhou, J Q Si, L Li","doi":"10.3760/cma.j.cn115330-20241120-00644","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20241120-00644","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the effect of tumor necrosis factor α (TNF-α) on the permeability of blood labyrinth barrier in C57BL/6J male mice and its possible mechanism. &lt;b&gt;Methods:&lt;/b&gt; As for the design of animal experiment, twenty male C57BL/6J mice aged 6-8 weeks were randomly divided into control group and cisplatin group with 10 mice in each group by software method. The control group was intraperitoneally injected with normal saline every day, and the cisplatin group was intraperitoneally injected with 4 mg/kg cisplatin for 4 consecutive days. After administration, auditory brainstem response (ABR) was used to detect hearing changes in mice. HE staining was used to observe the morphological changes of mouse cochlea vasculature. The expression of TNF-α was detected by immunohistochemistry and ELISA. The permeability of the blood labyrinth barrier was observed by Evans blue staining. With respect to the design of cell experiment, primarily cultured cochlea pericytes (PC) and endothelial cells (EC) were divided into EC group, EC+TNF-α group, EC+PC group, EC+PC+TNF-α group, EC+PC+TNF-α+SB-3CT (MMP-9/MMP-2 secretion inhibitor) group, PC group, PC+TNF-α group, PC+TNF-α+LY294002 (PI3K/AKT pathway inhibitor) group, PC+LY294002 group. The protein expressions of ZO-1, VE-cadherin, MMP-9, MMP-2, PI3K, p-PI3K, AKT, and p-AKT were detected by Western blot. TEER and FITC-dextran penetration experiment were used to detect EC resistance and monolayer EC permeability, respectively. The data were statistically analyzed using GraphPad Prism 8 software. &lt;b&gt;Results:&lt;/b&gt; In animal experiment, compared with control group, the ABR response threshold of mice in cisplatin group was increased (&lt;i&gt;P&lt;/i&gt;&lt;0.01). The vaccine ular structure of the cochlea was disordered red, wrinkled and vacuole increased. The extravasation of vascular red fluorescent dye increased (&lt;i&gt;P&lt;/i&gt;&lt;0.05), and also, levels of serum TNF-α and cochlear veins increased (&lt;i&gt;P&lt;/i&gt;&lt;0.01). In cell experiment, by treatment of EC with different concentrations of cisplatin, 20 μmol cisplatin led to the highest expression of TNF-α (&lt;i&gt;P&lt;/i&gt;&lt;0.01). The expression of TNF-α was the highest after 3 h intervention in EC (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Compared with those in EC+PC group, the resistance value of EC was decreased, the permeability of monolayers EC was increased, the expression of ZO 1 and VE cadherin proteins was decreased, and however, the resistance value was increased and the permeability of EC was decreased after the intervention of SB-3CT in EC+PC+TNF-α group. The expressions of ZO-1 and VE-cadherin proteins were increased (&lt;i&gt;P&lt;/i&gt;&lt;0.05). The expression of MMP-9 increased after TNF-α intervention (&lt;i&gt;P&lt;/i&gt;&lt;0.05), the expression of MMP-2 had no significant change, and the expression of p-PI3K/PI3K and p-AKT/AKT were increased (&lt;i&gt;P&lt;/i&gt;&lt;0.05). The expression of MMP-9 decreased in PC+TNF-α+LY294002 group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). &lt;b&gt;Conclusion:&lt;/b&gt; The hearing loss of C57BL/6J male mice induced by cisplatin","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 4","pages":"447-456"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Catheter dilatation for bilateral choanal atresia repair in a newborn: a treatment approach].","authors":"L Y Hu, J Y Li, W W He, Y J Li","doi":"10.3760/cma.j.cn115330-20240701-00396","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240701-00396","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 4","pages":"464-465"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Consensus on standard naming and system classification of bone conduction hearing devices].","authors":"","doi":"10.3760/cma.j.cn115330-20250207-00085","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250207-00085","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 4","pages":"377-381"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interpretation of guideline on diagnosis and treatment for chronic rhinosinusitis (2024)].","authors":"M Zeng, Y X Wu, Z Liu","doi":"10.3760/cma.j.cn115330-20250313-00145","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250313-00145","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 4","pages":"382-386"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cutaneous Rosai-Dorfman disease: one case with auricle, scalp mass and secretory otitis media as clinical manifestations].","authors":"L C Zhang, L Li, X J Wang","doi":"10.3760/cma.j.cn115330-20240804-00460","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240804-00460","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 4","pages":"466-467"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Full-frequency hearing curve analysis in patients with sensorineural hearing loss].","authors":"P P Ai, W Ma, H Y Xia, L Lan, L D Zhao, S M Yang","doi":"10.3760/cma.j.cn115330-20240708-00409","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240708-00409","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To combine the conventional audiometric curves and extended high frequency audiometric curves of patients with sensorineural deafness to form a full-frequency audiometric curve and to perform typing, so as to comprehensively understand the hearing status of patients with sensorineural deafness. &lt;b&gt;Methods:&lt;/b&gt; This study was a cross-sectional study. The study subjects included 249 patients with sensorineural hearing loss who visited the Otolaryngology-Head and Neck Surgery outpatient clinic of the PLA General Hospital between July 2019 and December 2020. Among them, 146 were male and 103 were female, aged 11 to 80 years. The cases included 123 with mild hearing loss, 70 with moderate hearing loss, 32 with moderately severe hearing loss, 17 with severe hearing loss, 6 with profound hearing loss, and 1 with total deafness. According to the national standard GB/T16403-1996, conventional pure-tone audiometry (125-8 000 Hz) was performed on the 249 patients with sensorineural hearing loss to obtain their conventional-frequency hearing curves, which were then classified. Extended high-frequency pure-tone threshold testing (9 000-20 000 Hz) was conducted using extended high-frequency headphones, specifically including eight frequencies: 9 000, 10 000, 11 200, 12 500, 14 000, 16 000, 18 000, and 20 000 Hz. Ultimately, the full-frequency hearing curves (125-20 000 Hz) of each patient were obtained. The K-means clustering analysis method was used to classify the hearing curves based on their characteristics, and the results of the K-means clustering analysis were partially adjusted through manual screening. &lt;b&gt;Results:&lt;/b&gt; The conventional hearing curves of all 249 patients were consistent with sensorineural hearing loss. The detection rates for extended high frequencies (9 000, 10 000, 11 200, 12 500, 14 000, 16 000, 18 000, and 20 000 Hz) were 96.79% (241/249), 94.38% (235/249), 87.95% (219/249), 78.31% (195/249), 65.46% (163/249), 22.09% (55/249), 10.84% (27/249), and 0.80% (2/249), respectively. The conventional-frequency hearing curves of the patients could be classified into the following types: low-frequency descending type (50/249, 20.08%), conventional-frequency steep descending type (78/249, 31.33%), conventional-frequency gradual descending type (58/249, 23.29%), conventional-frequency flat type (25/249, 10.04%), conventional-frequency 4 000 Hz notch type (30/249, 12.05%), and other types (8/249, 3.21%). By incorporating extended high-frequency hearing data, the full-frequency hearing curves of 235 patients were further classified into the following types based on different characteristics: full-frequency hill type (32/235, 13.62%), full-frequency ascending type (28/235, 11.91%), full-frequency 8 000 Hz notch type (14/235, 5.96%), full-frequency steep descending type (82/235, 34.89%), full-frequency gradual descending type (34/235, 14.47%), full-frequency shoulder-raising type (7/235, 2.98%), full-frequency shoulder-dropp","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 4","pages":"403-411"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}