Chinese journal of otorhinolaryngology head and neck surgery最新文献

{"title":"[Comparison of efficacy among different treatment strategies for cervical esophageal squamous cell carcinoma​].","authors":"W H Song, C Y Xu, C L Li, Z B Yu, D M Wei, W M Li, Y Qian, D P Lei","doi":"10.3760/cma.j.cn115330-20250827-00455","DOIUrl":"10.3760/cma.j.cn115330-20250827-00455","url":null,"abstract":"<p><p><b>Objective:</b> To compare the efficacy of different treatment strategies for cervical esophageal squamous cell carcinoma (CESCC) using inverse probability of treatment weighting (IPTW), and to explore the prognostic factors of CESCC. <b>Methods:</b> We retrospectively analyzed the clinical data of 307 patients with T1-4N0-3M0 stage CESCC admitted to Qilu Hospital of Shandong University from 2005 to 2019. There were 264 males and 43 females, aged from 39 to 84 years. The patients were divided into 4 groups: surgery alone (SA) group (<i>n</i>=46), definitive concurrent chemoradiotherapy (DCRT) group (<i>n</i>=123), postoperative concurrent chemoradiotherapy (S-CRT) group (<i>n</i>=99), and neoadjuvant chemoradiotherapy followed by surgery (NCRT-S) group (<i>n</i>=39). IPTW was used to balance baseline characteristics and to adjust for confounding factors. Survival analysis was performed, with overall survival (OS) and disease-specific survival (DSS) as primary endpoints. <b>Results:</b> After IPTW adjustment, baseline characteristics including age and gender were well balanced (all <i>P</i>>0.05). Log-rank test revealed statistically significant differences in OS and DSS survival curves among the 4 groups before and after IPTW (all <i>P</i><0.05). After IPTW, the median OS of the SA, DCRT, S-CRT, and NCRT-S groups were 78, 58, 92, and 86 months, with 5-year OS rates of 50.9%, 48.0%, 56.5% and 52.5%, respectively. The median DSS was 78, 60, 110, and 96 months, with 5-year DSS rates of 52.0%, 49.0%, 59.3% and 55.8%, respectively. Multivariate Cox regression analysis showed that drinking history (<i>HR</i>=1.324, 95%<i>CI</i>: 1.117-2.446), lymph node metastasis (<i>HR</i>=1.317, 95%<i>CI</i>: 1.199-1.929) and concomitant hypopharyngeal involvement (<i>HR</i>=0.574, 95%<i>CI</i>: 0.355-0.926) were independent prognostic factors for CESCC (all <i>P</i><0.05). <b>Conclusion:</b> Significant differences exist in long-term survival among the four treatment strategies for CESCC. Surgery-based multimodal therapy (S-CRT/NCRT-S) shows a more favorable survival trend numerically. Stratified intensive treatment and frequent follow-up are recommended for patients with drinking history and lymph node metastasis.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 ","pages":"403-409"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Radical surgery for cervical esophageal cancer involving the tracheal membranous part and its reconstruction].","authors":"Y Y Bao, S H Zhou, Z Chen, J T Zhong, H C Chen, Z Z Cao, C R Sun, C Zhang, P Ye, H Y Wang, H Li","doi":"10.3760/cma.j.cn115330-20260220-00105","DOIUrl":"10.3760/cma.j.cn115330-20260220-00105","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the feasibility of radical surgery for cervical esophageal cancer (CEC) invading the membranous part of the trachea and the optimal strategies for posterior tracheal wall reconstruction. <b>Methods:</b> A retrospective analysis was conducted on the clinical data of 7 patients with CEC invading the membranous part of the trachea who were admitted to the First Affiliated Hospital of Zhejiang University School of Medicine from March 2020 to March 2024. All 7 patients were male, with an age range of 49 to 69 years. Two cases were primary CECs involving the cervical tracheal membranous part; three cases were recurrent CECs after chemo-radiotherapy involving the tracheal membranous part, among which two had tracheoesophageal fistula (TEF); one case developed TEF after esophageal replacement with a gastric tube following CEC surgery; and one case was recurrent CEC involving the tracheal membranous part and complicated with TEF after surgery. All cases were discussed by a multidisciplinary team (MDT) to determine the optimal treatment plan. This study focused on the surgical plan design, posterior tracheal wall reconstruction techniques, and therapeutic efficacy. <b>Results:</b> All 7 patients successfully underwent tumor resection and posterior tracheal wall reconstruction. Four cases which underwent total laryngectomy, total hypopharyngectomy, and total esophagectomy were reconstructed by gastric tubes and pectoralis major myocutaneous flaps, using supraclavicular artery island flaps or strap muscle flaps to reconstruct the posterior tracheal wall. One case retained laryngeal function after gastric tube reconstruction and repairment of the membranous part of the trachea with a strap muscle flap. Two cases with postoperative TEF were repaired with vascularized flaps (one repair failed and the patient subsequently underwent stent implantation). The follow-up period ranged from 12 to 58 months, with five patients surviving free of recurrence and two patients dying at 25 and 42 months postoperative, respectively. The success rate of tracheal reconstruction was 100%, and six patients resumed oral feeding. <b>Conclusion:</b> Performing gastric tube reconstruction combined with vascularized tissue flaps (such as supraclavicular artery island flaps or strap muscle flaps) for primary reconstruction of the posterior tracheal wall is a safe, feasible, and effective radical strategy for treating CEC invading the tracheal membranous part.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 ","pages":"439-445"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Comparison of efficacy and safety among three treatment modalities for locally advanced cervical esophageal squamous cell carcinoma].","authors":"Y J Shuai, Y S Wu, K Yue, Y S Duan, R Y Xue, H Li, Y Fang, X D Wang","doi":"10.3760/cma.j.cn115330-20250930-00525","DOIUrl":"10.3760/cma.j.cn115330-20250930-00525","url":null,"abstract":"<p><p><b>Objective:</b> To compare the clinical efficacy and safety of different treatment modalities for locally advanced cervical esophageal squamous carcinoma. <b>Methods:</b> Clinicopathological data of patients with locally advanced cervical esophageal carcinoma treated at Tianjin Medical University Cancer Institute and Hospital from January 2019 to December 2024 were retrospectively analyzed. Patients were divided into three groups according to treatment modality: definitive chemoradiotherapy (dCRT) group, surgery group, and neoadjuvant therapy combined with surgery (NAT) group. Survival outcomes and adverse events were compared among the three groups using Kaplan-Meier curves and Cox regression models. <b>Results:</b> A total of 104 patients were enrolled, including 95 males and 9 females, aged from 43 to 80 years. In the dCRT group (<i>n</i>=55), the 1-and 3-year overall survival (OS) rates were 73.1% and 31.0%, and the 1-and 3-year progression-free survival (PFS) rates were 65.7% and 22.7%, respectively. In the surgery group (<i>n</i>=31), the 1-and 3-year OS rates were 92.7% and 48.5%, and the 1-and 3-year PFS rates were 75.4% and 34.0%, respectively. In the NAT group (<i>n</i>=18), the 1-and 3-year OS rates were 94.1% and 73.7%, and the 1-and 3-year PFS rates were 88.2% and 68.8%, respectively. Compared with the dCRT group, the NAT group showed significantly improved OS and PFS (both <i>P</i><0.05). Stratified analysis revealed that among patients with cN1-3 disease, the NAT group had superior OS and PFS compared with the surgery and dCRT groups (all <i>P</i><0.05), whereas, no significant differences were observed in cN0 patients (all <i>P</i>>0.05). For local control, the local recurrence rate was higher in the dCRT group than in the surgery group (27.3% <i>vs</i> 6.5%, <i>P</i>=0.023). Stratified analysis showed that local failure-free survival (LFFS) rate was higher in the surgery group compared with the dCRT group among cN1-3 patients (<i>P</i>=0.043), whereas, no significant difference was found in cN0 patients (<i>P</i>=0.298).In the NAT group, the pathological complete response(pCR) rate after neoadjuvant therapy was 27.8%, and the major pathological response(MPR) rate was 66.7%. Univariate Cox analysis identified cT1-T2 stage, cN0 stage, and neoadjuvant therapy as factors associated with favorable prognosis. Multivariate analysis demonstrated that neoadjuvant therapy and cN0 stage were independent prognostic factors for better OS (all <i>P</i><0.05). <b>Conclusion:</b> Neoadjuvant therapy combined with surgery provides favorable survival outcomes and pathological response rates in locally advanced cervical esophageal squamous carcinoma, especially in patients with lymph node positive disease.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 ","pages":"386-393"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Three cases of laryngeal myxoma].","authors":"M S Liu, F Y Wang, X Jiang","doi":"10.3760/cma.j.cn115330-20250910-00484","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250910-00484","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 4","pages":"457-458"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Construction and efficacy verification of a risk prediction model for cognitive function changes in patients with vestibular migraine].","authors":"X Guo, D Liu, R Q Zhai, D L Zhao","doi":"10.3760/cma.j.cn115330-20250908-00480","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250908-00480","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To construct a risk prediction model for cognitive function changes in patients with vestibular migraine and to validate its effectiveness. &lt;b&gt;Methods:&lt;/b&gt; 300 patients with vestibular migraine admitted to the First Affiliated Hospital of Zhengzhou University hospital from January 2022 to October 2024 were enrolled, with 54 male and 254 female, age from 22 to 77, with an average of 42.2 years old, who were randomly divided into a modeling group (to construct a risk prediction model for cognitive function changes, &lt;i&gt;n&lt;/i&gt;=210) and a validation group (to validate the effectiveness of the model, &lt;i&gt;n&lt;/i&gt;=90) using a random number table. All patients received routine treatment. During a 6-month following-up, the cognitive function of the subjects was evaluated using the Mini Mental State Examination (MMSE) scale. Based on this, the modeling group was divided into a cognitive function change group and a cognitive function normal group. The general information were compared between the cognitive function change group and cognitive function normal group. The influencing factors of cognitive function changes were explored through Logistic univariate and multivariate regression analysis. A nomogram was developed using the rms package in R. Calibration was assessed with calibration plots; discrimination was evaluated by the area under the receiver operating characteristic (ROC) curve. Decision curve analysis (DCA) was determined the benefits of the model. &lt;b&gt;Results:&lt;/b&gt; There was no statistically significant difference in the general data between the modeling group and the validation group (P&gt;0.05). The incidence of cognitive function changes was 39.73% (116/292), with modeling group and validation group being 39.71% (81/204) and 39.77% (35/88), respectively. Age [odds ratio (&lt;i&gt;OR&lt;/i&gt;)=1.361, 95% confidence interval (95%&lt;i&gt;CI&lt;/i&gt;): 1.256-1.475], duration of migraine attacks (&lt;i&gt;OR&lt;/i&gt;=1.096, 95%&lt;i&gt;CI&lt;/i&gt;: 1.052-1.142), migraine severity score (&lt;i&gt;OR&lt;/i&gt;=3.629, 95%&lt;i&gt;CI&lt;/i&gt;: 2.476-5.319), Dizziness Handicap Inventory (DHI) score (&lt;i&gt;OR&lt;/i&gt;=1.020, 95%&lt;i&gt;CI&lt;/i&gt;: 1.010-1.030), Pittsburgh sleep quality index (PSQI) score (&lt;i&gt;OR&lt;/i&gt;=1.818, 95%&lt;i&gt;CI&lt;/i&gt;: 1.460-2.265), and serum matrix metalloprotein-9 (MMP-9) level (&lt;i&gt;OR&lt;/i&gt;=1.256, 95%&lt;i&gt;CI&lt;/i&gt;: 1.182-1.335), serum 5-hydroxytryptamine (5-HT) level (&lt;i&gt;OR&lt;/i&gt;=0.940, 95%&lt;i&gt;CI&lt;/i&gt;: 0.920-0.960) and weekly exercise time (&lt;i&gt;OR&lt;/i&gt;=0.955, 95%&lt;i&gt;CI&lt;/i&gt;: 0.942~0.968) were all independent related factors for cognitive function changes (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Based on the above factors, a risk prediction Nomogram model for cognitive function changes in patients was developed, which showed good discrimination and predictive performance. The model predicted that the modeling group and the validation group achieved net benefits when the threshold probabilities for cognitive function changes ranged from 0.04 to 0.97 and from 0.04 to 0.98, respectively. &lt;b&gt;Conclusions:&lt;/b&gt; Age, duration of migraine attacks","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 4","pages":"424-431"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Consensus statement on the management of cervical esophageal carcinoma (2026)].","authors":"","doi":"10.3760/cma.j.cn115330-20260203-00080","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20260203-00080","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 4","pages":"371-380"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Retrospective of revised minimum speech test battery (MSTB) for adult cochlear implant users and resoponses from Chinese audiologists].","authors":"X Xi, D D Wang","doi":"10.3760/cma.j.cn115330-20250812-00420","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250812-00420","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 4","pages":"468-473"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on laryngitis in children infected with the Omicron variant of the Novel Coronavirus].","authors":"L Y Liu, Y S Xu","doi":"10.3760/cma.j.cn115330-20251102-00580","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20251102-00580","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 4","pages":"487-492"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Treatment of cervical esophageal cancer: current status and future perspectives].","authors":"C M An, F Zhang, S Y Liu","doi":"10.3760/cma.j.cn115330-20251229-00696","DOIUrl":"10.3760/cma.j.cn115330-20251229-00696","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 ","pages":"327-330"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of invasive fungal rhinosinusitis complicated with intracranial Aspergillosis presenting with blindness as the main complaint].","authors":"A Q Liu, Q Xue, Y Zhang, X C Song, L Wang","doi":"10.3760/cma.j.cn115330-20251017-00544","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20251017-00544","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 4","pages":"453-454"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}