Chinese journal of otorhinolaryngology head and neck surgery最新文献

{"title":"[Clinical features, diagnosis and treatment of the nasal cavity and skull base inflammatory myofibroblastic tumor].","authors":"W Zhong, X Yuan, L Meng, J X Jia, S B Xie, J Y Zhang, H Zhang, W H Jiang, Z H Xie","doi":"10.3760/cma.j.cn115330-20240911-00519","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240911-00519","url":null,"abstract":"<p><p><b>Objective:</b> To retrospectively analyze the cases of inflammatory myofibroblastic tumor (IMT) involving the sinonasal skull base, and to investigate their clinical characteristics, diagnostic approaches, and treatment outcomes, in order to improve understanding of this rare entity. <b>Methods:</b> Clinical data from five patients with pathologically confirmed sinonasal skull base IMT who underwent surgical treatment at Xiangya Hospital of Central South University between April 2010 and June 2023 were reviewed. Information on clinical presentation, laboratory findings, imaging features, histopathological and immunohistochemical results, treatment strategies, and follow-up outcomes was collected. A comprehensive analysis was performed in combination with a literature review to summarize the clinical features, diagnostic methods, and therapeutic approaches for sinonasal skull base IMT. <b>Results:</b> The five patients (aged 18 to 68 years) were all diagnosed based on histopathological and immunohistochemical examinations. The lesions primarily involved the nasopharynx, clivus, sphenoid sinus, and maxillary sinus. Major clinical symptoms included nasal obstruction, headache, blood-tinged nasal discharge, and facial numbness or pain. All patients underwent surgical resection; two of them also received adjunctive glucocorticoid therapy. During follow-up ranging from 1 to 143 months, two patients experienced tumor recurrence, three patients had no recurrence with significant symptomatic improvement. <b>Conclusions:</b> Histopathology combined with immunohistochemistry is critical for the diagnosis of sinonasal skull base IMT. Complete surgical excision when feasible remains the primary treatment strategy.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"961-966"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Juvenile ossifying fibroma originating in nasal septum: a case report].","authors":"X C Zhu, X F Shen","doi":"10.3760/cma.j.cn115330-20240903-00503","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240903-00503","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"971-972"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Kartagener syndrome with main complaint of nasal obstruction: a case report].","authors":"T Li, Y Z Wan, L Shi","doi":"10.3760/cma.j.cn115330-20241111-00626","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20241111-00626","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"973-974"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ossifying fibroadenoma invading the mastoid process in a child: a case report].","authors":"J S Xu, J J Qiu, D W Liu, Y Sun","doi":"10.3760/cma.j.cn115330-20241213-00690","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20241213-00690","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"969-970"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Early detection and management pathways for hearing loss in older people from the perspective of the development of domestic and international guidelines].","authors":"X Y Zhou, B Liu, Z Y Huang","doi":"10.3760/cma.j.cn115330-20241009-00565","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20241009-00565","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"1008-1012"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Event-related potential assessment of cognitive function in children with obstructive sleep-disordered breathing].","authors":"X X Zhang, Y H Zhang, Y Sun, X M Yuan, Q Y Li, Q Chen, X L Yang, D Chen, G P Yin","doi":"10.3760/cma.j.cn115330-20250327-00168","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250327-00168","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To assess cognitive impairment in children with obstructive sleep-disordered breathing (OSDB) using event-related potentials (ERPs). &lt;b&gt;Methods:&lt;/b&gt; This case-control study analyzed data from 143 OSDB children[94 males, 49 females, aged 9.0(7.0-11.0) years] scheduled for adenotonsillectomy at the Department of Otolaryngology-Head and Neck Surgery, Beijing Tsinghua Changgung Hospital, Tsinghua University, between June 2023 and September 2024, along with 17 healthy controls [control group: 10 males, 7 females, aged 10.0 (7.5-12.0) years]. Based on polysomnography results, OSDB children were divided into a mild group [obstructive apnea-hypopnea index (OAHI)≤5 events/hour, 49 males, 29 females, aged 9.0 (7.0-10.0) years] and a moderate-to-severe group [OAHI&gt;5 events/hour, 45 males, 20 females, aged 9.0 (8.0-10.0) years]. All children completed a face perception integration task. The occipital P100 and parietal, central and frontal P300 components of incomplete face stimuli (S1) and complete face stimuli (S2) were recorded. Amplitude and latency differences across groups were analyzed. Intergroup comparisons were performed using ANOVA, while independent samples t-tests were used for pairwise comparisons. Non-normally distributed data were analyzed using the Mann-Whitney &lt;i&gt;U&lt;/i&gt; test. &lt;b&gt;Results:&lt;/b&gt; (1) P100: Both the mild group [occipital P100 amplitude: O1-S1(12.44±5.96) μV, O2-S1(14.19±6.39) μV, O2-S2(30.34±11.30) μV] and moderate-to-severe group [O1-S1 (12.12±5.58) μV, O2-S1 (14.08±5.48) μV, O2-S2(29.12±10.89) μV] showed significantly higher amplitudes than the control group [O1-S1(8.46±4.74) μV,O2-S1(9.68±3.70) μV,O2-S2(23.09±9.16) μV] (&lt;i&gt;F&lt;/i&gt;=3.501, 4.486, 3.072; all &lt;i&gt;P&lt;&lt;/i&gt;0.05). No significant differences were found between the two OSDB subgroups (&lt;i&gt;P&lt;/i&gt;&gt;0.05), suggesting compensatory neuronal hyperactivity maintaining normal perceptual function. The moderate-to-severe group exhibited significantly prolonged P100 latency [O2-S1 (134.52±13.42) ms] compared to controls [O2-S1 (125.18±15.31) ms] (&lt;i&gt;F&lt;/i&gt;=3.156&lt;i&gt;, P&lt;/i&gt;&lt;0.05), while no significant difference was observed between the mild group and either the control or moderate-to-severe groups (&lt;i&gt;P&gt;&lt;/i&gt;0.05), indicating delayed visual processing in severely affected children. (2) P300: The mild group exhibited significantly higher P300 amplitudes in parietal regions [P4-S1(8.22±4.32) μV, P4-S2(17.67±9.42) μV] compared to controls [P4-S1 (4.84±2.89) μV, P4-S2 (13.19±7.23) μV] (&lt;i&gt;F&lt;/i&gt;=7.19, 4.771; both &lt;i&gt;P&lt;/i&gt;&lt;0.05), whereas no significant differences were observed between the moderate-to-severe group and either the control or mild groups (&lt;i&gt;P&lt;/i&gt;&gt;0.05), indicating mild group reduced alertness. The latency of P300 in the central region showed an increase in the mild group, although not significantly (&lt;i&gt;P&lt;/i&gt;&gt;0.05), indicating a potential decrease in attentional response speed. However, the moderate-to-severe group demonstrated significantly shorter P300 latenc","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"882-889"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of clinical manifestations and genetic characteristics of a late-onset auditory neuropathy pedigree caused by a mitochondrial <i>MT-TS1</i> gene mutation m.7471dup].","authors":"Y N Wang, T Zhang, H J Wang, Z Deng, D J Chen, X M Zhang, D J Seng, H E Xu, W X Tang, J Zhang, S F Wang","doi":"10.3760/cma.j.cn115330-20240924-00541","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240924-00541","url":null,"abstract":"<p><p><b>Objective:</b> The aim of this study is to analyze the clinical characteristics and genetic variants of a late-onset auditory neuropathy pedigree caused by maternally inherited- mitochondrial mutation. <b>Methods:</b> A male proband who presented with bilateral sensorineural hearing loss at Henan Children's Hospital in September 2023 was chosen, along with his family members (4 generations, 20 individuals) as the study subjects. Data from this pedigree were collected, organized, and analyzed for clinical genetic characteristics. Medical histories were obtained from family members, pedigree charts were drawn, audiological, imaging, and physical examinations were conducted. Pathogenic genes and mutations were screened using high-throughput sequencing. Sanger sequencing was employed for variant confirmation and segregation validation in the family. <b>Results:</b> In this family, a total of 12 members (10 members collected) had sensorineural hearing loss, characterized by late-onset hearing impairment with an onset age ranging from 9 to 30 years. The patients exhibited poor speech recognition rates, and audiometric examinations are consistent with auditory neuropathy. There was no history of ototoxic drug use. High-throughput sequencing identified the variant NC_012920.1:m.7471dup in the mitochondrial <i>MT-TS1</i> gene as the pathogenic variant. Sanger sequencing results confirmed that the pathogenic gene mutation site perfectly co-segregated with the auditory neuropathy phenotype in this family. According to the classification criteria and guidelines for genetic variations by the American College of Medical Genetics and Genomics, the variant was classified as a pathogenic mutation. <b>Conclusion:</b> The mitochondrial <i>MT-TS1</i> gene mutation m.7471dup is considered to be the pathogenic cause in this late-onset auditory neuropathy pedigree.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"917-927"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Significance of respiratory event duration in evaluating nocturnal hypoxemia and disease severity in adults with obstructive sleep apnea].","authors":"Y M Wang, C C Liu, W B Guo, L Sun, J P Zeng, Z Q Chen, H J Yue, W B Lei","doi":"10.3760/cma.j.cn115330-20250110-00033","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250110-00033","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the correlation between respiratory event duration and nocturnal oxygen saturation (SpO₂) in adults with obstructive sleep apnea (OSA), and to explore its significance in assessing nocturnal hypoxemia and OSA severity. <b>Methods:</b> A prospective study was conducted on adult OSA patients diagnosed via overnight standard polysomnography (PSG) at the Department of Otolaryngology, First Affiliated Hospital of Sun Yat-sen University from June 2019 to December 2023. Data collected included demographic information, PSG reports, scale scores, and comorbidities. Patients were first stratified by apnea-hypopnea index (AHI) severity. Relationships between respiratory event duration parameters,including total apnea-hypopnea time (TAHT), percentage of total sleep time with apnea-hypopnea (AHT%), total apnea time (TAT), total hypopnea time (THT), and mean apnea-hypopnea time (MAHT), and nocturnal SpO₂ parameters, including average SpO₂ (aSpO₂), minimal SpO₂ (mSpO₂), mean oxygen desaturation (MOD), and percentage of total sleep time with SpO₂<90% (CT90), were analyzed. Patients were then divided into two groups based on the median MAHT (27.6 s) for SpO₂ comparison. Finally, severe OSA patients were further subclassified using an AHI inflection point (50 events/h) identified via scatter plot analysis to compare nocturnal SpO₂. Statistical analysis was performed using SPSS 27.0. <b>Results:</b> Among the 250 study subjects, there were 201 males and 49 females, with ages ranging from 18 to 76 years (mean age: 41.6 ± 11.9 years).TAHT, AHT%, and TAT in OSA patients demonstrated significant negative correlations with aSpO₂(<i>r</i>=-0.698, -0.718, -0.646)and mSpO₂(<i>r</i>=-0.746, -0.746, -0.748), while showing positive correlations with MOD (<i>r</i>=0.783, 0.791, 0.823)and CT90 (<i>r</i>=0.868, 0.866, 0.852),<i>P</i><0.05. When stratified by MAHT median (<i>M</i>=27.6 s), the \"long-event\" subgroup (<i>n</i>=125) displayed significantly lower mSpO₂ and higher MOD and CT90 compared to the \"short-event\" subgroup (<i>n</i>=125), <i>Z</i>=-3.319, 3.288, 2.242;<i>P</i><0.05. No significant difference in aSpO₂ was observed (<i>P</i>>0.05). Subgrouping severe OSA patients at AHI=50 events/hour revealed significant differences in aSpO₂, mSpO₂, MOD, and CT90 between groups (<i>Z</i>=-5.011, -4.787, 5.142, 6.117, <i>P</i><0.05). <b>Conclusions:</b> TAHT, AHT%, and TAT significantly correlate with nocturnal SpO₂ parameters in OSA patients and can supplement AHI in assessing OSA severity. MAHT independently reflects nocturnal oxygenation status beyond AHI.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"868-874"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Type 1 diabetes mellitus in a child presenting with acute bacterial parotitis: a case report].","authors":"J J Guo, X L Zhu, N S Li","doi":"10.3760/cma.j.cn115330-20241209-00686","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20241209-00686","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"977-978"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case report on repairing hypopharyngeal defect and reconstructing pronunciation function using a free anterolateral thigh flap].","authors":"J Li, J L Liang, H W Liu","doi":"10.3760/cma.j.cn115330-20250126-00075","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250126-00075","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"975-976"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}