Chinese journal of otorhinolaryngology head and neck surgery最新文献

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[The retrospective clinical study of asymptomatic primary hyperparathyroidism]. [无症状原发性甲状旁腺功能亢进症的回顾性临床研究]。
Chinese journal of otorhinolaryngology head and neck surgery Pub Date : 2024-10-07 DOI: 10.3760/cma.j.cn115330-20240419-00220
X T Huang, L Zong, B Ma, Y X Zhang, X H Du, J D Zhao, Y P Zhang
{"title":"[The retrospective clinical study of asymptomatic primary hyperparathyroidism].","authors":"X T Huang, L Zong, B Ma, Y X Zhang, X H Du, J D Zhao, Y P Zhang","doi":"10.3760/cma.j.cn115330-20240419-00220","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240419-00220","url":null,"abstract":"<p><p><b>Objective:</b> To summarize and analyze the diagnostic and therapeutic characteristics of asymptomatic primary hyperparathyroidism (aPHPT). <b>Methods:</b> A retrospective analysis was conducted on the clinical data of 103 patients with aPHPT admitted to the Chinese PLA General Hospital from January 2012 to September 2023. The clinical characteristics, treatment modes, and prognoses of the patients were analyzed. GraphPad Prism 8.0 software was used for statistical analysis. <b>Results:</b> Among the 103 cases, there were 37 males and 66 females, aged from 25 to 78 years, with an average age of (53.81±11.34) years. Ninety-eight cases (95.15%) visited due to abnormal findings during physical examination and 5 cases (4.85%) due to hypertension, diabetes or other diseases. All patients underwent minimally invasive parathyroidectomy with small incision, with 96 cases (93.20%) pathologically diagnosed as adenomas and 7 cases as hyperplasia (6.80%). Postoperative mean serum calcium, parathyroid hormone (PTH) and alkaline phosphatase (ALP) levels were respectively significantly lower than preoperative levels, while postoperative serum phosphorus level was significantly higher than preoperative level (<i>P</i><0.05). The mean lesion volume was (3.32±6.72)cm<sup>3</sup> (range 0.05-49.50 cm<sup>3</sup>). Patients with different lesion volumes had significant differences in preoperative serum calcium, PTH and ALP levels. Lesion volume was positively correlated to preoperative serum calcium(ρ=0.36, <i>P</i><0.01), PTH(ρ=0.50, <i>P</i><0.01) and ALP(ρ=0.39, <i>P</i><0.01). Among 103 patients, 94 cases were followed up (91.26%), 9 cases were lost (8.74%), and the mean follow-up period was (60.15±29.23) months. The followed-up patients were alive and had no recurrence of lesions or complications, and their blood calcium levels were normal. <b>Conclusion:</b> aPHPT can be preliminarily diagnosed through blood biochemistry and imaging examination, and minimally invasive surgery can offer good prognosis without serious complications.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"59 10","pages":"1072-1078"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Analysis of the efficacy of vocal cord botulinum toxin injection for refractory laryngeal contact granuloma]. [声带肉毒毒素注射治疗难治性喉接触性肉芽肿疗效分析]。
Chinese journal of otorhinolaryngology head and neck surgery Pub Date : 2024-10-07 DOI: 10.3760/cma.j.cn115330-20240606-00340
J S Wang, J R Li, Y F Pan, Z Liu, C Zhang, W J Wang
{"title":"[Analysis of the efficacy of vocal cord botulinum toxin injection for refractory laryngeal contact granuloma].","authors":"J S Wang, J R Li, Y F Pan, Z Liu, C Zhang, W J Wang","doi":"10.3760/cma.j.cn115330-20240606-00340","DOIUrl":"10.3760/cma.j.cn115330-20240606-00340","url":null,"abstract":"<p><p><b>Objective:</b> To observe the efficacy of vocal cord botulinum toxin type A injection in the treatment of refractory laryngeal contact granuloma and to analyze the factors affecting the curative effect. <b>Methods:</b> Fifty-two patients with refractory laryngeal contact granuloma who received vocal cord botulinum toxin type A injection under topical anesthesia from May 2021 to May 2023 were analyzed retrospectively. Among them, 51 were males and 1 was female, aged 22-66 (48.98±8.87)years old. All patients were followed up for a minimum of 12 months. Outcome measures in terms of patient cure rate, total effective rate, complications and recurrence rate were calculated. The median [<i>M</i> (<i>Q</i><sub>1</sub>, <i>Q</i><sub>3</sub>)] was used to represent non-normally distributed measurement data, and Logistic regression analysis was used to determine independent risk factors affecting efficacy. <b>Results:</b> The cure rate of 52 patients with refractory laryngeal contact granuloma treated by vocal cord botulinum toxin type A injection was 78.8% (41/52), and the total effective rate (including cure, marked and effective) was 90.4% (47/52). The median number of injections was 1[1,2]. Following a single injection, the cure rate was 69.2% (36/52), and the median treatment duration for cured patients was 3 [3,3] months. Hoarseness occurred in 88.5% (46/52) of patients, with recovery within 3 months in all cases. Additionally, 21.2% (11/52) of the patients experienced cough, sore throat, dyspnea, all of whom recovered within 3 months. One patient among the 41 cured cases was lost to follow-up, and the recurrence rate at the 12th month was 17.5% (7/40). Multivariate regression analysis indicated that age, granuloma size, history of PPI treatment, previous corticosteroid injections, prior surgical excision, pharyngeal reflux, chronic cough, pharyngeal reflux, chronic cough and vocal overuse were not independent risk factors for cure and recurrence. <b>Conclusion:</b> Vocal cord botulinum toxin type A injection is an alternative for the treatment of refractory laryngeal contact granuloma, which offers benefits such ashigh cure rate, short treatment cycle and less injection times.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"59 ","pages":"1048-1053"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Unilateral arytenoid chondroplasty combined with minimally invasive mucosal flap plasty for bilateral vocal cord paralysis--clinical analysis of 66 cases]. [单侧杓状软骨成形术联合微创粘膜瓣成形术治疗双侧声带麻痹--66 例临床分析]。
Chinese journal of otorhinolaryngology head and neck surgery Pub Date : 2024-10-07 DOI: 10.3760/cma.j.cn115330-20240701-00395
J Deng, F Zhang, X M Wu, D Wang, L Chen, R Q Ma, Z F Wang, X L Zhu, W B Lei
{"title":"[Unilateral arytenoid chondroplasty combined with minimally invasive mucosal flap plasty for bilateral vocal cord paralysis--clinical analysis of 66 cases].","authors":"J Deng, F Zhang, X M Wu, D Wang, L Chen, R Q Ma, Z F Wang, X L Zhu, W B Lei","doi":"10.3760/cma.j.cn115330-20240701-00395","DOIUrl":"10.3760/cma.j.cn115330-20240701-00395","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the efficacy of unilateral arytenoid chondroplasty combined with minimally invasive mucosal flap plasty in the management bilateral vocal cord paralysis. <b>Methods:</b> A total of 66 patients with bilateral vocal cord paralysis hospitalized in the First Hospital of Sun Yat-sen University from January 2018 to December 2023 were retrospectively analyzed, among whom there were 8 males and 58 females, with ages ranging from 35 to 86 years old(mean age (57.8±11.6) years). All patients underwent suspension laryngoscopic CO<sub>2</sub> laser unilateral arytenoid chondroplasty and mucosal flap under general anesthesia. Postoperative follow-up period extended from 6 months to 6 years, with a median duration of 28 months. The study compared the degree of dyspnea and voice quality (subjective and objective evaluation) of the patients pre- and post-operatively, and analyzed the clinical differences between patients with and without preoperative or intraoperative tracheotomy, the extubation rate of tracheotomized patients, the recurrence rate, and the complication rate. Continuous variables conforming to normal distribution were tested by t-test and categorical variables by χ² test,the Wilcoxon rank-sum test was used to analyze the improvement in dyspnea before and after surgery. <b>Results:</b> Compared with the preoperative period, 59 patients showed improvement in postoperative dyspnea (<i>U</i>=161.5, <i>P</i><0.01); there was no significant difference in voice disorder index 10, subjective auditory-perceptual assessment, and maximal vocalization time (<i>P</i>>0.05), all of which remained within the relative normal range. Tracheotomy was performed in 32 out of 66 patients, with predominantly degree Ⅲ- dyspnea (46.9%, 15/32), including 26 patients with preoperative tracheotomy and 6 patients with intraoperative tracheotomy. Among the 34 patients who did not undergo tracheotomy, the majority presented with degree Ⅱ-dyspnea (82.4%, 28/34). All patients achieved successful extubation following surgery, with a mean median time to extubation of 1 month. <b>Conclusions:</b> The combination of unilateral arytenoid chondroplasty and minimally invasive mucosal flap plasty represents a refined and effective therapeutic approach for bilateral vocal cord paralysis. This minimally invasive technique has the potential to reduce the rate of tracheotomy.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"59 ","pages":"1037-1041"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Systematic evaluation of the correlation between serum metabolites and tinnitus]. [系统评估血清代谢物与耳鸣之间的相关性]。
Chinese journal of otorhinolaryngology head and neck surgery Pub Date : 2024-10-07 DOI: 10.3760/cma.j.cn115330-20231224-00324
Y P Zuo, H Xie, T T Zhao, X Y Zhang, H Jiang
{"title":"[Systematic evaluation of the correlation between serum metabolites and tinnitus].","authors":"Y P Zuo, H Xie, T T Zhao, X Y Zhang, H Jiang","doi":"10.3760/cma.j.cn115330-20231224-00324","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20231224-00324","url":null,"abstract":"<p><p><b>Objective:</b> We performed a Mendelian randomisation (MR) analysis to explore the relationship between serum metabolites and tinnitus. <b>Methods:</b> In this study, 486 serum metabolites were considered as exposure factors, and single nucleotide polymorphisms (SNP) significantly associated with them were used as instrumental variables (IV). The serum metabolite data were obtained from a public database (http://metabolomips.org/gwas/index.php), while the genome-wide association study (GWAS) summary association statistics for tinnitus were obtained from a Finnish database (https://r10.finngen.fi/pheno/H8_TINNITUS). The inverse variance weighting (IVW) method was employed as the primary determination method for MR analysis, with corrections for multiple comparisons made using the false discovery rate (FDR). Sensitivity tests were conducted using the MR-Egger regression, Mendelian random polymorphism residuals and outliers (MR-PRESSO) methods. The identified serum metabolites were subjected to chained disequilibrium regression analysis (LDSC) and metabolic pathway analysis. Reverse MR analysis was performed to investigate the possibility of reverse causality. Analyses were performed in R software (version 4.3.1). <b>Results:</b> A total of 17 serum metabolites (including 10 known and 7 unknown metabolites) associated with tinnitus were identified. The known metabolites included protective metabolites such as acetylcarnitine, hydroxyisovaleryl carnitine, glycine, monounsaturated glycerol ester, and glycine-L-valine, and hazardous metabolites such as allantoin, glycerylphosphorylcholine 1-eicosatrienoate, myo-inositol, 15-methylpalmitate, and pseudouridine; the strongest causally protective metabolites were acetylcarnitine, the followed by hydroxyisopentanoyl carnitine and glycine; the hazardous metabolite with the strongest causal effect was pseudouridine, followed by inositol and 15-methylpalmitate; and only hydroxyisopentanoyl carnitine (<i>P</i><sub>FDR</sub>=0.04) and glycerol monooleate (<i>P</i><sub>FDR</sub>=0.04) reached significance values after FDR correction. The findings were free of heterogeneity, pleiotropy and reverse causal associations. The metabolic pathways were mainly enriched in pathways such as ascorbic acid and aldolac metabolism. <b>Conclusions:</b> The study suggests a causal relationship between serum metabolites and tinnitus risk. Serum metabolite levels may influence tinnitus-related metabolic pathways.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"59 10","pages":"1054-1063"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A case of sclerosing microcystic adenocarcinoma of the tongue]. [舌硬化性微囊腺癌一例]。
Chinese journal of otorhinolaryngology head and neck surgery Pub Date : 2024-09-07 DOI: 10.3760/cma.j.cn115330-20240408-00203
M Xue, J Zhang, S S Yao, F Y Ma, W Zhang
{"title":"[A case of sclerosing microcystic adenocarcinoma of the tongue].","authors":"M Xue, J Zhang, S S Yao, F Y Ma, W Zhang","doi":"10.3760/cma.j.cn115330-20240408-00203","DOIUrl":"10.3760/cma.j.cn115330-20240408-00203","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"59 9","pages":"960-962"},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Selection of inner ear fenestration strategy and surgical effect of patients with oval window atresia accompanied by facial nerve aberration]. [卵圆窗闭锁伴面神经畸形患者的内耳开窗策略选择及手术效果]。
Z R Chen, R W Tang, J Xie, J Y Guo, P F Zhao, Z J Yang, G P Wang, S S Gong
{"title":"[Selection of inner ear fenestration strategy and surgical effect of patients with oval window atresia accompanied by facial nerve aberration].","authors":"Z R Chen, R W Tang, J Xie, J Y Guo, P F Zhao, Z J Yang, G P Wang, S S Gong","doi":"10.3760/cma.j.cn115330-20231023-00165","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20231023-00165","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To summarize the clinical features and postoperative efficacy of patients with oval window atresia accompanied by facial nerve aberration. &lt;b&gt;Methods:&lt;/b&gt; The clinical data of patients with congenital middle ear malformation with facial nerve aberration admitted to our hospital from January 2015 to March 2023 were retrospectively analyzed. There were 97 cases (133 ears) in total. Among them, 39 patients (44 ears) had complete follow-up data, including 27 male patients and 12 females, aged 7-48 years old, with an average age of 17.8 years old. Of these, 14 cases (16 ears) were patients combined with facial nerve aberration, and 25 cases (28 ears) were without facial nerve aberration. The results of imaging examination, pure-tone audiometry, selection of surgical strategy, intraoperative findings and postoperative hearing improvement were summarized and analyzed. The malformations of malleus, incus, stapes, oval window and facial nerve were recorded. Prism 9 software was used to statistically analyze the mean bone conductance and air-bone gap of patients before and after surgery. &lt;b&gt;Results:&lt;/b&gt; All the 14 patients (16 ears) with middle ear malformation accompanied by facial nerve aberration and oval window atresia showed poor hearing and no facial palsy since childhood. High resolution CT (HRCT) examination of temporal bone, pure tone audiometry and Gelle test were performed before surgery. The malformations of malleus, incus, stapes, oval window and facial nerve were recorded. Preoperative high-resolution CT (HRCT) examination of temporal bone found 12 ears with 4 or more deformities, accounting for 75.00%, in the group of patients with facial nerve malformation. The preoperative average bone conductive threshold was (15.3±10.4) dB and the average air-bone gap was (46.3±10.6) dB in pure-tone audiometry (0.5, 1, 2, 4kHz). According to the different degrees of facial nerve and ossicle malformation, we performed three different hearing reconstruction strategies for the 14 patients (16 ears) with facial nerve aberration and oval window atresia, including 7 ears of incus bypass artificial stape implantation, 7 ears of Malleostapedotomy (MS) and 2 ears of Malleus-cochlear-prothesis (MCP). After 3 months to 18 months of follow-up, all patients showed no facial paralysis. The postoperative mean bone conductive threshold was (15.7±7.9) dB and air-bone gap was (19.8±8.5) dB. There were significant differences in mean air-bone gap before and after operation (&lt;i&gt;t&lt;/i&gt;=7.766, &lt;i&gt;P&lt;/i&gt;&lt;0.05), and there was no significant difference between the mean bone conductive threshold before and after surgery (&lt;i&gt;t&lt;/i&gt;=0.225, &lt;i&gt;P&lt;/i&gt;=0.824). There was no significant difference of mean reduction of air-bone gap between patients with and without facial nerve aberration (&lt;i&gt;t&lt;/i&gt;=1.412, &lt;i&gt;P&lt;/i&gt;=0.165). There was no significant difference between the three hearing reconstruction strategies. There was no significant displacement of the Piston examine","PeriodicalId":23987,"journal":{"name":"Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery","volume":"59 9","pages":"902-908"},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances in the application of galvanic vestibular stimulation in treatment of vestibular disorders]. [应用电流前庭刺激治疗前庭障碍的进展]。
L L Wang, H J Xiao, B Liu
{"title":"[Advances in the application of galvanic vestibular stimulation in treatment of vestibular disorders].","authors":"L L Wang, H J Xiao, B Liu","doi":"10.3760/cma.j.cn115330-20240509-00272","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240509-00272","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery","volume":"59 9","pages":"967-972"},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Preliminary analysis of risk factors of tinnitus related to female menopause]. [与女性更年期有关的耳鸣风险因素初步分析]。
X Ma, Y Q Lu, Y X Zhao, L S Yu, W P Bai, R C Lai, L J E
{"title":"[Preliminary analysis of risk factors of tinnitus related to female menopause].","authors":"X Ma, Y Q Lu, Y X Zhao, L S Yu, W P Bai, R C Lai, L J E","doi":"10.3760/cma.j.cn115330-20240107-00017","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240107-00017","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the possible pathogenesis and possible risk factors of tinnitus related to female menopause. <b>Methods:</b> From April 2016 to October 2016, 59 female patients with menopausal syndrome were diagnosed in the menopause comprehensive management clinic. Tinnitus and menopause questionnaires were conducted, based on whether having tinnitus, those patients were divided into two groups: tinnitus group and no tinnitus group. Age, body mass index (BMI), Kupperman menopausal index (KMI) score, follicle-stimulating hormone (FSH) level of patients in the two groups were analyzed. Menopausal symptoms, related medical history and possible related factors of tinnitus were statistically analyzed. <b>Results:</b> A total of 59 cases were collected, 22 of which were accompanied by tinnitus. The incidence of idiopathic tinnitus was 35.1% (20/57) because 2 cases of thyroid related tinnitus with clear etiology were removed. Complete data were obtained from 17 of 20 patients with idiopathic tinnitus and 26 of 37 patients without tinnitus. Age, BMI, menopause KMI score, hormone level, menopause symptoms and possible factors related to tinnitus were statistically analyzed between the two groups, and the incidence of headache was statistically different between the two groups (<i>χ</i><sup>2</sup>=9.098, <i>P</i>=0.003), but no other factors were statistically significant(<i>P</i>>0.05). The severity of insomnia and tinnitus were further analyzed (<i>χ</i><sup>2</sup>=2.841, <i>P</i>=0.417), and there was no significant difference between the two groups. <b>Conclusion:</b> Headache history may be one of the high risk factors for the occurrence of menopausal tinnitus.</p>","PeriodicalId":23987,"journal":{"name":"Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery","volume":"59 9","pages":"916-921"},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Study on the impact of aging on the brain activity patterns in auditory speech comprehension dual-route regions]. [衰老对听觉言语理解双路区大脑活动模式的影响研究]。
Y Liu, Y N Chen, S J Wang, L Yang, Y Wang, S Wang
{"title":"[Study on the impact of aging on the brain activity patterns in auditory speech comprehension dual-route regions].","authors":"Y Liu, Y N Chen, S J Wang, L Yang, Y Wang, S Wang","doi":"10.3760/cma.j.cn115330-20231017-00156","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20231017-00156","url":null,"abstract":"<p><p><b>Objective:</b> To elucidate the patterns of neural activity alterations associated with auditory speech comprehension across the lifespan and the impact of varying listening environments on these dynamics. <b>Methods:</b> Functional near-infrared spectroscopy (fNIRS) was employed to measure the concentration of oxygenated hemoglobin in the brains of 93 adults aged from 20 to 70 with normal hearing. These participants were recruited from Beijing Tongren Hospital, affiliated with Capital Medical University, between March 2021 and February 2023. Brain activity was recorded as subjects passively listened to sentences in both silent and noise conditions with varying signal-to-noise ratios (SNR). The alterations in brain activity were analyzed to delineate the age-related trends under different auditory conditions. Statistical analysis was performed using SPSS 22.0 software. <b>Results:</b> The bilateral primary auditory cortex, superior temporal gyrus, and Wernicke's area, critical for sound signal discrimination and perception, exhibited enhanced activity post-stimulus presentation. Broca's area, pivotal for speech production, demonstrated an initial decrease in activity followed by an increment after stimulus onset. The ventral middle temporal gyrus and dorsal postcentral gyrus showed augmented activity in later time windows. Furthermore, it was observed that in quiet conditions and at low noise levels (SNR=10 dB), auditory cortical activity diminished with age. With increasing noise levels (SNR=5 dB), compensatory brain regions (right ventral middle temporal gyrus and dorsal postcentral gyrus) showed enhanced activity with advancing age. As noise intensity further escalated (SNR=0, SNR=-5 dB), not only did auditory cortical activity decline, but also the activity in regions associated with semantic processing and motor functions reduced with age. <b>Conclusion:</b> During auditory speech comprehension, dual-pathway brain regions exhibit distinct activity patterns. With heightened noise exposure, an increasing number of brain regions are influenced by aging, manifesting as a general decline in activity in most dual-pathway regions, alongside a selective augmentation in some compensatory regions on the right hemisphere.</p>","PeriodicalId":23987,"journal":{"name":"Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery","volume":"59 9","pages":"909-915"},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Laryngeal mucormycosis: a case report]. [喉粘液瘤病:病例报告]。
Chinese journal of otorhinolaryngology head and neck surgery Pub Date : 2024-09-07 DOI: 10.3760/cma.j.cn115330-20240424-00233
X H Liang, P Y Sun, B Ye
{"title":"[Laryngeal mucormycosis: a case report].","authors":"X H Liang, P Y Sun, B Ye","doi":"10.3760/cma.j.cn115330-20240424-00233","DOIUrl":"10.3760/cma.j.cn115330-20240424-00233","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"59 9","pages":"954-957"},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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