Chinese journal of otorhinolaryngology head and neck surgery最新文献

{"title":"[Advances in artificial intelligence-based nasal endoscopy in the diagnosis and treatment of rhinologic diseases].","authors":"H Qiao, D S R D Aodeng, J J Li, W Lyu","doi":"10.3760/cma.j.cn115330-20250630-00341","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250630-00341","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"304-308"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interaction of head and neck cancer with the nervous system: advances and clinical prospects].","authors":"H R Wang, Y K Mou, C Ren, H Shen, X C Song","doi":"10.3760/cma.j.cn115330-20251130-00637","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20251130-00637","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"317-326"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Two cases of disseminated herpes zoster complicated with Ramsay-Hunt syndrome].","authors":"T T Mao, S Feng, M L Qi","doi":"10.3760/cma.j.cn115330-20250903-00470","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250903-00470","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"292-293"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Primary prevention study of preimplantation genetic testing for <i>GJB2</i> gene mutation families].","authors":"W J Wang, X N Wu, J Guan, Q J Wang","doi":"10.3760/cma.j.cn115330-20250804-00410","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250804-00410","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to investigate the families with different <i>GJB2 g</i>ene mutations undergoing preimplantation genetic testing (PGT), in order to provide reference for clinical practice and implementation strategies. <b>Methods:</b> Five families undergoing PGT for <i>GJB2 g</i>ene mutations at Chinese People's Liberation Army (PLA) General Hospital from 2015 to 2024 were selected. All families received genetic counseling, and the audiological data of the patients and their relatives were collected. Blood samples from the probands and their related family members were taken for genetic sequencing. After entering the PGT process, oocyte retrieval, in vitro fertilization, embryo biopsy, and genetic testing were performed. Healthy embryos were selected for transfer, and the pregnant women were followed up. <b>Results:</b> The 5 families included in the study were as follows: one family with both parents being carriers of <i>GJB2</i> c.235delC, one family with both parents being carriers of <i>GJB2</i> c.109G>A, one family with one parent affected by autosomal dominant inheritance of <i>GJB2</i>, and in two other families, the probands were married to each other, and both <i>GJB2</i> and <i>SLC26A4</i> gene mutations were involved. Through different PGT strategies, the five families underwent a total of four assisted reproductive cycles, all of which resulted in clinical pregnancies. Four couples had delivered four healthy offsprings, all of whom passed hearing screening. <b>Conclusions:</b> <i>GJB2</i> gene mutations, due to their involvement in diverse phenotypes, varying disease severity, and different inheritance patterns, require careful consideration when performing PGT. Different linkage analysis strategies should be chosen for families with varying genetic inheritance modes. For <i>GJB2</i> c.109G>A with milder phenotypes, it is not recommended to proactively suggest prenatal or preimplantation interventions during genetic counseling, unless the couple strongly requests it, in which case, thorough genetic counseling and informed consent, should be obtained. Additionally, PGT may be performed for <i>GJB2</i> c.109G>A concurrently if the couple is involved in other high-risk genetic diseases.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"217-225"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical application of superimposed high-frequency jet ventilation in adult and pediatric laryngotracheal surgery].","authors":"H L Gu, Y H Zhang, W L Kong, M L Chen, B Zeng, H Yang","doi":"10.3760/cma.j.cn115330-20250929-00522","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250929-00522","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinical application of superimposed high-frequency jet ventilation (SHFJV) in laryngotracheal surgery. <b>Methods:</b> A retrospective analysis was conducted on 158 cases undergoing SHFJV-assisted laryngotracheal surgery at West China Hospital of Sichuan University from January 2018 to June 2023. Among these cases, 122 were adults (50 females and 72 males) and 36 were children (8 females and 28 males). The patients had a mean age of 39.82±23.91 years, with the oldest patient being 83.5 years old and the youngest only 6 days old. The inclusion criteria encompassed laryngotracheal stenosis, space-occupying lesions, and functional disorders. The surgical and anesthetic processes were closely monitored. Data were collected for all patients, including general demographic information, diagnoses, surgical records, anesthetic data, complications, and the success rate of SHFJV. For two groups of continuous variables conforming to a normal distribution, the independent-samples <i>t</i>-test was used; for categorical variables, the chi-square test or Fisher's exact test was applied. All statistical analyses were performed using R 4.0.5 and SPSS 26.0 software. A P-value <0.05 was considered statistically significant. <b>Results:</b> The clinical application of SHFJV in laryngotracheal surgery was mainly concentrated in the following three scenarios: (1) Patients with difficult or impossible orotracheal intubation due to laryngeal or tracheal stenosis; (2) Patients in whom endotracheal intubation impaired the exposure of lesions; and (3) Patients in whom endotracheal intubation interfered with surgical manipulation. All patients maintained stable intraoperative vital signs without SHFJV-related complications. The overall ventilation success rate reached 98.7%, with only 2 critical cases requiring emergent tracheostomy due to progressive hypoxemia. There was no statistically significant difference in the success rate of SHFJV-supported surgery between the adult group and the pediatric group[99.2%(121/122) <i>vs.</i> 97.2%(35/36), χ²=0.69, <i>P</i>=0.405]. <b>Conclusions:</b> SHFJV, leveraging its dual-flow synergistic mechanism, safely facilitates complex laryngotracheal surgeries in both adults and children. This demonstrates marked advantages in managing stenosis, optimizing anatomical exposure, and ventilation management, thereby expanding technical options for tubeless laryngotracheal surgery.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"247-252"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in cognitive impairment screening tools for age-related hearing loss population].","authors":"C X Wei, G D Lu","doi":"10.3760/cma.j.cn115330-20250818-00430","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250818-00430","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"298-303"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical efficacy of endoscopic transnasal orbital decompression combined with optic nerve decompression for Graves ophthalmopathy: a retrospective study].","authors":"T Y Wang, L Xu, X Y Lin, K J Zuo, J B Shi, Y Y Lai","doi":"10.3760/cma.j.cn115330-20250702-00351","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250702-00351","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To evaluate the efficacy of endoscopic transnasal orbital decompression combined with optic nerve decompression in the treatment of Graves ophthalmopathy (GO) and to analyze its influencing factors. &lt;b&gt;Methods:&lt;/b&gt; A retrospective case-series study was conducted. Clinical data were collected from 56 patients (79 eyes) with moderate-to-severe GO who underwent endoscopic transnasal orbital decompression combined with optic nerve decompression in the Department of Otorhinolaryngology Head and Neck Surgery at the First Affiliated Hospital of Sun Yat-sen University between January 2019 and September 2024. There were 30 males and 26 females, with a mean age of (52.00±9.88) years (x¯±s). Patient age, clinical activity score (CAS), and duration of ocular symptoms were recorded. Visual acuity, exophthalmos, and intraocular pressure (IOP) were documented preoperatively and postoperatively. Patients were divided into the following groups: by disease duration (&lt;12 months, 12-18 months, ≥18 months); by preoperative visual acuity (&lt;0.01 and ≥0.01); by preoperative intravenous glucocorticoid pulse therapy (treated and untreated); and by preoperative CAS (≥3 and&lt;3). The improvement in visual acuity, exophthalmos, and IOP was compared among groups. Linear mixed-effects models were employed to analyze the effects of various factors on surgical outcomes. Statistical analysis was performed using SPSS 26.0 software. &lt;b&gt;Results:&lt;/b&gt; Visual acuity improved from 0.20 (0.36) (median (IQR)) preoperatively to 0.50 (0.50) postoperatively; exophthalmos decreased from 20.50 (4.50) mm to 19.00 (5.50) mm; and IOP decreased from 20.70 (7.30) mm Hg to 19.00 (6.00) mm Hg. All changes were statistically significant (&lt;i&gt;Z&lt;/i&gt; value was -6.27, -5.95, and -2.63, respectively; all &lt;i&gt;P&lt;/i&gt;&lt;0.01). Patients with disease duration &lt;12 months demonstrated significantly greater improvement in visual acuity compared to other groups (&lt;i&gt;H&lt;/i&gt;=9.51, &lt;i&gt;P&lt;/i&gt;=0.009). Linear mixed-effects model analysis revealed an estimated improvement in visual acuity of 0.16 for the &lt;12-month group compared to the ≥18-month group; however, this difference did not reach statistical significance (&lt;i&gt;P&lt;/i&gt;=0.086). Gender, age, CAS, preoperative visual acuity, and steroid therapy had no significant effect on visual acuity improvement (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). Exophthalmos reduction was significantly greater in the preoperative visual acuity &lt;0.01 group than in the ≥0.01 group (&lt;i&gt;Z&lt;/i&gt;=-2.09, &lt;i&gt;P&lt;/i&gt;=0.036). Lower preoperative visual acuity was an independent predictor of greater exophthalmos improvement (&lt;i&gt;F&lt;/i&gt;=6.46, &lt;i&gt;P&lt;/i&gt;=0.016), with an estimated value of 2.15 (&lt;i&gt;P&lt;/i&gt;=0.016). CAS and preoperative steroid use demonstrated trends toward association with exophthalmos reduction (&lt;i&gt;P&lt;/i&gt;=0.188 and &lt;i&gt;P&lt;/i&gt;=0.131, respectively), though neither reached statistical significance, whereas, gender, age, and disease duration had no statistically significant effects (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). No signif","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"280-287"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Atypical Lemierre syndrome following blunt neck trauma: a case report].","authors":"J C Wang, S S Gong, J Tian","doi":"10.3760/cma.j.cn115330-20250520-00288","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250520-00288","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"296-297"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The clinical characteristics and vestibular aqueduct morphology of Meniere's disease with or without migraine].","authors":"X L Li, J L Zhang, Q Liu, S Y Zhao, Y Y Jing, X Ma, L S Yu","doi":"10.3760/cma.j.cn115330-20250813-00423","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250813-00423","url":null,"abstract":"<p><p><b>Objective:</b> To analyze and compare the clinical characteristics and vestibular aqueduct morphology, as indicated by the angular trajectory of the vestibular aqueduct (ATVA), in patients with Meniere's disease (MD) with and without comorbid migraine. <b>Methods:</b> This cross-sectional study included 92 patients diagnosed with MD at the Department of Otorhinolaryngology Head and Neck Surgery, Peking University People's Hospital, between January 1, 2018, and December 31, 2023, who had available temporal bone CT images. Patients were divided into two groups based on the presence or absence of migraine. Data on demographics, MD-related clinical features, and migraine history were collected. The ATVA was measured on temporal bone CT scans, with ATVA<120°suggesting endolymphatic sac degeneration and ATVA>140° suggesting endolymphatic sac hypoplasia. Statistical analysis was performed using SPSS 24.0 to compare clinical characteristics and ATVA subtypes between the groups. <b>Results:</b> Among the 92 MD patients (46 males, 46 females), 52 had comorbid migraine and 40 did not. Compared to MD patients without migraine, those with migraine had a higher proportion of females, a longer disease duration, and more frequent vertigo attacks (all <i>P</i><0.05). The proportion of patients with an ATVA<120° was significantly higher in the migraine group (84.6%, 44/52) than in the non-migraine group (25.0%, 10/40) (<i>P</i><0.001). Multivariate analysis identified ATVA<120° as an independent risk factor for MD with migraine (<i>P</i>=0.011). <b>Conclusions:</b> The clinical characteristics and vestibular aqueduct morphology differ between MD patients with and without migraine. A significant association exists between endolymphatic sac degeneration (indicated by ATVA<120°) and MD comorbid with migraine.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"226-231"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A real-world study on anlotinib-targeted neoadjuvant therapy for locally advanced thyroid cancer].","authors":"S Cheng, Y Zhang","doi":"10.3760/cma.j.cn115330-20250819-00436","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250819-00436","url":null,"abstract":"<p><p><b>Objective:</b> To assess the real-world data of thyroid cancer patients with neoadjuvant treatment of anlotinib, and to evaluate the clinical efficacy, safety and correlation with molecular characteristics. <b>Methods:</b> Patients with locally advanced thyroid cancer were treated with neoadjuvant therapy with 10 mg anlotinib from April 2021 to June 2025. Statistical analysis was performed on patient demographics, molecular characteristics, changes in target lesions before and after targeted therapy, treatment-related adverse events, imaging CT values, and surgical rates. <b>Results:</b> A total of 24 patients were enrolled, including 21 of papillary carcinoma, 2 of high-grade differentiated thyroid cancer, and 1 of follicular carcinoma with medullary carcinoma. Eighteen were treatment-naïve patients, and 6 were relapsed patients after treatment. Fifty percent of patients were in the T4b stage. Of 24 patients, 17 underwent genetic testing, and mutations were detected in 15 patients, including 8 with mutations in two genes and 2 with mutations in three genes. Six patients had an ECOG performance status of 0 score, 8 patients with 1 score, and 10 patients with 2 scores. There were 6 patients of partial response, 18 of stable disease, and no progressive disease patients. The objective response rate was 25% and the disease control rate was 100%. The CT value of imaging was significantly reduced after targeted therapy (<i>t</i>=2.589, <i>P</i>=0.017). Among of the 24 patients, 16 (66.67%) underwent surgery. The surgical conversion rate in T4b stage patients was 75%(9/12). The average medication cycle was 5.91 cycles. The main treatment-related adverse events were hypertension (6/24), proteinuria (3/24), and palmar-plantar erythrodysesthesia syndrome (5/24). Adverse events were grade Ⅰ-Ⅱ, and no Ⅲ-Ⅳ grade adverse events occurred. The average follow-up time was 24.79 months. <b>Conclusion:</b> Anlotinib can be used as a preoperative neoadjuvant treatment for patients with locally advanced thyroid cancer, and the initial dose of 10 mg can ensure both efficacy and safety.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"258-264"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}