Chinese journal of otorhinolaryngology head and neck surgery最新文献

{"title":"[Advancing precision medicine in OSA treatment].","authors":"J Y Ye, J B Zhang","doi":"10.3760/cma.j.cn115330-20250430-00264","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250430-00264","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"857-862"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application and prospect of vagus nerve stimulation in rehabilitation of vertigo disease].","authors":"Z B Zhou, Z G Zhang, Y Si","doi":"10.3760/cma.j.cn115330-20250206-00083","DOIUrl":"10.3760/cma.j.cn115330-20250206-00083","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"991-995"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress of traditional Chinese medicine formula in treating allergic rhinitis].","authors":"R Z Wang, M Zhou, Z H Xiao, H J Qiu, J B Shi, Y N Zhang, Q T Yang","doi":"10.3760/cma.j.cn115330-20241031-00609","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20241031-00609","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"1000-1007"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis and comparison of the trends in burden of otitis media in China and worldwide from 1992 to 2021].","authors":"R Y Liu, H Zhao, S M Yang","doi":"10.3760/cma.j.cn115330-20240928-00550","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240928-00550","url":null,"abstract":"<p><p><b>Objectives:</b> To describe, analyze, and compare the temporal trends of age and sex-specific burden of Otitis media(OM) in China and globally from 1992 to 2021. <b>Methods:</b> Data from the Global Burden of Disease(GBD) database from 1992 to 2021 were used to analyze the characteristics of OM burden in China and globally, including changes in incidence, prevalence, mortality, and disability-adjusted life years(DALYs). Epidemiological characteristics of OM were analyzed using methods such as Joinpoint analysis, age-period-cohort models, and decomposition analysis. Autoregressive Integrated Moving Average(ARIMA) models were used to forecast the incidence and prevalence rates over the next 15 years. <b>Results:</b> From 1992 to 2021, the age-standardized incidence rate (ASIR) of OM in China decreased from 4 183.54/100, 000 to 4 179.92/100, 000, while, the global ASIR increased from 5 345.09/100, 000 to 5 529.1/100, 000. The age-standardized prevalence rate (ASPR) in China decreased from 1 835.2/100, 000 to 1 332.11/100, 000, while, the global ASPR decreased from 1 786.56/100, 000 to 1 593.74/100, 000. The age-standardized mortality rate (ASMR) in China decreased from 0.01/100, 000 to 0, while, the global ASMR decreased from 0.03/100, 000 to 0.01/100, 000. The age-standardized DALY rate (ASDR) in China decreased from 37.39/100, 000 to 26.53/100, 000, while, the global ASDR decreased from 37.68/100, 000 to 32.54/100, 000. The average annual percent change (AAPC) for ASIR, ASPR, ASMR, and ASDR in China were -0.003%, -1.101%, -9.803%, and -1.178%, respectively, while, globally the AAPC were 0.116%, -0.395%, -4.396%, and -0.506%, respectively. The impact of age and sex on the burden of OM varied. The incidence rate was highest in children, especially in the group under 5 years old, followed by the elderly. The incidence and mortality of OM were higher in females than in males. Decomposition analysis indicated that the main factor contributing to the decline in DALYs in China was epidemiological changes, while, the main factor contributing to the increase in global DALYs was population growth. Over the next 15 years, it might be predicted that the prevalence of OM will decrease in both China and globally, with a decrease in incidence in China and an increase in the global incidence. <b>Conclusion:</b> From 1992 to 2021, the incidence, prevalence, mortality, and DALYs of OM in China have generally shown a declining trend, indicating a gradual reduction in the disease burden of OM in China. The disease burden of OM is age-related, with the highest incidence and prevalence observed in children and a higher mortality rate in the elderly population. OM remains a significant public health challenge in China.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"903-910"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Protective effect of NAD⁺ against noise-induced cochlear injury in mice and its transcriptional and metabolic regulation].","authors":"Y Q Cui, M Chen, H Y Wang, S K Yin, X L Shang, C Y Li","doi":"10.3760/cma.j.cn115330-20240928-00549","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240928-00549","url":null,"abstract":"<p><p><b>Objectives:</b> To investigate the protective effect of nicotinamide adenine dinucleotide (NAD⁺) against noise-induced cochlear damage and preliminarily explore its underlying transcriptional and metabolic regulatory mechanisms. <b>Methods:</b> During the study period (January 2023-February 2025), an oxidative stress model was established using House Ear Institute-organ of Corti 1 (HEI-OC1) cells, and cell viability was assessed using the Cell Counting Kit-8 (CCK8) assay. Flow cytometry was employed to analyze cell apoptosis. A mouse model of noise-induced hearing loss was developed, and the mice were divided into three groups: a noise-exposed saline group, a noise-exposed NAD⁺ intervention group, and a noise-free control group. Hearing protection effects were evaluated by auditory brainstem response (ABR) and immunofluorescence. Metabolomics and transcriptomics were used to analyze the regulatory effects of NAD⁺on transcription and metabolism in mouse cochlea. Enzyme-linked immunosorbent assay, quantitative real-time PCR, and western blot were used to verify the differential transcription and metabolic molecules and their functions. Data were statistically analyzed with GraphPad Prism 9.3.0. <b>Results:</b> NAD⁺at concentrations ranging from 10-80 μM effectively restored cell viability and reduced apoptosis induced by H₂O₂ in HEI-OC1 cells. NAD⁺ intervention significantly improved 16-32 kHz ABR thresholds after noise exposure (<i>P</i><0.05), reduced outer hair cell loss rates (<i>P</i><0.05), and attenuated ribbon synapse damage (<i>P</i><0.000 1). Metabolomics analysis revealed a significant downregulation in the glycerophospholipid metabolism pathway, with decreased levels of lysophosphatidic acid (LPA) and its related metabolites. ELISA results showed that LPA levels in the NAD⁺ intervention group were significantly lower (<i>P</i><0.05). LPA inhibitor (ATX inhibitor 1) exhibited a cell protective effect similar to that of NAD⁺. Transcriptomics analysis indicated a significant upregulation of key genes related to potassium ion channels, such as <i>Kcnq4</i>. qPCR and Western blot further confirmed the significant upregulation of <i>Kcnq4</i> and its encoded protein in the NAD⁺ intervention group (<i>P</i><0.05). In the presence of the KCNQ4 inhibitor (ML252), the protective effect of NAD⁺ was inhibited. <b>Conclusions:</b> NAD⁺ exerts effective protective effects against noise-induced cochlear injury. Its protective mechanism may be closely related to the inhibition of LPA metabolic pathway and the up-regulation of KCNQ4 channel function.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 8","pages":"943-953"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Thyroid metastasis of nasal malignant melanoma: a case report].","authors":"W Li, X Cheng, L Yang","doi":"10.3760/cma.j.cn115330-20250220-00112","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250220-00112","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 7","pages":"835-836"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical applications and prospects of spatial hearing research].","authors":"N Y Wang, J Zhang","doi":"10.3760/cma.j.cn115330-20250303-00120","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250303-00120","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 7","pages":"705-708"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of unilateral conductive hearing loss on sound localization in noisy environments].","authors":"J Q Shang, W B Wang, L Li, S S Tian, R Chen, Z M Fan, H B Wang, Y Ai","doi":"10.3760/cma.j.cn115330-20240705-00402","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240705-00402","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To evaluate the sound localization ability of patients with different degrees of unilateral conductive hearing loss (UCHL) in quiet and noisy environments, and to explore the changes and characteristics of sound localization. &lt;b&gt;Methods:&lt;/b&gt; This was a cross-sectional study. 41 patients with UCHL were hospitalized in Shandong Provincial ENT Hospital from January to April 2024, including 22 males and 19 females, aged 18-55 years old, with an average age of 36.9 years. According to the pure-tone average (PTA) of 500, 1000 and 2000 Hz in the suffered ear, subjects were divided into slight-mild UCHL group (20 numbers) and moderate-moderately severe UCHL group (21 numbers). 21 patients with normal hearing (NH) were enrolled as controls. All subjects were assessed through pure-tone audiometry, horizontal sound localization test (including azimuth identification test in quiet and noisy environments), Chinese edition short form of Spatial Hearing Questionnaire (C-SHQ12) and twelve-item version of Speech, Spatial, and Qualities of Hearing Scale (SSQ12). SPSS, version 26.0, was used for statistical analysis. &lt;b&gt;Results:&lt;/b&gt; There were significant differences in the root-mean-square errors (RMSE) of the sound localization azimuth identification test in quiet and noisy environments among the NH group, slight-mild UCHL group, and moderate-moderately severe UCHL group (Quiet: &lt;i&gt;F&lt;/i&gt;=29.109, &lt;i&gt;P&lt;/i&gt;&lt;0.001; Noisy: &lt;i&gt;F&lt;/i&gt;=24.351, &lt;i&gt;P&lt;/i&gt;&lt;0.001). This presented statistically marked difference in the RMSEs between the two listening environments in the slight-mild UCHL group (&lt;i&gt;t&lt;/i&gt;=-4.911, &lt;i&gt;P&lt;/i&gt;&lt;0.001). There was a statistical difference in the RMSEs between the normal and affected sides of the subjects in the slight-mild UCHL group in the quiet environment (&lt;i&gt;t&lt;/i&gt;=-2.055,&lt;i&gt;P&lt;/i&gt;&lt;0.05), but not in the noisy environment. For moderate-moderately severe UCHL subjects, there were no differences in the RMSEs between the quiet and noisy environments (&lt;i&gt;P&lt;/i&gt;&gt;0.05). What's more，no significant differences were found between normal side and affected side in both environments (&lt;i&gt;P&lt;/i&gt;&gt;0.05). The RMSEs of UCHL patients in quiet and noisy environments were positively correlated with PTA of air-conduction in the suffered ears (Quiet: &lt;i&gt;r&lt;/i&gt;=0.681, &lt;i&gt;P&lt;/i&gt;&lt;0.001; Noisy: &lt;i&gt;r&lt;/i&gt;=0.346, &lt;i&gt;P&lt;/i&gt;&lt;0.05). RMSEs in quiet and noisy environments were negatively correlated with the average localization scores in C-SHQ12 (Quiet: &lt;i&gt;r&lt;/i&gt;=-0.576, &lt;i&gt;P&lt;/i&gt;&lt;0.001, Noisy: &lt;i&gt;r&lt;/i&gt;=-0.613, &lt;i&gt;P&lt;/i&gt;&lt;0.001) and in SSQ12 (Quiet: &lt;i&gt;r&lt;/i&gt;=-0.634, &lt;i&gt;P&lt;/i&gt;&lt;0.001, Noisy: &lt;i&gt;r&lt;/i&gt;=-0.663, &lt;i&gt;P&lt;/i&gt;&lt;0.001). &lt;b&gt;Conclusions:&lt;/b&gt; The sound localization ability of UCHL subjects decreased compared with those with normal hearing, and the RMSE gradually increased with the worse of air conduction hearing threshold. The localization ability of UCHL subjects was further reduced in the noisy environment compared with that in the quiet environment. The slight-mild UCHL s","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 7","pages":"792-799"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in the treatment of anaplastic thyroid carcinoma].","authors":"R Y Li, X L Gao, J D Liang, Q Zhang","doi":"10.3760/cma.j.cn115330-20250402-00197","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250402-00197","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 7","pages":"844-851"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Observation and analysis of microstructure and ultrastructure of auricular pseudocyst].","authors":"P H Dang, J W Chen, A J Kang, X T Zhang","doi":"10.3760/cma.j.cn115330-20240708-00407","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20240708-00407","url":null,"abstract":"<p><p><b>Objective:</b> Through microscopic and ultrastructural observations,to explore the origin of the cartilage of the anteroposterior pseudocyst.Staging for the auricular pseudocyst according to the different pathological changes and exploring its clinical significance. <b>Methods:</b> 48 cases(51 ears)of the auricular pseudocyst were collected as the observation objects(46 males, 2 females, 15-76 years old) and 45 patients(45 ears)chronic suppurative otitis media hospitalized patients who underwent tympanic membrane repair as a normal control group(43 males, 2 females, 12-74 years old).The outer wall of the cyst was surgically resected and the residual auricular cartilage was retained in the control group for HE staining or transmission electron microscopy specimens, and the specimens were observed and analyzed under light microscope and transmission electron microscopy. <b>Results:</b> According to the data of this study, auricular pseudocyst was relatively common in people aged 21-60 years. The disease course of 4 ears was ≤ 10 days,the course of 16 ears was > 10 days yet ≤ 30 days, the course of 20 ears was > 1 month but ≤ 2 months,the course of 6 ears was > 2 months yet ≤ 1 year, the course of 3 ears was > one year but ≤ two years,and the course of 2 ears was > 2 years. The observation of microstructure and ultrastructure of the different course of outer walls of the auricle pseudocyst was shown:due to various causes of cartilage fluid that separated perichondrium and cartilage tissue, when the perichondrium was stimulated, the bone progenitor cells from the quiescence phase came to the activities period. With the extension of the course, the periosteum was thickening gradually, cartilage the bone progenitor cells idifferentiated into chondroblasts, which idifferentiated into chondrocytes last, from native to mature, from thin to thick. It was stable a period of time when the cartilage mature. The outer wall of the cyst was new cartilage, which reflected additional growth. The nucleus of the chondrocytes evolved into nucleolysis, and necrosis, when the lesions was stimulated.The control group had a thin layer of cartilage and periosteum, containing a small amount of osteoprogenitor cells; the cartilage layer was thick, the cartilage cells were small near the periosteum, and the deep cartilage cells were large, all of which were mature chondrocytes. <b>Conclusions:</b> The outer cartilage of auricle pseudocyst is newborn cartilage. The pathological staging is divided into early stage(cartilage formation), middle stage(cartilage maturity) and late stage(cartilage necrosis).This stage can provide a reference for exploring the pathogenesis of pseudocysts of the auricle and formulating surgical treatment principles.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 7","pages":"807-814"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}