Chinese journal of otorhinolaryngology head and neck surgery最新文献

{"title":"[Endotype classification of chronic rhinosinusitis based on unsupervised clustering analysis].","authors":"N Kang, X Luo, Z X Hua, Z Z Guo, W X Zhang, Y N Zhang, Q T Yang","doi":"10.3760/cma.j.cn115330-20250701-00347","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250701-00347","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"309-316"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Inflammatory bowel disease increases the risk of hearing loss via autoimmunity: a Mendelian randomization study].","authors":"X Y Xia, J Z Huang, K L Pu, H M Song","doi":"10.3760/cma.j.cn115330-20250425-00253","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250425-00253","url":null,"abstract":"<p><p><b>Objective:</b> This study investigates the intriguing causal relationship between inflammatory bowel disease (IBD) and the risk of hearing loss (HL). Furthermore, an attempt was made to quantify the role of immunization as a potential mediator. <b>Methods:</b> Our research process was meticulously designed and executed. We pooled data from gene-wide association studies (GWAS) obtained IBD data from the European IEU database (website: https://gwas.mrcieu.ac.uk/) and GWAS data for HL from the Finnish database (website: https://www.finngen.fi/fi). We then applied a range of rigorous statistical methods, including the inverse-variance weighted (IVW) method, Mendelian randomization (MR)-Egger regression method, weighted median (WME), simple mode (SM), and weighted mode (WM), to perform two-sample MR analysis and to evaluate a causal relationship of IBD on HL risk in terms of odds ratio (<i>O</i>R) and 95% confidence interval (<i>CI</i>). We also conducted Cochran's Q heterogeneity test by IVW and MR-Egger regression, respectively, and multiple validity test by MR_pleiotropy_test function, MR PRESSO, and sensitivity analysis by MR_leaveoneout_plot function, and F-values were computed to assess the presence of weak instrumental variable bias. <b>Results:</b> The IVW analysis indicated that IBD was a risk factor for HL (<i>OR</i>: 1.055, 95%<i>CI</i>: 1.006-1.105, <i>P</i>=0.026). Furthermore, the analysis demonstrated a causal relationship between IBD and autoimmunity (<i>OR</i>: 1.008, 95%<i>CI</i>: 1.005-1.010, <i>P</i><0.001). In addition, autoimmunity was found to be a risk factor for HL (<i>OR</i>: 2.822, 95%<i>CI</i>: 1.115-7.142, <i>P</i>=0.029). In the mediation analysis, the direct effect was not significant (95%<i>CI</i>:-0.002-0.092, <i>P</i>=0.062), while, the indirect effect was significant (95%<i>CI</i>:<0.001-0.015, <i>P</i>=0.048). <b>Conclusions:</b> IBD has been demonstrated to heighten the probability of developing HL through the action of autoimmunity-mediated mechanisms.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"239-246"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Multifrequency attenuation patterns in age-related hearing loss: a longitudinal analysis using spline mixed-effects models].","authors":"L M Han, A T Chen, T Lou, Y Han, Q Wang, M D Hong, Y Q Wang, Q Y Zhou, W W Guo, F Ji","doi":"10.3760/cma.j.cn115330-20250529-00299","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250529-00299","url":null,"abstract":"<p><p><b>Objective:</b> Based on longitudinal audiological data, this study explores the multifrequency dynamic decline patterns of age-related hearing loss (ARHL) to provide a theoretical foundation for early screening and intervention of ARHL. <b>Methods:</b> A total of 111 patients who visited the Otolaryngology Department of PLA General Hospital between January 2009 and May 2025 and underwent at least two pure-tone audiometry tests with an interval of no less than one year were included. The inclusion criteria were as follows: aged 50 years or older at the first test, no history of high noise exposure, otitis media, or sudden deafness, and symmetrical hearing in both ears. Their longitudinal audiological data were analyzed, and a spline mixed-effects model was constructed using R. Natural spline basis functions were employed to fit the nonlinear effects of hearing threshold shifts across frequencies with age, meanwhile, the growth rates of each frequency, age effect coefficients (β), and hearing threshold trends were calculated across frequencies, while calculating annual progression rates and age effect coefficients (<i>β</i>) for each frequency. <b>Results:</b> The average age at the first test was (72.9±9.9) years, with follow-ups ranging from 2 to 17 times and an average test interval of (7.2±4.3) years (maximum interval: 14.9 years). The model revealed: ① Hearing thresholds increased nonlinearly with age across all frequencies (<i>P</i><0.001), with the high-frequency group (6 000, 8 000 Hz) showing significantly higher age effect coefficients than the low-frequency group (125, 250 Hz) (8 000 Hz basis function B2: β=72.21, <i>t</i>=7.46 vs. 500 Hz basis function B3: β=39.12, <i>t</i>=9.95). ② The coefficient of PTA (mean of 500, 1 000, 2 000, 4 000 Hz) basis function B2 (β=46.97) was lower than the full-frequency mean (β=51.24), and its dynamic changes were highly synchronized with 2 000 Hz. ③ The 8000 Hz frequency exhibited the highest hearing threshold increase rate (1.10 dB/year), peaking at 70-74 years (1.39 dB/year) and declining to 0.56 dB/year at 90-100 years. In contrast, the 125 Hz rate increased steadily from 0 dB/year at 50-54 years to 1.04 dB/year at 80-84 years. <b>Conclusions:</b> The spline mixed-effects model accurately delineates the multifrequency nonlinear decline characteristics of ARHL, revealing a three-stage pattern of hearing deterioration across frequencies: \"early progression in the elderly, mid-term acceleration, and late-stage deceleration.\" The strong correlation between 2 000 Hz and PTA suggests its potential value as a screening indicator.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"232-238"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Image-enhanced endoscopy in the targeted biopsy of sinonasal inverted papilloma associated with squamous cell carcinoma: a case report].","authors":"M Li, B Zhou","doi":"10.3760/cma.j.cn115330-20250703-00353","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250703-00353","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 3","pages":"288-289"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of mixed follicular-papillary-eosinophilic adenocarcinoma of the thyroid gland].","authors":"H Yu, G B Zheng, Z L Liu, X C Song, X M Chen","doi":"10.3760/cma.j.cn115330-20250617-00319","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250617-00319","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 2","pages":"151-152"},"PeriodicalIF":0.0,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of tonsillar clear cell carcinoma].","authors":"Y Liu, Y N Pang, C B Xu","doi":"10.3760/cma.j.cn115330-20250607-00308","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250607-00308","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 2","pages":"149-150"},"PeriodicalIF":0.0,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of safety and efficacy of endoscopic thyroidectomy via sternocleidomastoid muscle posteroinferior approach].","authors":"X H Chen, Y X Jing, Y M Ding, J Zhou, J W Huang, X Chen, Z G Huang","doi":"10.3760/cma.j.cn115330-20250218-00109","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250218-00109","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the clinical efficacy and safety of endoscopic thyroidectomy via sternocleidomastoid muscle posteroinferior approach (ETSPIA). <b>Methods:</b> A retrospective analysis was conducted on the clinical data of 213 patients with thyroid lesions who underwent ETSPIA in the Thyroid and Head and Neck Surgery Department of Beijing Tongren Hospital from November 2022 to December 2024. The cohort included 64 males and 149 females, aged from 11 to 69 years. Among them, 188 cases were diagnosed with papillary thyroid carcinoma (PTC), and 25 cases presented with benign thyroid lesions. The clinical data included operative time, intraoperative blood loss, postoperative changes in parathyroid hormone (PTH) and calcium ion levels, complications, lymph node metastasis, and follow-up outcomes. Statistical analysis was performed using descriptive methods with SPSS version 26.0. <b>Results:</b> All 213 patients were successfully completed unilateral thyroid lobectomy combined with central compartment lymph node dissection, with or without lateral neck dissection. The median operative time was 3 hours and 43 minutes, with a median intraoperative blood loss of 10 ml and a median postoperative hospital stay of 4 days. The median follow-up duration was 26 months, and no patients reported anterior neck discomfort, such as pressure or swallowing-related pulling sensations. Two patients experienced chyle leakage, which resolved after standardized treatment, and twelve patients reported mild numbness behind the ears, which subsided within one month. No cases of transient recurrent laryngeal nerve injury leading to hoarseness were observed. Postoperative parathyroid function remained intact, with a slight increase in PTH levels observed three months postoperatively in patients with papillary thyroid carcinoma and benign thyroid lesions. Postoperative pathology revealed occult lateral cervical lymph node metastases in 39 cases. <b>Conclusion:</b> ETSPIA offers advantages in postoperative recovery and cosmetic outcomes while effective resections of tumors and metastatic lymph nodes. This novel endoscopic approach combines the benefits of minimally invasive surgery with functional preservation, making it a promising technique for thyroid surgery.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 2","pages":"140-144"},"PeriodicalIF":0.0,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Congenital triple nostrils malformation combined with patent ductus arteriosus: a case report].","authors":"X X Shao, Z N Xu, S Teng, B R Yan, S Liu, Q Y Li, Y N Sun","doi":"10.3760/cma.j.cn115330-20250611-00315","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250611-00315","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 2","pages":"147-148"},"PeriodicalIF":0.0,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in multidisciplinary diagnosis and treatment of odontogenic sinusitis: from etiopathogenesis to treatment strategies].","authors":"Y Jiang, J H Lao, R R Ge, X K Huang, Z H Shi, Q T Yang, S Wu","doi":"10.3760/cma.j.cn115330-20250528-00297","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250528-00297","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 2","pages":"185-190"},"PeriodicalIF":0.0,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of clinical diagnosis, treatment, and pathogenic variants of hypoparathyroidism- sensorineural deafness-renal dysplasia (HDR) syndrome].","authors":"B Zuo, W L He, M L Zhang, G E Xu, W Lu, S P Sun","doi":"10.3760/cma.j.cn115330-20250423-00246","DOIUrl":"https://doi.org/10.3760/cma.j.cn115330-20250423-00246","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to identify pathogenic variants in patients with hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome through whole-exome sequencing (WES), to elucidate the genotype-phenotype correlations, and to provide a basis for refining its clinical diagnostic criteria and genetic counseling. <b>Methods:</b> Three pedigrees presenting with hypoparathyroidism, sensorineural hearing loss, and renal dysplasia, who visited the First Affiliated Hospital of Zhengzhou University between January 2022 and January 2025, were enrolled. Clinical and genetic data from the probands and their family members were systematically collected. Variant screening was performed on the probands using whole-exome sequencing (WES). Detected variants were evaluated through bioinformatic analysis, validated by Sanger sequencing for segregation within the families, and classified according to the American College of Medical Genetics and Genomics (ACMG) guidelines. A genotype-phenotype analysis of HDR syndrome was further conducted through a comprehensive literature review. <b>Results:</b> A total of 5 patients with HDR syndrome were diagnosed across the three pedigrees. The most common clinical phenotypes included sensorineural hearing loss (5/5), hypoparathyroidism (2/5), renal abnormalities (1/5), and preauricular fistula (1/5). Three novel pathogenic variants in the <i>GATA</i>3 gene were identified: c.24_27del (p.Arg9GlyfsTer2), c.681del (p.Glu228SerfsTer38), and c.759_762del (p.Lys254ProfsTer11). These variants had not been previously reported in public databases. Segregation analysis within the families confirmed their complete co-segregation with the disease phenotype, and all were classified as pathogenic according to ACMG guidelines. <b>Conclusions:</b> We report three novel pathogenic <i>GATA3</i> variants for the first time, which expands the molecular diagnostic spectrum of HDR syndrome and provides molecular evidence for family genetic counseling and prenatal diagnosis. The combined use of WES and Sanger sequencing effectively improves the diagnostic yield for hereditary hearing loss, particularly in syndromic forms. Furthermore, a phenotype-driven targeted analysis strategy holds significant value in enhancing the detection rate of causative genes.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"61 2","pages":"110-118"},"PeriodicalIF":0.0,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}