中华流行病学杂志最新文献

{"title":"[A longitudinal study on the relationship between pre-pregnancy urolithiasis and pre-eclampsia: the mediating effect of hyperuricemia in early pregnancy].","authors":"Y Chen, M T Sun, Z Y Li, Q Zou, Y Peng, X R Ruan, M J Luo, T T Wang, J B Qin","doi":"10.3760/cma.j.cn112338-20240701-00389","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240701-00389","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the association between pre-pregnancy urolithiasis and pre-eclampsia and to further explore the mediating effect of hyperuricemia in early pregnancy on the relationship between urolithiasis and pre-eclampsia. <b>Methods:</b> Pregnant women attending prenatal care in early pregnancy at 7 Maternal and Child Health Hospitals in Hunan Province from August 2014 to December 2019 were recruited to construct a cohort of early pregnancy. The paper questionnaire collected demographic data on pregnant women, pre-pregnancy disease history, and living habits, <i>etc</i>. Besides, the early pregnancy laboratory examination and pregnancy outcome for this pregnancy were derived from the hospital's electronic medical record system. Logistic regression models were used to analyze the association between pre-pregnancy urolithiasis and pre-eclampsia, and causal mediation analysis was used to investigate the mediating role and magnitude of hyperuricemia in early pregnancy in the association pathway between pre-pregnancy urolithiasis and pre-eclampsia. <b>Results:</b> A total of 33 579 naturally conceived singleton pregnant women were included in the analysis, of which 3 230 cases (9.6%) had hyperuricemia in early pregnancy, and 666 cases (2.0%) had pre-eclampsia. The multivariate logistic regression analysis indicated that pre-pregnancy urolithiasis increased the risk of pre-eclampsia (<i>OR</i>=2.65, 95%<i>CI</i>: 1.56-4.51). Mediation analysis showed that after controlling for confounders, hyperuricemia in early pregnancy could mediate the association between pre-pregnancy urolithiasis and pre-eclampsia, with a mediation effect proportion of 46% (<i>P</i><0.05). <b>Conclusions:</b> Pre-pregnancy urolithiasis is an independent risk factor for pre-eclampsia, and early pregnancy hyperuricemia has a certain mediating effect between urolithiasis and pre-eclampsia.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 1","pages":"140-146"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prevalence of chronic kidney disease and influencing factors in adults in Hebei Province].","authors":"T T Guo, X L Liu, J J Zhao, M Li, L J Tang, F J Yue, Y J Cao","doi":"10.3760/cma.j.cn112338-20240506-00234","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240506-00234","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the prevalence of chronic kidney disease (CKD) and influencing factors of adults in Hebei Province, and provide scientific evidence for the development of comprehensive CKD prevention and control strategies. <b>Methods:</b> In China Adult Chronic Disease and Nutrition Surveillance in Hebei in 2018, a total of 7 562 permanent residents aged ≥18 years were selected by multi-stage stratified cluster random sampling from 13 surveillance points in Hebei for questionnaire survey, medical examination and laboratory test. <b>Results:</b> A total of 1 067 CKD patients were detected in the adults aged ≥18 years in this survey, with a weighted prevalence rate of 12.10%. The results of multivariate analysis showed that the daily total static behavior time (<i>OR</i>=1.07, 95%<i>CI</i>: 1.04-1.09), living in rural area (<i>OR</i>=1.50, 95%<i>CI</i>: 1.14-1.97), coal use (<i>OR</i>=1.37, 95%<i>CI</i>: 1.16-1.61), coal gas/liquefied gas/natural gas/biogas use (<i>OR</i>=2.92, 95%<i>CI</i>: 2.40-3.54) and solar energy/electricity use (<i>OR</i>=1.75, 95%<i>CI</i>: 1.36-2.25), insufficient fruit intake (<i>OR</i>=1.39, 95%<i>CI</i>: 1.06-1.83), insufficient physical activity (<i>OR</i>=1.35, 95%<i>CI</i>: 1.11-1.64), suffering from hypertension (<i>OR</i>=1.80, 95%<i>CI</i>: 1.44-2.24) and suffering from diabetes (<i>OR</i>=1.77, 95%<i>CI</i>: 1.27-2.45) were risk factors for CKD in adults in Hebei. High education level (<i>OR</i>=0.41, 95%<i>CI</i>: 0.19-0.91), excessive drinking (<i>OR</i>=0.53, 95%<i>CI</i>: 0.28-0.99), central obesity (<i>OR</i>=0.75, 95%<i>CI</i>: 0.58-0.97), history of allergic diseases (<i>OR</i>=0.44, 95%<i>CI</i>: 0.27-0.72) were protective factors for CKD. <b>Conclusions:</b> The prevalence of CKD in adults in Hebei was relatively high, especially in those who had too long average daily static behavior, lived in rural area, used coal, gas/liquefied gas/natural gas/biogas, solar energy/electricity, had inadequate intake of fruits, lacked physical activity and suffered from hypertension and diabetes. It is necessary to pay attention to the early prevention and treatment of CKD, strengthen the health education about healthy lifestyle and improve the management of patients with chronic disease, such as hypertension and diabetes, to further reduce the risk for CKD.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 1","pages":"107-117"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Challenges and suggestions for the prevention and control of chronic kidney disease in China].","authors":"Z P Zhao, L M Wang","doi":"10.3760/cma.j.cn112338-20240722-00448","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240722-00448","url":null,"abstract":"<p><p>Population aging, high prevalence of chronic disease, such as hypertension and diabetes, low chronic disease control rate and chronic disease related risk factors commonly observed in population are serious public health problems faced by China today, which have resulting in severe challenges in the prevention and control of chronic kidney disease (CKD) in China. Although the prevalence rate of CKD showed decrease in the past decade, the awareness of CKD in population remains low. To facilitate early detection and treatment of CKD, it is necessary to strengthen health education or promotion and opportunistic screening in high-risk populations, and improve the accessibility of testing and diagnosis. It is suggested to continue the surveillance for disease burden of CKD and related factors and strengthen the control of risk factors to further reduce the incidence and burden of CKD.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 1","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Distribution characteristics and heritability of alcohol consumption behavior in adult twins in China].","authors":"Y C Li, W J Gao, W H Cao, J Lyu, C Q Yu, S F Wang, T Huang, D J Y Sun, C X Liao, Y J Pang, R Q Gao, M Yu, J Y Zhou, X P Wu, Z Dong, F Wu, D Z Wang, Z H Xu, Y Liu, Y X Ma, J Yin, S L Yin, L M Li","doi":"10.3760/cma.j.cn112338-20240522-00294","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240522-00294","url":null,"abstract":"<p><p><b>Objective:</b> To describe the distribution characteristics of alcohol consumption in adult twins in the Chinese National Twin Registry (CNTR), and further explore the influence of genetic factors on alcohol consumption in adult twins. <b>Methods:</b> The subjects of the study were twins registered by CNTR in 11 project areas across China from 2010 to 2018. A total of 56 966 twins (28 483 pairs) aged 18 years and above who answered questions about drinking behavior were included, and the random effect model was used to describe the population and regional distribution characteristics of alcohol consumption. Intra-pair analysis was performed to calculate the concordance rate and heritability of their alcohol consumption. <b>Results:</b> The age of all subjects was (36.6±12.0) years, and current drinkers accounted for 16.6% (9 461/56 966) of all subjects. In men, those aged 50-59 years, those in northern China, those living in rural area, those with low education level and those with high BMI, the proportions of current drinkers were higher. After excluding 468 pairs of twins who had stopped alcohol use and 21 764 pairs of twins who had no drink or had small amount drink, an intra-pair analysis was conducted in 4 929 pairs of same-sex twins, and found that the concordance rate of alcohol consumption was 64.0% (2 059/3 215) in monozygotic twins, and 52.6% (902/1 714) in dizygotic twins, the difference was significant (<i>P</i><0.001), and the heritability of alcohol consumption was 24.1% (95%<i>CI</i>: 18.9%- 29.3%). The further stratified analysis found that in southern men, the heritability was highest in those aged 40-49 years (36.1%, 95%<i>CI</i>: 21.6%-50.7%), while in northern men, the heritability was highest in those aged 50-59 years (34.2%, 95%<i>CI</i>: 18.1%-50.3%). <b>Conclusions:</b> In adult twins in China, there were population and regional differences in the distribution of alcohol consumption behavior, and alcohol consumption was influenced by genetic factors, and gender, age and region had potential modifying effects.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 1","pages":"73-80"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Growing global public health challenges].","authors":"C X Liao, B Wang, J Lyu, L M Li","doi":"10.3760/cma.j.cn112338-20241230-00839","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20241230-00839","url":null,"abstract":"<p><p>Global public health is currently undergoing unprecedented and complex changes. The COVID-19 pandemic has exposed vulnerabilities and weaknesses of the global health system, urging nations globally to prioritize pandemic prevention and response strategies. Simultaneously, emerging infectious diseases such as mpox and avian influenza, as well as re-emerging infectious diseases including tuberculosis, AIDS, and viral hepatitis, continue to pose threats to global public health security. Moreover, the prevalence of chronic diseases remains significant, while concerns pertaining to environmental health and the well-being of children and adolescents are growing increasingly prominent. Addressing these challenges requires the formulation of effective public health policies, strengthened international cooperation, enhanced health education, improved public health literacy, and the establishment of a more resilient global public health system.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidemiological characteristics and spatiotemporal distribution of genital herpes in China, 2010-2023].","authors":"Z W Chen, S Q Liang, X L Yue, J Li, J H Zhang, X D Gong","doi":"10.3760/cma.j.cn112338-20240905-00552","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240905-00552","url":null,"abstract":"<p><p><b>Objective:</b> To understand the epidemiological characteristics and spatiotemporal distribution of genital herpes in China from 2010 to 2023 and provide evidence for the prevention and control of genital herpes. <b>Methods:</b> The reported data of genital herpes cases in 31 provinces (autonomous regions and municipalities) in China from 2010 to 2023 were collected from the National Notifiable Infectious Disease Reporting System of China Information System for Disease Control and Prevention. Software Joinpoint 5.2.0 was used to analyze the epidemiological characteristics of genital herpes, software ArcGIS 10.5 was used for spatial autocorrelation analysis, and software SaTScan 10.2.3 was used for spatiotemporal scanning analysis. <b>Results:</b> The reported incidence rate of genital herpes increased from 1.58/100 000 to 2.00/100 000 in China from 2010 to 2023, with an average annual percentage change of 0.90%. The upward trend of reported incidence rate was significant (<i>t</i>=2.35, <i>P</i>=0.037). There was a positive spatial autocorrelation in the reported incidence of genital herpes with the global Moran's <i>I</i> ranging from 0.36 to 0.51 (all <i>P</i><0.001). Local spatial autocorrelation analysis showed that the number of hotspots increased from 144 in 2010 to 232 in 2023, mainly distributed in provinces Zhejiang, Guangdong, Guangxi, Chongqing and Hunan. The number of hotspots in of Chongqing, Sichuan, Yunnan and Guizhou increased significantly from 7 to 57. A total of 67 spatiotemporal clusters were detected by spatiotemporal scanning analysis, mainly distributed in Guangdong from 2011 to 2015, in Zhejiang and Fujian from 2015 to 2019, and in Chongqing and Guizhou from 2019 to 2023. <b>Conclusions:</b> From 2010 to 2023, the reported incidence of genital herpes in China showed an upward trend, and there was an obvious spatiotemporal clustering of genital herpes. The distribution of hotspots was basically consistent with the distribution of spatiotemporal clustering areas, mainly distributed in the southeastern coastal area and southwestern region, and the spatiotemporal clustering areas gradually changed from the southeast coastal area to the southwest region.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 1","pages":"101-106"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between hypertension duration and chronic kidney disease in residents in China].","authors":"X Zhang, M Zhang, C Li, M T Yu, L M Wang","doi":"10.3760/cma.j.cn112338-20240411-00187","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240411-00187","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the association between hypertension duration and risk for chronic kidney disease in residents in China. <b>Methods:</b> Participants aged 18-74 years from the sixth round of China Chronic Disease and Risk Factor Surveillance in 2018 were included. The age/date at hypertension diagnosis was reported by them, and hypertension duration was calculated based on the age at diagnosis and the age at survey. The hypertension duration was calculated as 0 year (i.e., normotensive participants), 0.1- year, 5.0- years, 10.0- years, and ≥15.0 years. Serum creatinine, urinary albumin, and urinary creatinine levels were measured, and chronic kidney disease was diagnosed when glomerular filtration rate was <60 ml·min^-1·(1.73 m²)^-1 and/or urine albumin-to-creatinine ratio was ≥30 mg/g. Multivariable logistic regression analysis, which took intra-group correlation into account, was used to evaluate the association of hypertension duration with chronic kidney disease. <b>Results:</b> A total of 140 662 residents were finally included in the analysis. After adjusting the confounders, including blood pressure, the odds ratio of chronic kidney disease was 1.16 (95%<i>CI</i>: 1.09-1.23), 1.33 (95%<i>CI</i>: 1.20-1.48), 1.33 (95%<i>CI</i>: 1.18-1.49), and 1.43 (95%<i>CI</i>: 1.29-1.60) in study subjects with hypertension durations of 0.1-4.9 years, 5.0-9.9 years, 10.0-14.9 years, and ≥15.0 years, respectively, in comparison with normotensive people. This result was further supported by the positive association between hypertension duration and chronic kidney disease in people with previously diagnosed hypertension. The results of restricted cubic spline suggested that the risk for chronic kidney disease showed a steep increase within 0.1- 4.9 years after hypertension diagnosis, then showed neither increase nor decrease. The above association seemed to be stronger in those with hypertension diagnosed age <45 years. Compared with those with hypertension duration of 0.1-4.9 years, the odds ratio was 1.38 (95%<i>CI</i>: 1.04-1.84), 1.22 (95%<i>CI</i>: 0.91-1.65), and 1.47 (95%<i>CI</i>: 1.04-2.07) in those with hypertension durations of 5.0-9.9 years, 10.0-14.9 years, and ≥15.0 year, respectively. In those with hypertension diagnosis at ≥45 years, the corresponding odds ratio was 1.08 (95%<i>CI</i>: 0.98-1.19), 1.08 (95%<i>CI</i>: 0.97-1.21), and 1.16 (95%<i>CI</i>: 1.02-1.32), respectively. <b>Conclusions:</b> Hypertension duration is positively associated with the risk for chronic kidney disease in residents in China, and this association is independent of blood pressure level. Early diagnosis of hypertension and long-term control of blood pressure are effective strategies for secondary prevention of hypertension-related chronic kidney disease.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 1","pages":"26-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between possible sarcopenia and risk for frailty in middle-aged and elderly adults in China: a cohort study].","authors":"A Q Jiang, Y Wei, B Liang, L J Pei","doi":"10.3760/cma.j.cn112338-20240823-00517","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240823-00517","url":null,"abstract":"<p><p><b>Objective:</b> To assess the association between possible sarcopenia and the risk for frailty in middle-aged and elderly adults in China. <b>Methods:</b> A prospective cohort study design was used in this study. Data were from the China Health and Retirement Longitudinal Study during 2011-2018 and the baseline data in 2011, the follow up was conducted in 2013, 2015 and 2018, respectively. Frailty index was used to evaluate frailty status, and grip strength and repetitive sitting-up time were measured to detect possible sarcopenia. Cox proportional hazards regression model was used to estimate the association between possible sarcopenia and the risk for frailty in middle-aged and older adults. <b>Results:</b> In a 44 884 person-years follow-up, a total of 586 cases with frailty were recorded, and the incidence density of frailty was 13.06 per 1 000 person-year. The risk for frailty was also higher in those who were aged 60 years and above (<i>HR</i>=2.05, 95%<i>CI</i>: 1.71-2.45), had a primary school education level or below (<i>HR</i>=1.55, 95%<i>CI</i>: 1.29-1.85), had waist-to-height ratio ≥0.5 (<i>HR</i>=1.39, 95%<i>CI</i>: 1.11-1.75) and had depression (<i>HR</i>=1.52, 95%<i>CI</i>: 1.28-1.81). Drinking was associated with reduced risk for frailty (<i>HR</i>=0.76, 95%<i>CI</i>: 0.62-0.94). The risk for frailty increased (<i>HR</i>=1.73, 95%<i>CI</i>: 1.47-2.05) in those who might has possible sarcopenia. <b>Conclusions:</b> In middle-aged and elderly adults, those with possible sarcopenia, lower education level, central obesity and depression might be at high risk for frailty, and early interventions for high-risk population can be taken to slow the progression of frailty.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 1","pages":"81-86"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Adiposity-related anthropometric parameters, indoles and atherosclerotic cardiovascular disease in Chinese adults: a prospective cohort study].","authors":"J H Si, S Cheng, C Q Yu, D J Y Sun, Y J Pang, P Pei, H D Du, J S Chen, Z M Chen, L M Li, J Lyu","doi":"10.3760/cma.j.cn112338-20240603-00325","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240603-00325","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the relationship of several adiposity-related anthropometric parameters, including BMI, waist circumference (WC), waist-to-hip ratio (WHR), body fat percentage (BFP) and indoles in plasma with the incidence of atherosclerotic cardiovascular disease (ASCVD) in adults in China. <b>Methods:</b> In China Kadoorie Biobank (CKB) study, blood samples were collected from 2 183 participants in the first resurvey in 2008 to detect indoles. Participants' body weight, body height, WC, hip circumference, and BFP were measured at baseline survey in 2004 and resurvey in 2008, the BMI and WHR were calculated with standardized methods. The long-term follow-up of all participants started from the completion of the resurvey in 2008 until the occurrence of incident ASCVD, death, loss to follow-up or until December 31, 2018. CKB ascertained outcome status (incident ASCVD) through death and disease registries and national health insurance databases, supplemented by active follow-up. Multivariate linear regression model was used to estimate the associations of anthropometric measurements at baseline survey and the first resurvey, and changes in these measurements with 3 indoles [indole, indole-3-acetic acid (IAA), and indole-3-propionic acid (IPA)]. Cox proportional hazard regression model was used to estimate the associations between indoles and the risk for ASCVD. <b>Results:</b> Anthropometric measurements at baseline survey or the first resurvey were negatively associated with plasma IPA level. The regression coefficient (<i>β</i>) of baseline BMI (per 1.0 kg/m²) with 0.1 standard deviation (<i>SD</i>) IPA was -0.23 (95%<i>CI</i>: -0.36 - -0.10) (false discovery rate=0.004). After adjusting for baseline BMI, the <i>β</i> of baseline WC, WHR and BFP with 0.1 <i>SD</i> IPA were -0.09 (95%<i>CI</i>: -0.18 - -0.01), -0.12 (95%<i>CI</i>: -0.19 - -0.05), and -0.20 (95%<i>CI</i>: -0.32 - -0.08), respectively. The annual change in BMI (difference between BMI in 2008 and 2004 divided by the time interval) was associated with indole and IAA, with <i>β</i> of 1.40 (95%<i>CI</i>: 0.58 - 2.21) and -1.07 (95%<i>CI</i>: -1.91 - -0.23), respectively, at each 0.1 increase of <i>SD</i>. Over a median (<i>Q</i>₁, <i>Q</i>₃) follow-up of 10.46 (10.36, 10.53) years after 2008 resurvey, 236 cases of ASCVD were recorded. IAA and IPA levels were negatively associated with the risk for ASCVD, with hazard ratios for one <i>SD</i> increase of IAA and IPA of 0.87 (95%<i>CI</i>: 0.76 - 0.99) and 0.84 (95%<i>CI</i>: 0.73 - 0.96), respectively. <b>Conclusions:</b> Our results suggested that anthropometric measurements and their changing trends affect the levels of plasma imicrobial tryptophan metabolite levels, decreased levels of IAA and IPA levels are associated with increased risk of ASCVD and indoles in plasma including IPA and IAA might be the mediating factors for adiposity-induced ASCVD.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 1","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Health economic evaluation of minimally invasive surgery in treatment of digestive tract cancers: a Meta-analysis].","authors":"X Y Yin, N Zhou, X L Yang, Z Y Sun, Y H Bao, S S Wang, K Han, J Long, M Zhao, H W Li, R R Li, S M Chen, J H Yang, H H Li, Y T Shi, G N Zhu, J H Wang, S S Yang, B Y Li, W C Wang, S Y Du, Y He, E J Ling-Hu, H K Li, M Liu, J Xie","doi":"10.3760/cma.j.cn112338-20240530-00318","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240530-00318","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To compare minimally invasive surgery with traditional open surgery, analyze the current application status of health economic evaluations in the treatment of digestive tract cancers, such as esophageal cancer, gastric cancer, and colorectal cancer by minimally invasive surgery and provide evidence for the rational selection of clinical treatment, alleviation of disease-related economic burdens, and rational allocation of healthcare resources. &lt;b&gt;Methods:&lt;/b&gt; By using five databases, i.e. China National Knowledge Infrastructure, Wanfang data, Chinese Biomedical Literature Database, PubMed, and Embase, a database was established to retrieve all the papers about health economic studies of minimally invasive surgery for esophageal cancer, gastric cancer, and colorectal cancer published until December 31, 2023. Literature was analyzed by using software NoteExpress 3.8, and data were processed using Excel 2021. The quality of included papers was evaluated using the CHEERS 2022 checklist, and Meta-analysis was conducted by using software Stata 17.0. &lt;b&gt;Results:&lt;/b&gt; A total of 10 919 relevant papers were retrieved, and 59 studies were included. Only 14 studies (23.7%) used standard health economic evaluation methods. Meta-analysis results revealed no significant differences in direct medical expenditure and total expenditure between minimally invasive surgery and open surgery. However, the expenditure for minimally invasive surgery exhibited a significant increase [mean difference (&lt;i&gt;MD&lt;/i&gt;)=5 973.12 yuan, &lt;i&gt;P&lt;/i&gt;&lt;0.001], while hospital stay and indirect expenditure significantly decreased (&lt;i&gt;MD&lt;/i&gt;: -4.85 days and -733.79 yuan, &lt;i&gt;P&lt;/i&gt;&lt;0.001). In China, for gastric cancer, the direct medical expenditure of endoscopic surgery was lower than that of open surgery (&lt;i&gt;MD&lt;/i&gt;=-33 000.00 yuan) with no significant difference (&lt;i&gt;P&lt;/i&gt;&lt;0.001). In colorectal cancer cases, the direct medical and surgical expenditures for laparoscopic surgery were higher than those for open surgery (&lt;i&gt;MD&lt;/i&gt;: 4 277.94 yuan and 4 267.80 yuan, &lt;i&gt;P&lt;/i&gt;&lt;0.001), while the indirect and total medical expenditures decreased (&lt;i&gt;MD&lt;/i&gt;: -768.34 yuan and -159.10 yuan). Hospital stays in patients who had minimally invasive surgery for all three types of cancer were shorter than those who had open surgery (&lt;i&gt;P&lt;/i&gt;&lt;0.001). &lt;b&gt;Conclusions:&lt;/b&gt; In the treatment of gastrointestinal cancer, compared with open surgery, minimally invasive surgery shows higher expenditure, but has advantages, such as shorter hospital stay and lower indirect expenditure, and there were no significant differences in direct medical and total expenditures between the two approaches. When conducting health economic evaluation, factors such as postoperative complications, hospital stay, and patient's economic status should be considered for their impact on total medical expenditure. It is necessary to pay attention to the application of health economic evaluations in healthcare decision-maki","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 1","pages":"154-165"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}