World Journal of Pediatrics最新文献

{"title":"Effectiveness and safety of biosimilars in pediatric inflammatory bowel diseases: an observational longitudinal study on the French National Health Data System.","authors":"Hugo Jourdain, Léa Hoisnard, Emilie Sbidian, Mahmoud Zureik","doi":"10.1007/s12519-024-00873-4","DOIUrl":"10.1007/s12519-024-00873-4","url":null,"abstract":"<p><strong>Background: </strong>Data on biosimilar use in pediatric inflammatory bowel diseases (IBD) are scarce compared to the status of studies in adults, resulting in limitations in its treatment. We compared effectiveness and safety of biosimilars versus originators in this population.</p><p><strong>Methods: </strong>We used data from the French National Health Data System to identify children (less than 18 years old at treatment initiation) initiating treatment with a biosimilar or the originator infliximab or adalimumab for Crohn's disease (CD) or ulcerative colitis (UC), from first biosimilar launch (January 2015 and October 2018, respectively) to 31 December 2022. Patients' follow-up went until 30 June 2023. We compared the risks of treatment failure and overnight hospitalization in biosimilar versus originator new users using inverse harzard ratio (HR) of probability of treatment weighted Cox regressions (IPTW).</p><p><strong>Results: </strong>We included 5870 patients (infliximab: n = 3491; adalimumab: n = 2379) in the study. Biosimilars represented, respectively, 76.0% (n = 2652) and 29.0% (n = 691) of infliximab and adalimumab initiations. CD represented 70.9% (n = 2476) and 69.0% (n = 1642) of infliximab and adalimumab initiations. Biosimilar use was not associated with increased risks of treatment failure [IPTW HR (95% confidence interval, CI): infliximab 0.92 (0.78-1.09) in CD, 0.98 (0.76-1.27) in UC; adalimumab 0.98 (0.85-1.14) in CD, 1.01 (0.82-1.24) in UC]. Occurrence of all-cause hospitalization was not different between exposure groups [IPTW HR (95% CI): infliximab 0.96 (0.78-1.18); adalimumab 1.03 (0.80-1.33)]. No difference in occurrence of serious infections, mainly gastro-intestinal or dermatological, was found.</p><p><strong>Conclusion: </strong>We provide reassuring results on the use, effectiveness and safety of biosimilars in a large unselected pediatric population suffering from IBD.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"62-72"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerometry-assessed sleep clusters and obesity in adolescents and young adults: a longitudinal analysis in GINIplus/LISA birth cohorts.","authors":"Mingming Wang, Claudia Flexeder, Carla P Harris, Sara Kress, Tamara Schikowski, Annette Peters, Marie Standl","doi":"10.1007/s12519-024-00872-5","DOIUrl":"10.1007/s12519-024-00872-5","url":null,"abstract":"<p><strong>Background: </strong>Some studies have revealed various sleep patterns in adolescents and adults using multidimensional objective sleep parameters. However, it remains unknown whether these patterns are consistent from adolescence to young adulthood and how they relate to long-term obesity.</p><p><strong>Methods: </strong>Seven-day accelerometry was conducted in German Infant Study on the influence of Nutrition Intervention PLUS environmental and genetic influences on allergy development (GINIplus) and Influence of Lifestyle factors on the development of the Immune System and Allergies in East and West Germany (LISA) birth cohorts during the 15-year and 20-year follow-ups, respectively. Five sleep clusters were identified by k-means cluster analysis using 12 sleep characteristics at each follow-up. Adjusted linear and logistic regression models using generalized estimating equations were examined. Further, the interaction effects with time of follow-ups and polygenic risk scores (PRS) for body mass index (BMI) were tested.</p><p><strong>Results: </strong>Five sleep clusters were classified consistently in both adolescence (n = 1347, aged 14.3-16.4 years) and young adulthood (n = 1262, aged 19.5-22.4 years). Adolescents in the \"good sleep\", \"delayed sleep phase\", and \"fragmented sleep\" clusters displayed greater stability transitioning into young adulthood, while those in the \"sleep irregularity and variability\", and \"prolonged sleep latency\" clusters showed lower stability (n = 636). Compared to the \"good sleep\" cluster, the \"prolonged sleep latency\" cluster exhibited associations with higher BMI [β = 0.56, 95% confidence interval (CI) = (0.06, 1.05)] and increased odds of overweight/obesity [Odds ratio = 1.55, 95% CI = (1.02, 2.34)]. No significant PRS-sleep cluster interaction was found for BMI or overweight/obesity. Among males only, the \"delayed sleep phase\", \"sleep irregularity and variability\" and \"fragmented sleep\" clusters showed stronger associations with overweight/obesity as age increased.</p><p><strong>Conclusion: </strong>Adolescents and young adults shared five consistent sleep patterns, with the \"prolonged sleep latency\" pattern linked to higher BMI and overweight/obesity.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"48-61"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex dimorphic associations of Prader-Willi imprinted gene expressions in umbilical cord with prenatal and postnatal growth in healthy infants.","authors":"Berta Mas-Parés, Gemma Carreras-Badosa, Ariadna Gómez-Vilarrubla, Antonio De Arriba-Muñoz, Olivia Lafalla-Bernard, Anna Prats-Puig, Francis De Zegher, Lourdes Ibañez, Andrea M Haqq, Judit Bassols, Abel Lopez-Bermejo","doi":"10.1007/s12519-024-00865-4","DOIUrl":"10.1007/s12519-024-00865-4","url":null,"abstract":"<p><strong>Background: </strong>The impact of Prader-Willi syndrome (PWS) domain gene expression on the growth of healthy children is not well understood. This study investigated associations between PWS domain gene expression in umbilical cord tissue and prenatal and postnatal growth, considering potential sex differences.</p><p><strong>Methods: </strong>Relative gene expression of paternally expressed MAGEL2, NDN, and SNURF-SNRPN, and the small nucleolar RNAs SNORD116 and SNORD115 were determined by real-time quantitative polymerase chain reaction in umbilical cord tissue from 122 healthy newborns (59 girls and 63 boys). Gene expression levels were correlated with auxological measures at birth, infancy, and childhood (ages 2, 4, and 6 years).</p><p><strong>Results: </strong>MAGEL2, NDN, SNORD116, and SNORD115 expression in the umbilical cord was negatively associated with birth weight, length, and placental weight (P < 0.001). Postnatally, these genes were positively associated with weight and length at 3 months (P < 0.001) and weight gain from birth to ages 1, 2, and 4 years (P < 0.01). Negative associations at birth were stronger in girls (P < 0.001), while positive associations during infancy and childhood were stronger in boys (P < 0.001). MAGEL2, SNORD116, and SNORD115 expression predicted early-postnatal growth, explaining the higher growth rate in boys compared to girls and accounting for sex differences up to 1.5 kg in weight and 3 cm in height during infancy.</p><p><strong>Conclusions: </strong>Paternally expressed PWS domain gene expression in the umbilical cord was negatively associated with prenatal growth and positively with early-postnatal growth in healthy infants. This gene expression may predict early human postnatal growth and promote the well-known sex dimorphism in growth. These results can also help in understanding the etiology of PWS, which remains unclear.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"100-112"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term safety of childhood growth hormone treatment: evidences from real-world study and future directions.","authors":"Cai Zhang, Yan Liang, Xiao-Ping Luo","doi":"10.1007/s12519-024-00862-7","DOIUrl":"10.1007/s12519-024-00862-7","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"3-7"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic acidosis and sudden infant death syndrome: overlooked data provides insight into SIDS pathogenesis.","authors":"Paul N Goldwater, Dov Jordan Gebien","doi":"10.1007/s12519-024-00860-9","DOIUrl":"10.1007/s12519-024-00860-9","url":null,"abstract":"<p><strong>Background: </strong>Decades of mainstream SIDS research based on the Triple Risk Model and neuropathological findings have failed to provide convincing evidence for a primary CNS-based mechanism behind putative secondary dyshomeostasis (respiratory or cardiac) or impaired arousal. Newly revealed data indicate that severe metabolic acidosis (and severe hyperkalemia) is a common accompaniment in SIDS. This supports the direct effect of sepsis on vital-organ function and occurrence of secondary CNS changes accompanied by the dyshomeostasis leading to SIDS.</p><p><strong>Data sources: </strong>Using PubMed and Google Scholar literature searches, this paper examines how metabolic acidosis and sepsis might contribute to the underlying pathophysiologic mechanisms in SIDS.</p><p><strong>Results: </strong>The discovery of a series of non-peer-reviewed publications provided the basis for a serious examination of the role of metabolic acidosis and sepsis in SIDS. Most SIDS risk factors relate directly or indirectly to infection. This consequently elevated the position of septic or superantigenic shock and viremia in causing secondary organ failure leading to SIDS. The latter could include diaphragmatic failure, as evidenced by peripheral respiratory (muscle) arrests in experimental septic shock, as well as infectious myositis and diaphragm myopathy in sudden unexpected deaths, including SIDS. In addition, just as acidosis lowers the threshold for ventricular fibrillation and sudden cardiac arrest, it could also contribute to similarly unstable diaphragm excitation states leading to respiratory failure.</p><p><strong>Conclusions: </strong>This paper uniquely reveals compelling evidence for a connection between metabolic acidosis, sepsis, viral infections, and sudden unexpected child deaths and provides a solid basis for further work to define which pathway (or pathways) lead to the tragedy of SIDS. It is recommended that all autopsies in sudden unexpected deaths should include pH, bicarbonate, lactate, and electrolyte measurements, as well as diaphragm histology.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"29-40"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national trends in type 2 diabetes mellitus burden among adolescents and young adults aged 10-24 years from 1990 to 2021: a trend analysis from the Global Burden of Disease Study 2021.","authors":"Si-Te Xu, Mu Sun, Yu Xiang","doi":"10.1007/s12519-024-00861-8","DOIUrl":"10.1007/s12519-024-00861-8","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) poses an escalating public health challenge among adolescents and young adults worldwide. Despite the rising incidence, comprehensive data on the burden and trends of T2DM in this demographic remain scarce. This study aims to evaluate the burden of T2DM among individuals aged 10-24 years globally, regionally, and nationally from 1990 to 2021.</p><p><strong>Methods: </strong>Utilizing data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, we assessed incidence rates, disability-adjusted life-years (DALYs), and average annual percentage changes (AAPCs) for T2DM in the specified age group. Analyses accounted for variations by age, sex, and socio-demographic index (SDI). Joinpoint regression analysis identified years of significant trend shifts.</p><p><strong>Results: </strong>The global incidence of T2DM among adolescents and young adults rose from 56.02 per 100,000 (95% UI 43.03-72.32) in 1990 to 123.86 per 100,000 (95% UI 100.43-149.79) in 2021, reflecting an AAPC of 3.01 (95% CI 2.78-3.23). Notable increases were recorded in 1995, 2002, and 2009, with joinpoints indicating significant trend stabilization post-2010 for prevalence and DALYs. The largest relative incidence increase was observed in the 15-19 age group [AAPC 2.97 (95% CI 2.71-3.24)]. Although T2DM mortality was 2.4 times higher in the 15-19 age group compared to the 20-24 age group, the latter exhibited a significantly higher overall mortality rate. Regionally, Oceania recorded the highest incidence rates in 2021, while North Africa and the Middle East showed the greatest AAPCs. High-SDI countries experienced the most substantial increase in T2DM burden, with males comprising 54.8% of cases.</p><p><strong>Conclusions: </strong>From 1990 to 2021, the global burden of T2DM among adolescents and young adults has markedly increased, underscoring the necessity for targeted, region-specific interventions to address this issue. The observed demographic disparities in mortality rates necessitate the implementation of age-specific strategies. Furthermore, the emergent trends in T2DM indicators warrant urgent attention to mitigate the rising burden in this vulnerable population.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"73-89"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonspecific increase of αβTCR⁺ double-negative T cells in pediatric rheumatic diseases.","authors":"Kuanysh Dossybayeva, Gulsamal Zhubanova, Assel Mussayeva, Zaure Mukusheva, Aiken Dildabayeva, Galiya Nauryzbayeva, Lyudmila Akhmaltdinova, Ulbolsyn Orumbayeva, Matthew Tanko, Dimitri Poddighe","doi":"10.1007/s12519-024-00854-7","DOIUrl":"10.1007/s12519-024-00854-7","url":null,"abstract":"<p><strong>Background: </strong>An increased number of double-negative T (DNT) cells expressing the αβ T cell receptor (αβ⁺DNT cells) is one of the diagnostic criteria for autoimmune lymphoproliferative syndrome (ALPS). Moreover, these cells are expanded in a widely used murine model for lupus. However, the homeostasis of αβ⁺DNT cells remains inadequately investigated in rheumatic disorders, especially in pediatric patients.</p><p><strong>Methods: </strong>In this cross-sectional, prospective, and observational study, children with rheumatic disorders and healthy controls were recruited to analyze the quantity and characteristics of circulating DNT cells using flow cytometry.</p><p><strong>Results: </strong>Overall, the two study groups did not differ in their total DNT cell pool in the bloodstream. However, the number of αβ⁺DNT cells was significantly higher in rheumatic children than that in the controls, whereas the γδ⁺DNT cells remained similar. This expansion in the circulating pool of αβ⁺DNT cells was comparable across different rheumatic diseases, all showing significant differences from the controls in this regard. Moreover, no significant correlation was found between αβ⁺DNT cell numbers and disease activity.</p><p><strong>Conclusions: </strong>These preliminary results indicate that circulating αβ⁺DNT cells are significantly expanded in children with rheumatic disorders; however, this finding appears to be a nonspecific (disease-unrelated) marker of autoimmunity. Further and larger studies are necessary to better investigate and define the role of DNT cells in pediatric rheumatic diseases.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"1283-1292"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal microbiota transplants in pediatric autism: opportunities and challenges.","authors":"Jian Wang, Rong Yang, Hui Zhong, Yan-Jun Liu","doi":"10.1007/s12519-024-00855-6","DOIUrl":"10.1007/s12519-024-00855-6","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"1201-1204"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus for pertussis in children: new concepts in diagnosis and treatment.","authors":"Yu-Mei Mi, Ji-Kui Deng, Ting Zhang, Qing Cao, Chuan-Qing Wang, Sheng Ye, Ying-Hu Chen, Han-Qing He, Bei-Bei Wu, Yan Liu, Mei Zeng, Wei Li, Fang Wu, Hong-Mei Xu, Shi-Yong Zhao, Gang Liu, Wang Hua, Dan Xu, Guan-Nan Bai, Ying Yang, Li-Su Huang, Yi-Ping Chen, Kai-Hu Yao, Zhu-Jun Shao, Chun-Zhen Hua","doi":"10.1007/s12519-024-00848-5","DOIUrl":"10.1007/s12519-024-00848-5","url":null,"abstract":"<p><strong>Background: </strong>Pertussis resurgence has been reported worldwide in the past two decades. Pertussis is still endemic and difficult to control though with universal vaccination in children. The resurgence may be related to multiple variables, such as increased disease awareness and laboratory tests, waning of immunity following vaccination, and/or genetic mutations of Bordetella pertussis. For better pertussis prevention, diagnosis, and management, we called up an expert panel to develop this expert consensus to provide new concepts in diagnosis and treatment for clinical practice.</p><p><strong>Data sources: </strong>The expert groups collected clinical evidence, summarized their clinical experiences, evaluated preliminary recommendations or guidelines, and then organized open-ended discussions to form the recommendations. This consensus was developed by reviewing the literature and studies in databases, including PubMed, Cochrane, EMBASE, the China Biomedical Database, and the Chinese Journal Full-text Database up to May 2024. The search terms included \"pertussis\" or \"whooping cough\", \"children\", \"diagnosis\", and \"treatment\".</p><p><strong>Results: </strong>The burden of pertussis has also changed from infants to  school children and adults, and these age groups have consequently become the main source of infection for vulnerable population including infants and newborns. In China, a high prevalence of erythromycin-resistant Bordetella pertussis (ERBP) has been reported in the past decade. ERBP may lead to failed clinical empirical treatment with macrolides, which poses a great challenge for pertussis management and control. For better management of pertussis, a flow diagram for diagnosis and treatment of pertussis was presented in this consensus. This consensus also described the diagnostic criteria for pertussis, high-risk cases, and severe pertussis. Macrolides can still be used to treat confirmed erythromycin-sensitive B. pertussis (ESBP) infections, whereas oral trimethoprim-sulfamethoxazole therapy is the initial treatment option for children older than two months. For infants younger than two months, severe patients, or those exhibiting a high degree of sulfonamide allergy, intravenous administration of piperacillin or cefoperazone-sulbactam is advised.</p><p><strong>Conclusions: </strong>This expert consensus provides a comprehensive guidance and a reference for the diagnosis and treatment of pertussis in children.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"1209-1222"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemic risks of measles and rubella in China: a systematic review and meta-analysis.","authors":"Yi-Tong Lin, Yi-Xuan Gao, Yan Zhang, Ai-Li Cui, Hui-Ling Wang, Zhen Zhu, Nai-Ying Mao","doi":"10.1007/s12519-024-00859-2","DOIUrl":"10.1007/s12519-024-00859-2","url":null,"abstract":"<p><strong>Background: </strong>Seroprevalence studies across various countries can contribute to achieving the elimination target for measles and rubella. However, in the Mainland of China, the concept of herd immunity remains unclear due to the lack of a nationwide serosurvey.</p><p><strong>Methods: </strong>This systematic review and meta-analysis was conducted by retrieving literature reporting the seroprevalence of measles and rubella published between 2012 and 2023. The pooled positive rates and estimated geometric mean concentrations (GMCs) of measles and rubella immunoglobulin G antibodies were calculated.</p><p><strong>Results: </strong>This study analysed 135 studies on measles and 77 on rubella, including data from 368,023 and 177,422 healthy individuals, respectively. Between 2010 and 2022, the overall pooled positive rates for measles and rubella antibodies were 88.8% and 79.91%, respectively. The age-specific susceptibility analysis showed that infants aged < 1 year had the lowest pooled positive rates. Other age groups had a roughly U-shaped distribution, with relatively higher positive rates and GMC of measles and rubella antibodies in young children and older age groups. However, the positive rates for both measles and rubella antibodies fell below the elimination threshold in almost all age groups other than young children aged 1-4 years, especially in recent years. In addition, antibody positivity rates varied by geographical region and decreased with economic level.</p><p><strong>Conclusion: </strong>Our findings provide preliminary insights into herd immunity for measles and rubella, highlighting the challenges to achieving their elimination in China.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"1223-1239"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}