World Journal of Pediatrics最新文献

{"title":"Potential diagnostic value of serum bile acid profiling in girls with central precocious puberty.","authors":"Shan Wang, A Na Liu, Xin-Yi Liang, Ling Jiang, Wei Wu, Guan-Ping Dong, Pei-Fang Jiang, Yan Ni, Jun-Fen Fu","doi":"10.1007/s12519-025-00937-z","DOIUrl":"https://doi.org/10.1007/s12519-025-00937-z","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis of central precocious puberty (CPP) relies on a gonadotropin releasing hormone stimulation test to assess the activation of the hypothalamic-pituitary-gonadal axis; this is costly and painful. Bile acids (BAs) have emerged as pivotal signaling molecules in the reproductive system. This study aimed to identify circulating BA profile signatures and explored if they may serve as biomarkers for CPP diagnosis in girls.</p><p><strong>Methods: </strong>We enrolled 431 girls, including 241 in the training cohort and 190 in the validation cohort. Participants were divided into four groups based on their body mass index Z-score and whether they were diagnosed with CPP. Ultra-performance liquid chromatography coupled with tandem mass spectrometry was performed to quantify 38 serum BAs.</p><p><strong>Results: </strong>There were 18 individual BAs that were statistically different between CPP and non-CPP counterparts. The majority of these BAs (14/18) correlated significantly with sex-related hormones (P < 0.05). In girls with normal weight (NW), a logistic regression model combining chenodeoxycholic acid, tauroα-muricholic acid, and 6-ketolithocholic acid achieved an area under the receiver operating characteristic curve (AUC) of 0.885. For girls who were overweight/obese (OB), hyocholic acid and taurohyocholic acid enhanced the diagnostic efficiency of basal luteinizing and follicle stimulating hormones to an AUC value 0.914. In validation cohort, 75.34% NW girls and 84.09% OB girls were accurately classified.</p><p><strong>Conclusions: </strong>Serum BA profiles of CPP girls showed significant changes that were associated with serum sex-related hormone levels. BA profiles could be potential biomarkers in CPP diagnosis and screening.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive role of neutrophil percentage-to-albumin ratio in acute fulminant myocarditis patients receiving extracorporeal membrane oxygenation.","authors":"Jing-Jing Zhou, Jun-Jie Shao, Shuai Yue, Hao-Jie Yan, Hai-Ming Wang, Min Jiang, Shu-Jin Shi, Shuai Xu, Jun-Jie Su, Fan Han, Xiao-Yang Hong, Ran Zhang","doi":"10.1007/s12519-025-00940-4","DOIUrl":"https://doi.org/10.1007/s12519-025-00940-4","url":null,"abstract":"<p><strong>Background: </strong>Venoarterial extracorporeal membrane oxygenation induces an inflammatory response upon initiation. The neutrophil percentage-to-albumin ratio is a promising biomarker for predicting mortality in patients with systemic inflammation. This study aimed to investigate the association between neutrophil percentage-to-albumin ratio and in-hospital mortality in pediatric patients with acute fulminant myocarditis undergoing extracorporeal membrane oxygenation and to develop a PEACE model for predicting mortality in these patients.</p><p><strong>Methods: </strong>This retrospective study included pediatric patients diagnosed with acute fulminant myocarditis who underwent venoarterial extracorporeal membrane oxygenation between July 2015 and August 2022. Multivariable logistic regression analysis was used to investigate the independent association between the neutrophil percentage-to-albumin ratio and the risk of in-hospital mortality. In addition, we utilized least absolute shrinkage and selection operator regression to select predictive factors, ultimately developing a nomogram to predict outcomes in pediatric patients receiving venoarterial extracorporeal membrane oxygenation.</p><p><strong>Results: </strong>A total of 125 patients eligible for analysis were included in this study, with an in-hospital mortality rate of 28.8%. Multivariable logistic regression revealed that the neutrophil percentage-to-albumin ratio was an independent risk factor for in-hospital mortality in venoarterial extracorporeal membrane oxygenation patients. Restricted cubic splines revealed a positive association between the two (P_nonlinearity = 0.84). Least absolute shrinkage and selection operator regression and backward stepwise logistic regression identified age, cardiopulmonary resuscitation, lactate levels, and the neutrophil percentage-to-albumin ratio as key predictive factors. Using these factors, a nomogram (PEACE model) was developed to predict in-hospital mortality in venoarterial extracorporeal membrane oxygenation patients. The area under the receiver operating characteristic curve was 0.83 [95% confidence interval (CI), 0.74-0.92], with the inclusion of the neutrophil percentage-to-albumin ratio significantly enhancing the model's predictive accuracy.</p><p><strong>Conclusions: </strong>The neutrophil percentage-to-albumin ratio may serve as a potential predictor for venoarterial extracorporeal membrane oxygenation in-hospital mortality in pediatric patients with acute fulminant myocarditis, suggesting that inflammatory responses are associated with patient prognosis. The PEACE model is superior in predicting the prognosis of pediatric patients supported by venoarterial extracorporeal membrane oxygenation, and can help in clinical decision making.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty years' development and application of flow cytometry.","authors":"Hong-Qiang Shen","doi":"10.1007/s12519-025-00949-9","DOIUrl":"https://doi.org/10.1007/s12519-025-00949-9","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain injury and neurodevelopmental trajectory in neonates with complex congenital heart disease: current status and challenges.","authors":"Shan-Shan Shi, Qian-Nan Zhang, Qiang Shu","doi":"10.1007/s12519-025-00948-w","DOIUrl":"https://doi.org/10.1007/s12519-025-00948-w","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood infectious diseases: experiences and challenges.","authors":"Yue-Tong Li, Xiang-Min Dong, Qi Zheng, Lan-Juan Li","doi":"10.1007/s12519-025-00941-3","DOIUrl":"https://doi.org/10.1007/s12519-025-00941-3","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of congenital heart disease: successes and challenges over the last 20 years.","authors":"Wei-Ze Xu, Qiang Shu","doi":"10.1007/s12519-025-00934-2","DOIUrl":"https://doi.org/10.1007/s12519-025-00934-2","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental vulnerability in children from culturally and linguistically diverse backgrounds in Western Australia: a population-based study.","authors":"Kendalem Asmare Atalell, Gavin Pereira, Bereket Duko, Sylvester Dodzi Nyadanu, Vegard Skirbekk, Gizachew A Tessema","doi":"10.1007/s12519-025-00936-0","DOIUrl":"https://doi.org/10.1007/s12519-025-00936-0","url":null,"abstract":"<p><strong>Background: </strong>Early childhood developmental adversities have long-term effects on educational and overall health outcomes. However, the developmental outcomes of children from culturally and linguistically diverse (CALD) backgrounds remain unclear. This study aimed to investigate the association between having a CALD backgrounds and developmental vulnerability in Western Australia.</p><p><strong>Methods: </strong>We conducted a retrospective population-based cohort study using data from the Australian Early Development Censuses, Midwives Notification System, and Hospital Morbidity Data Collections. Developmental vulnerability was defined as domain scores < 10th percentile in five Australian Early Development Censuses domains. Covariate-adjusted logistic regression, incorporating propensity score weighting, was applied, and the population attributable risk calculations results were informed.</p><p><strong>Results: </strong>Among 10,048 CALD children and 49,877 non-CALD children, 23.7% [95% confidence interval (CI) 22.9, 24.5%] of CALD children experienced developmental vulnerability in one or more Australian Early Development Censuses domain(s) (DV1) compared with 19.6% (95% CI 19.3, 20.0%) of non-CALD children. Adjusted analyses revealed that CALD children had 23% greater odds of DV1 [odds ratio (OR) 1.23; 95% CI 1.16, 1.31] and developmental vulnerability in two or more Australian Early Development Censuses domains (DV2) (OR 1.23; 95% CI 1.13, 1.33). CALD children had more than twice the odds of vulnerability in terms of communication skills and general knowledge (OR 2.16; 95% CI 1.99, 2.34) and 37% greater odds in language and cognitive skills (school-based) (OR 1.37; 95% CI 1.25, 1.51). The population attributable risk was 3.77% for DV1, 3.67% for DV2, 5.90% for language and cognitive skills (school-based), and 16.24% for communication skills and general knowledge.</p><p><strong>Conclusions: </strong>This study revealed a greater developmental vulnerability burden among CALD children than among their non-CALD peers, particularly in the domains of communication skills and general knowledge. Strengthening culturally responsive policies, enhancing early childhood support programs, and ensuring equitable access to educational resources for children from CALD backgrounds may help reduce developmental disparities and promote long-term educational outcomes.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the complexities of pediatric Behçet's disease clusters.","authors":"Jun Zou, Jian-Long Guan","doi":"10.1007/s12519-025-00933-3","DOIUrl":"https://doi.org/10.1007/s12519-025-00933-3","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food allergy: emerging therapies in the twenty-first century.","authors":"Agnes Sze-Yin Leung, Yu-Han Xing, Gary Wing-Kin Wong","doi":"10.1007/s12519-025-00928-0","DOIUrl":"https://doi.org/10.1007/s12519-025-00928-0","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal care in the twenty-first century: innovations and challenges.","authors":"Ayhan Çeri, Nazlı Dilay Gültekin, Doğukan Mustafa Keskin","doi":"10.1007/s12519-025-00927-1","DOIUrl":"https://doi.org/10.1007/s12519-025-00927-1","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}