Wiener medizinische Wochenschrift最新文献

{"title":"Tinea pseudoimbricata: a narrative literature review and five new cases.","authors":"Anca Chiriac, Pietro Nenoff, Uwe Wollina","doi":"10.1007/s10354-024-01065-5","DOIUrl":"10.1007/s10354-024-01065-5","url":null,"abstract":"<p><strong>Background: </strong>Tinea pseudoimbricata is a variant of tinea incognito, with multiple erythematous concentric rings (ring in a ring) and pruritus. Misuse of topical corticosteroids is a major exogenous factor.</p><p><strong>Objective: </strong>We provide an overview of published cases and report the first case series from Romania.</p><p><strong>Patients and methods: </strong>A narrative review of the literature was conducted in PubMed and amended by ResearchGate. A series of pediatric cases from Romania with clinical suspicion of tinea pseudoimbricata was investigated by clinical examination, KOH preparations of skin scrapings, and mycological culture when possible.</p><p><strong>Results: </strong>We collected 137 cases of tinea pseudoimbricata from the literature and added a series of 5 pediatric patients from Romania. Oral treatment with fluconazole was effective in all of them. Worldwide, most reports came from India (86%), 3.5% were from other Asian countries, 3.5% were from the Americas, and 7% were from Europe. M. canis and T. mentagrophytes were identified in 2 patients from Romania. T. mentagrophytes, T. rubrum, and T. tonsurans are the dominant species worldwide, but molecular diagnostics were available for only a minor part of cases.</p><p><strong>Conclusion: </strong>Tinea pseudoimbricata is most common in India. This is the first case series on tinea pseudoimbricata from Romania. Tinea pseudoimbricata is an emerging disease in Europe. Identification of fungi has rarely been done by molecular mycology. This may have caused an overestimation of T. mentagrophytes and an underestimation of T. indotineae.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"340-345"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lichen planus-the role of age and gender in clinical appearance and treatment : A narrative review.","authors":"Uwe Wollina, André Koch, Monika Fida, Anca Chiriac, Abdulkarim Hasan, Ayman Abdelmaksoud","doi":"10.1007/s10354-024-01057-5","DOIUrl":"10.1007/s10354-024-01057-5","url":null,"abstract":"<p><p>Lichen planus is a common pruritic inflammatory disorder of the skin with an autoimmune background. It affects < 1% of the general population. The disease has significant comorbidities that must be considered in a holistic approach. Skin and skin adnexa, mucosa, eyes, and the esophagus may be affected. There are various clinical subtypes in addition to classical cutaneous lichen planus. These subtypes depend on age and gender. Nail involvement can result in functional and psychological impairment. Lichen planopilaris in adults leads to irreversible cicatrical alopecia. Erosive and ulcerated lichen planus of the mucosa carries an increased risk of malignant transformation, at least in adults. Treatment must consider the affected area, the severity of disease, age, gender, and comorbidities.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"311-330"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired digital periungual fibrokeratoma in a 36-year-old male: case report and an update.","authors":"G Tchernev, D Linkwinstar, A Shine, V Broshtilova, S Kordeva","doi":"10.1007/s10354-025-01073-z","DOIUrl":"10.1007/s10354-025-01073-z","url":null,"abstract":"<p><p>Acquired digital fibrokeratoma (ADFK) is a rare benign mesenchymal tumor often presenting as a small, firm, hyperkeratotic lesion, typically located in the periungual or subungual regions of the digits. Though benign, ADFK can lead to significant functional or cosmetic issues and may be mistaken for more serious conditions such as squamous cell carcinoma or pyogenic granuloma. We report the case of a 36-year-old male with a 3- to 4‑year history of a progressively enlarging periungual tumor leading to nail deformity and mild pressure effects on the underlying bone. The patient's history included minor trauma, possibly contributing to the lesion's development. Dermatological and histopathological evaluations revealed a well-demarcated mesenchymal lesion with orthohyperkeratosis, irregular acanthosis, and stellate fibroblasts within a vascular stroma, consistent with ADFK. A CT scan confirmed mild deformity of the distal phalanx but no bone infiltration. Surgical excision was offered but deferred by the patient, who preferred monitoring of the lesion. This case highlights the importance of accurate diagnosis through clinical, histopathological, and imaging evaluations to distinguish ADFK from other periungual tumors and underscores the need for individualized treatment based on patient preferences and the lesion's impact.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"358-362"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of RUNX1-mutated patients with chronic myelomonocytic leukemia in a national (ABCMML) and international cohort (cBioPortal).","authors":"Sarah Bayat, Klaus Geissler","doi":"10.1007/s10354-025-01074-y","DOIUrl":"10.1007/s10354-025-01074-y","url":null,"abstract":"<p><p>Big data collected in large international cooperations now allow validation of findings from traditional national patient cohorts for proving consistency. In this study, we compared findings in RUNX1-mutated patients of the Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) with the CMML cohort documented in cBioPortal. In the cBioPortal cohort, RUNX1-mutated patients had significantly inferior survival and AML-free survival as compared to nonmutated patients. In the ABCMML cohort, survival and AML-free survival were numerically shorter in RUNX1-mutated patients than in wildtype patients, but this did not reach significance. Regarding phenotype, in both cohorts, RUNX1-mutated patients had a significantly higher proportion of patients with thrombocytopenia and lower metric values for platelets as compared to wildtype patients. Validation of data, as we have done in this study in CMML patients using two independent cohorts, ensures the quality standards that are required for their use in clinical decision making.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"296-301"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of NRAS-mutated patients with chronic myelomonocytic leukemia in a national (ABCMML) and an international cohort (cBioPortal).","authors":"Alexandra Qian, Klaus Geissler","doi":"10.1007/s10354-025-01080-0","DOIUrl":"10.1007/s10354-025-01080-0","url":null,"abstract":"<p><p>Big data from large international cooperations allow proving consistency of findings in national patient cohorts. We compared features in NRAS-mutated patients of the Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) with the chronic myelomonocytic leukemia (CMML) cohort documented in cBioPortal. It is consistently demonstrated in both CMML cohorts that NRAS mutations are associated with shorter overall survival, acute myeloid leukemia-free survival, increased white blood cell count, decreased platelet values and the presence of blast cells in peripheral blood. Hemoglobin values did not differ between patients with or without NRAS mutations in either cohort. Validation of data in CMML patients using two independent cohorts, ensures the quality standards for clinical decision making.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"267-273"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of TP53-mutated patients with chronic myelomonocytic leukemia in a national (ABCMML) and international cohort (cBIOPORTAL).","authors":"Magdalena Grass, Klaus Geissler","doi":"10.1007/s10354-025-01072-0","DOIUrl":"10.1007/s10354-025-01072-0","url":null,"abstract":"<p><p>Big data collected in large international cooperations allow validation of findings from traditional national patient cohorts for proving consistency. In this study we analyzed outcomes and phenotypic features of TP53-mutated chronic myelomonocytic leukemia (CMML) patients in the Austrian biodatabase for CMML (ABCMML; n = 322) and in the international platform cBIOPORTAL (n = 399). The prevalences of TP53 mutations were 1.58 and 3.66, respectively. Numerically, overall survival was shorter in TP53-mutated patients in both cohorts (ABCMML 10.0 vs. 30.0 months and cBIOPORTAL 8.9 vs. 34.5 months), but this was statistically significant only in the cBIOPORTAL cohort. Decreased hemoglobin values and the presence of blast cells in peripheral blood were significantly associated with TP53 mutations in the cBIOPORTAL group but not in the ABCMML database. Our study indicates the necessity of sufficient patient numbers for the comparison of CMML patients regarding outcome and phenotype according to their molecular subtype, particularly in the case of rare mutations.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"302-308"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of art preferences in patient rooms between chronic pain patients, palliative care patients and physicians.","authors":"Alina Balandin, Martin Wallenfang, Kerstin Wagener, Martin Gleim, Dag Konetzka, Dieter Siebrecht, Anke Müffelmann, Susanne Kollmann, Regina Göckede, Christiane Zippel, Almut Linde, Annette Hüsch, Stine Louring Nielsen, Markus Steinfath, Axel Fudickar","doi":"10.1007/s10354-025-01086-8","DOIUrl":"10.1007/s10354-025-01086-8","url":null,"abstract":"<p><strong>Background: </strong>Art in patient rooms can have positive effects on wellbeing and clinical outcomes. Patients' art preferences may differ from the preferences of medical providers. In this study, chronic pain and palliative care patients' preferences regarding art in patient rooms were compared with physicians' preferences.</p><p><strong>Methods: </strong>From a selection of abstract art photographs by artists of the Muthesius University of Fine Arts and Design, Kiel, and figurative paintings from the Kunsthalle zu Kiel, 79 physicians and 79 chronic pain patients were asked to choose a picture. The physicians were also asked which picture they would choose for their patients. Furthermore, 79 palliative care patients were investigated to compare their choices with those of pain patients and physicians.</p><p><strong>Results: </strong>Both patient groups preferred figurative art more often than did physicians for their patients. Among palliative care patients, 65% chose figurative art, while only 42% of physicians did (p < 0.0001). Similarly, 67% of chronic pain patients preferred figurative art, in contrast to 42% of physicians (p = 0.0002). The incidence of physicians' art choices for figurative art in patient rooms and for themselves as patients differed significantly (42 vs. 58, p = 0.013). Views with natural elements were preferred by physicians for patients and themselves (49 vs. 30 and 44 vs. 35), by palliative care patients (41 vs. 38), and by chronic pain patients (54 vs. 25).</p><p><strong>Conclusion: </strong>Patients' art preferences differ significantly from physicians' art preferences.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"237-244"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombo-CARE-cardioembolic stroke etiology in cryptogenic stroke suggested by fibrin-/platelet-rich clot histology : Thrombo-CARE (configuration analysis to refine etiology).","authors":"Daniel C Schwarzenhofer, Tim von Oertzen, Serge Weis, Michael Sonnberger, Joachim Gruber, Anna Tröscher, Helga Wagner, Philipp Hermann, Birgit Grubauer, Judith Wagner","doi":"10.1007/s10354-024-01060-w","DOIUrl":"10.1007/s10354-024-01060-w","url":null,"abstract":"<p><strong>Background: </strong>Despite extensive diagnostic efforts, the etiology of stroke remains unclear in up to 30% of patients. Mechanical thrombectomy (MT) potentially enhances etiological determination by (immuno)histological analysis of retrieved thrombotic material.</p><p><strong>Methods: </strong>In this monocentric exploratory study, clots from 200 patients undergoing MT were investigated by hematoxylin and eosin, CD3, and CD45 staining. Semiquantitative and computer-based image analysis defined the histological composition and relative fractions of immunohistochemically stained areas. First, we correlated these results with strokes of known etiology. Subsequently, clots of unknown source were characterized with regard to their (immuno)histological profile to attempt etiological classification.</p><p><strong>Results: </strong>Samples from 198 patients were accessible for analysis. Fibrin-/platelet-rich histology appeared in 45 (23%), erythrocyte-rich in 18 (9%), and mixed histology in 123 (62%) patients. Etiology was classified as cardioembolic in 87 (44%), arterioembolic in 37 (19%), and as cryptogenic stroke (CS) in 26 (13%) cases. 20 (23%) patients with cardioembolic stroke and 5 (14%) patients with arterioembolic stroke had fibrin-/platelet-rich clots. 8 (22%) patients with arterioembolic stroke and 1 (1%) patient with cardioembolic stroke had erythrocyte-rich clots. In CS, cardioembolic clot features appeared more than twice as often as arterioembolic clot features. Whereas the association between histology and etiology was significant (p = 0.0057), CD3/CD45 staining did not correlate.</p><p><strong>Conclusion: </strong>A significant association between histology and etiology was observed, with the proportion of erythrocyte-rich thrombi being largest among arterioembolic strokes and the proportion of fibrin-/platelet-rich thrombi highest among cardioembolic strokes. A high number of clots from CS presented histological features of cardioembolic clots. Thus, patients with CS and fibrin-/platelet-rich clots particularly require long-term cardiac rhythm monitoring and may benefit from oral anticoagulation.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"227-236"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the portrayal of #autism and #neurodiversity on TikTok: creators, content, and representation.","authors":"Verena Steiner-Hofbauer, Yvette Annabel Pintér, Gloria Mittmann","doi":"10.1007/s10354-025-01076-w","DOIUrl":"10.1007/s10354-025-01076-w","url":null,"abstract":"<p><strong>Background: </strong>Social media is a significant source of information on health-related topics and neurodevelopmental disorders such as autism spectrum disorder (ASD). The public perception of ASD, as reflected on social media, can raise awareness but also increase stigma. This study examined ASD portrayal on TikTok, focusing on neurodiversity, content themes, creator identities, and the depiction of autistic individuals.</p><p><strong>Materials and methods: </strong>This exploratory study analyzed 100 TikTok videos: the 50 most-watched for #autism and the 50 most-watched for both #autism and #neurodiversity. The study reviewed metadata and content using publicly available data.</p><p><strong>Results: </strong>Videos from the #autism sample encompassed 97% of all views and primarily portrayed entertaining content. Neurodiversity videos were more educational and less popular. Creators and portrayed individuals were primarily white. Adult autistic individuals are more ferequently represented in the #neurodiversity sample (30%), but children sill appear frequently (30% in the # neurodiversity and 38% in the #autism sample). Healthcare professionals (HCPs) were absent in the autism sample but appeared in 32% of neurodiversity videos.</p><p><strong>Conclusion: </strong>The portrayal of ASD differed widely in both samples. Both samples underrepresented ethnic minorities. As TikTok shapes public perception of ASD, HCPs should be aware of trending ASD-related content on TikTok in order to be able to combat misinformation.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"245-252"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dystonia: pathophysiology and the role of acupuncture in treatment.","authors":"Wang Kefei, Huang Zhisheng, Yang Shunzhen, Yin Yin","doi":"10.1007/s10354-025-01083-x","DOIUrl":"10.1007/s10354-025-01083-x","url":null,"abstract":"<p><p>Dystonia is a complex neurological disorder characterized by involuntary muscle contractions, abnormal postures, and repetitive movements, which can lead to significant functional impairment and reduced quality of life. The disorder's pathophysiology involves a range of factors including genetic mutations, neurochemical imbalances, and structural abnormalities in the brain. Acupuncture has emerged as a promising complementary treatment for various types of dystonia, including post-stroke, cerebral palsy (CP)-related, limb, and cervical dystonia, as well as other hyperkinetic movement disorders. Clinical studies indicate that acupuncture may help to alleviate symptoms, decrease muscle spasticity, and improve overall patient outcomes. However, the effectiveness of acupuncture can vary depending on the specific type and severity of dystonia, with some studies reporting significant improvements, while others show more modest results. The variability in treatment response highlights the need for more robust research to better understand the mechanisms underlying acupuncture's effects and to develop standardized treatment protocols. The aim of this review is to provide a comprehensive overview of dystonia's pathophysiology and to assess the current evidence on the role of acupuncture in its treatment, identifying areas in which further research is needed to optimize therapeutic approaches.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"211-226"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}