Wiener Klinische Wochenschrift最新文献

{"title":"[Consensus recommendation of the Austrian Society of Cardiology: anatomy, pathophysiology, diagnosis and treatment of arrhythmias in adult patients with congenital heart disease].","authors":"Barbara Wichert-Schmitt, Stefan Kurath-Koller, Lore Schrutka, Johannes Mair, Hermann Blessberger, Karim Saleh, Georgios Kollias, Stefan Stojkovic, Tomaz Podnar, Ante Burmas, Daniel Scherr, Christoph Schukro","doi":"10.1007/s00508-026-02801-0","DOIUrl":"10.1007/s00508-026-02801-0","url":null,"abstract":"<p><p>This consensus recommendation of the Working Group for Congenital and Acquired Heart Disease and the Working Group for Rhythmology of the Austrian Society of Cardiology (ÖKG) describes the pathophysiological foundations, clinical presentation, diagnosis and treatment of arrhythmias in adult patients with congenital heart defects. It also illuminates malformation-specific aspects with respect to the anatomy, typical corrective interventions, risk of arrhythmia and treatment.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"805-829"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13569525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of bilateral multicystic encephalomalacia secondary to neonatal hypoglycemia in a 6-month-old girl.","authors":"Gökhan Polat, Furkan Akman, Fatih Enes Çay","doi":"10.1007/s00508-026-02715-x","DOIUrl":"10.1007/s00508-026-02715-x","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"578-580"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147345249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving landscape of glioblastoma research : A 75-year bibliometric study on survival, treatment and gender in authorship.","authors":"Jana Breu, Bernhard Baumann, Jason K Sa, Anna Sophie Berghoff, Matthias Preusser, Karl-Heinz Nenning, Adelheid Woehrer","doi":"10.1007/s00508-026-02725-9","DOIUrl":"10.1007/s00508-026-02725-9","url":null,"abstract":"<p><strong>Background: </strong>Glioblastoma is the most aggressive type of brain tumor. Here, we examine the evolution of glioblastoma treatment and survival across different study types over nearly a century. Furthermore, we map the landscape of glioblastoma research to track the potential influence of publication bias on perceived progress and assess sex disparities in authorship across time, study type and geographic region.</p><p><strong>Methods: </strong>We analyzed a comprehensive dataset of glioblastoma research published from 1947-2022. A manual review of 19,668 articles yielded 2232 articles passing the inclusion criteria.</p><p><strong>Results: </strong>Overall, we observed an increased median overall survival (OS, slope = 0.16 months per year, Pearson's r = 0.23, p = 1.65e-44) for all study types. Nevertheless, reported survival outcomes varied by treatment modality. Only tumor treating fields (fitted median OS from 14.5 to 21.4 months, slope = 0.53 months per year) showed a stronger increase in positive outcomes than radiotherapy with concomitant and adjuvant temozolomide (fitted median overall survival from 12.0 to 20.0 months, slope = 0.31 months per year). Despite making up only 5.6% of all studies, randomized controlled trials had the highest cumulative impact factor and citation count and US-based researchers dominated across all study types (33.9%). Women continued to be underrepresented, particularly as last authors (25.2% female first, 18.5% female last).</p><p><strong>Conclusion: </strong>The 75 years of reported survival of patients with glioblastoma document a slow increase in overall survival. While research by women as first authors shows an upward trend, gender inequality persists, particularly in the last authorship.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"533-544"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forschungsförderung im Fokus: Wissenschaftliche Preise der Gesellschaft der Ärzte in Wien.","authors":"","doi":"10.1007/s00508-026-02816-7","DOIUrl":"https://doi.org/10.1007/s00508-026-02816-7","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":"138 17-18","pages":"584"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-based early cardiac rehabilitation after percutaneous coronary intervention for acute myocardial infarction : A randomized pilot trial.","authors":"Kaiyuan Cen, Fatimah Ahmedy, Mexmollen Marcus, Mohd Fadzli Shukor, Sukhbeer Kaur Darsin Singh","doi":"10.1007/s00508-026-02806-9","DOIUrl":"https://doi.org/10.1007/s00508-026-02806-9","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of exercise-based early cardiac rehabilitation (EB-ECR) initiated within 24 h after acute myocardial infarction (AMI) and percutaneous coronary intervention (PCI) on cardiac function and functional capacity at 12 weeks.</p><p><strong>Design: </strong>Single-center, parallel-group randomized pilot trial.</p><p><strong>Setting: </strong>a tertiary hospital with dedicated cardiac rehabilitation services.</p><p><strong>Participants: </strong>clinically stable AMI patients within 24 h of successful PCI.</p><p><strong>Interventions: </strong>participants were randomized 1:1 to EB-ECR, consisting of an individualized, phased rehabilitation program initiated in-hospital and continued postdischarge, or usual care without structured cardiac rehabilitation (NO-CR).</p><p><strong>Main outcome measures: </strong>Primary endpoints included left ventricular ejection fraction (LVEF), peak oxygen uptake (VO₂ peak), 6‑minute walk distance (6 MWT) and B‑type natriuretic peptide (BNP) at 12 weeks.</p><p><strong>Results: </strong>In this study 24 participants were randomized (EB-ECR n = 12; NO-CR n = 12). Compared to NO-CR, baseline-adjusted analyses favored EB-ECR: LVEF was higher by 2.8% (95% confidence interval, CI 0.9-4.8%; p = 0.007), VO₂ peak by 2.7 mL·kg^-1·min^-1 (95% CI 1.5-4.0 mL·kg^-1·min^-1; p < 0.001), 6 MWT by 24.0 m (95% CI 5.6-42.3m; p = 0.013) and BNP was lower by 18.3% (geometric mean ratio [GMR] 0.82; 95% CI -25.7% to -10.1%; p < 0.001). No serious adverse events occurred; one MACE event occurred in the EB-ECR group and none in the NO-CR group.</p><p><strong>Conclusion: </strong>Initiation of EB-ECR within 24 h post-PCI was associated with higher LVEF, greater exercise capacity, and lower BNP at 12 weeks without an observed excess of short-term major adverse cardiovascular events. These findings support the feasibility and potential efficacy of early structured rehabilitation after AMI and PCI.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic determinants of disease severity in a public healthcare system : Evidence from keratoconus patients in Austria.","authors":"Leon Pomberger, Sophia Anna Reifeltshammer, Sabrina Stojanov, Andreas Honeder, Matthias Bolz, Nino Hirnschall","doi":"10.1007/s00508-026-02803-y","DOIUrl":"https://doi.org/10.1007/s00508-026-02803-y","url":null,"abstract":"<p><strong>Purpose: </strong>To assess whether sociodemographic factors are associated with disease severity in patients with keratoconus treated at a tertiary care center within a publicly funded healthcare system.</p><p><strong>Setting: </strong>Kepler University Clinic and Johannes Kepler University, Linz, Austria.</p><p><strong>Methods: </strong>This monocentric cross-sectional study assessed socioeconomic factors, quality of life, and objective measurement parameters in patients with keratoconus. Clinical data included best-corrected distance visual acuity (BCDVA) and corneal parameters using anterior segment optical coherence tomography (AS-OCT), including anterior and posterior maximum corneal curvature (K_max), minimum pachymetry (Th_min), and epithelial thickness index (ETI). Sociodemographic factors and access-to-care variables were assessed using a structured questionnaire. Disease severity and patient-reported outcomes were analyzed according to the Austrian urban-rural typology in order to explore regional and sociodemographic differences. Quality of life and subjective symptoms were assessed using the Rasch-validated Keratoconus Outcomes Research Questionnaire (KORQ).</p><p><strong>Results: </strong>A total of 105 patients (70.48% male; 29.52% female) were included in this study. The highest anterior K_max values were observed in patients from medium-sized urban centers (right eye 55.79 ± 13.43 D; left eye 59.78 ± 13.30 D). Visual acuity was lowest for major and medium sized urban centers (right eye 0.41 ± 0.45 logMAR; left eye 0.47 ± 0.38 logMAR). KORQ Scores were highest in medium sized (51.71 ± 7.21 points) and major urban centers (47.38 ± 14.08 points), indicating greater patient-reported disease burden.</p><p><strong>Conclusion: </strong>Sociodemographic factors may contribute to differences in disease severity among keratoconus patients, even within a publicly funded healthcare system. Universal health coverage alone may not ensure equitable access to timely diagnosis and specialized care. Larger studies with multivariable adjustment are needed for underlying these observations.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148832152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of complex perianal fistulas with fistula laser closure : Application of the IDEAL 2A framework.","authors":"Matthew Joseph Marino, Benjamin Dimbleby, Lukas Schlager, Patrick Campbell, David Roland Christopher James, Simon Buczacki, Helen Jones, Lukas Walter Unger","doi":"10.1007/s00508-026-02797-7","DOIUrl":"10.1007/s00508-026-02797-7","url":null,"abstract":"<p><strong>Aim: </strong>Fistula laser closure (FiLaC) is a minimally invasive treatment option for perianal fistulas with acceptable healing rates. We report implementation and include short-term results in line with the IDEAL (Idea, Development, Exploration, Assessment, Long-term study) 2A framework in patients with complex fistulas and previous surgical repair attempts.</p><p><strong>Method: </strong>Prospective audit data from 56 consecutive patients with perianal fistulas treated between June 2024 and January 2025. The FiLaC procedure included cleaning the fistula tract, application of approximately 100 J/cm fistula length and closing of the internal opening with a stitch. All patients refused more invasive operations and/or were not suitable for advanced repair.</p><p><strong>Results: </strong>Patients were diagnosed with fistulas after a median of 34.5 months (interquartile range, IQR 13.8-54.2 months), with a median of 3 months (IQR 1.8-4.0 months) following previous fistula-related surgery. Most patients had cryptoglandular fistulas (80.4%) while 19.6% had inflammatory bowel disease-related fistulas. Most fistulas were transsphincteric (69.6%), and only 32.1% of patients were seton-free before the procedure. During the first postprocedural outpatient visit at 7.9 weeks (median; IQR 6.4-10.9 weeks), clinical healing was evident in 14 (24.1%) cases, and 23 (39.7%) patients reported relevant symptomatic improvement. A total of 21 patients (36.2%) did not report any improvement, 3 patients (5.2%) experienced a postoperative complication, with 1 (1.7%) requiring a return to theatre due to an abscess. After a median of 10.4 months, the \"seton-free rate\" was 67.9%, This represents a relevant improvement to 32.1% before FiLaC.</p><p><strong>Conclusion: </strong>The use of FiLaC is a safe, sphincter-preserving treatment for complex perianal fistulas and was associated with a marked increase in the seton-free rate. While complete fistula healing rates were lower than previously reported, FiLaC remains an option for patients with complex disease.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining patient-centered vs. doctor-centered attitudes among Austrian general practitioners : A cross-sectional study on time constraints and care orientation.","authors":"Lisa Niehoff, Erika Zelko, Kathryn Hoffmann, Goranka Petriček","doi":"10.1007/s00508-026-02802-z","DOIUrl":"https://doi.org/10.1007/s00508-026-02802-z","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between patient load or time constraints and attitudes towards person-centered care vs. doctor or disease-centered care within the context of primary care and family medicine in Austria.</p><p><strong>Methods: </strong>A cross-sectional questionnaire-based study was conducted in Austria as part of the international Person-centered care Attitudes among European General Practitioners/Family Physicians (PACE GP/FP) study [1]. The primary analysis examined the association between continuous patient-practitioner orientation scale (PPOS) scores and self-reported patient load using multivariable linear regression adjusted for age, sex and perceived stress. For a secondary analysis, participants were assigned to one of three care-approach groups, based on PPOS scores (patient-centered, medium patient-centered and doctor/disease-centered) and compared regarding the self-reported number of patients seen per day using a Kruskal-Wallis test.</p><p><strong>Results: </strong>In multivariable linear regression analyses, higher patient load remained independently associated with lower continuous PPOS scores (B = -0.003, 95% CI -0.005 to -0.001, p = 0.002). In our sample, patient load differed significantly across the different care approaches, H(2) = 6.112, p = 0.047, η² = 0.058. General practitioners (GPs) in the doctor/disease-centered group saw significantly more patients per day (median = 90, interquartile range, IQR = 68) compared to the patient-centered group (median = 50, IQR = 65). Additionally, a high workload, characterized by high clinical demands and time pressure, was the most commonly reported barrier for person-centered care in daily practice.</p><p><strong>Conclusion: </strong>Higher patient load was associated with a lower patient-centered orientation among Austrian general practitioners. Our findings suggest the need to address systematic factors contributing to time constraints and emphasize the importance of equipping general practitioners with the resources needed to integrate person-centered care into their practice.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of living related kidney donors of recipients with familial mediterranean fever-associated Amyloid A Amyloidosis.","authors":"Ozgur Akin Oto, Tuba Elif Ozler, Arzu Velioglu, Dilek Barutcu Atas, Gizem Kumru, Abdulmecit Yildiz, Sultan Ozkurt, Rabia Hacer Hocaoglu, Yagmur Tahillioglu, Muge Doksan, Vefa Suleymanova, Ece Ük, Zeynep Celebi, Ayse Serra Ucar, Safak Mirioglu, Ahmet Burak Dirim, Halil Yazici, Krista L Lentine, Yasar Caliskan","doi":"10.1007/s00508-026-02764-2","DOIUrl":"https://doi.org/10.1007/s00508-026-02764-2","url":null,"abstract":"<p><strong>Background: </strong>Living kidney donation among carefully selected individuals is generally considered safe but post-donation health risks vary by factors including family history. Data on long-term outcomes of related living kidney donors of recipients with familial Mediterranean fever (FMFLRD) are limited.</p><p><strong>Methods: </strong>This retrospective multicenter study reviewed the medical records of living donors who donated between 2010 and 2021 across six transplantation centers. Cardiovascular and kidney outcomes were compared between 37 FMFLRD and a propensity-matched control group of 74 donors to recipients without FMF (non-FMFLRD). Propensity score matching was based on donor age, sex, and follow-up time. Outcome measures included major cardiac events (MACE), new-onset hypertension, new-onset diabetes mellitus, proteinuria and estimated glomerular filtration rate (eGFR).</p><p><strong>Results: </strong>The median follow-up duration of all donors was 4.0 years (interquartile range, IQR 2.0-11.0 years). The mean age of the FMFLRD group was 48.9 ± 9.3 years, The FMFLRD group showed a significantly lower proportion of MACE (2.7% vs. 17.6%, p = 0.026) and new-onset hypertension (13.5% vs. 39.2%, p = 0.004) and a trend towards a lower proportion of new-onset diabetes mellitus (2.7% vs. 14.9%, p = 0.052) compared to the non-FMFLRD group. There were no significant differences in long-term kidney function, as evidenced by similar eGFR and proteinuria levels between the groups.</p><p><strong>Conclusion: </strong>The FMFLRD group showed similar kidney outcomes and lower rates of cardiovascular and metabolic complications during follow-up compared with matched non-FMFLRD; however, given the retrospective design and relatively short follow-up duration, long-term donor safety remains uncertain and the results should be interpreted cautiously.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative anesthesia management for video-assisted thoracoscopic surgery procedures in Austria : A national survey.","authors":"Manuela Ranalter, Simon Mathis, Hannes Dejaco, Judith Martini, Barbara Sinner","doi":"10.1007/s00508-026-02800-1","DOIUrl":"https://doi.org/10.1007/s00508-026-02800-1","url":null,"abstract":"<p><strong>Background: </strong>Video-assisted thoracoscopic surgery (VATS) is widely used for anatomical lung resections. Despite available enhanced recovery after surgery (ERAS) recommendations, perioperative management may vary between institutions. This survey assessed current perioperative practice for VATS procedures in Austria.</p><p><strong>Methods: </strong>A structured questionnaire comprising 19 items was distributed to all anesthesia departments performing thoracic surgery in Austria (n = 13) in February 2024. The survey addressed institutional characteristics, airway management, intraoperative anesthesia strategies, monitoring practices and perioperative analgesia. Data were analyzed descriptively.</p><p><strong>Results: </strong>A total of 10 centers responded (response rate 76.7%) but 1 center did not perform VATS procedures and was excluded from the practice-based analysis; therefore, 9 centers performing VATS were analyzed. Annual VATS case volume ranged from 48-800 procedures. An established ERAS program was reported by three centers (33.3%), while implementation was planned in two centers (22.2%). Airway management varied, with direct laryngoscopy, video laryngoscopy and user-dependent intubation strategies reported. Conventional double-lumen tubes were used as the primary device in six centers (66.7%), whereas camera-assisted double-lumen tubes were used in three centers (33.3%). Routine invasive arterial monitoring was reported by six centers (66.7%) and immediate extubation in the operating room was routine in eight centers (88.9%). Regional anesthesia techniques varied considerably, whereas systemic analgesia was applied more consistently.</p><p><strong>Conclusion: </strong>This national survey demonstrates substantial intercenter variability in perioperative management of VATS procedures in Austria, particularly regarding ERAS implementation, airway management and regional analgesia strategies. The clinical impact of this variability remains unknown because patient outcomes were not assessed.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}