Wiener Klinische Wochenschrift最新文献_第6页

Distance to thrombus, ischemic lesion volume and clinical outcome after thrombectomy for M1 middle cerebral artery occlusion. M1 大脑中动脉闭塞症血栓切除术后的血栓距离、缺血性病灶体积和临床疗效。

IF 1.9 4区医学

Wiener Klinische Wochenschrift Pub Date : 2025-03-01 Epub Date: 2024-05-15 DOI: 10.1007/s00508-024-02364-y

Katharina Millesi, Monika Killer-Oberpfalzer, Johannes A R Pfaff, J Sebastian Mutzenbach, Christoph J Griessenauer, Michael Sonnberger, Milan Vosko, Judith Wagner, Matthias Millesi, Slaven Pikija, Constantin Hecker

{"title":"Distance to thrombus, ischemic lesion volume and clinical outcome after thrombectomy for M1 middle cerebral artery occlusion.","authors":"Katharina Millesi, Monika Killer-Oberpfalzer, Johannes A R Pfaff, J Sebastian Mutzenbach, Christoph J Griessenauer, Michael Sonnberger, Milan Vosko, Judith Wagner, Matthias Millesi, Slaven Pikija, Constantin Hecker","doi":"10.1007/s00508-024-02364-y","DOIUrl":"10.1007/s00508-024-02364-y","url":null,"abstract":"Background: Stroke resulting from occlusion of the middle cerebral artery (MCA) can have devastating consequences, potentially leading to a loss of independence. This study aimed to investigate the relationship between the distance to the thrombus (DT) and both ischemic lesion volume (ILV) and clinical outcomes.Methods: We retrospectively evaluated patients with thromboembolic MCA M1 segment occlusion who underwent neurovascular imaging followed by endovascular thrombectomy (EVT) at two comprehensive stroke centers over a 3-year period (2018-2020). Preinterventional computed tomography (CT) or magnetic resonance (MR) angiography was used to measure DT, defined as the distance from the carotid‑T bifurcation to the proximal surface of the M1 occlusion. Postinterventional CT or MR imaging was employed to determine the ILV and clinical outcomes were assessed using the modified Rankin scale (mRS) at 3 months.Results: There were 346 patients evaluated. The median DT was 9.4 mm (interquartile range, IQR 6.0-13.7 mm) and the median ILV was 13.9 ml (IQR 2.2-53.1 ml). After adjustment, an increase in DT was associated with a decrease in odds for a larger ILV (odds ratio, OR 0.96, 95% confidence interval, CI 0.92-0.99, p = 0.041). Through this association, more distal thrombi were associated with good clinical outcome (mRS 0-2; clinical outcome available in 282 patients, p = 0.018). The ILV was inversely associated with better clinical outcome OR 0.52 (95% CI 0.40-0.67).Conclusion: Based on the findings, DT was identified as an independent albeit weak predictor for ILV and clinical outcomes in patients with MCA M1 occlusion who underwent EVT.","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"163-171"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monoclonal anti-amyloid antibody treatment: the epidemiological profile of the target patients in Austria and the status of treatment-eligible patients registered at an outpatient memory clinic. 单克隆抗淀粉样蛋白抗体治疗：奥地利目标患者的流行病学概况以及在记忆门诊登记的符合治疗条件的患者状况。

IF 1.9 4区医学

Wiener Klinische Wochenschrift Pub Date : 2025-03-01 Epub Date: 2024-10-23 DOI: 10.1007/s00508-024-02465-8

Seungjune Lee, Elisabeth Stögmann

{"title":"Monoclonal anti-amyloid antibody treatment: the epidemiological profile of the target patients in Austria and the status of treatment-eligible patients registered at an outpatient memory clinic.","authors":"Seungjune Lee, Elisabeth Stögmann","doi":"10.1007/s00508-024-02465-8","DOIUrl":"10.1007/s00508-024-02465-8","url":null,"abstract":"The development of monoclonal anti-amyloid antibodies, a disease-modifying treatment for Alzheimer's disease (AD), has raised the necessity to identify the epidemiological profile of the possible target patients who would benefit from such therapy. These are patients in the early stages of AD with biomarker-confirmed brain amyloid positivity. In this study, the epidemiological profile of possible target patients in Austria and Vienna was estimated. The number of patients in the stage of amyloid-beta (Aβ)-positive prodromal AD in Austria and Vienna are 193,500 and 34,700 patients, respectively. The expected patient demand for the upcoming therapy in Austria and Vienna are 61,200 and 11,100 patients, respectively.In the memory clinic of the Vienna General Hospital, the number of treatment-eligible patients for an upcoming anti-amyloid antibody was on average 52.8 patients per year, which is about 10% of the total number of patients visiting the memory clinic every year. Several challenges to provide therapy to the general population include expanding the MCI screening in primary care and increasing the capacity of the healthcare system for biomarker testing, infusion delivery, and ARIA management. The study primarily addresses the status quo of identifying patients on memory clinics through cognitive screening and biomarker testing.","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"189-192"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amyloid-beta antibody treatment in Alzheimer's disease : An update on recent data and outlook on implementation in clinical routine. 阿尔茨海默病的淀粉样蛋白-β 抗体治疗：最新数据和临床常规实施展望。

IF 1.9 4区医学

Wiener Klinische Wochenschrift Pub Date : 2025-03-01 Epub Date: 2024-11-06 DOI: 10.1007/s00508-024-02466-7

Elisabeth Stögmann, Reinhold Schmidt

引用次数: 0

MUW researcher of the month. 本月MUW研究员。

IF 1.9 4区医学

Wiener Klinische Wochenschrift Pub Date : 2025-03-01 DOI: 10.1007/s00508-025-02523-9

引用次数: 0

Assessing the effects of spontaneous intracranial hypotension on quality of life, work ability and disability. 评估自发性颅内低血压对生活质量、工作能力和残疾的影响。

IF 1.9 4区医学

Wiener Klinische Wochenschrift Pub Date : 2025-03-01 Epub Date: 2024-09-03 DOI: 10.1007/s00508-024-02423-4

Ali Kapan, Thomas Waldhör, Christian Wöber

{"title":"Assessing the effects of spontaneous intracranial hypotension on quality of life, work ability and disability.","authors":"Ali Kapan, Thomas Waldhör, Christian Wöber","doi":"10.1007/s00508-024-02423-4","DOIUrl":"10.1007/s00508-024-02423-4","url":null,"abstract":"Background: Spontaneous intracranial hypotension (SIH), characterized by headaches due to cerebrospinal fluid leaks or low pressure, is a challenging condition to diagnose and treat and affects the quality of life.Methods: An 8‑week online survey was conducted to assess the impact of SIH on symptoms, sociodemographics and quality of life. The cohort was comprised of patients who had a self-reported diagnosis of SIH and were divided into two groups: those with radiological evidence of SIH and those with clinical suspicion but no radiological evidence. Mental health and disability were evaluated using the Depression, Anxiety and Stress Scale-21 (DASS-21) and the Henry Ford Hospital Headache Disability Inventory (HDI).Results: A total of 86 participants were included in the study, 59 with radiological evidence and 27 without. Most participants were female (84.9%) with a mean age of 44.8 years. Orthostatic headache was more common in participants without radiological evidence (74.1% vs. 42.4%). The severity in those with radiological evidence was 27.1% mild, 27.1% moderate, 30.5% severe and 15.3% extremely severe, while those without had 7.4% mild, 18.5% moderate, 63.0% severe and 11.1% extremely severe headaches. Mental health assessment using the DASS-21 scale showed that 77.9% of all participants reported signs of depression, 96.5% reported anxiety and 89.5% reported stress. The HDI showed 2.3% total disability, 40.7% severe, 19.8% moderate and 37.2% mild. The impact on employment was significant: 15.1% were able to work full-time, 48.8% part-time, 30.2% were unable to work and 5.8% retired early due to SIH.Conclusion: The study demonstrates the broad impact of SIH affecting physical health, mental well-being, and socioeconomic status, and calls for multifaceted and robust management approaches to address its complex effects on patients.","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"148-162"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the hidden power of the subconscious: 30 years of the postgraduate course in Vienna. 开启潜意识隐藏的力量：维也纳研究生课程 30 年。

IF 1.9 4区医学

Wiener Klinische Wochenschrift Pub Date : 2025-03-01 Epub Date: 2024-10-21 DOI: 10.1007/s00508-024-02455-w

Heidemarie Zach

引用次数: 0

Diagnosis and treatment of iron deficiency in chronic heart failure : Position statement of the heart failure working group of the Austrian Society of Cardiology. 慢性心力衰竭缺铁的诊断和治疗：奥地利心脏病学会心力衰竭工作组的立场声明。

IF 1.9 4区医学

Wiener Klinische Wochenschrift Pub Date : 2025-03-01 Epub Date: 2025-05-06 DOI: 10.1007/s00508-025-02521-x

Moritz Messner, Gerhard Pölzl, Christopher Adlbrecht, Johann Altenberger, Johann Auer, Robert Berent, Jakob Dörler, Marc-Michael Zaruba, Christian Ebner, Friedrich Fruhwald, Martin Hülsmann, Deddo Mörtl, Peter P Rainer, Anna Rab, Thomas Weber, Rudolf Berger

{"title":"Diagnosis and treatment of iron deficiency in chronic heart failure : Position statement of the heart failure working group of the Austrian Society of Cardiology.","authors":"Moritz Messner, Gerhard Pölzl, Christopher Adlbrecht, Johann Altenberger, Johann Auer, Robert Berent, Jakob Dörler, Marc-Michael Zaruba, Christian Ebner, Friedrich Fruhwald, Martin Hülsmann, Deddo Mörtl, Peter P Rainer, Anna Rab, Thomas Weber, Rudolf Berger","doi":"10.1007/s00508-025-02521-x","DOIUrl":"https://doi.org/10.1007/s00508-025-02521-x","url":null,"abstract":"Iron deficiency (ID) is a common comorbidity in heart failure (HF), affecting 55% of chronic and up to 80% of acute HF patients, regardless of ejection fraction (EF). An ID is associated with reduced quality of life, impaired exercise capacity (VO2 peak), higher hospitalization rate and lower survival rate. It is also an independent predictor of HF outcomes. This consensus statement critically reviews the diagnostic criteria for ID in HF and provides recommendations for their use. The efficacy and safety of intravenous iron supplements, including ferric carboxymaltose (FCM) and ferric derisomaltose (FDI), are analyzed highlighting the indications and potential adverse effects. Key clinical trials and guideline recommendations are summarized. In summary, the document addresses the diagnostics, treatment and monitoring of ID in HF.","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":"137 Suppl 3","pages":"143-156"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

mitteilungen der gesellschaft der ärzte in wien. 维也纳医生协会通讯。

IF 1.9 4区医学

Wiener Klinische Wochenschrift Pub Date : 2025-03-01 DOI: 10.1007/s00508-025-02525-7

引用次数: 0

Lymphangioleimyomatose. Lymphangioleimyomatose .

IF 1.9 4区医学

Wiener Klinische Wochenschrift Pub Date : 2025-03-01 DOI: 10.1007/s00508-025-02517-7

引用次数: 0

Response to: Comments on "Determinants of undergraduate medical students' satisfaction with clinical supervision". 对“影响医学生临床督导满意度的因素”的意见回应。

IF 1.9 4区医学

Wiener Klinische Wochenschrift Pub Date : 2025-02-27 DOI: 10.1007/s00508-025-02514-w

Michaela Wagner-Menghin, Anna-Maria Mayer, Angelika Hofhansl, Gerhard Zlabinger

引用次数: 0