World Psychiatry最新文献

{"title":"Childhood gender non-conformity, sexual orientation and mental health problems among 18 to 89 year-old Danes.","authors":"Josefine B Andresen, Christian Graugaard, Mikael Andersson, Mikkel K Bahnsen, Morten Frisch","doi":"10.1002/wps.21096","DOIUrl":"https://doi.org/10.1002/wps.21096","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"22 2","pages":"334-335"},"PeriodicalIF":73.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168161/pdf/WPS-22-334.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapist-supported Internet-based cognitive behaviour therapy yields similar effects as face-to-face therapy for psychiatric and somatic disorders: an updated systematic review and meta-analysis.","authors":"Erik Hedman-Lagerlöf,&nbsp;Per Carlbring,&nbsp;Frank Svärdman,&nbsp;Heleen Riper,&nbsp;Pim Cuijpers,&nbsp;Gerhard Andersson","doi":"10.1002/wps.21088","DOIUrl":"https://doi.org/10.1002/wps.21088","url":null,"abstract":"<p><p>Providing therapist-guided cognitive behaviour therapy via the Internet (ICBT) has advantages, but a central research question is to what extent similar clinical effects can be obtained as with gold-standard face-to-face cognitive behaviour therapy (CBT). In a previous meta-analysis published in this journal, which was updated in 2018, we found evidence that the pooled effects for the two formats were equivalent in the treatment of psychiatric and somatic disorders, but the number of published randomized trials was relatively low (n=20). As this is a field that moves rapidly, the aim of the current study was to conduct an update of our systematic review and meta-analysis of the clinical effects of ICBT vs. face-to-face CBT for psychiatric and somatic disorders in adults. We searched the PubMed database for relevant studies published from 2016 to 2022. The main inclusion criteria were that studies had to compare ICBT to face-to-face CBT using a randomized controlled design and targeting adult populations. Quality assessment was made using the Cochrane risk of bias criteria (Version 1), and the main outcome estimate was the pooled standardized effect size (Hedges' g) using a random effects model. We screened 5,601 records and included 11 new randomized trials, adding them to the 20 previously identified ones (total n=31). Sixteen different clinical conditions were targeted in the included studies. Half of the trials were in the fields of depression/depressive symptoms or some form of anxiety disorder. The pooled effect size across all disorders was g=0.02 (95% CI: -0.09 to 0.14) and the quality of the included studies was acceptable. This meta-analysis further supports the notion that therapist-supported ICBT yields similar effects as face-to-face CBT.</p>","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"22 2","pages":"305-314"},"PeriodicalIF":73.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168168/pdf/WPS-22-305.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Violence and schizophrenia: the role of social determinants of health and the need for early intervention.","authors":"Paolo Fusar-Poli, Charlene Sunkel, Carlos A Larrauri, Peter Keri, Patrick D McGorry, Graham Thornicroft, Vikram Patel","doi":"10.1002/wps.21074","DOIUrl":"10.1002/wps.21074","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"22 2","pages":"230-231"},"PeriodicalIF":73.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168150/pdf/WPS-22-230.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and psychiatrists' responsibilities: an update of the WPA position paper.","authors":"Donna E Stewart,&nbsp;Danuta Wasserman,&nbsp;Paul S Appelbaum","doi":"10.1002/wps.21103","DOIUrl":"https://doi.org/10.1002/wps.21103","url":null,"abstract":"World Psychiatry 22:2 June 2023 congresses in Europe, Asia, Africa and the Americas during the current triennium. When approaching the conclusion of the triennium, we continue to face challenges following the global crises and their consequential impact on mental health. The WPA, however, stands motivated and inspired by the commitment and hard work of our fellow professionals when dealing with such difficult situations. The WPA looks forward to the future with enthusiasm and confidence, convinced that it will be able to transform new challenges into opportunities. Let’s shape the future of psychiatry and mental health together.","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"22 2","pages":"342-343"},"PeriodicalIF":73.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168153/pdf/WPS-22-342.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term efficacy of antipsychotic drugs in initially acutely ill adults with schizophrenia: systematic review and network meta-analysis.","authors":"Stefan Leucht,&nbsp;Johannes Schneider-Thoma,&nbsp;Angelika Burschinski,&nbsp;Natalie Peter,&nbsp;Dongfang Wang,&nbsp;Shimeng Dong,&nbsp;Maximilian Huhn,&nbsp;Adriani Nikolakopoulou,&nbsp;Georgia Salanti,&nbsp;John M Davis","doi":"10.1002/wps.21089","DOIUrl":"https://doi.org/10.1002/wps.21089","url":null,"abstract":"<p><p>Most acute phase antipsychotic drug trials in schizophrenia last only a few weeks, but patients must usually take these drugs much longer. We examined the long-term efficacy of antipsychotic drugs in acutely ill patients using network meta-analysis. We searched the Cochrane Schizophrenia Group register up to March 6, 2022 for randomized, blinded trials of at least 6-month duration on all second-generation and 18 first-generation antipsychotics. The primary outcome was change in overall symptoms of schizophrenia; secondary outcomes were all-cause discontinuation; change in positive, negative and depressive symptoms; quality of life, social functioning, weight gain, antiparkinson medication use, akathisia, serum prolactin level, QTc prolongation, and sedation. Confidence in the results was assessed by the CINeMA (Confidence in Network Meta-Analysis) framework. We included 45 studies with 11,238 participants. In terms of overall symptoms, olanzapine was on average more efficacious than ziprasidone (standardized mean difference, SMD=0.37, 95% CI: 0.26-0.49), asenapine (SMD=0.33, 95% CI: 0.21-0.45), iloperidone (SMD=0.32, 95% CI: 0.15-0.49), paliperidone (SMD=0.28, 95% CI: 0.11-0.44), haloperidol (SMD=0.27, 95% CI: 0.14-0.39), quetiapine (SMD=0.25, 95% CI: 0.12-0.38), aripiprazole (SMD=0.16, 95% CI: 0.04-0.28) and risperidone (SMD=0.12, 95% CI: 0.03-0.21). The 95% CIs for olanzapine versus aripiprazole and risperidone included the possibility of trivial effects. The differences between olanzapine and lurasidone, amisulpride, perphenazine, clozapine and zotepine were either small or uncertain. These results were robust in sensitivity analyses and in line with other efficacy outcomes and all-cause discontinuation. Concerning weight gain, the impact of olanzapine was higher than all other antipsychotics, with a mean difference ranging from -4.58 kg (95% CI: -5.33 to -3.83) compared to ziprasidone to -2.30 kg (95% CI: -3.35 to -1.25) compared to amisulpride. Our data suggest that olanzapine is more efficacious than a number of other antipsychotic drugs in the longer term, but its efficacy must be weighed against its side effect profile.</p>","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"22 2","pages":"315-324"},"PeriodicalIF":73.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168166/pdf/WPS-22-315.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First evidence of a general disease (\"d\") factor, a common factor underlying physical and mental illness.","authors":"Valerie Brandt, Yuning Zhang, Hannah Carr, Dennis Golm, Christoph U Correll, Gonzalo Arrondo, Joseph Firth, Lamiece Hassan, Marco Solmi, Samuele Cortese","doi":"10.1002/wps.21097","DOIUrl":"10.1002/wps.21097","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"22 2","pages":"335-337"},"PeriodicalIF":73.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168148/pdf/WPS-22-335.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The non-ergodic nature of mental health and psychiatric disorders: implications for biomarker and diagnostic research.","authors":"Andreas Meyer-Lindenberg","doi":"10.1002/wps.21086","DOIUrl":"10.1002/wps.21086","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"22 2","pages":"272-274"},"PeriodicalIF":73.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168159/pdf/WPS-22-272.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing the beautiful and the good in pursuit of biomarkers for depression.","authors":"Helen S Mayberg,&nbsp;Boadie W Dunlop","doi":"10.1002/wps.21081","DOIUrl":"https://doi.org/10.1002/wps.21081","url":null,"abstract":"265 nia, and antipsychotic medications used to treat or prevent recurrence of mania/hy pomania impact dopamine transmission. More over, the prefrontal corticalstriatal reward neural network, which has been implicat ed in bipolar disorder and predisposition to mania/hypomania, has extensive dopa mine projections: midbrain ventral teg men tal area to ventral striatum (mesolimbic), midbrain substantia nigra pars compacta to dorsal striatum (nigro striatal), and ventral tegmental area to prefrontal cortex (mesocortical) pathways. Furthermore, amphetamineinduced ventral striatal dopamine release was positively associated with increase in mania/ hypomania in adults with bipolar disorder vs. non-psychiatric control participants; and a large rodent literature associates elevated reward network ventral tegmental area dopamine transmission with rewarddriven impulsive behavior, as well as other features of mania/hypomania, such as reduced sleep and increased energy. Together, these findings indicate that the combination of specific reward expectan cy paradigms and multimodal imaging ap p roaches examining reward expectancyrelated neural network activity and underlying dopaminergic modulation is a promising way to identify biomarkers reflecting neurobiological mechanisms predisposing to mania/hypomania. Bipolar disorder has also been conceptualized as a disorder of energy regulation, involving high levels of mitochondrial dysfunction and oxidative stress that might result from elevated dopamine transmission. Elegant translational work in mice and hu mans has shown that sustained elevated do pamine synthesis results in ele vated cy tosolic dopamine, which in turn leads to increased metabolism of dopamine by mon oamine oxidase. In this pro cess, mon oamine oxidase anchors to the outer mito chondrial membrane and transfers ele ctrons generated by dopamine deamination into the mitochondri al intermembrane space, increasing electron transport chain activity and supporting elevated dopamine synthesis and release. Increased metabolic demand can, however, ultimately lead to impaired mitochondrial function and a toxic cascade in which elevated oxidative stressinduced mitochondrial dysfunction results in cytosolic dopamine oxidation, with elevat ed cytosolic dopamine further contributing to mitochondrial oxidative stress. Thus, elevated dopamine transmis sion and asso ciated mitochondrial dysfunction is a putative mechanism underlying the energy regulation dysfunction characterizing mania/ hypo mania in bipolar disorder. These examples provide possible app roaches that can be adopted by future studies aiming to identify biomarkers reflecting core neurobiological mechanisms underlying key features characterizing and predis pos ing to mania/hypomania. An im portant point to note, however, is that these features, especially rewarddriven impulsive decisionmaking and behavior, are associated, at least in part, with other disorders, such as substance use disorders. Thus, th","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"22 2","pages":"265-267"},"PeriodicalIF":73.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168145/pdf/WPS-22-265.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health at work: WHO guidelines.","authors":"Aiysha Malik, José Luis Ayuso-Mateos, Gergő Baranyi, Corrado Barbui, Graham Thornicroft, Mark van Ommeren, Aemal Akhtar","doi":"10.1002/wps.21094","DOIUrl":"10.1002/wps.21094","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"22 2","pages":"331-332"},"PeriodicalIF":73.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10138876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keeping Dr. Google under control: how to prevent and manage cyberchondria.","authors":"Vladan Starcevic","doi":"10.1002/wps.21076","DOIUrl":"10.1002/wps.21076","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"22 2","pages":"233-234"},"PeriodicalIF":73.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168140/pdf/WPS-22-233.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}