World Psychiatry最新文献

{"title":"Do generative AI chatbots increase psychosis risk?","authors":"Matcheri Keshavan,John Torous,Walid Yassin","doi":"10.1002/wps.70017","DOIUrl":"https://doi.org/10.1002/wps.70017","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"4 1","pages":"150-151"},"PeriodicalIF":73.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric advance directives: challenges emerging from implementation and possible steps forward.","authors":"Marvin S Swartz,Jeffrey W Swanson","doi":"10.1002/wps.70037","DOIUrl":"https://doi.org/10.1002/wps.70037","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"30 1","pages":"145-146"},"PeriodicalIF":73.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stanford neuromodulation therapy for treatment-resistant depression: a randomized controlled trial confirming efficacy, and an EEG study providing insight into mechanism of action and a potentially predictive biomarker of efficacy.","authors":"Ian H Kratter,Christopher W Austelle,Jennifer I Lissemore,Masataka Wada,Andrew Geoly,Anna Chaiken,Irakli Kaloiani,Noriah Johnson,Stephanie Wan,Lena Kozyr,Ethan Makarewycz,Brendan Wong,Malvika Sridhar,Flint M Espil,Nick Bassano,Bora Kim,Jarrod Ehrie,Adi Maron-Katz,Claudia Tischler,Romina Nejad,Jean-Marie Batail,Angela L Phillips,Eleanor J Cole,Tiffany J Ford,Brandon S Bentzley,Booil Jo,Alan F Schatzberg,David Spiegel,Cammie Rolle,Gregory L Sahlem,Nolan R Williams","doi":"10.1002/wps.70032","DOIUrl":"https://doi.org/10.1002/wps.70032","url":null,"abstract":"Stanford neuromodulation therapy (SNT) is a rapid-acting, high-dose, intermittent theta-burst stimulation protocol. Although it has previously demonstrated efficacy for treatment-resistant depression (TRD) in a randomized controlled trial (RCT), replication in a larger sample is needed. Additionally, the electrophysiological effects of SNT remain unknown. Here we report results from a new double-blind, sham-controlled RCT along with electroencephalography (EEG) findings from the initial and current trials. In the current RCT, 53 participants with TRD were enrolled, and 48 who continued to meet entry criteria were randomized to receive active (N=24) or sham (N=24) SNT. At 1-month, remission (primary outcome) was achieved in 50.0% of active vs. 20.8% of sham participants (χ2 1,48=4.5, p=0.035), and response (secondary outcome) similarly favored active treatment (54.2% vs. 25.0%; χ2 1,48=4.3, p=0.039). Beta band EEG findings converged across trials: frontal beta power decreased significantly following active but not sham SNT in both the initial pilot study and the current trial. Additionally, beta baseline activity and post-SNT changes related to treatment efficacy in the current study. Specifically, greater post-SNT reduction in left anterior cingulate cortex (L-ACC) beta power correlated with greater clinical improvement immediately (rho=0.48, p=0.019) and 1-month after (rho=0.51, p=0.012) active SNT. Moreover, higher pre-treatment L-ACC beta power predicted greater subsequent clinical benefit from active SNT (immediate-post: β=-10.26, p=0.0042; 1-month after: β=-9.00, p=0.024). Neither of these L-ACC beta power findings was observed with sham stimulation. In sum, this study replicates SNT's therapeutic efficacy, identifies left frontal beta suppression as a potential mechanism of action, and highlights baseline L-ACC beta power as a candidate scalable pre-treatment biomarker of efficacy.","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"141 1","pages":"105-116"},"PeriodicalIF":73.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social inclusion in mental health: a Latin American perspective.","authors":"Franco Mascayano","doi":"10.1002/wps.70011","DOIUrl":"https://doi.org/10.1002/wps.70011","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"17 1","pages":"93-94"},"PeriodicalIF":73.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Euthanasia for mental suffering in young people: a critical global perspective.","authors":"Jim van Os,Damiaan Denys","doi":"10.1002/wps.70036","DOIUrl":"https://doi.org/10.1002/wps.70036","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"39 1","pages":"143-144"},"PeriodicalIF":73.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do early intervention services for psychosis maintain their effects after transition to usual/modular care? A systematic review and meta-analysis.","authors":"Gonzalo Salazar de Pablo,Joao Almeida,Jesus Camacho,José Suárez Campayo,Ana Catalan,Mihai Pop,Claudia Aymerich,Maria Rogdaki,Delbert G Robinson,Nina Schooler,Philip McGuire,Wing-Chung Chang,Eric Yu-Hai Chen,Merete Nordentoft,Carsten Hjorthøj,Nikolai Albert,Marie Starzer,Vinod Srihari,Marcelo Valencia,Celso Arango,John Kane,Paolo Fusar-Poli,Christoph U Correll","doi":"10.1002/wps.70012","DOIUrl":"https://doi.org/10.1002/wps.70012","url":null,"abstract":"Early intervention services (EIS) for psychosis have demonstrated superiority to usual care/modular care (UC/MC) until the end of their delivery. However, the maintenance effects of EIS care after transition to UC/MC are less clear. We aimed to compare these effects vs. UC/MC at least one year after the end of EIS care. This PRISMA and MOOSE-compliant systematic review searched PubMed, EMBASE, PsycINFO and Web of Science databases and Cochrane Central Register of Reviews, without time or language restrictions. We included studies initially designed as randomized controlled trials (RCTs) comparing EIS vs. UC/MC in patients with early-phase psychosis, in which both the intervention and control groups were followed for at least 12 months after cessation of EIS care in the intervention group. Co-primary outcomes were psychiatric hospitalization, duration of hospitalization, and drop-out at the end of follow-up (preferably 5 years post-EIS initiation). Secondary outcomes were severity of total, positive and negative symptoms; quality of life, work involvement, remission, legal offences, antipsychotic use, and suicide attempts. We meta-analyzed six RCTs with data from 13 papers, including 1,416 individuals (mean age: 23.9 years, females: 36.7%). After 2-3 years of receiving UC/MC, subsequent to 2-3 years of EIS care or UC/MC, individuals who originally received EIS care spent less days hospitalized than those continuing UC/MC (n=5, standardized mean difference, SMD=0.128, 95% CI: 0.019-0.237, p=0.021). However, although we confirmed the superiority of EIS care to UC/MC at the end of the intervention period (except for work involvement and legal offences), the two groups did not differ significantly at 2-3 years post-EIS care regarding hospitalization, all-cause drop-out, quality of life; severity of total, positive and negative symptoms; work involvement, remission, legal offences, antipsychotic use, and suicide attempts. In summary, EIS care did not maintain its superiority over UC/MC 2-3 years after its cessation across meta-analyzable outcomes, except for duration of hospitalizations. These results support the need to further develop and potentially extend full or individualized EIS delivery.","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"81 1","pages":"95-104"},"PeriodicalIF":73.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Off-label use of medications in psychiatry: the need and the caveats.","authors":"Eduard Vieta","doi":"10.1002/wps.70035","DOIUrl":"https://doi.org/10.1002/wps.70035","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"21 1","pages":"142-143"},"PeriodicalIF":73.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional psychiatry on the move: the activities of the ECNP Nutrition Network to leverage nutrition for brain health.","authors":"Francesca Cirulli,Suzanne L Dickson","doi":"10.1002/wps.70020","DOIUrl":"https://doi.org/10.1002/wps.70020","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"34 1","pages":"155-156"},"PeriodicalIF":73.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing psychiatry of intellectual developmental disorders: from margins to mainstream, from classification to care.","authors":"Kerim Munir,Ashok Roy,Marco Bertelli,Gregorio Katz,Luis Salvador-Carulla","doi":"10.1002/wps.70023","DOIUrl":"https://doi.org/10.1002/wps.70023","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"101 1","pages":"157-158"},"PeriodicalIF":73.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New WHO guidance on mental health and well-being across government sectors.","authors":"Michelle Funk,Natalie Drew,Celline Cole,Maria Francesca Moro","doi":"10.1002/wps.70016","DOIUrl":"https://doi.org/10.1002/wps.70016","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":"34 1","pages":"147-148"},"PeriodicalIF":73.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}