World Journal of Surgical Oncology最新文献

{"title":"Radioligand therapy, vascular deprivation and surgical resection as a step-up-approach for locally advanced pancreatic neuroendocrine bleeding mass.","authors":"Giacomo Deiro, Marsia Tancredi, Donata Campra, Andrea Discalzi, Roberta Tutino, Alberto Bona, Alberto Nieri, Mirko Bartolomei, Mauro Santarelli","doi":"10.1186/s12957-025-03965-1","DOIUrl":"10.1186/s12957-025-03965-1","url":null,"abstract":"<p><strong>Background: </strong>Surgery for symptomatic non-functioning pancreatic neuroendocrine tumors (NF-PanNETs) represents the only definitive curative treatment option and improves the overall survival rate. The new frontier in locally advanced NF-PanNETs treatment is Radioligand therapy (RLT) in a neoadjuvant setting. Acute gastrointestinal bleeding is a rare complication that requires immediate treatment with a multidisciplinary approach.</p><p><strong>Case presentation: </strong>We present a case of a 36-year-old male diagnosed with locally advanced non-functioning PanNET in the pancreatic body-tail diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). RLT, proposed to reduce mass dimension in the planning of surgical resection, was performed to obtain a downstaging tumor and enabling access to radical surgery. For the acute onset of hemorrhagic shock caused by lower gastrointestinal bleeding, tumor endovascular embolization was performed using microspheres and gelatin sponge. On vascular deprivation day 4, a posterior radical antegrade modular pancreatosplenectomy (P-RAMPS), left lateral duodenectomy (III and IV portion) and resection of the left colic flexure were performed. Reconstruction of intestinal continuity was ensured by isoperistaltic side-to-side duodeno-jejuno and colo-colic anastomosis. The patient had a short hospital stay with quick recovery and a good outcome at 6 months follow-up after the surgery.</p><p><strong>Conclusions: </strong>Symptomatic non-functioning PanNETs are infrequent slow-growing tumors and some of them may present in advanced stages with local involvement of surrounding structures. Our case suggests that a step-up-approach for locally advanced pancreatic neuroendocrine bleeding mass is mandatory and aggressive surgical management is a mainstay.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Antitumor efficacy and molecular mechanism of lenvatinib combined with vitamin K2 against hepatocellular carcinoma.","authors":"Yuli Zhang, Dinggui Chen, Xianfeng Qian, Chunmei Long, Zhongwei Zheng","doi":"10.1186/s12957-026-04477-2","DOIUrl":"10.1186/s12957-026-04477-2","url":null,"abstract":"","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"24 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13321659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLTC expression in oral squamous cell carcinoma: insights into prognostic value and immune microenvironment modulation.","authors":"Zifeng Cui, Yan Gao, Kaige Chen, Jianguang Zhao, Kaicheng Yang","doi":"10.1186/s12957-026-04436-x","DOIUrl":"10.1186/s12957-026-04436-x","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) has a poor prognosis because of its high metastatic potential and frequent chemoresistance. Although CLTC is aberrantly expressed and involved in fusion events in several tumors, its role in OSCC remains poorly defined.</p><p><strong>Methods: </strong>We integrated transcriptomic and clinical data from TCGA and GEO, scRNA-seq data, immune infiltration analysis, ligand-receptor based cell-cell communication analysis, drug sensitivity prediction, molecular docking, and in vitro functional validation to evaluate CLTC expression, prognostic value, and its association with the OSCC immune microenvironment.</p><p><strong>Results: </strong>CLTC was significantly overexpressed in OSCC and several other cancers. High CLTC expression was associated with poorer survival and improved prognostic stratification when combined with tumor mutation burden (TMB). Immune analyses showed that high CLTC expression was associated with reduced CD8 + T-cell infiltration, decreased cytotoxic activity, and increased immune exclusion- and suppression-related signatures. Single-cell analysis showed that CLTC was broadly expressed across OSCC cell populations, with relatively high expression in epithelial, inflammatory epithelial, macrophage, inflammatory macrophage, and endothelial cells. Macrophage-centered communication analysis further revealed prominent MIF-, CXCL-, and SPP1-related signaling interactions between macrophages and tumor, stromal, and immune cell populations. Drug sensitivity prediction and molecular docking suggested potential associations between CLTC expression and responses to several chemotherapeutic agents, although these computational results indicate possible physical interactions rather than confirmed functional drug effects. In vitro experiments confirmed that CLTC was upregulated in OSCC tissues and that CLTC knockdown suppressed SCC25 cell proliferation, migration, and invasion.</p><p><strong>Conclusion: </strong>CLTC may serve as a prognostic biomarker in OSCC and may contribute to tumor progression by promoting malignant cellular phenotypes and immunosuppressive remodeling of the tumor microenvironment. Future mechanistic studies are required to determine whether CLTC directly regulates chemotherapy response through clathrin-mediated trafficking, receptor recycling, adhesion signaling, or tumor-immune interactions.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silencing of ELFN1-AS1 induces prostate cancer cell apoptosis and autophagy by regulating miR-28-5p/BCAM axis.","authors":"Shuai Luo, Dingwen Gui, Yankuang Guo, Zuwei Xu, Zheng Fang, Geng Huang, Wenbing Wu","doi":"10.1186/s12957-026-04474-5","DOIUrl":"10.1186/s12957-026-04474-5","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer (PCa) is the most frequently diagnosed non-cutaneous malignancy in men worldwide and constitutes a leading contributor to cancer-related mortality globally. This study aimed to investigate the biological functions and molecular mechanisms of long noncoding RNA ELFN1-AS1 in regulating PCa cell phenotypes.</p><p><strong>Methods: </strong>ELFN1-AS1 expression in PCa cells was quantified via RT-qPCR analysis. CCK-8, Transwell, and flow cytometry analysis were carried out to measure PCa cell viability, invasion, and apoptosis. Monodansylcadaverine staining was used to visualize and assess autophagosome formation in PCa cells. Western blot analysis was performed to measure protein levels of apoptotic markers, autophagic markers, and the downstream factor basal cell adhesion molecule (BCAM). The binding relationship among ELFN1-AS1, miR-28-5p, and BCAM were validated by luciferase reporter assay and RNA immunoprecipitation assays.</p><p><strong>Results: </strong>The results demonstrated that ELFN1-AS1 and BCAM were highly expressed in PCa cells, while miR-28-5p expression was downregulated compared with normal prostate epithelial cells. Silencing of ELFN1-AS1 effectively reduced optical density values and numbers of invaded cells while concurrently elevating apoptotic proportion. Moreover, ELFN1-AS1 knockdown promoted the formation of autophagosomes and increased LC3II/LC3I ratio. Importantly, ELFN1-AS1 acted as a molecular sponge for miR-28-5p to regulate BCAM expression. Additionally, the inhibitory effects of ELFN1-AS1 depletion on the malignant biological behaviors of PCa cells were notably reversed by BCAM overexpression.</p><p><strong>Conclusion: </strong>Our findings indicate that the silencing of ELFN1-AS1 promotes PCa cell apoptosis and autophagy by interacting with miR-28-5p to regulate BCAM expression.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of an innovative embedded parallel pancreaticojejunostomy technique in laparoscopic pancreaticoduodenectomy.","authors":"Xing Li, Hao Chen, Hongtai Duan, Qiong Ye, Jie Wang, Haibiao Wang, Kaijie Qiu","doi":"10.1186/s12957-026-04471-8","DOIUrl":"10.1186/s12957-026-04471-8","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical value of an innovative embedded parallel pancreaticojejunostomy technique for laparoscopic pancreaticoduodenectomy.</p><p><strong>Methods: </strong>We retrospectively analyzed the clinical data of 108 patients who underwent successful laparoscopic pancreaticoduodenectomy at The Affiliated Lihuili Hospital of Ningbo University, from January 2016 to July 2025. Patients were divided according to the type of pancreaticojejunostomy: the experimental group (n = 57) underwent an embedded parallel pancreaticojejunostomy, while the control group (n = 51) underwent duct-to-mucosa pancreaticojejunostomy. The baseline characteristics, tumor features, intraoperative and postoperative conditions, and complications were compared between the two groups. And through a multivariate logistic regression model, the independent effects of the surgical groups (experimental group, control group) were evaluated.</p><p><strong>Results: </strong>The incidence of grade B/C postoperative pancreatic fistula in the experimental group (5.3%) was significantly lower than that of the control group (19.6%), and the difference was statistically significant (P < 0.05). The pancreaticojejunostomy time (21.33 ± 2.73 min), postoperative drainage tube removal time (14.00, 10.00-17.50 days), and postoperative hospitalization (16.00, 12.50-21.00 days) in the experimental group were all significantly shorter than those in the control group (31.43 ± 2.30 min; 17.00, 11.00-28.00 days; 20.00, 13.00-29.00 days, respectively; all P < 0.05). There were no significant differences (P > 0.05) between the two groups in age, American Society of Anesthesiologists, Fistula Risk Score, main pancreatic duct diameter, sex, body mass index, pathological type, maximal tumor diameter, pancreatic texture, intraoperative margin status, lymph node metastasis, operative time, intraoperative blood loss, delayed gastric emptying, or postoperative bleeding. And the intervention measure (experimental group, control group) was independent protective factors for reducing postoperative pancreatic fistula (OR=0.19, 95% Cl, 0.05-0.75, P < 0.05).</p><p><strong>Conclusion: </strong>The embedded parallel pancreaticojejunostomy technique can effectively reduce the incidence of postoperative pancreatic fistula and shorten pancreaticojejunostomy time. This technique is a simple and effective new method for pancreaticojejunostomy and is worthy of application in laparoscopic pancreaticoduodenectomy.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current practices and trends of axillary surgery de-escalation and lymphedema management for breast cancer in China: a nationwide cross-sectional survey.","authors":"Yue Zhou, Yongsheng Wang, Xuli Meng, Bingqiu Xiu, Benlong Yang, Yingying Zhang, Jingyan Xue, Zhi-Ming Shao, Jiajian Chen, Shuang Hao, Jiong Wu","doi":"10.1186/s12957-026-04466-5","DOIUrl":"10.1186/s12957-026-04466-5","url":null,"abstract":"<p><strong>Background: </strong>Axillary management in breast cancer has evolved toward de-escalation to reduce complications, particularly breast cancer-related lymphedema (BCRL). This study aimed to assess current practices and trends of axillary surgery and BCRL management in China.</p><p><strong>Methods: </strong>A nationwide survey was conducted across hospitals performing ≥ 200 breast cancer surgeries annually in 2022. The questionnaire evaluated institutional characteristics, clinical practices of axillary surgery and BCRL care. Data were compared with those from the 2017 national survey involving 110 hospitals to assess temporal changes in hospital-reported practice patterns.</p><p><strong>Results: </strong>The 198 hospitals surveyed performed a total of 123,237 breast cancer surgeries in 2022. SLNB for cN0 patients was routine practice, with 59.6% of hospitals performing SLNB in > 90% of these cases, whereas the use of SLNB in patients with clinically suspicious axillary nodes and FNA-confirmed metastasis remained cautious. The omission of ALND for patients with limited SLN metastasis (1-2 positive SLNs) remained conservative, particularly for mastectomy cases. However, significant increases were observed compared with the 2017 survey (breast-conserving surgery: median 30.0% vs. 9.0%, P = 0.001; mastectomy: median 11.0% vs. 6.6%, P < 0.001). The timing of SLNB in patients receiving neoadjuvant chemotherapy (NAC) shifted toward the post-NAC setting compared with 2017 (54.0% vs. 45.5%). Comprehensive assessment after NAC, including targeted axillary dissection (TAD) with dual-tracer mapping, was underutilized (23.7%). Hospital-reported BCRL care teams had been established in 52.0% of hospitals, while surgical BCRL interventions remained rare (11.6%).</p><p><strong>Conclusion: </strong>Compared with the 2017 national survey, hospital-reported adoption of axillary de-escalation strategies in China was broader, although implementation remained cautious and uneven across clinical scenarios and institutional settings. As a hospital-level practice-mapping survey, this study describes implementation patterns rather than patient-level oncologic safety or efficacy. These findings suggest that tracer accessibility, evidence-based protocols, and multidisciplinary BCRL care may be important areas for future improvement.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and validation of stemness-associated hub genes in cervical cancer: a bioinformatics and experimental study.","authors":"Shama Prasada Kabekkodu, Alfa Florence Rodrigues, Pratheeksha Hebbar, Samatha Bhat","doi":"10.1186/s12957-026-04472-7","DOIUrl":"10.1186/s12957-026-04472-7","url":null,"abstract":"<p><p>Cancer stem cells (CSCs) are a subpopulation with self-renewal and differentiation capacity that drive the progression, recurrence, and therapeutic resistance of patients with cervical cancer (CC). However, the complete set of genes that maintain stemness in CC remains incompletely defined. We aimed to identify key stemness-related genes and evaluate their prognostic utility, immune associations, and drug sensitivity. Through literature mining and CellMarker 2.0, we identified 1345 stemness-associated genes that overlapped with differentially expressed genes (DEGs) from the TCGA-CESC dataset (log2FC > 2, p < 0.05), yielding 216 stemness-related DEGs. A protein-protein interaction network (STRING) and CytoHubba (MCC algorithm) revealed ten hub genes (HGs): CCNB1, CCNA2, BUB1B, UBE2C, KIF11, CCNB2, KIF23, CDC20, CDC6, and FOXM1. Gene ontology and KEGG analyses revealed predominant enrichment in cell cycle progression. Cox regression and Kaplan‒Meier analyses identified BUB1B, CCNA2, CDC20, FOXM1, and KIF23 as risk factors for poor overall survival, with KIF11 emerging as an independent prognostic factor. HGs overexpression significantly correlated with altered infiltration of 15 immune cell types, including negative associations with CD8 + T and NK cells. We identified 661 unique drugs/chemicals targeting these HGs, including FDA-approved repurposed agents. Experimental validation via RT‒PCR confirmed significant overexpression of FOXM1 and KIF11 in CC tissues and cell lines compared with normal samples. These stemness-associated HGs, particularly FOXM1 and KIF11, may serve as potential prognostic biomarkers and therapeutic targets, warranting further investigation of stemness-driven CC progression.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148340428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tertiary lymphoid structures in breast cancer: Mechanistic insights, subtype-specific patterns, and therapeutic implications.","authors":"Ying Liang, Kongming Wu, Lihui Pan, Miaomiao Jia, Wenrong Zhang, Xiaojun Zhang, Jinnan Gao","doi":"10.1186/s12957-026-04467-4","DOIUrl":"10.1186/s12957-026-04467-4","url":null,"abstract":"<p><p>Breast cancer exhibits substantial molecular and immunological heterogeneity, with tertiary lymphoid structures (TLSs) emerging as key modulators of local antitumor immunity. TLSs display subtype-specific prevalence and maturity, with mature TLSs enriched in triple-negative (TNBC) and human epidermal growth factor receptor 2-positive (HER2+) tumors, correlating with improved prognosis, response to neoadjuvant therapy, and sensitivity to immune checkpoint inhibitors, whereas hormone receptor-positive (HR+) tumors often lack organized TLSs and show limited immunogenicity. TLS formation is orchestrated by cytokine-chemokine networks, lymphoid tissue organizer/inducer interactions, and vascular remodeling via high endothelial venules, yet the regulatory mechanisms and functional heterogeneity across subtypes remain incompletely understood. Detection strategies range from histopathology and multiplex immunohistochemistry to spatial transcriptomics and radiomics, but standardization, reproducibility, and clinical scalability remain major hurdles. Emerging interventions-including chemotherapy, immune checkpoint blockade, chemokine delivery, and combinatorial strategies-can induce or mature TLSs, offering potential therapeutic leverage, yet safety, phenotypic fidelity, and context-dependent efficacy require careful evaluation. Collectively, TLSs represent a dynamic, therapeutically targetable component of the tumor microenvironment; however, translating TLS biology into precision immuno-oncology demands mechanistic insight, standardized assessment, and integration with spatial multi-omic frameworks to inform subtype-specific, clinically actionable strategies.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148333328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fatty acid metabolism-based deep learning model predicts biochemical recurrence and identifies NUDT19 as a candidate metabolic factor in prostate cancer.","authors":"Chen Wang, Li-Jing Zhu, Yan Zhang, Xiao-Fen Wu, Su-Qin Lei, Sheng-Ping Hu, Ming-Jie Sun, Qin-Zhou Yu, Ying Zhou, Jie Li","doi":"10.1186/s12957-026-04446-9","DOIUrl":"10.1186/s12957-026-04446-9","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a fatty acid metabolism-based deep learning model for predicting biochemical recurrence (BCR) in prostate cancer (PCa) and to identify recurrence-associated metabolic regulators.</p><p><strong>Methods: </strong>Transcriptomic data from TCGA and GEO GSE70769 were integrated to identify fatty acid metabolism-related genes and construct a deep learning model for BCR prediction. Tumor-infiltrating lymphocytes (TILs) were quantified from H&E-stained slides using a convolutional neural network-based approach. Single-cell RNA sequencing data were analyzed to identify candidate metabolic regulators enriched in malignant epithelial cells. Immunohistochemistry was performed to examine the protein expression patterns of NUDT19 and its expression associations with key fatty acid metabolism enzymes, including FASN, ACACA, and CPT1A. Functional roles were further evaluated using in vitro assays, xenograft models, and serum metabolomics.</p><p><strong>Results: </strong>The model effectively stratified PCa patients into high- and low-risk groups with distinct BCR-free survival outcomes. The high-risk group showed increased TIL infiltration, suggesting a more immune-infiltrated or inflammatory tumor microenvironment. Integrated single-cell and bulk transcriptomic analyses identified NUDT19 as a candidate metabolic regulator predominantly expressed in malignant epithelial cells and positively correlated with FASN, ACACA, and CPT1A. NUDT19 knockdown suppressed PCa cell proliferation, migration, and invasion, induced apoptosis, and inhibited tumor growth in vivo. Serum metabolomics further revealed that differential metabolites were enriched in fatty acid metabolism-related pathways.</p><p><strong>Conclusions: </strong>This study establishes a fatty acid metabolism-based deep learning model for BCR prediction and identifies NUDT19 as a candidate metabolic regulator associated with lipid metabolic remodeling and PCa progression. These findings suggest a metabolically active, inflammation-associated recurrence subtype and support further investigation of NUDT19 as a potential therapeutic target in PCa.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148333348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long non-coding RNA SOCS2-AS1 inhibits gastric cancer progression via the miR-324-3p/GRIK3 axis: a mechanistic study.","authors":"Houyun Zhang, Zhisheng Xia, Yuan Xu, Xiaolan Ouyang","doi":"10.1186/s12957-026-04458-5","DOIUrl":"10.1186/s12957-026-04458-5","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer (GC) remains a formidable threat to global health. Although SOCS2-AS1 is abnormally expressed in various cancers, its precise function and operational mechanisms in the context of GC have not been fully elucidated.</p><p><strong>Methods: </strong>This study collected 102 pairs of GC and adjacent normal tissue samples and cultured multiple GC cell lines. SOCS2-AS1, miR-324-3p, and glutamate ionotropic receptor kainate type subunit 3 (GRIK3) expression were detected by qRT-PCR. Bioinformatics analysis was performed using databases such as GEPIA and Starbase. Functional experiments including CCK-8 assay and Transwell assay were conducted to evaluate cellular functions. Subcellular localization was determined using nuclear-cytoplasmic separation technology. Direct molecular interactions were validated via dual luciferase reporter assays.</p><p><strong>Results: </strong>The downregulation of SOCS2-AS1 in GC tissues and cell lines is significantly associated with an unfavorable patient prognosis. Overexpression of SOCS2-AS1 markedly suppressed GC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) progression. Mechanistic studies revealed that SOCS2-AS1 targets miR-324-3p. and re-expression experiments confirmed its ability to reverse the anti-cancer effects of SOCS2-AS1. GRIK3 was identified as a direct downstream target of miR-324-3p. Ultimately, SOCS2-AS1 exerts its tumor-suppressive function through the miR-324-3p/GRIK3 axis.</p><p><strong>Conclusion: </strong>This research identifies SOCS2-AS1 as an anti-cancer lncRNA in GC and uncovers its mechanism of action via the SOCS2-AS1/miR-324-3p/GRIK3 axis in suppressing tumor progression. Thus, SOCS2-AS1 may serve as a potential diagnostic biomarker and therapeutic target for GC.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148333299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}