World Journal of Surgical Oncology最新文献

{"title":"Evaluation of C-reactive protein levels in patients with penile cancer: a systematic review and meta-analysis.","authors":"Tao Qin, Shuixian Du, Kening Zhang, Likai Wang, Lin Zong, Litong Wang, Wenjun Yu","doi":"10.1186/s12957-025-03664-x","DOIUrl":"10.1186/s12957-025-03664-x","url":null,"abstract":"<p><strong>Background: </strong>C-reactive protein (CRP) is an essential biomarker for evaluating penile cancer prognosis. Previous studies have reported conflicting outcomes concerning the correlation between CRP levels and penile cancer prognosis. This study aimed to investigate this relationship by conducting a meta-analysis of published literature.</p><p><strong>Methods: </strong>A systematic literature search was conducted using the Cochrane Library, PubMed, and Embase databases to analyze the prognostic significance of serum CRP levels in individuals diagnosed with penile cancer. Pooled risk estimates were calculated using fixed-effects or random-effects models, depending on the degree of interstudy heterogeneity.</p><p><strong>Results: </strong>Sixty-eight articles were reviewed, identifying 8 articles and 989 patients that met the inclusion criteria for the meta-analysis. The pooled analysis revealed a significant association between serum CRP levels and adverse outcomes in penile cancer cases (hazard ratio [HR] = 2.37, 95% confidence interval [CI] = 1.46-3.858). Additional meta-analysis findings showed a negative correlation between elevated CRP levels and overall survival (HR = 1.97, 95% CI = 1.23-3.16, p<0.01), cancer-specific survival (HR = 3.42, 95% CI = 1.38-8.47, p<0.01), and disease-specific survival (HR = 3.23, 95% CI = 1.79-5.8, p<0.01) in patients with penile cancer. In the subgroup analysis, the HRs (95% CI) were 1.66 (0.61-4.48) in Europeans, 3.08 (2-4.74) in Asians, 3.04 (1.93-4. 77) in Chinese, 2.07 (1.21-3.53) in the group of cutoff value ≥ 5 mg/L, 2.43 (1.44-4.12) in the group of cutoff value ≥ 10 mg/L, 2.12 (1.04-4.32) in the group of surgical intervention, and 3.07 (1.76-5.37) in the group of multitherapy. This study also found a significant relationship between serum CRP levels and lymph node metastasis in patients with penile cancer (relative risk = 2.27, 95% CI = 1.61-3.2, p<0.01).</p><p><strong>Conclusion: </strong>This meta-analysis indicates that increased CRP levels were associated with a poorer prognosis in penile cancer. Therefore, CRP levels could potentially serve as a prognostic indicator of penile cancer.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"78"},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between BMI and chemotherapy-induced peripheral neuropathy in cancer patients: a dose-response meta-analysis.","authors":"Li Yanbing, Li Zijun, Zuo Hongbo, Wang Zhi","doi":"10.1186/s12957-025-03716-2","DOIUrl":"10.1186/s12957-025-03716-2","url":null,"abstract":"<p><strong>Objective: </strong>This meta-analysis aimed to evaluate the dose-response relationship between body mass index (BMI) and the risk of chemotherapy-induced peripheral neuropathy (CIPN) in cancer patients.</p><p><strong>Methods: </strong>We conducted a dose-response meta-analysis of 10 studies involving 6,841 cancer patients. Studies reporting BMI and CIPN outcomes were selected. The relationship between BMI and CIPN was assessed using random-effects models and restricted cubic splines to model the dose-response association.</p><p><strong>Results: </strong>Pooled analysis revealed a significant association between higher BMI and increased risk of CIPN, with an odds ratio (OR) of 1.55 (95% CI, 1.20-1.99). A dose-response analysis demonstrated a clear linear relationship between BMI and the risk of CIPN. For every 5 kg/m² increase in BMI, the relative risk of CIPN increased by approximately 15%. Subgroup analyses showed stronger associations in breast cancer patients and those treated with taxane or platinum-based regimens. Sensitivity analyses confirmed the robustness of the results, and mild publication bias was observed.</p><p><strong>Conclusions: </strong>Higher BMI is significantly associated with an increased risk of CIPN, with a dose-dependent effect. Weight management interventions, such as dietary modifications and physical activity, may reduce CIPN risk, particularly in patients with elevated BMI undergoing chemotherapy with neurotoxic regimens.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"77"},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of superficial cervical plexus nerve block with Ropivacaine or a combination of different adjuvants on perioperative analgesia and quality of postoperative recovery in patients undergoing radical thyroid cancer surgery under general anesthesia: a prospective randomized controlled trial.","authors":"Xiaoyu Kang, Caifen Li, Liuyu Lu, Xiaotong Qin, Yonghao Wang, Yang Lu, Li Ma, Shaoliang Zhu, Zheng Gong","doi":"10.1186/s12957-025-03721-5","DOIUrl":"10.1186/s12957-025-03721-5","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of ultrasound-guided bilateral superficial cervical plexus nerve blocks with Ropivacaine or a combination of different adjuvants on perioperative analgesia and quality of postoperative recovery in patients undergoing radical thyroid cancer surgery under general anesthesia with nerve monitoring without muscarinic maintenance.</p><p><strong>Methods: </strong>A total of 140 patients undergoing elective radical thyroid cancer surgery were randomly divided into four groups, with 35 cases in each group: general anesthesia alone group (Group C), general anesthesia + Ropivacaine group (Group R), general anesthesia + Ropivacaine combined with dexmedetomidine group (Group R1), and general anesthesia + Ropivacaine combined with dexamethasone group (Group R2). The primary observation index were postoperative resting and active Visual Analogue Score. The secondary observation index were hemodynamics, intraoperative sedative and analgesic medication use, postoperative analgesic requirements, postoperative recovery indicators, Richards-Campbell Sleep Questionnaire scores, Quality of Postoperative Recovery-15 scores, and adverse reactions.</p><p><strong>Results: </strong>Compared with group C, the resting and active VAS scores in group R were lower within 12 h after surgery (P < 0.05), the resting and active VAS scores in groups R1 and R2 were lower within 24 h after surgery (P < 0.05). Compared with group R, the VAS scores of patients in groups R1 and R2 were lower within 6 to 24 h after operation (P < 0.05). Compared with group R2, only the sedation score after extubation was higher in R1 group (P < 0.05), and there was no statistical difference in any other aspects (P < 0.05).</p><p><strong>Conclusion: </strong>Bilateral superficial cervical plexus nerve blocks with Ropivacaine or a combination of different adjuvants are superior to general anesthesia alone in terms of intraoperative hemodynamics, the amount of sedative and analgesic drugs, and analgesic efficacy and quality of recovery in patients undergoing radical thyroid cancer surgery with nerve monitoring without muscarinic maintenance. Ropivacaine combined with an adjuvant has better analgesic effectiveness and quality of recovery than without an adjuvant, and Ropivacaine combined with dexmedetomidine has a better sedation level than dexamethasone.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"74"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of PSOX (paclitaxel, oxaliplatin, S-1) and SOX (oxaliplatin, S-1) as postoperative adjuvant chemotherapy for stage II-III gastric cancer.","authors":"Fei-Yu Wang, Xiang-Ming Huang, Yu-Qing Cao, Jie Cao, Meng Song, Zhi-Jun Fang, Xin-En Huang","doi":"10.1186/s12957-025-03723-3","DOIUrl":"10.1186/s12957-025-03723-3","url":null,"abstract":"<p><strong>Background: </strong>Adjuvant chemotherapy is the conventional treatment for stage II and III gastric cancer(GC). Postoperative doublet chemotherapy has consistently shown improved survival outcomes in advanced-stage GC patients compared to single-agent regimens. Triplet regimens have shown significant survival benefits in the perioperative settings. This retrospective study evaluated the efficacy and safety of paclitaxel/S-1/oxaliplatin (PSOX) compared to S-1/oxaliplatin (SOX) as postoperative adjuvant chemotherapy in stage II-III GC patients following D2 gastrectomy.</p><p><strong>Methods: </strong>A retrospective review was conducted on patients with histologically confirmed stage II-III gastric cancer who underwent D2 gastrectomy at Jiangsu Cancer Hospital, categorizing them into two groups. A total of 75 patients were included in PSOX group and 81 patients in the SOX group between April 2018 and August 2021. Patients in PSOX group received paclitaxel (120 mg/m²), oxaliplatin (100 mg/m²) and S-1 (80 - 60 mg/d) per cycle, while those patients in SOX group were administrated oxaliplatin (130 mg/m²) and S-1 (80-120 mg/d) per cycle. Patients from both groups were matched in a 1:1 ratio using propensity scores to assess differences in disease-free survival (DFS) and safety.</p><p><strong>Results: </strong>The 3-year DFS rate was 78.2% for the PSOX group and 74.0% for the SOX group (P = 0.355), with a hazard ratio for peritoneal relapse of 0.287 (95% CI, 0.090-0.915; P = 0.035). Subgroup analysis indicated that stage IIIC GC patients in the PSOX group had a higher DFS rate than those in the SOX group(P = 0.032). Grade 3 or 4 adverse events, as per the National Cancer Institute Common Toxicity Criteria, such as leucopenia (10.6% vs. 4.5%), neutropenia (10.6% vs. 9.1%), nausea/vomiting (4.5% vs. 3.0%), and diarrhea (4.5% vs. 3.0%) were relatively common in the PSOX group compared to the SOX group, with no statistically significant differences between the two groups.</p><p><strong>Conclusion: </strong>Our findings suggested that adjuvant PSOX chemotherapy offers superior survival benefits compared to the SOX regimen in patients with staged IIIC GC after D2 gastrectomy. The incidence of adverse events with PSOX chemotherapy was comparable to that of SOX chemotherapy.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"75"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national mortality of larynx cancer from 1990 to 2021: results from the global burden of disease study.","authors":"Deqian Han, Hoi Leong Lee, Qi Wei Oung, Chia Hau Lee","doi":"10.1186/s12957-025-03720-6","DOIUrl":"10.1186/s12957-025-03720-6","url":null,"abstract":"<p><strong>Background: </strong>Larynx cancer, a major upper respiratory tract malignancy, remains a global public health challenge, driven by smoking, alcohol use, and chronic inflammation, despite medical and public health advancements.</p><p><strong>Methods: </strong>Data from the Global Burden of Disease 2021 study were used to assess larynx cancer mortality trends from 1990 to 2021 across global, regional, and national levels. Death rates, absolute mortality numbers, and Estimated Annual Percentage Change (EAPC) were calculated.</p><p><strong>Results: </strong>Globally, the number of deaths from larynx cancer increased by 36.67% between 1990 and 2021, while death rates slightly declined, with an EAPC of -0.41. Males consistently accounted for the majority of deaths, with 100,393 deaths in 2021, though female mortality showed a larger percentage increase of 60.13% compared to 33.39% in males. Significant regional disparities were evident, with the highest death rates reported in Eastern Europe and Central Latin America, where countries like Bulgaria and Cuba recorded rates exceeding 6 per 100,000 population. In contrast, Oceania reported the lowest rates, below 0.5 per 100,000. The elderly (75 + years) experienced the largest increase in mortality, rising by 85.4%, while deaths among the 15-49 age group remained relatively stable. Additionally, larynx cancer death rates were correlated with SDI.</p><p><strong>Conclusion: </strong>Despite slight declines in global death rates, the absolute burden of larynx cancer has increased due to population growth and aging. Regional disparities emphasize the need for targeted interventions and improved healthcare access. This study offers valuable insights for policy and resource planning.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"76"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report of clostridium difficile infection after rectal resection with ileostomy.","authors":"Hongwei Guo, Huiyuan Jiang, Haiyi Liu","doi":"10.1186/s12957-025-03713-5","DOIUrl":"10.1186/s12957-025-03713-5","url":null,"abstract":"<p><p>Colorectal cancer is the third most common cancer worldwide, with high incidence and mortality rates. Surgical resection is the primary treatment for rectal cancer. To reduce the occurrence and severity of postoperative complications such as anastomotic leakage, prophylactic ileostomy is often performed concurrently. However, following ileostomy creation, there is a disruption in intestinal ecology, making patients susceptible to clostridium difficile infection. clostridium difficile is a Gram-positive anaerobic spore-forming bacterium that is resistant to most antibiotics due to spore formation, leading to high recurrence rates and treatment failure. Additionally, in the early stages of clostridium difficile infection, increased ileostomy output can be challenging to differentiate from normal postoperative conditions, potentially resulting in missed diagnosis, delayed treatment, and increased healthcare burden.This case report describes a case of high out-put ileostomy caused by clostridium difficile infection following rectal resection with ileostomy, which was successfully treated by fecal microbiota transplantation, providing evidence-based medicine for clinical practice.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"70"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk prediction model for surgical site infection in patients with gastrointestinal cancer: a systematic review and meta-analysis.","authors":"Yu Wang, Yao Shi, Li Wang, Wenli Rong, Yunhong Du, Yuliang Duan, Lili Peng","doi":"10.1186/s12957-025-03726-0","DOIUrl":"10.1186/s12957-025-03726-0","url":null,"abstract":"<p><strong>Background: </strong>Currently, various risk prediction models for surgical site infection (SSI) in patients with gastrointestinal tumors have been developed, but comprehensive comparisons regarding the model construction process, performance, and data sample bias are lacking. This study conducts a systematic review of relevant research to evaluate the risk bias and clinical applicability of these models.</p><p><strong>Materials and methods: </strong>The Web of Science, PubMed, Cochrane Library, Embase, CINAHL, CBM, CNKI, Wanfang, and VIP databases were searched for studies related to SSI prediction models in gastrointestinal cancer patients published up to August 19, 2024. Two researchers independently screened the literature, extracted the data, and evaluated the quality. A meta-analysis was conducted on the common predictive factors included in the model, using odds ratio (OR) values and 95% confidence interval (CI) as effect statistics. The Q test and heterogeneity index I² were used to assess heterogeneity. All the statistical analyses were performed via Stata 16.0 software. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist was submitted as a supplement.</p><p><strong>Results: </strong>A total of 28 articles were included, and 39 models were constructed. The area under the receiver operating characteristic curve (AUC) for the models ranged from 0.660 to 0.950, indicating good predictive performance. Eight studies conducted internal validation, eight studies conducted external validation, and two studies used a combination of internal and external validation for model evaluation. The overall risk of bias in the literature was high, but the applicability was good. The results of the meta-analysis revealed that factors such as underlying diseases, surgical factors, demographic factors, and laboratory-related indicators are the main predictors of surgical site infections in patients with gastrointestinal tumors.</p><p><strong>Conclusions: </strong>Currently, risk prediction models for surgical site infections in patients with gastrointestinal cancer remain in the developmental phase, and there is a high risk of bias in the areas of study subjects, outcomes, and analysis. Researchers need to enhance research methodologies, conduct large-scale prospective studies, and refer to the reporting standards of the bias risk assessment tool for predictive models to construct predictive models with low bias risk and high applicability.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"72"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An update on the molecular mechanisms underlying the progression of miR-21 in oral cancer.","authors":"Monisha Prasad, D Hamsa, Mohammad Fareed, Mohmed Isaqail Karobari","doi":"10.1186/s12957-025-03732-2","DOIUrl":"10.1186/s12957-025-03732-2","url":null,"abstract":"<p><p>Globally, oral cancer ranks among the top ten cancers, with a higher prevalence in lower-income countries, where risk factors such as tobacco use, excessive alcohol consumption, and poor oral hygiene are widespread. Metastasis plays a critical role in cancer progression. miR-21 is a crucial regulator of cancer metastasis, profoundly influencing cellular and molecular pathways that contribute to tumour aggressiveness. As a microRNA, miR-21 downregulates tumour suppressor genes, promoting cell proliferation, survival, invasion, and migration. Its role in epithelial-mesenchymal transition (EMT) further facilitates metastatic behaviour. miR-21 also modulates the tumour microenvironment by promoting angiogenesis and altering immune responses, thus enhancing cancer progression.Moreover, miRNA - 21 influences the various signalling pathways like PI3K/ AKT, TGF-β, NF-κB, and STAT3, as well as involved in the cell fate mechanisms known as Autophagy and apoptosis. Clinically, elevated miR-21 levels are associated with poor prognosis, advanced tumour stages, and decreased survival rates, making it a valuable prognostic marker. Additionally, miR-21 expression levels can predict resistance to chemotherapy and targeted therapies, aiding in personalized treatment planning. Therapeutically, targeting miR-21 through anti-miR-21 oligonucleotides, small molecule inhibitors, and miRNA sponges shows promise in pre-clinical studies, potentially inhibiting tumour growth and improving sensitivity to existing treatments. Overall, miR-21's multifaceted role in cancer biology, its prognostic and predictive value, and its potential as a therapeutic target highlight its significance in advancing cancer diagnosis, treatment, and patient outcomes. Further research and clinical trials are essential to exploit miR-21's capabilities in oncology fully.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"73"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EDN1 facilitates cisplatin resistance of non-small cell lung cancer cells by regulating the TNF signaling pathway.","authors":"Jie Zhen, Long Sun, Li Ji, Shaochong Zhou, Yijin Cui, Zhenwei Li","doi":"10.1186/s12957-025-03692-7","DOIUrl":"10.1186/s12957-025-03692-7","url":null,"abstract":"<p><strong>Background: </strong>Cisplatin (DDP) is a commonly utilized chemotherapeutic agent. Nevertheless, the development of resistance to DDP significantly diminishes the effectiveness of DDP-based chemotherapy in patients with non-small cell lung cancer (NSCLC). In this study, we investigated the impact of endothelin 1 (EDN1) on the resistance to DDP in NSCLC.</p><p><strong>Methods: </strong>The proliferation, invasion, and migration of NSCLC cells were detected by cell counting kit-8 and Transwell migration and invasion assays. ELISA was performed to analyze the inflammatory cytokines concentrations. The related protein levels of tumor necrosis factor (TNF) signaling pathway were analyzed by Western blot. Besides, a xenograft tumor mice model was established to explore the role of EDN1 in vivo.</p><p><strong>Results: </strong>The results showed that DDP-resistance upregulated EDN1 expression, cell viability, invasion, migration, and inflammation in NSCLC cells, while the results were reversed after EDN1 inhibition. EDN1 affected DDP-resistance of NSCLC by regulating TNF signaling pathway. Overexpression of TNF receptor-1 (TNFR1) reversed the decreased cell viability, invasion, migration, and inflammation induced by silencing EDN1 in A549/DDP cells. Moreover, silencing EDN1 inhibited tumor growth and the protein levels of EDN1 and TNFR1.</p><p><strong>Conclusion: </strong>EDN1 promoted DDP resistance in NSCLC cells through the modulation of the TNF signaling pathway, suggesting a potential therapeutic intervention strategy for NSCLC.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"71"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic instruments and concurrent antithrombotic medication in mastectomy: safe and effective.","authors":"Anselm Tamminen, Riitta I Aaltonen, Marko T Ristola","doi":"10.1186/s12957-025-03712-6","DOIUrl":"10.1186/s12957-025-03712-6","url":null,"abstract":"<p><strong>Background: </strong>Postoperative bleeding is one of the most common complications after mastectomy. Antithrombotic medications increase the risk of these complications but discontinuing them may predispose the patient to thromboembolic events. This study aimed to evaluate whether antithrombotic medications can be safely continued perioperatively when ultrasonic instrument is used in surgery.</p><p><strong>Methods: </strong>The study included all breast cancer patients who underwent mastectomy with an ultrasonic instrument and were on uninterrupted antithrombotic medication during a 12-year study period (2010-2022) at a single university hospital. The medical records were investigated for patients who had concurrent anticoagulant or antiplatelet therapy at the time of surgery. All bleeding complications during the 30 days following surgery were recorded.</p><p><strong>Results: </strong>In total 315 mastectomies in 299 patients were performed with three different ultrasonic instruments under concurrent antithrombotic medication. The mean age of the patients was 81 years, and 82% (258 of 299) had an ASA Classification of level 3 or 4. The indications for antithrombotic medication varied, with the most prevalent being cardiac arrhythmia (38%) and previously suffered stroke (14%). Warfarin, acetylsalicylic acid (aspirin), and direct oral anticoagulants (DOAC) each accounted for approximately a quarter of the studied patients. Bleeding complications were observed in five cases (1.6%, 5/315) during the 30-day postoperative period. Three patients underwent re-operation. None of the patients underwent reoperation on the day of the mastectomy, and in only one patient the need for reoperation was directly associated with the mastectomy procedure. In the other two patients the bleeding complications were preceded by seroma puncture and a drainage issue. The results indicate a low incidence rate of postoperative bleeding despite the continuation of antithrombotic medication when an ultrasonic instrument is utilized in the operation.</p><p><strong>Conclusion: </strong>The utilization of ultrasonic instruments in mastectomy permits safe continuation of antithrombotic medications, thereby reducing the risk of thromboembolic events and streamlining surgical preparation.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"68"},"PeriodicalIF":2.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}