Zeitschrift fur Gastroenterologie最新文献_第4页

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1055/a-2542-6781

Lea Pueschel, Katharina Hupa-Breier, Heiner Wedemeyer, Henrike Lenzen, Miriam Wiestler

{"title":"Food-related Quality of Life in patients with Inflammatory Bowel Disease: Translation and Validation of the German version of FR-QoL-29.","authors":"Lea Pueschel, Katharina Hupa-Breier, Heiner Wedemeyer, Henrike Lenzen, Miriam Wiestler","doi":"10.1055/a-2542-6781","DOIUrl":"10.1055/a-2542-6781","url":null,"abstract":"The psychosocial effects of eating and drinking - summarized as food-related quality of life (FR-QoL) - are underexplored in inflammatory bowel disease (IBD). Currently, there is no German instrument to assess FR-QoL in IBD patients. This study aimed to translate the validated English FR-QoL-29 questionnaire into German and evaluate its validity and reliability.A monocentric, cross-sectional study was conducted at a tertiary referral center with IBD patients and healthy controls. Participants completed questionnaires on sociodemographics, disease history, the Malnutrition Universal Screening Tool (MUST), the German Short Health Scale (SHS), and the FR-QoL-29-German. The FR-QoL-29 was translated into German using a forward-backward method. Its reliability and validity was assessed using Pearson correlation coefficients, intraclass correlation coefficients, and Cronbach's α.N=200 IBD patients (Crohn's disease: 61.8%; women: 50.8%; remission: 56.2%) and n=10 healthy controls completed the questionnaires. Overall, 113 IBD patients repeated the questionnaires after an average of six weeks. Significant differences in FR-QoL-29-German sum scores were found between all levels of IBD disease activity, except for remission - mild disease (p = 0.423) and moderate - severe disease (p = 0.999). FR-QoL-29-German scores significantly correlated with age (p = 0.041), disease activity (p < 0.001), MUST (p = 0.015), fecal Calprotectin (p = 0.011) and SHS (p < 0.001). Overall, the FR-QoL-29-German showed excellent internal consistency (Cronbach's α = 0.965) and good test-retest reliability (ICC = 0.85 [95% CI: 0.78-0.89]).The FR-QoL-29-German is a valid and reliable tool for assessing food-related quality of life in German-speaking individuals with IBD.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 5","pages":"477-485"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Major clinical overlap of the new and former definition of steatotic liver disease in Germany - evidence from the Wuerzburg Fatty Liver Cohort. 德国脂肪变性肝病新定义和旧定义的主要临床重叠-来自维尔茨堡脂肪肝队列的证据

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1055/a-2350-7508

Andreas Geier, Johanna Kestel, Monika Rau

引用次数: 0

Impact of distinct antiviral treatment regimens on the long-term outcome after HCV cure - Data from the German Hepatitis C-Registry (DHC-R). 不同抗病毒治疗方案对丙型肝炎治愈后长期预后的影响——来自德国丙型肝炎登记处（DHC-R）的数据

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1055/a-2543-5205

Valerie Ohlendorf, Yvonne Serfert, Peter Buggisch, Stefan Mauss, Hartwig Klinker, Gerlinde Teuber, Markus Cornberg, Krzysztof Tomasiewicz, Heiner Wedemeyer

{"title":"Impact of distinct antiviral treatment regimens on the long-term outcome after HCV cure - Data from the German Hepatitis C-Registry (DHC-R).","authors":"Valerie Ohlendorf, Yvonne Serfert, Peter Buggisch, Stefan Mauss, Hartwig Klinker, Gerlinde Teuber, Markus Cornberg, Krzysztof Tomasiewicz, Heiner Wedemeyer","doi":"10.1055/a-2543-5205","DOIUrl":"https://doi.org/10.1055/a-2543-5205","url":null,"abstract":"Direct-acting antiviral (DAA) regimens for the treatment of hepatitis C virus (HCV) infection are endowed with sustained virological response (SVR) rates >95%. However, HCV cure does not completely eliminate the risk of hepatocellular carcinoma (HCC) development and liver decompensation. The present study investigated the impact of the administered DAA regimen on clinical long-time outcomes after SVR.Matched-pair survival analyses of 5802 chronically HCV infected patients from the German Hepatitis C-Registry compared the incidence of liver-related events 2.5 years after SVR in patients receiving either sofosbuvir (SOF)-based treatment or NS3/NS4A-protease inhibitor (PI)-containing DAA regimens. Hypothesis driven logistic regression analyses were performed to identify independent predictors for the occurrence of liver-related events.Matched-pair survival analyses revealed a borderline significant difference in the incidence of liver-related endpoints (except of HCC development) in patients receiving SOF-based treatment (4.1%) compared to PI-containing DAA regimens (2.6%) 2.5 years after SVR (p=0.061). Numerically, a trend towards a benefit of PI-based DAA treatment was observed (PI 65 events vs SOF 102 events). Hypothesis driven logistic regression analyses could not confirm SOF-based treatment as an independent predictor for the occurrence of liver-related events after HCV cure (p=0.072, OR=0.670).The incidence of liver-related events 2.5 years after HCV cure did not differ significantly between SOF-based DAA treatment and PI-containing regimens. However, numerically a trend towards a benefit of PI-based DAA treatment was observed. Therefore, a minor effect of the applied DAA regimen on the long-term incidence of liver-related events cannot be excluded.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 5","pages":"486-496"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Practical guideline for short bowel syndrome]. [短肠综合征的实用指南]。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1055/a-2375-4601

Stefanie Dabsch, Christian Datz, Clemens Dejaco, Felix Harpain, Elisabeth Hütterer, Ludwig Kramer, Nina Loschko, Alexander Moschen, Anton Stift, Harald Vogelsang

{"title":"[Practical guideline for short bowel syndrome].","authors":"Stefanie Dabsch, Christian Datz, Clemens Dejaco, Felix Harpain, Elisabeth Hütterer, Ludwig Kramer, Nina Loschko, Alexander Moschen, Anton Stift, Harald Vogelsang","doi":"10.1055/a-2375-4601","DOIUrl":"10.1055/a-2375-4601","url":null,"abstract":"Short bowel syndrome is a rare complex disease that mainly develops due to extensive bowel resections and can lead to chronic intestinal failure. Due to the decreased intestinal surface absorption of macronutrient, micronutrient and/or fluids is reduced. Correspondingly manifold symptoms arise as diarrhoea, weight loss, vitamin deficiencies, chronic kidney disease, hepatopathy and others with great impact on quality of life of patients. Therapy is complex and needs interdisciplinary collaboration between dieticians, gastroenterologists, surgeons and also a dense monitoring of general practitioners. Commonly patients need permanent home-parenteral support. Therapies have to be decided individually and have to be reviewed regularly for effectivity and side effects. Furthermore, periodic monitoring of several clinical and laboratory tests should be performed. Morbidity and mortality of this disease complex is high and lead by appearance and management of complications. This practical guide should give an overview about the disease, diagnostics and management and should enable the best possible care of these complex patients.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 5","pages":"502-511"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement and Normal Values, Pathologies, Interpretation of findings, and Interventional Ultrasound as part of student ultrasound education. 测量和正常值，病理，结果的解释，介入超声作为学生超声教育的一部分。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1055/a-2550-0160

Anna Maria Gschmack, Thomas Karlas, Claudia Lucius, Gregor Barth, Michael Blaivas, Nils Daum, Yi Dong, Adrian Goudie, Beatrice Hoffmann, Christian Jenssen, Michael Kallenbach, Michael Keil, Kathleen Möller, Ricarda Neubauer, Nasenien Nourkami-Tutdibi, Florian Recker, Johannes Peter Ruppert, Roxana Sirli, Johannes Weimer, Susan Campbell Westerway, Constantinos Zervides, Christoph F Dietrich

{"title":"Measurement and Normal Values, Pathologies, Interpretation of findings, and Interventional Ultrasound as part of student ultrasound education.","authors":"Anna Maria Gschmack, Thomas Karlas, Claudia Lucius, Gregor Barth, Michael Blaivas, Nils Daum, Yi Dong, Adrian Goudie, Beatrice Hoffmann, Christian Jenssen, Michael Kallenbach, Michael Keil, Kathleen Möller, Ricarda Neubauer, Nasenien Nourkami-Tutdibi, Florian Recker, Johannes Peter Ruppert, Roxana Sirli, Johannes Weimer, Susan Campbell Westerway, Constantinos Zervides, Christoph F Dietrich","doi":"10.1055/a-2550-0160","DOIUrl":"https://doi.org/10.1055/a-2550-0160","url":null,"abstract":"Ultrasound diagnostics is a widely used, radiation-free, cost-effective, and bedside-applicable imaging technique. Given its numerous advantages and broad application, it appears reasonable to integrate practical use and theory into medical education at an early stage. Since the content of student ultrasound courses varies significantly on an international scale, the aim of this paper is to establish foundations for a more standardized approach to student's ultrasound education (SUSE) especially with focus on abdominal ultrasound. This review examines to what extent measurements can be effectively incorporated into student ultrasound training and under which conditions the teaching of pathologies should be included in these courses. Additionally, the handling of false-positive and false-negative findings in student training is discussed. Considering the growing relevance of interventional ultrasound (INVUS), the paper further explores the extent to which interventional procedures should already be taught during SUSE.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 5","pages":"513-520"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Bacteroides on Crohn's disease. Bacteroides 对克罗恩病的影响。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-04-01 Epub Date: 2024-11-25 DOI: 10.1055/a-2435-2659

Xuanyu Wei, Dong Tang

引用次数: 0

[Guideline on functional dyspepsia, a disorder of gut-brain-interaction (DGBI): S1 Guideline of the German Society for Neurogastroenterology and Motility (DGNM)]. [功能性消化不良，一种肠-脑相互作用障碍（DGBI）指南：德国神经胃肠病学和运动学会（DGNM） S1指南]。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-04-01 Epub Date: 2025-04-08 DOI: 10.1055/a-2518-1430

Martin Storr, Viola Andresen, Thomas Frieling, Jürgen M Gschossmann, Jutta Keller, Jost Langhorst, Christian Pehl, Andreas Stengel, Johannes Tebbe, Kai Wiemer, Ahmed Madisch, Miriam Stengel

引用次数: 0

Severe gastroparesis complicated by gastric perforation caused by lightchain amyloidosis. 轻链淀粉样变性引起的严重胃痉挛并发胃穿孔。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-04-01 Epub Date: 2024-11-25 DOI: 10.1055/a-2442-7944

Michael Rietz, Tobias Weber, Tina Schaller, Jan Hendrik Luitjens, Luise Uhrmacher, Helmut Messmann, Andreas Probst

{"title":"Severe gastroparesis complicated by gastric perforation caused by lightchain amyloidosis.","authors":"Michael Rietz, Tobias Weber, Tina Schaller, Jan Hendrik Luitjens, Luise Uhrmacher, Helmut Messmann, Andreas Probst","doi":"10.1055/a-2442-7944","DOIUrl":"10.1055/a-2442-7944","url":null,"abstract":"AL-Amyloidosis is a rare systemic disease that can occur in patients with monoclonal gammopathy or multiple myeloma. As multiple organs may be affected by deposition of amyloid fibrils, the clinical presentation varies considerably, and the diagnostic process may be challenging.We report on a 59-year-old female who suffered from gastroesophageal reflux symptoms, nausea, epigastric pain, and meteorism over several years. Repeated upper GI endoscopies including biopsies and CT scans were unremarkable except for unspecific enlargement of mesenterial lymph nodes.A few weeks after a surgical hiatal hernia repair with fundoplication, the patient developed massive distension of the stomach and the proximal duodenum resulting in gastric perforation. Histopathological staining of gastric biopsies and mesenterial lymph nodes using hematoxylin and eosin was unremarkable. Because of endoscopic findings (submucosal hematomas, and ulcerations) and the unexplained severe motility disorder, histopathological staining was performed using Congo red. Extensive amyloid deposits were seen. Further workup confirmed AL amyloidosis caused by monoclonal gammopathy. Specific oncological treatment was started.The rare differential diagnosis of amyloidosis should be taken into account in patients with unexplained motility disorders, unspecific gastrointestinal symptoms, and abdominal lymphadenopathy. In the presented case, delayed diagnosis of AL amyloidosis in the gastrointestinal tract led to severe gastroparesis resulting in gastric perforation. Specific histopathologic staining can confirm the diagnosis.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"387-392"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Correction: Position paper of the Society for Paediatric Gastroenterology and Nutrition (GPGE) on the off-label use of biologics and signal inhibitors in children and adolescents with IBD that have already been approved for adults]. [更正：儿科胃肠病学和营养学会（GPGE）关于已批准用于成人IBD的生物制剂和信号抑制剂在儿童和青少年中的超说明书使用的立场文件]。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-03-01 Epub Date: 2025-03-05 DOI: 10.1055/a-2543-1671

Jan Däbritz, Martin Classen, Kathrin Krohn, Andreas Krahl, Stephan Buderus, Elke Lainka, Jan de Laffolie, Carsten Posovszky

引用次数: 0

Mirikizumab for the treatment of chronic antibiotic-refractory pouchitis. 米利珠单抗用于治疗慢性抗生素难治性肠袋炎。

IF 1.6 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-03-01 Epub Date: 2024-09-25 DOI: 10.1055/a-2404-4518

Johannes Reiner, Anne-Sophie Becker, Astrid Huth, Georg Lamprecht, Maria Witte

引用次数: 0