Thomas Seufferlein, Julia Mayerle, Stefan Boeck, Thomas Brunner, Thomas J Ettrich, Lars Grenacher, Thomas Mathias Gress, Thilo Hackert, Volker Heinemann, Angelika Kestler, Marianne Sinn, Andrea Tannapfel, Ulrich Wedding, Waldemar Uhl
{"title":"S3-Leitlinie Exokrines Pankreaskarzinom – Version 3.1.","authors":"Thomas Seufferlein, Julia Mayerle, Stefan Boeck, Thomas Brunner, Thomas J Ettrich, Lars Grenacher, Thomas Mathias Gress, Thilo Hackert, Volker Heinemann, Angelika Kestler, Marianne Sinn, Andrea Tannapfel, Ulrich Wedding, Waldemar Uhl","doi":"10.1055/a-2338-3533","DOIUrl":"https://doi.org/10.1055/a-2338-3533","url":null,"abstract":"","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"62 10","pages":"e874-e995"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johannes Reiner, Anne-Sophie Becker, Astrid Huth, Georg Lamprecht, Maria Witte
{"title":"Mirikizumab for the treatment of chronic antibiotic-refractory pouchitis.","authors":"Johannes Reiner, Anne-Sophie Becker, Astrid Huth, Georg Lamprecht, Maria Witte","doi":"10.1055/a-2404-4518","DOIUrl":"https://doi.org/10.1055/a-2404-4518","url":null,"abstract":"<p><p>The current standard of care for the definitive surgical treatment of complicative ulcerative colitis is a continence-preserving proctocolectomy with the creation of an ileal pouch anal anastomosis. In addition to structural and functional disorders, pouchitis of the J-pouch is a common phenomenon, typically well responsive to antimicrobial therapy. However, sometimes chronic antibiotic-refractory pouchitis occurs, most often due to not completely understood multifactorial pathomechanisms. While high-quality evidence is available only for anti-integrin therapy, the role of advanced therapy, i.e., cytokine-antibodies or small molecules in the treatment of chronic antibiotic-refractory pouchitis (CARP), is emerging.This case demonstrates a successful induction treatment of CARP with the novel p19-selective IL-23-targeted antibody mirikizumab.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[\"Tailored therapy\" in a 36 year old female patient with persistent dysphagia].","authors":"Felix Gundling, Christopher Moritz Schad","doi":"10.1055/a-2309-5915","DOIUrl":"https://doi.org/10.1055/a-2309-5915","url":null,"abstract":"","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"62 9","pages":"1369-1370"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pia Lorenz, Niklas Aehling, Tony Bruns, Wolf Bechstein, Thomas Becker, Thomas Berg, Paul Freudenberger, Christian Trautwein, Lars Klug, Petra Lynen Jansen
{"title":"Leitlinienreport der S2k-Leitlinie Lebertransplantation der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Allgemein und Viszeralchirurgie (DGAV).","authors":"Pia Lorenz, Niklas Aehling, Tony Bruns, Wolf Bechstein, Thomas Becker, Thomas Berg, Paul Freudenberger, Christian Trautwein, Lars Klug, Petra Lynen Jansen","doi":"10.1055/a-2255-7355","DOIUrl":"https://doi.org/10.1055/a-2255-7355","url":null,"abstract":"","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"62 9","pages":"e537-e554"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Berg, Niklas F Aehling, Tony Bruns, Martin-Walter Welker, Tobias Weismüller, Jonel Trebicka, Frank Tacke, Pavel Strnad, Martina Sterneck, Utz Settmacher, Daniel Seehofer, Eckart Schott, Andreas Anton Schnitzbauer, Hartmut H Schmidt, Hans J Schlitt, Johann Pratschke, Andreas Pascher, Ulf Neumann, Steffen Manekeller, Frank Lammert, Ingo Klein, Gabriele Kirchner, Markus Guba, Matthias Glanemann, Cornelius Engelmann, Ali E Canbay, Felix Braun, Christoph P Berg, Wolf O Bechstein, Thomas Becker, Christian Trautwein
{"title":"S2k-Leitlinie Lebertransplantation der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV).","authors":"Thomas Berg, Niklas F Aehling, Tony Bruns, Martin-Walter Welker, Tobias Weismüller, Jonel Trebicka, Frank Tacke, Pavel Strnad, Martina Sterneck, Utz Settmacher, Daniel Seehofer, Eckart Schott, Andreas Anton Schnitzbauer, Hartmut H Schmidt, Hans J Schlitt, Johann Pratschke, Andreas Pascher, Ulf Neumann, Steffen Manekeller, Frank Lammert, Ingo Klein, Gabriele Kirchner, Markus Guba, Matthias Glanemann, Cornelius Engelmann, Ali E Canbay, Felix Braun, Christoph P Berg, Wolf O Bechstein, Thomas Becker, Christian Trautwein","doi":"10.1055/a-2255-7246","DOIUrl":"https://doi.org/10.1055/a-2255-7246","url":null,"abstract":"","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"62 9","pages":"1397-1573"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carsten Posovszky, Stephan Buderus, Johannes Huebner, Rüdiger Adam, Cihan Papan, Bernd Gruber, Florian Schmid, Kathrin Krohn, Philip Wintermeyer, Reto Schwenke, Jande Laffolie, Ulrichvon Both, Hans-Jörg Epple, Philipp A Reuken, Florian Kipfmüller, Anna-Maria Schneider, Angelika Fruth, Sandra Simon, Anne Schmitt, Almuthe Christina Hauer
{"title":"S2k Leitlinie akute infektiöse Gastroenteritis im Säuglings-, Kindes- und Jugendalter – Update 2024.","authors":"Carsten Posovszky, Stephan Buderus, Johannes Huebner, Rüdiger Adam, Cihan Papan, Bernd Gruber, Florian Schmid, Kathrin Krohn, Philip Wintermeyer, Reto Schwenke, Jande Laffolie, Ulrichvon Both, Hans-Jörg Epple, Philipp A Reuken, Florian Kipfmüller, Anna-Maria Schneider, Angelika Fruth, Sandra Simon, Anne Schmitt, Almuthe Christina Hauer","doi":"10.1055/a-2327-6247","DOIUrl":"https://doi.org/10.1055/a-2327-6247","url":null,"abstract":"<p><p>The aim of the interdisciplinary S2k guideline \"Acute infectious gastroenteritis in infants, children and adolescents\" is to summarise the current state of knowledge on the clinical presentation, diagnosis, treatment, prevention and hygiene of acute infectious gastroenteritis, including nosocomial gastrointestinal infections, in infants, children and adolescents on the basis of scientific evidence, to evaluate it by expert consensus and to derive practice-relevant recommendations from it. The guideline provides a corridor for action for frequent decisions. It also serves the purpose of evidence-based further education and training and is thus intended to improve the medical care of children with acute gastroenteritis. In particular, the guideline aims to avoid unnecessary hospitalisation of children with AGE and to take preventive measures to avoid and spread infection.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"62 9","pages":"1574-1643"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Management of gastroparesis care in Germany - a survey by the working group of guiding gastroenterologic clinicians (Arbeitsgemeinschaft Leitender Gastroenterologischer Krankenhausärzte, ALGK)].","authors":"Felix Gundling, Thomas Frieling","doi":"10.1055/a-2350-7432","DOIUrl":"10.1055/a-2350-7432","url":null,"abstract":"<p><strong>Introduction: </strong>The treatment of gastroparesis can be difficult in everyday clinical practice. The aim of this anonymous survey of members of the Arbeitsgemeinschaft Leitender Gastroenterologischer Krankenhausärzte e.V. (ALGK) was to investigate the management of gastroparesis care in Germany.</p><p><strong>Material and methods: </strong>The ALGK conducted a member survey using a standardized anonymous questionnaire including 11 questions from 14.04.2023 to 29.04.2023. The questions covered diagnostic and therapeutic procedures as well as various aspects of the management of gastroparesis.</p><p><strong>Results: </strong>The response rate was 21.4% (62 members). Only 6.56% of all respondents assessed the prevalence of gastroparesis correctly as estimated by current epidemiological publications. 68.85 % of all respondents used gastric emptying scintigraphy for diagnosis. 51.61% regarded an individualized therapy as the most important treatment goal, taking into account etiology and impact of symptoms, compared to symptomatic treatment of leading clinical symptom in 43,55 %. First choice treatment was medical treatment in 41.94%, dietary recommendations in 27.42% and endoscopic interventions in 24.2%. 100% of respondents used prokinetics, 40.32% used antiemetics while only 4.84% used analgesics. Insufficient availability of medical treatment options represents a need of action for 85.48%, compared to lacking official approval of available drugs for this indication for 48,39% of all respondents. Treatment options with little evidence were used quite frequently (e.g. use of herbal therapies in 43.55%).</p><p><strong>Discussion: </strong>Overall, the frequency of gastroparesis was underestimated in the current survey. Endoscopic options are quite often used as first-line treatment. Although symptom-guided treatment is important for the majority of respondents, prokinetics are predominantly used.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"1371-1378"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Valentina Bieneck, Annegrit Decker, Annette Schmitt-Graeff, Wolfgang Kreisel, Franziska Schauer
{"title":"Remission of refractory esophageal lichen planus induced by tofacitinib.","authors":"Valentina Bieneck, Annegrit Decker, Annette Schmitt-Graeff, Wolfgang Kreisel, Franziska Schauer","doi":"10.1055/a-2300-0375","DOIUrl":"10.1055/a-2300-0375","url":null,"abstract":"<p><p>As of now, there exists no established therapy for ELP. Retinoids, which are standard in treating cutaneous LP, do not exhibit positive effects in ELP. While topical glucocorticosteroids often yield favorable responses in esophageal inflammation, some cases prove recalcitrant or refractory. In such instances, various immunosuppressive therapies have been attempted with variable success.This report details a severe case of ELP that showed resistance to prednisolone, acitretin, alitretinoin, adalimumab, tacrolimus, hydroxychloroquine plus mycophenolate mofetil, and cyclophosphamide. The initiation of the JAK inhibitor tofacitinib induced an impressive clinical, endoscopic, and histological remission. This positive response to a JAK inhibitor is discussed in the context of our evolving understanding of the immune-mediated pathogenesis of this disease.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"1384-1388"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11383619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simon Sirtl, Eric Hohmann, Georg Beyer, Jacob Hamm, Albrecht Neesse, Christoph Ammer-Herrmenau
{"title":"The four seasons of pancreatitis - Etiology of acute pancreatitis during the course of the year.","authors":"Simon Sirtl, Eric Hohmann, Georg Beyer, Jacob Hamm, Albrecht Neesse, Christoph Ammer-Herrmenau","doi":"10.1055/a-2293-7813","DOIUrl":"10.1055/a-2293-7813","url":null,"abstract":"<p><strong>Background/objectives: </strong>Whether seasonality is a factor that influences the incidence of acute pancreatitis (AP) is an under-investigated area. If seasonal incidence peaks can be detected, specifically with regard to biliary pancreatitis, has so far been answered in contradictory ways in the literature.</p><p><strong>Methods: </strong>All AP cases from two tertiary German referral centers were identified between 2016 and 2022 based on ICD-10 discharge codes. The <i>χ2</i> test for goodness of fit was applied to test significant differences in monthly and seasonal distributions of AP admissions.</p><p><strong>Results: </strong>In total, 3597 AP cases were included. We observed significantly more idiopathic and biliary cases in May to July (p-values 0.041 and 0.027, respectively). Furthermore, most drug-induced APs were identified during the winter months (p-value 0.006). Moreover, there was a significant peak of alcohol-induced pancreatitis in summer and fall (p-value 0.038).</p><p><strong>Conclusions: </strong>Our data indicate a seasonal impact on AP incidences for certain etiologies.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"1207-1210"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jule K Adams, Maike R Pollmanns, Miriam Haverkamp, Philipp Hohlstein, Jan Clusmann, Christian Trautwein, Samira Abu Jhaisha, Alexander Koch
{"title":"Atraumatic splenic rupture - unexpected consequences of a world trip.","authors":"Jule K Adams, Maike R Pollmanns, Miriam Haverkamp, Philipp Hohlstein, Jan Clusmann, Christian Trautwein, Samira Abu Jhaisha, Alexander Koch","doi":"10.1055/a-2213-1047","DOIUrl":"10.1055/a-2213-1047","url":null,"abstract":"<p><p>Diagnostic routine and knowledge about the therapy regimes of infectious diseases like malaria gain in importance due to globalization, global warming, and increasing numbers of refugees. We report a case of a 66-year-old patient who presented with severe abdominal pain, most prominent in the left upper abdomen. He was recently hospitalized with severe falciparum malaria, diagnosed after returning from a trip around the world. Upon readmission, laboratory results showed post-artesunate delayed hemolysis. The ultrasound examination was highly suspicious of splenic rupture, confirmed by the immediately performed CT scan. In this case, the prompt diagnosis allowed the initiation of adequate conservative therapy including intensive care monitoring and hemodynamic stabilization.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"1216-1219"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}