Zeitschrift fur Gastroenterologie最新文献

{"title":"[Correction: Version 3.1].","authors":"Thomas Seufferlein, Julia Mayerle, Stefan Boeck, Thomas Brunner, Thomas J Ettrich, Lars Grenacher, Thomas Mathias Gress, Thilo Hackert, Volker Heinemann, Angelika Kestler, Marianne Sinn, Andrea Tannapfel, Ulrich Wedding, Waldemar Uhl","doi":"10.1055/a-2618-6482","DOIUrl":"10.1055/a-2618-6482","url":null,"abstract":"","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"783"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From guidelines to evidence-based practice - A German perspective on mesalazine as first-line therapy for mild-to-moderate ulcerative colitis.","authors":"Elisabeth Schnoy, Axel Dignass, Matthew Gaskins, Torsten Kucharzik","doi":"10.1055/a-2596-8934","DOIUrl":"https://doi.org/10.1055/a-2596-8934","url":null,"abstract":"<p><p>Mesalazine is the first-line treatment for mild-to-moderate ulcerative colitis (UC) of any extent, as recommended by all major international and national guidelines. Approximately 85% of UC cases are classified as mild-to-moderate, making mesalazine a cornerstone therapy for the majority of patients. It rapidly induces clinical response and clinical remission, sustains steroid-free clinical, endoscopic, and histologic remission over the long term, and has a safety profile comparable to placebo. This paper reviews the recommendations for mesalazine use in the German UC guideline and provides practical advice (including do's and don'ts) for their implementation in daily clinical practice. Examples include explaining the expected timeline and nature of the clinical response to mesalazine treatment; outlining the practical implications of the dose-dependency of the drug's therapeutic effect; and emphasizing the importance of rectal mesalazine as the first-line treatment for proctitis. Additionally, we conducted a systematic literature search to evaluate whether mesalazine should be continued after escalation to biologics or small molecules. While no clear evidence of short-term clinical benefit was found, there was also no evidence of harm. In light of the potential long-term chemoprotective effect of mesalazine, continuation may be considered on a case-by-case basis. Lastly, we provide an overview of the various mesalazine formulations available in Germany, detailing how they are not interchangeable due to differences in drug-release profiles, excipients, and dosing strengths. Understanding these differences may help clinicians personalize treatment, improving adherence and clinical outcomes.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In memoriam: John S. Fordtran (1931-2025) Honorary Member of the Austrian Society of Gastroenterology and Hepatology.","authors":"","doi":"10.1055/a-2602-7792","DOIUrl":"https://doi.org/10.1055/a-2602-7792","url":null,"abstract":"","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 6","pages":"689"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Guideline report of the updated S3 guideline \"Rare liver diseases (LeiSe LebEr) - Autoimmune liver diseases from paediatrics to adulthood\" of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS)].","authors":"Nadine Fischer, Paul Freudenberger, Ansgar W Lohse, Pia Lorenz, Petra Lynen Jansen, Marcial Sebode, Nadine Steubesand","doi":"10.1055/a-2558-5300","DOIUrl":"https://doi.org/10.1055/a-2558-5300","url":null,"abstract":"","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 6","pages":"366-388"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[S3 guideline \"Rare liver diseases (LeiSe LebEr) - Autoimmune liver diseases from paediatrics to adulthood\" of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS)].","authors":"","doi":"10.1055/a-2558-5204","DOIUrl":"https://doi.org/10.1055/a-2558-5204","url":null,"abstract":"","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 6","pages":"604-688"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evidence-based guidelines in gastroenterological medical care: a survey among members of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS) on acceptance, application and optimization].","authors":"Joschka Bachmann, Pia Lorenz, Lars Klug, Ulrike Denzer, Heiner Wedemeyer, Petra Lynen Jansen","doi":"10.1055/a-2571-6123","DOIUrl":"10.1055/a-2571-6123","url":null,"abstract":"<p><p>Evidence-based guidelines are an important basis for medical action. The methodological effort to develop guidelines is high. Nevertheless, a high methodological effort in the development of guidelines does not automatically guarantee the success of a guideline, but it must be ensured that guidelines are also accepted and thus applied. Currently (as of October 2024), 28 guidelines are available, which were created under the leadership of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS). How these guidelines are perceived and used in everyday clinical practice and what obstacles exist in their implementation has been little researched so far.This study examines the acceptance and use of the DGVS guidelines with the aim of optimizing the guideline process and implementation.A questionnaire with 32 questions was designed, which included closed questions, Likert scales and free-text answers. The questionnaire was sent by e-mail to 7015 DGVS members. Answering the questionnaire was anonymous and voluntary. In subgroup analyses, physicians in outpatient care, hospitals and university hospitals, as well as physicians with or without experience in guideline development were compared.604 responses were evaluated (response rate 8.6%). The DGVS guidelines are ubiquitously well known and are considered extremely useful by 66% of respondents. They are the main source of information in everyday clinical practice, but their structure is considered to need improvement. Users trust the quality of guidelines regardless of the guideline classification. There are subgroup differences regarding the extent of use or the various reasons for the use of guidelines. In outpatient care, guidelines are more often used to protect oneself against causing a medical error compared to university hospitals, and the avoidance of overtreatment generally seems to be more important at non-university hospitals.Overall, the DGVS guidelines are rated positively. In different areas of medical practice there are different wishes and requirements for guidelines. Improving the topicality of the guidelines is the priority for most respondents. Further starting points for improvement are the structure of the guidelines and focusing on relevant content for everyday cliclinical practice, especially in outpatient care.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"571-584"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic findings of Bouveret syndrome.","authors":"Johann von Felden, Julian Schulze Zur Wiesch, Tarik Ghadban, Thomas Rösch, Karsten Ohlhoff","doi":"10.1055/a-2515-3808","DOIUrl":"10.1055/a-2515-3808","url":null,"abstract":"<p><p>Bouveret syndrome is a rare complication of gallstone disease. We present a 76-year old male patient in whom the diagnosis was complicated by the reporting of coffee-ground emesis suggesting upper gastrointestinal bleeding. Considering the diagnosis of Bouveret syndrome is commonly made through cross-sectional imaging, these patients rarely undergo diagnostic endoscopy. However, this case presented with typical findings during emergency esophagogastroduodenoscopy (EGD) underscoring its educational value for gastroenterologists and endoscopists.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"593-595"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Safety and Care After Outpatient Endoscopic Retrograde Cholangiopancreatography (ERCP): A Single-Center Experience in Germany.","authors":"Kien Vu Trung, Juergen Feisthammel, Albrecht Hoffmeister, Thomas Karlas","doi":"10.1055/a-2543-3380","DOIUrl":"10.1055/a-2543-3380","url":null,"abstract":"<p><p>The current goal of adapting care structures in the German healthcare system is to increase the provision of interventional treatments in outpatient settings. Endoscopic Retrograde Cholangiopancreatography (ERCP) procedures were traditionally performed in an inpatient setting until 2022. However, with the introduction of a new Ambulatory Surgery Contract (according to Section 115b, Paragraph 1 of the Social Code, Book V) on January 1, 2023, these procedures are now intended to be carried out more strictly on an outpatient basis, meaning that hospitalization will no longer be reimbursed in most cases.Between June 1, 2023, and December 31, 2023 all ERCP procedures performed in an outpatient setting were included in this study. This cohort had standard ERCP indications and a low comorbidity burden according to the §115b specifications. Using propensity score matching (nearest-neighbor), these cases were matched with patients who underwent ERCP procedures in an inpatient setting between June 1, 2022, and December 31, 2022.Propensity-score matching identified a cohort of 166 patients (83 outpatients and 83 inpatients) with similar baseline characteristics. The most common indications for ERCP were choledocholithiasis and biliary strictures. Reported complications comprised pancreatitis, bleeding and cholangitis and were rare in both groups, occurring in 7% of inpatient procedures and in 6% of outpatient procedures. The latter cases required inpatient admission after self-presenting to the emergency department. No serious adverse events were reported.Outpatient ERCP is a safe procedure for selected patients with a low risk profile. Complications occurred rarely and could be adequately managed.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"585-592"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Therapeutics and (hypothetical) vaccinations against human cryptosporidia].","authors":"Yannick Borkens","doi":"10.1055/a-2551-1670","DOIUrl":"10.1055/a-2551-1670","url":null,"abstract":"<p><p><i>Cryptosporidium</i> (or cryptosporidiosis caused by them) is one of the most relevant infections of the intestinal tract. The unicellular parasites infect the intestinal cells and cause cramps, weight loss and diarrhea. Cryptosporidia play a special role in AIDS patients. Here they are counted among the diseases that define the acquired immunodeficiency syndrome. Because of this relevance, the search for vaccines is a relevant goal of gastroenterological research. But how realistic are such vaccines? This article describes the disease cryptosporidiosis and reviews current therapeutics and hypothetical vaccine candidates.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"596-603"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Well-differentiated Adenocarcinoma Arising from Gastric Cystica Profunda Treated by Endoscopic Submucosal Dissection: A case report and literature review.","authors":"Cao Huang, Jiang Liu","doi":"10.1055/a-1920-4161","DOIUrl":"10.1055/a-1920-4161","url":null,"abstract":"<p><p>Gastritis cystica profunda (GCP) is a rare disease that is often observed at the stoma site of patients undergoing gastric surgery. Specific symptoms are often lacking, making it difficult to diagnose. GCP may develop into cancer. Endoscopic resection is a good method to reduce surgical injury, and the therapeutic effect depends on the status of the primary disease.The patient was a 77-year-old male who was admitted to the hospital for repeated epigastric distention. The man had never undergone gastric surgery and did not have <i>Helicobacter pylori</i> infection. Physical and laboratory tests showed no abnormality. Computed tomography showed no significant abnormality. Endoscopy revealed multiple ulcers on the posterior wall of the gastric body, but biopsy showed no evidence of malignancy. The patient subsequently underwent ESD surgery with a lesion of 1.5 cm×2.3 cm. Pathological results showed the cystic dilatation of gastric glands in the submucosa, with some well-differentiated adenocarcinoma. The final diagnosis was GCP with well-differentiated gastric adenocarcinoma.Herein, we describe a case of ESD therapy for GCP with well-differentiated gastric adenocarcinoma. When gastric mucosal lesions are difficult to diagnose, further treatment and diagnosis with EMR or ESD can be considered. For patients with early gastric cancer, long-term postoperative monitoring should be carried out.</p>","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"497-501"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}