Zeitschrift fur Gastroenterologie最新文献

[40-year-old-patient with perianal pain, signs of inflammation and stool retention]. [40岁，肛周疼痛，有炎症和大便潴留的征象]。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.1055/a-2446-1043

Martin Killermann, Edith Weigert, Marc Dauer

引用次数: 0

[Percutaneous endoscopic gastrostomy in a 42-year-old patient with suspected variant of Creutzfeld Jakob disease using a disposable bronchoscope]. [使用一次性支气管镜为一名 42 岁疑似克雅氏病变异型患者进行经皮内镜胃造瘘术]。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI: 10.1055/a-2406-9419

Michael Klausner, Roman Feller, Wolfgang Vogt, Henning Wege

引用次数: 0

Tissue Determinants of Antiviral Immunity in the Liver. 肝脏中抗病毒免疫的组织决定因素。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.1055/a-2365-3900

Dirk Wohlleber, Percy A Knolle

{"title":"Tissue Determinants of Antiviral Immunity in the Liver.","authors":"Dirk Wohlleber, Percy A Knolle","doi":"10.1055/a-2365-3900","DOIUrl":"10.1055/a-2365-3900","url":null,"abstract":"The liver is an organ bearing important metabolic and immune functions. Hepatocytes are the main metabolically active cells of the liver and are the target of infection by hepatotropic viruses. Virus-specific CD8 T cells are essential for the control of hepatocyte infection with hepatotropic viruses but may be subject to local regulation of their effector function. Here, we review our current knowledge of the tissue determinants of antiviral immunity in the liver. Liver Sinusoidal Endothelial Cells (LSECs) not only allow through their fenestrations the access of circulating virus-specific CD8 T cells to engage in direct contact with infected hepatocytes without the need for extravasation but also cross-present viral antigens released from infected hepatocytes to these CD8 T cells. Two important features of LSECs and hepatocytes contribute to antiviral immune surveillance and liver failure. First, CD8 T cell immunity targeting LSECs leads to widespread endothelial cell death and results in sinusoidal microcirculation failure, causing fulminant viral hepatitis, whereas immune-mediated loss of hepatocytes is rapidly compensated by the regenerative capacity of the liver. Second, virus-infected hepatocytes support clearance of infection by responding to TNF, which is released from virus-specific CD8 T cells, with the selective induction of apoptosis. This increased sensitivity for TNF-induced death is caused by reduced mitochondrial resilience in virus-infected hepatocytes and may assist antiviral immunity in preferential targeting of virus-infected hepatocytes. Thus, hepatocytes and LSECs actively contribute to the outcome of antiviral CD8 T cell immunity in the liver. The knowledge of the mechanisms determining CD8 T cell control of hepatotropic viral infection will help to improve strategies to increase antiviral immune surveillance.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 1","pages":"65-72"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Significant increase in newly diagnosed hepatitis B and C cases in Germany due to screening]. [德国新诊断的乙型和丙型肝炎病例因筛查而显著增加]。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI: 10.1055/a-2435-5069

Dietrich Hüppe, Yvonne Serfert, Markus Cornberg, Heiner Wedemeyer

{"title":"[Significant increase in newly diagnosed hepatitis B and C cases in Germany due to screening].","authors":"Dietrich Hüppe, Yvonne Serfert, Markus Cornberg, Heiner Wedemeyer","doi":"10.1055/a-2435-5069","DOIUrl":"10.1055/a-2435-5069","url":null,"abstract":"In 2016, the World Health Organization (WHO) decided on an initiative to identify 90% of the world's existing hepatitis B and C virus infections by 2030, treat 80% and reduce the mortality by 65%. In 2016, the federal government endorsed these goals. From Oct 1, 2021, the G-BA included a one-time screening for hepatitis B and C in the health examination (GU) for people aged 35 and over who have statutory health insurance. The previous participation rates in the GU were evaluated and the effectiveness of the program is documented using the reporting data on hepatitis B and C of Robert Koch Institute (RKI).Notifications from Central Institute of Statutory Health Insurance (ZI) and Scientific Institute of the local health insurance companies (WIdO) were compiled with regard to the GU, the reporting data from the RKI were collected and analyzed using SURVSTAT@RKI 2.0 as well as billing data from the Association of Statutory Health Insurance Physicians (KBV).Between 2007 and 2021, around 83% of all insured persons took part in a GU at least once. From the fourth quarter of 2021, the number of newly diagnosed cases of hepatitis B and C increased. In 2022, the increase for hepatitis B was 91.9% and for hepatitis C 68%. This trend continued in 2023, with new diagnoses of hepatitis B increasing by 160% (to 22,795 cases) and hepatitis C increasing by 121% (to 10,508 cases) compared to 2021. The analysis of the KBV billing data showed that the increase in new diagnoses shows a strong correlation between the number of new diagnoses within the GU and the total number of diagnoses.The decision of the Federal Joint Committee (G-BA) to include hepatitis B and C screening in the GU seems to be a success in detecting previously undetected cases of the disease. Based on the billing data from the KBV, a high level of agreement could be demonstrated between the number of new diagnoses within the GU and the increase in the total number of diagnoses. The goals of the WHO may be achievable.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"31-38"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver damage and immune responses. 肝损伤和免疫反应。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.1055/a-2365-3796

Carl-Philipp Hackstein

{"title":"Liver damage and immune responses.","authors":"Carl-Philipp Hackstein","doi":"10.1055/a-2365-3796","DOIUrl":"https://doi.org/10.1055/a-2365-3796","url":null,"abstract":"Chronic liver disease (CLD) has massive systemic repercussions including major impacts on the body's immune system. Abnormalities in phenotype, function and numbers of various immune cell subsets have been established by a large number of clinical and pre-clinical studies. The loss of essential immune functions renders CLD-patients exceptionally susceptible to bacterial and viral infections and also impairs the efficacy of vaccination. Consequently, infections represent a major clinical issue causing significant morbidity and mortality in these patients. Mechanistically, the immune dysfunction associated with CLD results from the increased translocation of bacteria and bacterial cues from the intestine. These trigger a signaling axis around the cytokines IFN I and IL-10 in hepatic myeloid cells, which aside from impairing the function of the myeloid cells themselves, also has notable negative impacts on the functionality of other immune cells. T cells in CLD-patients and -models are especially affected by this signaling axis and display a variety of quantitative and qualitative defects. Due to the high clinical relevance, understanding the mechanisms underlaying CED-associated immune dysfunction is of critical importance to discover and develop new therapeutic targets.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 1","pages":"56-64"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Gastric electrostimulation in refractory gastroparesis: results of a explorative observational study]. 胃电刺激治疗难治性胃轻瘫：一项探索性观察研究的结果。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.1055/a-2451-0116

Igors Iesalnieks, Natascha von Rebay, Robert Patejdl, Maximilian Tiller, Tobias Müller, Florian Schertl, Holger Seidl, Sophia Patejdl, Martin Motschmann, Sebastian Roggenbrod, Ayman Agha, Wolfgang Schepp, Felix Gundling

{"title":"[Gastric electrostimulation in refractory gastroparesis: results of a explorative observational study].","authors":"Igors Iesalnieks, Natascha von Rebay, Robert Patejdl, Maximilian Tiller, Tobias Müller, Florian Schertl, Holger Seidl, Sophia Patejdl, Martin Motschmann, Sebastian Roggenbrod, Ayman Agha, Wolfgang Schepp, Felix Gundling","doi":"10.1055/a-2451-0116","DOIUrl":"https://doi.org/10.1055/a-2451-0116","url":null,"abstract":"High-frequency electrical stimulation therapy (gastric electrical stimulation, GES) is a treatment option for gastroparesis of various genesis. The best indication and prognostic parameters have not yet been conclusively determined.Retrospective analysis of all gastroparesis patients implanted with a GES device between 2011 and 2020. Clinical response was measured before and after implantation using a validated Gastroparesis Cardinal Symptom Index (GCSI) (maximum score: 5, minimum score: 0). Other study endpoints included: subjective symptom course (no improvement, partial improvement, or severe improvement) and change in gastroparesis medication.A GES device was implanted in 42 patients (16 M: 26 F, mean age 45 years). The etiology of gastroparesis was diabetic (n=23), idiopathic (n=10) or postoperative (n=9). Eleven patients (26%) had undergone one or more invasive treatments before. GCSI score of the total group was 3.23 preoperatively. The median follow-up time was 12 months. In the overall group, significant improvement in GCSI score was found 3, 6, 9, and 12 months postoperatively-regardless of indication. In multivariate analysis, disease duration of >30 months was associated with a significantly decreased GCSI score at 12 months (p<0.001). Approximately 40% of patients were able to discontinue or significantly reduce gastroparesis medication. At the end of follow-up, 81% of patients reported partial or major improvement in symptoms. During the follow-up period, three patients (7%) died.Gastric electrical neurostimulation is an effective and safe option for refractory gastroparesis-regardless of the underlying disease.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 1","pages":"39-48"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alveolar Echinococcosis - Diagnostic challenges of a parasitic disease on the rise in Europe - a case report. 肺泡棘球蚴病--一种在欧洲呈上升趋势的寄生虫病的诊断难题--病例报告。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI: 10.1055/a-2414-1320

Jonas Schumacher, Henning Trawinski, Hans-Michael Tautenhahn, Hendrik Bläker, Johannes Wiegand

{"title":"Alveolar Echinococcosis - Diagnostic challenges of a parasitic disease on the rise in Europe - a case report.","authors":"Jonas Schumacher, Henning Trawinski, Hans-Michael Tautenhahn, Hendrik Bläker, Johannes Wiegand","doi":"10.1055/a-2414-1320","DOIUrl":"10.1055/a-2414-1320","url":null,"abstract":"A 45-year-old male presented with jaundice, abdominal discomfort, and weight loss. Abdominal ultrasound revealed intrahepatic cholestasis and cholelithiasis indicative of Caroli-syndrome. Subsequent magnetic resonance imaging demonstrated a corresponding 5 × 4 cm polycyclic, calcified mass and a distant 12 mm subhilar stenosis of the common bile duct resembling cholangiocarcinoma. Calcifications seemed unusual and brought up differential diagnosis of echinococcosis. Serology revealed an echinococcus antibody-titer of 33 U (cut-off > 11.5 U). However, the clinical presentation with jaundice, weight loss, and a distant subhilar stenosis of the common bile duct without association to the intrahepatic process led to underestimation of the positive antibody-titer. Thus, the patient underwent right hemihepatectomy for potential cholangiocarcinoma. Dense infiltrative small cysts interspersed the resected right lobe of the liver. Histopathology revealed a granulomatous inflammation surrounding typical cuticulas, confirming hepatobiliary alveolar echinococcosis. Alveolar echinococcosis is considered as one of the neglected diseases by the World Health Organization, although incidence is rising worldwide and specifically in Germany. Our case illustrates hurdles in diagnosing alveolar echinococcosis and underlines the importance to be aware of classical and rare clinical manifestations.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"49-52"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysphagia with recurrent severe aspiration due to cervical diffuse idiopathic skeletal hyperostosis (Forestier's disease). 颈椎弥漫性特发性骨骼增生症（弗雷斯蒂埃病）导致吞咽困难和反复严重吸入。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2024-12-01 Epub Date: 2024-09-25 DOI: 10.1055/a-2367-8409

Seyed Alireza Shahvaran, Martin Kliment, Stefan Prax, Tobias Paul, Oliver Heese, Daniel Schmitz

引用次数: 0

Amendment "New nomenclature for MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)" to the S2k guideline "Non-alcoholic fatty liver disease" (v.2.0/April 2022) of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS). 德国胃肠病学、消化和代谢疾病学会（DGVS） S2k指南“非酒精性脂肪性肝病”（v2.0 / 2022年4月）修订“MASLD（代谢功能障碍相关脂肪性肝病）的新命名法”。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2024-12-01 Epub Date: 2024-12-06 DOI: 10.1055/a-2408-3429

引用次数: 0

[DRESS as a rare differential diagnosis in eosinophilia, skin rash and acute hepatitis]. [DRESS 是嗜酸性粒细胞增多症、皮疹和急性肝炎的罕见鉴别诊断]。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2024-12-01 Epub Date: 2024-05-15 DOI: 10.1055/a-2300-0620

Daniela Prechal, David Arntzen, Lioba Klaas, Maren Paulmann, Maja Mockenhaupt, Robert Thimme, Marcus Schuchmann

{"title":"[DRESS as a rare differential diagnosis in eosinophilia, skin rash and acute hepatitis].","authors":"Daniela Prechal, David Arntzen, Lioba Klaas, Maren Paulmann, Maja Mockenhaupt, Robert Thimme, Marcus Schuchmann","doi":"10.1055/a-2300-0620","DOIUrl":"10.1055/a-2300-0620","url":null,"abstract":"A 21-year-old female patient presented with fever, pharyngitis, lymphadenopathy and generalized exanthema that had started 2 weeks prior. Allergies were not known, the family and travel history were negative. Due to depression, Duloxetine had been taken for 1.5 years, and due to bipolar disorder, a treatment with Lamotrigine was started four weeks prior but was stopped because of increased transaminase levels. Laboratory findings on admission showed eosinophilia (1.327 /nl), lymphocytosis and acute hepatitis (GOT 428 U/l, GPT 438 U/l) with deranged coagulation. Inflammatory parameters were increased. Ultrasound revealed hepatosplenomegaly with ascites. Acute viral or parasitic infection was excluded serologically. A skin biopsy showed a perivascular inflammatory infiltrate, compatible with a drug reaction. An inflammatory infiltrate was found in the liver biopsy, consistent with drug-induced hepatitis. Cough, dyspnea and pleural effusion occurred. In summary of the findings and with the help of the RegiSCAR-Score, the diagnosis of drug reaction with eosinophilia and systemic symptoms (DRESS) could be made. Under high-dose prednisolone therapy, a gradual decrease of transaminases and reconstitution of liver synthesis could be observed.In patients with eosinophilia, lymphadenopathy, acute hepatitis and generalized exanthema, DRESS is a rare but-due to its potentially life-threatening consequences-important differential diagnosis. The most important measure is to stop the suspected inducing medication immediately. Severe cases should be treated with high-dose systemic corticosteroids.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"2056-2060"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0