Zeitschrift fur Gastroenterologie最新文献

Effect of Bacteroides on Crohn's disease. Bacteroides 对克罗恩病的影响。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-04-01 Epub Date: 2024-11-25 DOI: 10.1055/a-2435-2659

Xuanyu Wei, Dong Tang

引用次数: 0

[Guideline on functional dyspepsia, a disorder of gut-brain-interaction (DGBI): S1 Guideline of the German Society for Neurogastroenterology and Motility (DGNM)].

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-04-01 Epub Date: 2025-04-08 DOI: 10.1055/a-2518-1430

Martin Storr, Viola Andresen, Thomas Frieling, Jürgen M Gschossmann, Jutta Keller, Jost Langhorst, Christian Pehl, Andreas Stengel, Johannes Tebbe, Kai Wiemer, Ahmed Madisch, Miriam Stengel

引用次数: 0

Severe gastroparesis complicated by gastric perforation caused by lightchain amyloidosis. 轻链淀粉样变性引起的严重胃痉挛并发胃穿孔。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-04-01 Epub Date: 2024-11-25 DOI: 10.1055/a-2442-7944

Michael Rietz, Tobias Weber, Tina Schaller, Jan Hendrik Luitjens, Luise Uhrmacher, Helmut Messmann, Andreas Probst

{"title":"Severe gastroparesis complicated by gastric perforation caused by lightchain amyloidosis.","authors":"Michael Rietz, Tobias Weber, Tina Schaller, Jan Hendrik Luitjens, Luise Uhrmacher, Helmut Messmann, Andreas Probst","doi":"10.1055/a-2442-7944","DOIUrl":"10.1055/a-2442-7944","url":null,"abstract":"AL-Amyloidosis is a rare systemic disease that can occur in patients with monoclonal gammopathy or multiple myeloma. As multiple organs may be affected by deposition of amyloid fibrils, the clinical presentation varies considerably, and the diagnostic process may be challenging.We report on a 59-year-old female who suffered from gastroesophageal reflux symptoms, nausea, epigastric pain, and meteorism over several years. Repeated upper GI endoscopies including biopsies and CT scans were unremarkable except for unspecific enlargement of mesenterial lymph nodes.A few weeks after a surgical hiatal hernia repair with fundoplication, the patient developed massive distension of the stomach and the proximal duodenum resulting in gastric perforation. Histopathological staining of gastric biopsies and mesenterial lymph nodes using hematoxylin and eosin was unremarkable. Because of endoscopic findings (submucosal hematomas, and ulcerations) and the unexplained severe motility disorder, histopathological staining was performed using Congo red. Extensive amyloid deposits were seen. Further workup confirmed AL amyloidosis caused by monoclonal gammopathy. Specific oncological treatment was started.The rare differential diagnosis of amyloidosis should be taken into account in patients with unexplained motility disorders, unspecific gastrointestinal symptoms, and abdominal lymphadenopathy. In the presented case, delayed diagnosis of AL amyloidosis in the gastrointestinal tract led to severe gastroparesis resulting in gastric perforation. Specific histopathologic staining can confirm the diagnosis.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"387-392"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Landscape and Treatment Paradigms of Hepatocellular and Cholangiocarcinoma: A Multinational Review.

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-03-31 DOI: 10.1055/a-2548-0108

Kristijan Skok, Judith Stift, Peter Schirmacher, Karl Kashofer, Rudolf Stauber, Branislava Ranković, Karoline Lackner

{"title":"Molecular Landscape and Treatment Paradigms of Hepatocellular and Cholangiocarcinoma: A Multinational Review.","authors":"Kristijan Skok, Judith Stift, Peter Schirmacher, Karl Kashofer, Rudolf Stauber, Branislava Ranković, Karoline Lackner","doi":"10.1055/a-2548-0108","DOIUrl":"https://doi.org/10.1055/a-2548-0108","url":null,"abstract":"Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) represent the most prevalent primary liver cancers and pose significant challenges in oncology. While their etiology and incidence vary globally, the molecular landscape of these tumors is increasingly understood, offering new opportunities for precision medicine. In this joint multinational review, we present a comprehensive analysis of the key molecular pathways involved in the pathogenesis of HCC and CCA, highlighting actionable targets for emerging therapies. Recent advances in molecular diagnostics have significantly influenced treatment paradigms for both cancers. In HCC, while genetic alterations have not yet led to established diagnostic or therapeutic applications, targeting vascular endothelial growth factor (VEGF), immune checkpoints, and tyrosine kinase pathways has demonstrated considerable therapeutic potential. In CCA, genetic profiling has uncovered actionable alterations, such as FGFR2 fusions and IDH1 mutations, driving the development of targeted therapies. The growing complexity of precision oncology underscores the need for standardized molecular testing and streamlined diagnostic workflows to ensure timely and effective treatment. This review also emphasizes the importance of collaborative efforts between clinicians, pathologists, and oncologists to optimize outcomes. By synthesizing the latest molecular insights and treatment trends, this review provides a valuable resource to guide the personalized management of HCC and CCA.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Podcasts for psychoeducation in irritable bowel syndrome: A mixed-methods analysis].

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-03-31 DOI: 10.1055/a-2550-9549

Pia Gerhold, Bernd Löwe, Samuel Huber, Angelika Weigel

{"title":"[Podcasts for psychoeducation in irritable bowel syndrome: A mixed-methods analysis].","authors":"Pia Gerhold, Bernd Löwe, Samuel Huber, Angelika Weigel","doi":"10.1055/a-2550-9549","DOIUrl":"https://doi.org/10.1055/a-2550-9549","url":null,"abstract":"Irritable bowel syndrome (IBS) constitutes a significant proportion of gastroenterological consultations. Psychoeducation for IBS can improve clinical outcomes. Podcasts might be a valuable medium for psychoeducation. The aim of this study was therefore to evaluate German-language podcasts on IBS with regard to their suitability for patient education and to identify both podcast recommendations and practice-oriented formulation examples for practitioners.In a key date survey, podcasts produced by specialists on explanatory models of IBS were identified and a mixed methods analysis conducted. Content was evaluated quantitatively using a guideline-based checklist and qualitatively using a thematic analysis for an in-depth analysis of the contained explanatory models.From a total of 132 identified podcast episodes, 53 (duration M = 31 minutes, SD = 15.5) were included in the analysis. On average, the podcast episodes scored 16 out of a possible 60 points, with the best-rated episode scoring 37 points. Alongside helpful formulation examples, the qualitative analysis revealed stigmatizing to misleading statements.Podcasts comprise high-quality explanatory models for IBS. Practitioners can use a combination of podcast episodes as a valuable resource to facilitate psychoeducation.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic findings of Bouveret syndrome.

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-03-31 DOI: 10.1055/a-2515-3808

Johann von Felden, Julian Schulze Zur Wiesch, Tarik Ghadban, Thomas Rösch, Karsten Ohlhoff

引用次数: 0

Patient Safety and Care After Outpatient Endoscopic Retrograde Cholangiopancreatography (ERCP): A Single-Center Experience in Germany.

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-03-31 DOI: 10.1055/a-2543-3380

Kien Vu Trung, Juergen Feisthammel, Albrecht Hoffmeister, Thomas Karlas

{"title":"Patient Safety and Care After Outpatient Endoscopic Retrograde Cholangiopancreatography (ERCP): A Single-Center Experience in Germany.","authors":"Kien Vu Trung, Juergen Feisthammel, Albrecht Hoffmeister, Thomas Karlas","doi":"10.1055/a-2543-3380","DOIUrl":"https://doi.org/10.1055/a-2543-3380","url":null,"abstract":"The current goal of adapting care structures in the German healthcare system is to increase the provision of interventional treatments in outpatient settings. Endoscopic Retrograde Cholangiopancreatography (ERCP) procedures were traditionally performed in an inpatient setting until 2022. However, with the introduction of a new Ambulatory Surgery Contract (according to Section 115b, Paragraph 1 of the Social Code, Book V) on January 1, 2023, these procedures are now intended to be carried out more strictly on an outpatient basis, meaning that hospitalization will no longer be reimbursed in most cases.Between June 1, 2023, and December 31, 2023 all ERCP procedures performed in an outpatient setting were included in this study. This cohort had standard ERCP indications and a low comorbidity burden according to the §115b specifications. Using propensity score matching (nearest-neighbor), these cases were matched with patients who underwent ERCP procedures in an inpatient setting between June 1, 2022, and December 31, 2022.Propensity-score matching identified a cohort of 166 patients (83 outpatients and 83 inpatients) with similar baseline characteristics. The most common indications for ERCP were choledocholithiasis and biliary strictures. Reported complications comprised pancreatitis, bleeding and cholangitis and were rare in both groups, occurring in 7% of inpatient procedures and in 6% of outpatient procedures. The latter cases required inpatient admission after self-presenting to the emergency department. No serious adverse events were reported.Outpatient ERCP is a safe procedure for selected patients with a low risk profile. Complications occurred rarely and could be adequately managed.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Rethinking Endoscopy: Strategies from Aviation and their Transfer to Medicine - An Overview].

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-03-28 DOI: 10.1055/a-2545-9524

Dominik Schweikart, Matthias Baur, Dominique Walter, Benjamin Walter

{"title":"[Rethinking Endoscopy: Strategies from Aviation and their Transfer to Medicine - An Overview].","authors":"Dominik Schweikart, Matthias Baur, Dominique Walter, Benjamin Walter","doi":"10.1055/a-2545-9524","DOIUrl":"https://doi.org/10.1055/a-2545-9524","url":null,"abstract":"The demands on modern endoscopy have grown rapidly in various areas in recent decades. These include challenges for the endoscopy team due to more demanding interventional procedures, but also the rapidly changing conditions that today's working reality entails. In order to continue to meet the necessary safety and quality standards, it can help to look at similarly complex areas such as civil aviation to find inspiration for effective concepts in endoscopy.Crew Resource Management (CRM) and Threat and Error Management (TEM) are important concepts from civil aviation that currently make aviation the safest mode of transportation in the world. Elements such as communication, teamwork, situational awareness, decision-making and an open error culture can also be used in medicine. Some of these have already been successfully transferred to acute medical areas by using CRM-based training and general or specific checklists. In order to also benefit as much as possible from the findings in endoscopy, workshops tailored to the individual requirements of the respective endoscopy unit are available, in which measures can be developed in collaboration with professional CRM trainers. Examples of this would be a standardized communication guideline for endoscopic procedures, a pre-interventional safety checklist or a TEM-based dialogical team time-out. After implementation, regular evaluation and further development of the measures are essential for long-term success.Elements transferred from civil aviation have the potential to promote communication, situation-aware teamwork, structured decision-making and an open error culture in endoscopic teams and thus contribute to safe and high-quality interventions.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Correction: Position paper of the Society for Paediatric Gastroenterology and Nutrition (GPGE) on the off-label use of biologics and signal inhibitors in children and adolescents with IBD that have already been approved for adults].

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-03-01 Epub Date: 2025-03-05 DOI: 10.1055/a-2543-1671

Jan Däbritz, Martin Classen, Kathrin Krohn, Andreas Krahl, Stephan Buderus, Elke Lainka, Jan de Laffolie, Carsten Posovszky

引用次数: 0

Mirikizumab for the treatment of chronic antibiotic-refractory pouchitis. 米利珠单抗用于治疗慢性抗生素难治性肠袋炎。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-03-01 Epub Date: 2024-09-25 DOI: 10.1055/a-2404-4518

Johannes Reiner, Anne-Sophie Becker, Astrid Huth, Georg Lamprecht, Maria Witte

引用次数: 0