Zeitschrift fur Gastroenterologie最新文献

[Correction: AWMF-Registernummer: 032-010OL - Leitlinie (Kurzversion)]. [更正：AWMF注册号：032-010OL -指南（短版本）]。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-27 DOI: 10.1055/a-2618-6445

Thomas Seufferlein, Julia Mayerle, Stefan Boeck, Thomas Brunner, Thomas J Ettrich, Lars Grenacher, Thomas Mathias Gress, Thilo Hackert, Volker Heinemann, Angelika Kestler, Marianne Sinn, Andrea Tannapfel, Waldemar Uhl, Ulrich Wedding

引用次数: 0

[Correction: Version 3.1]. [更正：3.1版]。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-27 DOI: 10.1055/a-2618-6482

Thomas Seufferlein, Julia Mayerle, Stefan Boeck, Thomas Brunner, Thomas J Ettrich, Lars Grenacher, Thomas Mathias Gress, Thilo Hackert, Volker Heinemann, Angelika Kestler, Marianne Sinn, Andrea Tannapfel, Ulrich Wedding, Waldemar Uhl

引用次数: 0

A narrative review on alcohol and alimentary tract cancer with special emphasis on acetaldehyde and oxidative stress. 关于酒精和消化道癌症的综述，特别强调乙醛和氧化应激。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-16 DOI: 10.1055/a-2588-6849

Helmut Karl Seitz

{"title":"A narrative review on alcohol and alimentary tract cancer with special emphasis on acetaldehyde and oxidative stress.","authors":"Helmut Karl Seitz","doi":"10.1055/a-2588-6849","DOIUrl":"https://doi.org/10.1055/a-2588-6849","url":null,"abstract":"Approximately 4% of all cancer cases worldwide are caused by alcohol consumption (oropharynx, larynx, esophagus, stomach, colorectum, liver and the female breast). Various mechanisms contribute to ethanol-mediated carcinogenesis, including the action of acetaldehyde, the first metabolite of ethanol oxidation and oxidative stress primarily promoted through the induction of cytochrome P4502E1. Acetaldehyde is toxic and carcinogenic, binds to DNA and proteins, inhibits the oxidative defense- and the nuclear repair system, and prevents DNA methylation. High levels of acetaldehyde occur through increased production in the presence of a hyperactive alcohol dehydrogenase (ADH1C*1,1) or decreased degradation in the presence of low active aldehyde dehydrogenase (ALDH2*1,2). In addition, microbes of the upper alimentary tract and the colorectum effectively produce acetaldehyde from ethanol. In addition, ethanol induces cytochrome P4502E1 resulting in an enhanced ethanol metabolism and the generation of reactive oxygen species (ROS). ROS may cause lipid peroxidation (LPO) with the LPO-products 4-hydroxynonenal or malondialdehyde, which may form highly carcinogenic etheno DNA-adducts CYP2E1 is also involved in the activation of a variety of dietary and tobacco procarcinogens and in the degradation of retinoic acid. Alcohol also influences tumor promotion, such as epigenetics with a change in DNA methylation and histone modification, and affects a variety of cancer genes and signaling pathways. Preventive measures include reducing alcohol consumption, quitting smoking and keeping good oral hygiene. Alcohol consumers - especially when they smoke or belong to genetic risk groups - should be regularly checked for cancer of the upper alimentary tract, for alcohol- associated liver disease, and for breast cancer. Cessation or reduction of alcohol consumption definitively reduces cancer risk.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clinical Ultrasound Part II - Sonopsychology or Psychological Interactions using Ultrasound]. [临床超声第二部分-超声心理学或使用超声的心理相互作用]。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-15 DOI: 10.1055/a-2581-4225

Claudia Lucius, Christian Jenssen, Dieter Nürnberg, Daniel Merkel, Dagmar G Schreiber-Dietrich, Eberhard Merz, Christoph F Dietrich

引用次数: 0

Evaluating Resmetirom Eligibility Among Patients with MASH: Insights from the German Steatotic Liver Disease-Registry. 评价雷美替罗在MASH患者中的应用资格：来自德国脂肪肝疾病登记处的见解。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-15 DOI: 10.1055/a-2592-6109

Eva Katharina Messer, David Petroff, Jörn Schattenberg, Stefan Zeuzem, Manfred von der Ohe, Leopold Ludwig, Münevver Demir, Peter Buggisch, Kerstin Stein, Yvonne Serfert, Heiner Wedemeyer, Thomas Berg, Wolf P Hofmann, Andreas Geier, Johannes Wiegand

{"title":"Evaluating Resmetirom Eligibility Among Patients with MASH: Insights from the German Steatotic Liver Disease-Registry.","authors":"Eva Katharina Messer, David Petroff, Jörn Schattenberg, Stefan Zeuzem, Manfred von der Ohe, Leopold Ludwig, Münevver Demir, Peter Buggisch, Kerstin Stein, Yvonne Serfert, Heiner Wedemeyer, Thomas Berg, Wolf P Hofmann, Andreas Geier, Johannes Wiegand","doi":"10.1055/a-2592-6109","DOIUrl":"https://doi.org/10.1055/a-2592-6109","url":null,"abstract":"The THR-β agonist resmetirom is the first treatment approved for metabolic dysfunction-associated steatohepatitis (MASH) in the US so far. It can be prescribed given MASH and F2/F3-fibrosis (\"at-risk MASH\").We analyzed how many patients qualify for resmetirom in a recently recruited Steatotic Liver Disease-cohort involving both tertiary and secondary care centers, the German SLD-Registry.Indication for resmetirom was assessed by three different approaches: (i) biopsy-proven MASH with F2/3 fibrosis and NAS-score ≥ 4; (ii) FibroScan-AST (FAST) score ≥ 0.67 and vibration controlled transient elastography (VCTE) < 15 kPa; (iii) US expert recommendations with VCTE 10-15 kPa and platelets ≥ 140×109/L or VCTE 8-15 kPa.1113 patients were recruited across 8 tertiary and 12 secondary care centers. NAS grading and staging were available for 180 cases (16%) with 179/180 conducted at tertiary care level. Of these, 61 (34%) qualified for resmetirom. FAST score without histologic assessment was available for 638 cases (57.3%), of which 612 (87%) were from tertiary and 26 (11%) from secondary care centers. Based on approach (ii), 41 (6%) of these individuals qualified for resmetirom compared to 117 (18.3%) using approach (iii). Combining approach (iii) with FAST ≥ 0.67 leads to 191 (30.0%) eligible patients. Using VCTE 8-15 kPa results in 182 (28.5%) eligible patients.Eligibility for resmetirom treatment depends on the available method used to identify \"at-risk MASH\". Availability of VCTE was highest among different levels of care.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Well-differentiated Adenocarcinoma Arising from Gastric Cystica Profunda Treated by Endoscopic Submucosal Dissection: A case report and literature review. 内镜下粘膜剥离术治疗胃深囊高分化腺癌1例并文献复习。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-01 Epub Date: 2025-02-18 DOI: 10.1055/a-1920-4161

Cao Huang, Jiang Liu

{"title":"Well-differentiated Adenocarcinoma Arising from Gastric Cystica Profunda Treated by Endoscopic Submucosal Dissection: A case report and literature review.","authors":"Cao Huang, Jiang Liu","doi":"10.1055/a-1920-4161","DOIUrl":"10.1055/a-1920-4161","url":null,"abstract":"Gastritis cystica profunda (GCP) is a rare disease that is often observed at the stoma site of patients undergoing gastric surgery. Specific symptoms are often lacking, making it difficult to diagnose. GCP may develop into cancer. Endoscopic resection is a good method to reduce surgical injury, and the therapeutic effect depends on the status of the primary disease.The patient was a 77-year-old male who was admitted to the hospital for repeated epigastric distention. The man had never undergone gastric surgery and did not have Helicobacter pylori infection. Physical and laboratory tests showed no abnormality. Computed tomography showed no significant abnormality. Endoscopy revealed multiple ulcers on the posterior wall of the gastric body, but biopsy showed no evidence of malignancy. The patient subsequently underwent ESD surgery with a lesion of 1.5 cm×2.3 cm. Pathological results showed the cystic dilatation of gastric glands in the submucosa, with some well-differentiated adenocarcinoma. The final diagnosis was GCP with well-differentiated gastric adenocarcinoma.Herein, we describe a case of ESD therapy for GCP with well-differentiated gastric adenocarcinoma. When gastric mucosal lesions are difficult to diagnose, further treatment and diagnosis with EMR or ESD can be considered. For patients with early gastric cancer, long-term postoperative monitoring should be carried out.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":" ","pages":"497-501"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1055/a-2542-6781

Lea Pueschel, Katharina Hupa-Breier, Heiner Wedemeyer, Henrike Lenzen, Miriam Wiestler

{"title":"Food-related Quality of Life in patients with Inflammatory Bowel Disease: Translation and Validation of the German version of FR-QoL-29.","authors":"Lea Pueschel, Katharina Hupa-Breier, Heiner Wedemeyer, Henrike Lenzen, Miriam Wiestler","doi":"10.1055/a-2542-6781","DOIUrl":"10.1055/a-2542-6781","url":null,"abstract":"The psychosocial effects of eating and drinking - summarized as food-related quality of life (FR-QoL) - are underexplored in inflammatory bowel disease (IBD). Currently, there is no German instrument to assess FR-QoL in IBD patients. This study aimed to translate the validated English FR-QoL-29 questionnaire into German and evaluate its validity and reliability.A monocentric, cross-sectional study was conducted at a tertiary referral center with IBD patients and healthy controls. Participants completed questionnaires on sociodemographics, disease history, the Malnutrition Universal Screening Tool (MUST), the German Short Health Scale (SHS), and the FR-QoL-29-German. The FR-QoL-29 was translated into German using a forward-backward method. Its reliability and validity was assessed using Pearson correlation coefficients, intraclass correlation coefficients, and Cronbach's α.N=200 IBD patients (Crohn's disease: 61.8%; women: 50.8%; remission: 56.2%) and n=10 healthy controls completed the questionnaires. Overall, 113 IBD patients repeated the questionnaires after an average of six weeks. Significant differences in FR-QoL-29-German sum scores were found between all levels of IBD disease activity, except for remission - mild disease (p = 0.423) and moderate - severe disease (p = 0.999). FR-QoL-29-German scores significantly correlated with age (p = 0.041), disease activity (p < 0.001), MUST (p = 0.015), fecal Calprotectin (p = 0.011) and SHS (p < 0.001). Overall, the FR-QoL-29-German showed excellent internal consistency (Cronbach's α = 0.965) and good test-retest reliability (ICC = 0.85 [95% CI: 0.78-0.89]).The FR-QoL-29-German is a valid and reliable tool for assessing food-related quality of life in German-speaking individuals with IBD.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 5","pages":"477-485"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Major clinical overlap of the new and former definition of steatotic liver disease in Germany - evidence from the Wuerzburg Fatty Liver Cohort. 德国脂肪变性肝病新定义和旧定义的主要临床重叠-来自维尔茨堡脂肪肝队列的证据

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1055/a-2350-7508

Andreas Geier, Johanna Kestel, Monika Rau

引用次数: 0

Impact of distinct antiviral treatment regimens on the long-term outcome after HCV cure - Data from the German Hepatitis C-Registry (DHC-R). 不同抗病毒治疗方案对丙型肝炎治愈后长期预后的影响——来自德国丙型肝炎登记处（DHC-R）的数据

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1055/a-2543-5205

Valerie Ohlendorf, Yvonne Serfert, Peter Buggisch, Stefan Mauss, Hartwig Klinker, Gerlinde Teuber, Markus Cornberg, Krzysztof Tomasiewicz, Heiner Wedemeyer

{"title":"Impact of distinct antiviral treatment regimens on the long-term outcome after HCV cure - Data from the German Hepatitis C-Registry (DHC-R).","authors":"Valerie Ohlendorf, Yvonne Serfert, Peter Buggisch, Stefan Mauss, Hartwig Klinker, Gerlinde Teuber, Markus Cornberg, Krzysztof Tomasiewicz, Heiner Wedemeyer","doi":"10.1055/a-2543-5205","DOIUrl":"https://doi.org/10.1055/a-2543-5205","url":null,"abstract":"Direct-acting antiviral (DAA) regimens for the treatment of hepatitis C virus (HCV) infection are endowed with sustained virological response (SVR) rates >95%. However, HCV cure does not completely eliminate the risk of hepatocellular carcinoma (HCC) development and liver decompensation. The present study investigated the impact of the administered DAA regimen on clinical long-time outcomes after SVR.Matched-pair survival analyses of 5802 chronically HCV infected patients from the German Hepatitis C-Registry compared the incidence of liver-related events 2.5 years after SVR in patients receiving either sofosbuvir (SOF)-based treatment or NS3/NS4A-protease inhibitor (PI)-containing DAA regimens. Hypothesis driven logistic regression analyses were performed to identify independent predictors for the occurrence of liver-related events.Matched-pair survival analyses revealed a borderline significant difference in the incidence of liver-related endpoints (except of HCC development) in patients receiving SOF-based treatment (4.1%) compared to PI-containing DAA regimens (2.6%) 2.5 years after SVR (p=0.061). Numerically, a trend towards a benefit of PI-based DAA treatment was observed (PI 65 events vs SOF 102 events). Hypothesis driven logistic regression analyses could not confirm SOF-based treatment as an independent predictor for the occurrence of liver-related events after HCV cure (p=0.072, OR=0.670).The incidence of liver-related events 2.5 years after HCV cure did not differ significantly between SOF-based DAA treatment and PI-containing regimens. However, numerically a trend towards a benefit of PI-based DAA treatment was observed. Therefore, a minor effect of the applied DAA regimen on the long-term incidence of liver-related events cannot be excluded.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 5","pages":"486-496"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Practical guideline for short bowel syndrome]. [短肠综合征的实用指南]。

IF 1.4 4区医学

Zeitschrift fur Gastroenterologie Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1055/a-2375-4601

Stefanie Dabsch, Christian Datz, Clemens Dejaco, Felix Harpain, Elisabeth Hütterer, Ludwig Kramer, Nina Loschko, Alexander Moschen, Anton Stift, Harald Vogelsang

{"title":"[Practical guideline for short bowel syndrome].","authors":"Stefanie Dabsch, Christian Datz, Clemens Dejaco, Felix Harpain, Elisabeth Hütterer, Ludwig Kramer, Nina Loschko, Alexander Moschen, Anton Stift, Harald Vogelsang","doi":"10.1055/a-2375-4601","DOIUrl":"10.1055/a-2375-4601","url":null,"abstract":"Short bowel syndrome is a rare complex disease that mainly develops due to extensive bowel resections and can lead to chronic intestinal failure. Due to the decreased intestinal surface absorption of macronutrient, micronutrient and/or fluids is reduced. Correspondingly manifold symptoms arise as diarrhoea, weight loss, vitamin deficiencies, chronic kidney disease, hepatopathy and others with great impact on quality of life of patients. Therapy is complex and needs interdisciplinary collaboration between dieticians, gastroenterologists, surgeons and also a dense monitoring of general practitioners. Commonly patients need permanent home-parenteral support. Therapies have to be decided individually and have to be reviewed regularly for effectivity and side effects. Furthermore, periodic monitoring of several clinical and laboratory tests should be performed. Morbidity and mortality of this disease complex is high and lead by appearance and management of complications. This practical guide should give an overview about the disease, diagnostics and management and should enable the best possible care of these complex patients.","PeriodicalId":23853,"journal":{"name":"Zeitschrift fur Gastroenterologie","volume":"63 5","pages":"502-511"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0