Effect of Bacteroides on Crohn's disease.

IF 1.4 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY
Xuanyu Wei, Dong Tang
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引用次数: 0

Abstract

Crohn's disease (CD), also known as cicatrizing enteritis, is an inflammatory bowel disease that occurs in the distal ileum and right colon of unknown cause and is also called inflammatory bowel disease (IBD) with ulcerative colitis (UC). In recent years, intestinal biota have been confirmed to play a significant role in various gastrointestinal diseases. Studies have found that intestinal microbiota disorders are closely associated with the onset and progression of Crohn's disease. Bacteroidetes, the second largest microbiota in the intestine, are crucial for equilibrium in the microbiota and intestinal environment. Certain Bacteroides can induce the development of Crohn's disease and aggravate intestinal inflammation directly or through their metabolites. Conversely, certain Bacteroides can reduce intestinal inflammation and symptoms of Crohn's disease. This article reviews the effect of several intestinal Bacteroides in the onset and progression of Crohn's disease and their impact on its treatment.

Bacteroides 对克罗恩病的影响。
克罗恩病(Crohn's disease,CD)又称糜烂性肠炎,是一种发生在回肠远端和右侧结肠的原因不明的炎症性肠病,也被称为炎症性肠病(IBD)伴溃疡性结肠炎(UC)。近年来,肠道生物群已被证实在各种胃肠道疾病中发挥着重要作用。研究发现,肠道微生物群紊乱与克罗恩病的发病和进展密切相关。类杆菌是肠道中第二大微生物群,对微生物群和肠道环境的平衡至关重要。某些类杆菌能直接或通过其代谢产物诱导克罗恩病的发生并加重肠道炎症。相反,某些乳酸菌可减轻肠道炎症和克罗恩病症状。本文综述了几种肠道乳杆菌在克罗恩病发病和发展过程中的作用及其对治疗的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Zeitschrift fur Gastroenterologie
Zeitschrift fur Gastroenterologie 医学-胃肠肝病学
CiteScore
1.40
自引率
15.40%
发文量
562
审稿时长
6-12 weeks
期刊介绍: Die Zeitschrift für Gastroenterologie ist seit über 50 Jahren die führende deutsche Fachzeitschrift auf dem Gebiet der Gastroenterologie. Sie richtet sich an Gastroenterologen und alle anderen gastroenterologisch interessierten Ärzte. Als offizielles Organ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten sowie der Österreichischen Gesellschaft für Gastroenterologie und Hepatologie informiert sie zuverlässig und aktuell über die wichtigen Neuerungen und Entwicklungen in der Gastroenterologie.
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