Veterinary ophthalmology最新文献_第3页

Annual Scientific Meeting of the International Equine Ophthalmology Consortium, Ocala, Florida, USA June 18-20, 2026. 国际马眼科学联盟年度科学会议，奥卡拉，佛罗里达州，美国，2026年6月18日至20日。

IF 1.1 4区农林科学

Veterinary ophthalmology Pub Date : 2026-09-01 DOI: 10.1111/vop.70256

引用次数: 0

Equine Fungal Keratitis due to Cladorrhinum bulbillosum. 马真菌性角膜炎引起的球孢枝孢杆菌。

IF 1.1 4区农林科学

Veterinary ophthalmology Pub Date : 2026-09-01 DOI: 10.1111/vop.70249

Abigail Hamilton, Loretta Lacy, Nicole Scherrer

{"title":"Equine Fungal Keratitis due to Cladorrhinum bulbillosum.","authors":"Abigail Hamilton, Loretta Lacy, Nicole Scherrer","doi":"10.1111/vop.70249","DOIUrl":"10.1111/vop.70249","url":null,"abstract":"Objective: To describe the case details and treatment of an equine fungal keratitis case caused by Cladorrhinum bulbillosum.Animal studied: A 14-year-old Bashkir Curly gelding with a complicated corneal ulcer of the left eye.Procedures: Corneal cytology was performed, and intraoperative samples were collected for polymerase chain reaction and for aerobic and mycologic cultures. Under general anesthesia, an inferior eyelid subpalpebral lavage system (SPL) was placed to facilitate postoperative therapy. Anterior stromal keratectomy was performed followed by cryotherapy of the keratectomy bed. A biological scaffold graft was secured within the defect and temporary tarsorrhaphy performed to protect the surgical site. Postoperatively, the horse received systemic anti-inflammatories and topical medications via SPL: antibacterials (ofloxacin, cefazolin), antifungals (voriconazole, luliconazole), and anticollagenase (serum) as well as atropine. Reevaluations were performed every 2-3 weeks until discontinuation of medications.Results: Following surgical and medical management, the horse showed improvement with resolution of the corneal ulcer over an 8-week treatment period. Next-generation sequencing identified C. bulbillosum as the predominant organism, and fungal culture supported filamentous fungal infection.Conclusion: C. bulbillosum infection caused equine fungal keratitis in this case. The use of topical voriconazole and luliconazole, combined with surgical intervention (keratectomy, cryotherapy, bio scaffold graft), resulted in a good response. The corneal ulcer healed well with minor scarring over 8 weeks following surgical intervention. To the authors' knowledge, this was the second report of equine fungal keratitis caused by C. bulbillosum. This case highlights the utility of next-generation DNA sequencing and multimodal treatment with adjunctive contemporary therapies.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70249"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological and Biomechanical Characterization of Amniotic Membranes Across Species: Equine, Canine, Porcine, Ovine, and Human Samples-A Pilot Study. 跨物种羊膜的形态和生物力学特征：马、犬、猪、羊和人类样本-一项初步研究。

IF 1.1 4区农林科学

Veterinary ophthalmology Pub Date : 2026-09-01 DOI: 10.1111/vop.70236

Michelle Becker Petersen, Maiara Poersch Seibel, Eduarda Correa Freitas, Claudete Inês Locatelli, Ana Bárbara Krummenauer Formenton, Jakson Manfredini Vassoler, Sérgio Kwitko, Diane Ruschel Marinho, João Antonio Tadeu Pigatto

{"title":"Morphological and Biomechanical Characterization of Amniotic Membranes Across Species: Equine, Canine, Porcine, Ovine, and Human Samples-A Pilot Study.","authors":"Michelle Becker Petersen, Maiara Poersch Seibel, Eduarda Correa Freitas, Claudete Inês Locatelli, Ana Bárbara Krummenauer Formenton, Jakson Manfredini Vassoler, Sérgio Kwitko, Diane Ruschel Marinho, João Antonio Tadeu Pigatto","doi":"10.1111/vop.70236","DOIUrl":"10.1111/vop.70236","url":null,"abstract":"Introduction: The use of amniotic membrane (AM) has become well established in the treatment of ocular surface disorders in both humans and animals. However, comparative studies of AM from different species remain scarce.Objective: To compare the thickness and biomechanical properties of equine, canine, porcine, and ovine AMs with those of human AM.Methods: Placentas were collected, and AMs were manually separated from the chorion. All AM samples were cryopreserved in a 1:1 solution of Dulbecco's Modified Eagle's Medium (DMEM) and glycerin at -80°C for 60 days. After thawing, samples underwent thickness, histological, and biomechanical analyses.Results: Porcine and canine AMs had an average thickness of 0.054 mm, while ovine AM averaged 0.017 mm. Equine and human AMs had average thicknesses of 0.070 and 0.068 mm, respectively. The key mechanical properties evaluated were maximum tensile force (in Newtons) and stiffness (N/mm), derived from the force-displacement curve. Equine AM exhibited the highest mean maximum tensile force (5.21 N), followed by human (2.17 N), ovine (1.35 N), canine (1.34 N), and porcine (0.52 N). Equine AM also demonstrated the highest mean stiffness (0.91 N/mm), followed by human (0.51 N/mm), ovine (0.46 N/mm), canine (0.27 N/mm), and porcine (0.15 N/mm).Conclusion: Equine AM closely resembles human AM in terms of thickness and mechanical behavior. Moreover, equine AM demonstrated superior biomechanical performance, suggesting its potential as a robust alternative biomaterial for ocular surface reconstruction.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70236"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Compounded 0.03% Tacrolimus in Cross-Linked Hyaluronate Improves Ocular Surface Health in Dogs With Evaporative Dry Eye Disease. 交联透明质酸复合0.03%他克莫司改善蒸发性干眼病犬眼表健康

IF 1.1 4区农林科学

Veterinary ophthalmology Pub Date : 2026-09-01 DOI: 10.1111/vop.70251

Lionel Sebbag, Eunice Q A Neta, Catharina R de Farias, Ana Cláudia S Raposo, Arianne P Oriá

{"title":"Compounded 0.03% Tacrolimus in Cross-Linked Hyaluronate Improves Ocular Surface Health in Dogs With Evaporative Dry Eye Disease.","authors":"Lionel Sebbag, Eunice Q A Neta, Catharina R de Farias, Ana Cláudia S Raposo, Arianne P Oriá","doi":"10.1111/vop.70251","DOIUrl":"10.1111/vop.70251","url":null,"abstract":"Objective: To assess the clinical effects of a compounded 0.03% tacrolimus in 0.75% cross-linked hyaluronic acid (XHA) on tear quantity, quality, and ocular surface health in dogs with evaporative dry eye disease (EDED).Procedures: Sixteen client-owned dogs diagnosed with EDED (normal aqueous production yet reduced stability) were enrolled in this prospective, open-label clinical trial. Patients were treated with the compounded formulation in affected eyes twice daily for 45 days. Ophthalmic assessments, including Schirmer tear test-1 (STT-1), tear film breakup time (TFBUT), punctate fluorescein staining (PFS), lissamine green staining, and conjunctival hyperemia scoring, were performed during designated morning appointments at Day 0, Day 15, and Day 45. Data were analyzed using repeated-measures ANOVA and post hoc tests.Results: STT-1 values increased significantly from 18.7 ± 2.3 mm/min at baseline to 21.7 ± 4.1 mm/min at Day 45 (p = 0.004). Tear film stability improved markedly, with TFBUT rising from 3.3 ± 0.7 s to 5.2 ± 1.4 s (Day 15) and 8.1 ± 2.4 s (Day 45) (p < 0.001). Ocular surface health improved, evidenced by PFS scores decreasing from 1.8 ± 0.9 to 0.3 ± 0.4 (p < 0.001) and lissamine green scores dropping from 1.9 ± 1.1 to 0.1 ± 0.3 (p < 0.001). Conjunctival hyperemia scores declined significantly by Day 45 (p = 0.041).Conclusions: Twice-daily administration of compounded XHA/tacrolimus resulted in significant improvements in tear quantity, stability, and corneoconjunctival integrity. Combining immunomodulation with long-acting lubrication in a single formulation offers a promising, practical therapeutic strategy for efficiently managing canine qualitative dry eye disease in clinical practice.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70251"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous Superficial Ulcerative Keratitis in Client-Owned Cats: Risk Factors for Delayed Healing, Corneal Sequestration, or Corneal Stromal Vascularization. 客户养猫的自发性浅表性溃疡性角膜炎：延迟愈合、角膜隔离或角膜基质血管化的危险因素。

IF 1.1 4区农林科学

Veterinary ophthalmology Pub Date : 2026-09-01 DOI: 10.1111/vop.70260

Benjamin D Reynolds, Cameron J Whittaker, Kelly A Caruso, Jeffrey S Smith, William Weinstein, Paul G McCarthy, William M Irving, David J Maggs

{"title":"Spontaneous Superficial Ulcerative Keratitis in Client-Owned Cats: Risk Factors for Delayed Healing, Corneal Sequestration, or Corneal Stromal Vascularization.","authors":"Benjamin D Reynolds, Cameron J Whittaker, Kelly A Caruso, Jeffrey S Smith, William Weinstein, Paul G McCarthy, William M Irving, David J Maggs","doi":"10.1111/vop.70260","DOIUrl":"10.1111/vop.70260","url":null,"abstract":"Purpose: To investigate risk factors for delayed healing, corneal sequestration, or corneal stromal vascularization in cases of spontaneous superficial feline ulcerative keratitis.Methods: A retrospective review was performed of 71 corneal ulcers in 68 cats. Patient factors, medications, treatments and time until first recheck were each assessed to determine relationships with delayed ulcer healing (> 1 SD above mean healing time), corneal sequestration, or corneal stromal vascularization after ulcer healing.Results: Delayed healing (8/71; 11.3%), corneal sequestration (20/71; 28.2%) and corneal stromal vascularization after ulcer healing (9/71; 12.7%) occurred commonly. Corneal ulcers were significantly more likely to experience delayed healing if chemosis was initially present (p = 0.04), or if therapy included oral lysine (p = 0.04), topical nonsteroidal anti-inflammatory drugs (NSAIDS; p = 0.03) or topical ethylenediaminetetraacetic acid (EDTA; p = 0.04). Ulcerated corneas were significantly more likely to undergo sequestration following cotton-tipped applicator (CTA) debridement (OR = 4.1, p = 0.03), or if faint corneal brunescence was initially present (OR = 5.0, p = 0.01). Corneal stromal vascularization after ulcer healing was significantly more likely in Persian cats (OR = 7.3, p = 0.02) or if corneal vascularization was initially present (OR = 8.6, p = 0.01).Conclusions: Delayed healing, corneal sequestration, and corneal stromal vascularization appear to be common sequelae of feline ulcerative keratitis. Clinicians should use caution when treating feline ulcers using oral lysine, topical NSAIDs, topical EDTA, or CTA debridement.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70260"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Annual Scientific Meeting of the European College of Veterinary Ophthalmologists, Madrid, Spain May 27-29, 2026. 欧洲兽医眼科学院年度科学会议，西班牙马德里，2026年5月27-29日。

IF 1.1 4区农林科学

Veterinary ophthalmology Pub Date : 2026-09-01 DOI: 10.1111/vop.70255

引用次数: 0

Canine Tear Proteomics: A New Frontier in Veterinary Ophthalmology. 犬泪液蛋白质组学：兽医眼科的新前沿。

IF 1.1 4区农林科学

Veterinary ophthalmology Pub Date : 2026-09-01 DOI: 10.1111/vop.70223

Albert L D'Agostino, Elizabeth A Giuliano, Brandie R Morgan-Jack, Grace R Kick, Juri Ota-Kuroki, Rebecca E H Whiting

{"title":"Canine Tear Proteomics: A New Frontier in Veterinary Ophthalmology.","authors":"Albert L D'Agostino, Elizabeth A Giuliano, Brandie R Morgan-Jack, Grace R Kick, Juri Ota-Kuroki, Rebecca E H Whiting","doi":"10.1111/vop.70223","DOIUrl":"10.1111/vop.70223","url":null,"abstract":"Canine tear proteomics is an emerging field with significant potential for advancing both veterinary ophthalmology and comparative biomedical research. Tears are a readily accessible, non-invasive biofluid that contain a mixture of proteins involved in ocular surface protection, immune defense, and intercellular signaling. In dogs, tear proteomics studies have revealed biomarkers associated with various ocular and non-ocular diseases including keratoconjunctivitis sicca (KCS), glaucoma, neoplasia, and diabetes mellitus. This review compiles all previous studies conducted on the comprehensive canine tear proteome and highlights some of the key tear proteomic studies in human biomedical research. Tear film composition, study design, technological advancements, and select tear proteins are discussed along with key protein alterations and their use as potential biomarkers of disease. Fundamental challenges, clinical implications, and future directions of this rapidly growing field are discussed in detail. As proteomic technology and analytical techniques continue to evolve, canine tear proteomics will become a valuable tool for the veterinary ophthalmologist, enabling the early identification and diagnosis of ocular disease as well as providing a means for monitoring treatment outcomes, disease progression, and overall prognosis for the canine patient.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70223"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Not Attending ARVO? A Missed Opportunity. 不参加ARVO？错失的机会。

IF 1.1 4区农林科学

Veterinary ophthalmology Pub Date : 2026-07-01 DOI: 10.1111/vop.70207

Brian C Gilger

引用次数: 0

Lateral Continuous Blepharo-Canthoplasty: A Combination of Hotz-Celsus and Lateral Canthus Wedge Resection for the Correction of Entropion and Macroblepharon in Cats (58 Eyes). 外侧连续眼睑-眦成形术：结合hotz - celus和外侧眦楔形切除矫正猫睑内翻和巨睑（58眼）。

IF 1.1 4区农林科学

Veterinary ophthalmology Pub Date : 2026-07-01 DOI: 10.1111/vop.70225

Laura Barachetti, Irene Cancelli, Giuliano Ravasio, Erica Bassani

{"title":"Lateral Continuous Blepharo-Canthoplasty: A Combination of Hotz-Celsus and Lateral Canthus Wedge Resection for the Correction of Entropion and Macroblepharon in Cats (58 Eyes).","authors":"Laura Barachetti, Irene Cancelli, Giuliano Ravasio, Erica Bassani","doi":"10.1111/vop.70225","DOIUrl":"10.1111/vop.70225","url":null,"abstract":"Purpose: To describe a surgical technique for the correction of entropion and macroblepharon in cats, which combines Hotz-Celsus and lateral canthus wedge resection (\"lateral continuous blepharo-canthoplasty\").Methods: A retrospective study on cats with entropion and macroblepharon undergoing surgery was carried out. A Hotz-Celsus procedure on the lower eyelid was merged with a lateral canthal excision via a wedge resection.Results: Thirty-nine cats were treated. Average age was 2.92 years (range 1-6.83 years). Surgery was performed bilaterally in 19 cats (48.7%), and unilaterally in 20 cats (51.3%) for a total of 58 eyes. The most represented breed was Maine Coon (28 cats, 71.8%). Median follow-up was 287.5 days (range 30-809 days). Minor complication was wound dehiscence (n = 2 eyes) by self-injury. All the patients had favorable outcome, resolution of clinical signs and excellent eyelid conformation.Conclusion: The technique resulted in an effective procedure for combined entropion and macroblepharon in cats, with the benefits of eyelid shortening and lateral canthus stabilization.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 4","pages":"e70225"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148377100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Circadian Variations of Central Corneal Thickness and Its Correlation With Intraocular Pressures in Healthy Horses. 评估健康马中央角膜厚度的昼夜变化及其与眼压的相关性。

IF 1.1 4区农林科学

Veterinary ophthalmology Pub Date : 2026-07-01 DOI: 10.1111/vop.70194

Carolina Iturregui, Chin-Chi Liu, Renee T Carter, Pilar Camacho-Luna

{"title":"Evaluation of Circadian Variations of Central Corneal Thickness and Its Correlation With Intraocular Pressures in Healthy Horses.","authors":"Carolina Iturregui, Chin-Chi Liu, Renee T Carter, Pilar Camacho-Luna","doi":"10.1111/vop.70194","DOIUrl":"10.1111/vop.70194","url":null,"abstract":"Justification: Circadian variations in central corneal thickness (CCT) and their correlation with intraocular pressure (IOP) have not been reported in horses. This information may be clinically relevant when interpreting IOP readings.Procedures: Twenty-four eyes of 6 healthy adult gelded males and 6 healthy adult intact mares were evaluated. Rebound tonometry (TonoVet, Jorgensen Laboratories) followed by ultrasonic pachymetry (iPac Pachymeter, Reichert technologies) was performed in both eyes every 3 h over 24 h during the natural 14-h daylight summer photoperiod.Results: Central corneal thickness varied significantly over time (F = 5.296, df = 8, 184, p < 0.0001), being significantly greater during the dark phase compared with the light phase (mean difference = 4.47 μm, 95% CI: 2.11 to 6.84; p = 0.0003). Intraocular pressure varied significantly over time (F = 2.886, df = 8, 184, p = 0.0047). The largest difference was observed between 0 h (7 a.m.) and 15 h (10 p.m.), with IOP being higher at 15 h by 3.96 mmHg (95% CI: 0.90 to 7.01). There was no significant correlation between CCT and IOP at any time point (β = -0.044 mmHg per μm increase in CCT, 95% CI: -0.100 to 0.013; p = 0.14).Conclusions: In healthy horses, CCT showed minimal circadian variation that was statistically significant but not clinically relevant and was not associated with intraocular pressure. Intraocular pressure exhibited a modest diurnal rhythm, peaking at the end of the light phase, supporting species-specific differences in circadian ocular physiology.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 4","pages":"e70194"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147975875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0