Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan最新文献_第7页

[Redox Biology Involved in the Toxicity of Enterohemorrhagic Escherichia coli Toxin SubAB]. [涉及肠出血性大肠杆菌毒素 SubAB 毒性的氧化还原生物学]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2024-01-01 DOI: 10.1248/yakushi.23-00162-4

Hiroyasu Tsutsuki, Tianli Zhang, Tomohiro Sawa

{"title":"[Redox Biology Involved in the Toxicity of Enterohemorrhagic Escherichia coli Toxin SubAB].","authors":"Hiroyasu Tsutsuki, Tianli Zhang, Tomohiro Sawa","doi":"10.1248/yakushi.23-00162-4","DOIUrl":"10.1248/yakushi.23-00162-4","url":null,"abstract":"AB5 toxins of pathogenic bacteria enter host cells and utilize the retrograde trafficking pathway to translocate to the cytoplasm and exert its pathogenesis. Cholera toxin and Shiga toxin reach the endoplasmic reticulum (ER), and the A subunit undergoes redox regulation by ER proteins to become active fragments, which pass through the ER membrane and translocate to the cytoplasm. By acting on molecular targets in the cytoplasm, the normal function of host cells are disrupted, causing diseases. ER chaperone proteins such as protein disulfide isomerase (PDI) and binding immunoglobulin protein (BiP) induce conformational changes triggered by the reduction of disulfide bonds in the A subunit. This is thought to be dependent on cysteine thiol-mediated redox regulation, but the detailed mechanism remains unclear. On the other hand, subtilase cytotoxin (SubAB), produced by enterohemorrhagic Escherichia coli (EHEC), localizes to the ER without translocating to the cytoplasm and cleaves BiP as a substrate. Therefore, it is thought that ER stress-based cytotoxicity and intestinal bleeding occur without translocating to the cytoplasm. We reported that PDI is involved in BiP cleavage through SubAB localization to the ER. Like other AB5 toxins, this indicates the involvement of redox regulation via chaperone proteins in the ER, but also suggests that SubAB does not translocate to the cytoplasm because it cleaves BiP. Although there are few reports on the redox state of ER protein thiols, it is suggested that polysulfidation, which is discussed in this symposium, may be involved.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"144 1","pages":"57-60"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139088706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Japanese Code of Ethics for Pharmacists and Professionalism]. [日本药剂师职业道德守则]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2024-01-01 DOI: 10.1248/yakushi.23-00172-3

Atsushi Toyomi

引用次数: 0

[Chemical Species Change of Radionuclides by Microorganisms: Effects of Exudated Siderophores]. [微生物对放射性核素化学性质的改变：渗出苷元的影响]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2024-01-01 DOI: 10.1248/yakushi.23-00197-4

Toshihiko Ohnuki

{"title":"[Chemical Species Change of Radionuclides by Microorganisms: Effects of Exudated Siderophores].","authors":"Toshihiko Ohnuki","doi":"10.1248/yakushi.23-00197-4","DOIUrl":"10.1248/yakushi.23-00197-4","url":null,"abstract":"Microbial exudates including siderophore, which changes chemical species of actinides and lanthanides. We have investigated effects of desferrioxamine B (DFOB; one of the siderophores) and siderophore-like organic molecules (SLOM) on the adsorption of lanthanides by microbial cells, aluminium oxide (Al2O3), and manganese (Mn) oxides. When DFOB was present, the distribution coefficients of cerium (Ce) were measured to be lower than those of neighboring elements of lanthanum (La) and praseodymium (Pr) (Negative anomaly of Ce adsorption). Even though initial oxidation state of Ce in the solution was III, that was changed to IV after the addition of DFOB, indicating that Ce(III) was oxidized by forming complex with DFOB. When lanthanides were adsorbed by biogenic Mn(IV) oxides, negative anomaly of Ce adsorption was observed in the sorption in alkaline solution. Ce(III) was oxidized to forme the complexes of Ce(IV) with SLOM in the solution. These results show that siderophore possesses high performance of oxidation of Ce(III) to Ce(IV) during association, affectiong the adsorption behavior of Ce. After Fukushima accident, radioactive Cs accumulation by Eleutherococcus sciadophylloides (Koshiabura) caused by the dissolution of Fe from soil around the roots, that was dominated by siderophore releasing microorganisms (SB). These SBs may enhance dissolution of iron (Fe) and uranium (U) phases in the nuclear fuel debris formed in the nuclear reactors in Fukushima Daiichi nuclear power plant. Thus, in the interaction between microorganisms and radionuclides, SLOMs discharged by microorganisms are deeply involved in the chemical state change of radionuclides.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"144 6","pages":"651-657"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Medical Professionalism as a Pivotal Goal in the Postgraduate Clinical Training]. [医学职业精神是研究生临床培训的关键目标]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2024-01-01 DOI: 10.1248/yakushi.23-00172-2

Tsuguya Fukui

引用次数: 0

Utilization and Issues Related to Discharge Medication Summaries from Hospital Pharmacies to Community Pharmacies. 从医院药房到社区药房出院用药摘要的使用情况和相关问题。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2024-01-01 DOI: 10.1248/yakushi.23-00214

Yuko Fukuda, Mayu Suzuki, Risa Ito, Junko Inaba, Tetsuji Kanemoto, Toshiyuki Sahara, Masahiko Tsujikawa, Mitsuko Onda

{"title":"Utilization and Issues Related to Discharge Medication Summaries from Hospital Pharmacies to Community Pharmacies.","authors":"Yuko Fukuda, Mayu Suzuki, Risa Ito, Junko Inaba, Tetsuji Kanemoto, Toshiyuki Sahara, Masahiko Tsujikawa, Mitsuko Onda","doi":"10.1248/yakushi.23-00214","DOIUrl":"https://doi.org/10.1248/yakushi.23-00214","url":null,"abstract":"In 2020, the Japan Community Healthcare Organization (JCHO) Hoshigaoka Medical Center started providing information to community pharmacies about patients admitted to the acute care ward using discharge medication summaries (the summaries). We conducted an online self-recording survey of 149 pharmacies belonging to the Hirakata City Pharmacists Association to clarify the usability of the summaries, any related issues, and to further discuss future collaboration between hospitals and pharmacies. 46 pharmacies have received the summaries in the past, of which 44 pharmacies answered that they have utilized the summaries with patient instruction and prescription queries of doctors. However, two pharmacies responded they did not utilize the summaries, and the reasons were (a) the information was not timely and (b) patients whom the discharge medical summary was sent for did not come to the pharmacy. There were some requests regarding the summaries such as, \"I would like to know what kind of information hospital pharmacists want from community pharmacists.\" Preference for sharing information other than the summaries (e.g., online tools) with hospital pharmacists was related to whether the pharmacy was providing home pharmaceutical visit services. The survey revealed that, in addition to the usability of the summaries, there are also events that prevent them from being utilized. Some of the challenges include the timing of sending the summaries, the accurate identification of the family pharmacy and the communication of follow-up after discharge from hospital. Collaborating with pharmacies providing home pharmaceutical visit services would be beneficial in creating new system of bidirectional information sharing.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"144 7","pages":"741-748"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The Role of Laboratory Data on Outpatient Prescriptions in Improving Collaboration with the Community and Health Outcomes]. [门诊处方的实验室数据在改善与社区合作和健康结果中的作用]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2024-01-01 DOI: 10.1248/yakushi.24-00084-3

Itsuko Ishii

引用次数: 0

[The Roles of Pharmacists and Pharmacies in Sustainable Medical Care: Current Status and Outlook Three Years After the Issuance of Recommendations by the Science Council of Japan]. [药剂师和药房在可持续医疗保健中的作用：日本科学委员会发布建议三年后的现状和展望]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2024-01-01 DOI: 10.1248/yakushi.24-00084-1

Masato Yasuhara

引用次数: 0

[Analysis of Overdose-related Posts on Social Media]. [社交媒体上与药物过量相关的帖子分析]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2024-01-01 DOI: 10.1248/yakushi.24-00154

Ryuya Sato, Masami Tsuchiya, Rintaro Ichiyama, Soma Hisamura, Satoshi Watabe, Yuki Yanagisawa, Tomohiro Nishiyama, Shuntaro Yada, Eiji Aramaki, Hayato Kizaki, Shungo Imai, Satoko Hori

{"title":"[Analysis of Overdose-related Posts on Social Media].","authors":"Ryuya Sato, Masami Tsuchiya, Rintaro Ichiyama, Soma Hisamura, Satoshi Watabe, Yuki Yanagisawa, Tomohiro Nishiyama, Shuntaro Yada, Eiji Aramaki, Hayato Kizaki, Shungo Imai, Satoko Hori","doi":"10.1248/yakushi.24-00154","DOIUrl":"https://doi.org/10.1248/yakushi.24-00154","url":null,"abstract":"Intentional overdose (OD) of over-the-counter (OTC) and prescription drugs is becoming a significant social issue all over the world. While previous research has focused on drug misuse, there has been limited analysis using social networking service data. This study aims to analyze posts related to a drug overdose on Twitter® (X®) to understand the characteristics and trends of drug misuse, and to examine the applicability of social media in understanding the current situation of OD through natural language processing techniques. We collected posts in Japanese containing the term \"OD\" from January 10 to February 8, 2023, and analyzed 30203 posts. Using a pre-trained, fine-tuned bidirectional encoder representations from transformers (BERT) model, we classified the posts into categories, including direct mentions of OD. We examined the content for drug types and emotional context. Among the 5283 posts categorized as \"Posts describing ODing,\" about one-third included specific drug names or related terms. The most frequently mentioned OTC drugs included active ingredients such as codeine, dextromethorphan, ephedrine, and diphenhydramine. Prescription drugs, particularly benzodiazepines and pregabalin, were also common. Tweets peaked at midnight, suggesting a link between negative emotions and potential OD incidents. Our classifier showed high accuracy in distinguishing OD-related posts. Analyzing Twitter® posts provides valuable insights into the patterns and emotional contexts of drug misuse. Monitoring social networking services for OD-related content could help identify high-risk individuals and inform prevention strategies. Enhanced monitoring and public awareness are crucial to reducing the risks associated with both OTC and prescription drug misuse.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"144 12","pages":"1125-1135"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Implementation of Clinical Research Aimed at Antimicrobial Stewardship]. [实施以抗菌药物管理为目标的临床研究]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2024-01-01 DOI: 10.1248/yakushi.24-00133

Takehiro Yamada

{"title":"[Implementation of Clinical Research Aimed at Antimicrobial Stewardship].","authors":"Takehiro Yamada","doi":"10.1248/yakushi.24-00133","DOIUrl":"10.1248/yakushi.24-00133","url":null,"abstract":"The implementation of antimicrobial stewardship (AS) is an important issue that pharmacists should promote through cooperation with physicians and other medical professionals. A core strategy for AS is \"proactive intervention and feedback\" on antimicrobial prescriptions. We evaluated the AS program to optimize antimicrobial chemotherapy in patients with positive blood cultures. For patients with bacteremia, the rate of bacterial disappearance significantly improved in cases in which the feedback based on the antimicrobial susceptibility testing results by the AS team was accepted than in cases in which it was not. Additionally, we attempted to conduct therapeutic drug monitoring for important antimicrobial agents, such as colistin (anti-multidrug-resistant Pseudomonas aeruginosa agent), vancomycin, daptomycin (antibiotics for methicillin-resistant Staphylococcus aureus), and voriconazole (antifungal drug), to optimize dosage and administration for efficacy and safety. For daptomycin, we found a correlation between plasma through concentration and musculoskeletal toxicity in a clinical study. Moreover, direct toxicity to human skeletal cells was observed in an in vitro study using human myoblast cultures. Overall, the results of these studies indicate that further clinical research on AS may aid the improvement of patient efficacy and safety.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"144 11","pages":"969-972"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Survey of Preventing Exposure Regarding Sweat in Patients Receiving Antineoplastic Agents at Base Hospitals for Promoting Hematopoietic Stem Cell]. [为促进造血干细胞在基地医院接受抗肿瘤药物治疗的患者防止接触汗液的调查]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2024-01-01 DOI: 10.1248/yakushi.24-00098

Hiromu Tanigawa, Kento Kohara, Makoto Onizuka, Atsuko Otsuka, Yuji Suzuki, Masayoshi Hirohara

{"title":"[Survey of Preventing Exposure Regarding Sweat in Patients Receiving Antineoplastic Agents at Base Hospitals for Promoting Hematopoietic Stem Cell].","authors":"Hiromu Tanigawa, Kento Kohara, Makoto Onizuka, Atsuko Otsuka, Yuji Suzuki, Masayoshi Hirohara","doi":"10.1248/yakushi.24-00098","DOIUrl":"https://doi.org/10.1248/yakushi.24-00098","url":null,"abstract":"This survey aimed to reveal the actual preventing exposure for handling of clothing and sweat of patients treated with anticancer drugs, following the publication of \"Guideline for Preventing Occupational Exposure in Cancer Chemotherapy Drugs, 2019 Edition\" (Guideline 2019). A survey was conducted among nurses working at 95 hematopoietic stem cell transplantation promotion base hospitals from September 1, 2023 to October 31, 2023. The response rate was 84.2% (80 facilities). Of the respondents, 45% wore gloves when touching patients' skin to administer anticancer drugs. Almost the nurses identified \"urine\" and \"feces\" as fluids on contaminated linen, while 14.1% also identified \"sweat.\" For new staff, the results for preventing exposure education on \"if touching the patients' skin\" and \"if handling clothing and linen\" were 23.8% and 34.9%, respectively. This survey shows that nurses may not be following the Guideline 2019 for use of personal protective equipment and handling of clothes. Medical institutions handling anticancer drugs need to educate their staff for preventing occupational exposure.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"144 10","pages":"957-962"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0