Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan最新文献_第6页

[Approaches to the Treatment of Lifestyle-related Diseases Through the Regulation of Phospholipid Biosynthesis in the Liver]. [通过调节肝脏中磷脂的生物合成治疗生活方式相关疾病的方法]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00177-1

Kahori Shimizu, Hideo Shindou, Koji Tomita, Toru Nishinaka

{"title":"[Approaches to the Treatment of Lifestyle-related Diseases Through the Regulation of Phospholipid Biosynthesis in the Liver].","authors":"Kahori Shimizu, Hideo Shindou, Koji Tomita, Toru Nishinaka","doi":"10.1248/yakushi.24-00177-1","DOIUrl":"10.1248/yakushi.24-00177-1","url":null,"abstract":"The incidence of type 2 diabetes mellitus (T2DM), a major lifestyle-related disease, is increasing worldwide. T2DM, which accounts for approximately 90-95% of all diabetes mellitus cases, is caused by deficient insulin secretion, tissue insulin resistance, or both. Many therapeutic drugs for T2DM have been developed that target the pancreas, which secretes insulin. The liver is the central organ for glucose and lipid metabolism, and failure of hepatic regulatory mechanisms leads to hyperglycemia, insulin resistance, and lipid accumulation. Here, we focused on the liver as a novel therapeutic target for T2DM. The fatty acid composition of phospholipids, a major component of biological membranes, has received considerable research attention owing to their involvement in T2DM onset and progression. Fatty acids in phospholipids are cleaved by phospholipase A to form lysophospholipids, which are subsequently remodeled back into phospholipids by lysophospholipid acyltransferases (LPLATs). LPLATs play an important role in lipid metabolism and homeostasis by regulating the abundance of various phospholipid species in multiple cell and tissue types. We investigated whether overexpression of LPLAT10, also called LPCAT4 and LPEAT2, in the liver could improve abnormalities in glucose metabolism and help treat T2DM. For overexpression, we generated an LPLAT10-expressing adenovirus (Ad) vector using an improved Ad vector named Ad-E4-122aT, which exhibited higher and longer-term transgene expression and lower hepatotoxicity than conventional Ad vectors. In this article, we review the current findings that changes in hepatic phospholipid species due to liver-specific LPLAT10 overexpression affect the pancreas and suppress postprandial hyperglycemia by increasing postprandial insulin secretion.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 3","pages":"171-176"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clinical Impact of Vonoprazan on the Use of Midazolam during Upper Gastrointestinal Endoscopy]. [Vonoprazan对上消化道内镜中咪达唑仑使用的影响]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00196

Akihito Kodama, Makiko Komai, Tomotaka Imai, Koji Nagaike, Masato Katsuura

{"title":"[Clinical Impact of Vonoprazan on the Use of Midazolam during Upper Gastrointestinal Endoscopy].","authors":"Akihito Kodama, Makiko Komai, Tomotaka Imai, Koji Nagaike, Masato Katsuura","doi":"10.1248/yakushi.24-00196","DOIUrl":"10.1248/yakushi.24-00196","url":null,"abstract":"Despite that the Japanese package insert for vonoprazan (VPZ) includes a precaution that the potassium ion-competitive acid blocker may potentiate the effects of midazolam (MDZ), reports on the actual effects in clinical practice are lacking. Therefore, in this study, we evaluated whether VPZ-taking patients experience clinical effects under MDZ sedation during endoscopy. The participants were outpatients who underwent upper gastrointestinal endoscopy under MDZ anesthesia between April 2021 and April 2022. Comparisons were made between the VPZ(+) and VPZ(-) groups, and the patient background was adjusted using propensity score matching. The post-examination observation time was prolonged in 16.4% of patients in the VPZ(+) group and 13.7% in the VPZ(-) group, but the difference was not statistically significant (p=0.818). The two patients groups also showed no statistically significant differences in the percentage of individuals who received oxygen administration during the examination or in post-examination oxygen saturation and blood pressure values. These results suggest that the use of MDZ for sedation during upper gastrointestinal endoscopy may have minimal clinical effects arising from drug interaction with VPZ.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 4","pages":"359-364"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Anti-skin Aging Effects of Kale-derived Exosome-like Nanoparticles]. [甘蓝衍生的外泌体样纳米颗粒的抗皮肤衰老作用]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00173-3

Shigeru Katayama

{"title":"[Anti-skin Aging Effects of Kale-derived Exosome-like Nanoparticles].","authors":"Shigeru Katayama","doi":"10.1248/yakushi.24-00173-3","DOIUrl":"https://doi.org/10.1248/yakushi.24-00173-3","url":null,"abstract":"In an aging society, there is a growing interest in functional foods that offer anti-aging benefits. Food-derived bioactive compounds such as carotenoids and polyphenols can enhance skin elasticity and delay aging. However, the mechanisms by which these orally ingested compounds directly impact the skin are not fully understood. Recent studies on exosomes have suggested significant physiological functions, including their potential for intercellular communication. Similar to mammalian exosomes, plant-derived exosomes are known for their functional roles, including cross-kingdom communication, and their ability to target specific organs in animal models as delivery vehicles. The authors have been investigating the anti-aging effects of kale and have previously reported its benefits on cognitive function and skin aging in mouse models. Long-term oral administration of glucoraphanin-enriched kale suppresses the senescence symptoms in skin and hair and increases type I collagen and antioxidant enzyme expression in skin tissues, indicating its role in promoting skin health. Exosome-like nanoparticles (ELNs) from glucoraphanin-enriched kale appear to modulate the expression of extracellular matrix-related genes. Kale-derived ELNs exhibit great potential for ameliorating skin aging, suggesting their ability to promote skin health through targeted cellular mechanisms and supporting their use as an active natural compound in nutraceuticals and functional beverages.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 1","pages":"29-33"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Chemistry and Biological Activity of Diterpenoid Alkaloids]. [二萜类生物碱的化学和生物活性]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00211

Koji Wada

{"title":"[Chemistry and Biological Activity of Diterpenoid Alkaloids].","authors":"Koji Wada","doi":"10.1248/yakushi.24-00211","DOIUrl":"10.1248/yakushi.24-00211","url":null,"abstract":"Diterpenoid alkaloids are major pharmaceutically active constituents of Aconitum plants. In phytochemical investigations on Aconitum japonicum subsp. subcuneatum, Aconitum yesoense var. macroyesoens, and Delphinium elatum cv. Pacific Giant (Ranunclaceae), the structures of isolated C19- and C20-diterpenoid alkaloids were elucidated. Three aconitine-type C19-diterpenoid alkaloids, jesaconitine, aconitine, and mesaconitine, which are main components of A. japonicum subsp. subcuneatum, are significantly toxic to the central nervous system. However, lycoctonine-type C19-diterpenoid alkaloids and C20-diterpenoid alkaloids are less toxic. Several diterpenoid alkaloids from the genera Aconitum and Delphinium and their derivatives exhibited slight cytotoxic activity against several human tumor cell lines [A549 (lung carcinoma), DU145 (prostate carcinoma), MDA-MB-231 (triple-negative breast cancer), MCF-7 (estrogen receptor-positive, HER2-negative breast cancer), KB (identical to cervical carcinoma HeLa derived AV-3 cell line), and multidrug-resistant (MDR) subline KB-VIN]. In our course of studies on synthetic derivatives of the C19-diterpenoid alkaloids delcosine and delpheline and the C20-diterpenoid alkaloids lucidusculine, pseudokobusine, and kobusine, we found several derivatives showing significant cytotoxic activity and, thus, providing promising new leads for further development as antitumor agents. Notably, several diterpenoid alkaloids were more potent against MDR subline KB-VIN cells than the parental drug-sensitive KB cells. Among non-cytotoxic synthetic analogues, several lycoctonine-type C19-diterpenoid alkaloid derivatives effectively and significantly sensitized MDR cells to three anticancer drugs, paclitaxel, vincristine, and doxorubicin.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 4","pages":"313-349"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The Roles and Operations of Registered Conformity Assessment Body]. [注册合格评定机构的角色和运作]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00164-3

Takayuki Asakura

{"title":"[The Roles and Operations of Registered Conformity Assessment Body].","authors":"Takayuki Asakura","doi":"10.1248/yakushi.24-00164-3","DOIUrl":"10.1248/yakushi.24-00164-3","url":null,"abstract":"As of August 2023, 99 organizations were registered as conformity assessment bodies by the Ministry of Health, Labour, and Welfare in accordance with Article 33 of the Food Sanitation Act. These registered organizations are authorized to conduct inspections of imported food as well as domestic expropriation inspections. In recent years, we have actively participated in a project to develop new test methods, aiming to enhance our contribution as a registered testing organization and to maintain food hygiene by widely applying these developed methods. There is a need to develop new test methods for pesticides and veterinary medicines used in Japan, as well as for several drugs used internationally. Previously, gas chromatography and high-performance liquid chromatography were the standard methods, and only parent compounds were analyzed. Recently, the demand for test methods applicable not only to agricultural products but also to livestock and marine foods has increased, necessitating the analysis of metabolites in addition to parent compounds. Although developing analytical methods to detect certain metabolites has been challenging, advancements in the variety of separation and pretreatment columns, along with the widespread use of LC-MS/MS and GC-MS/MS techniques, have enabled the development of test methods for many compounds. In this study, we introduce a method to solve the challenges and problems associated with test method development.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 2","pages":"105-108"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Graduation Research: Fostering Mutual Understanding between Teachers and Students]. [毕业研究：促进师生之间的相互理解]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00167-1

Keiko Odera

{"title":"[Graduation Research: Fostering Mutual Understanding between Teachers and Students].","authors":"Keiko Odera","doi":"10.1248/yakushi.24-00167-1","DOIUrl":"https://doi.org/10.1248/yakushi.24-00167-1","url":null,"abstract":"In the Model Core Curriculum for Pharmaceutical Education, revised in 2022, graduation research is mainly conducted in the later years of undergraduate studies and is designed to cultivate scientific inquiry. At pharmaceutical universities, graduation research spans diverse fields. Furthermore, there are two programs in the Faculty of Pharmacy: a 6-year and 4-year program, leading to different career paths for undergraduate students depending on the program taken. Some students aiming to become pharmacists may be unable to actively work on their graduation research because of the uncertainty of its relevance to their future careers. On the other hand, many Japanese university faculty members face challenges balancing teaching and research activities. To achieve the learning goals of graduation research, both faculty members and students must solve their own problems. In this symposium review, I would like to address the current situation of graduation research at pharmaceutical universities and consider how we should approach it in the future to make it meaningful for both the students who conduct graduation research and the faculty involved.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 5","pages":"405-410"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Qualitative Research Focusing on the Psychology of Patients and Pharmacists: What I Learned from Discussions with Students During Graduation Research Guidance]. 【以患者与药师心理为中心的质性研究：毕业科研指导中与学生讨论的心得】。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00167-4

Rieko Takehira

{"title":"[Qualitative Research Focusing on the Psychology of Patients and Pharmacists: What I Learned from Discussions with Students During Graduation Research Guidance].","authors":"Rieko Takehira","doi":"10.1248/yakushi.24-00167-4","DOIUrl":"https://doi.org/10.1248/yakushi.24-00167-4","url":null,"abstract":"In the 2022 version of the Model Core Curriculum for Pharmacy Education, scientific inquiry is highlighted as a crucial professional competency for pharmacists. Graduation research offers pharmacy students an excellent opportunity to develop an inquisitive and scientific perspective. While various types of pharmacy-related research exist, qualitative research is essential for understanding human psychology and behavior. At the laboratory where I am affiliated, students undertake qualitative research focused on the psychological aspects of patients and pharmacists as their graduation research themes. Students conducting qualitative research encounter various challenges. For instance, they might (1) rephrase text data using inappropriate terms when coding or (2) select unsuitable terms due to a lack of contextual understanding of the text data. My goal during graduate research supervision is to provide tailored guidance based on students' common analytical errors. Furthermore, to support students' independent research efforts, I engage in thorough discussions with them regarding the appropriateness of the coded terms they use. Even if these interventions seem inefficient, the persistent repetition of conversations with students is believed to enhance their scientific inquiry skills.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 5","pages":"421-426"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Formulation Design that Contributes to the Development of Pediatric-friendly Drugs]. [促进儿科友好型药物开发的配方设计]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00171-3

Tsutomu Harada

{"title":"[Formulation Design that Contributes to the Development of Pediatric-friendly Drugs].","authors":"Tsutomu Harada","doi":"10.1248/yakushi.24-00171-3","DOIUrl":"10.1248/yakushi.24-00171-3","url":null,"abstract":"Age-appropriate pediatric formulations are needed to achieve optimal medication adherence in children. In Europe and the United States, mini-tablets (MTs) have garnered interest as a new pediatric formulation that is easier to swallow than liquid formulations (LFs). In Japan, fine granules (FGs) are also common for children. Acceptability of a medicine is likely to have significant impact on pediatric adherence. We examined the acceptability of drug-free MTs and compared it with that of FGs and LFs in children aged 6 months to 8 years who were visiting a pediatric department in Showa University Hospital. The primary endpoint was the measure of acceptability by observation of healthcare professionals according to pre-defined evaluation criteria. We compared the percentage of children who could swallow MTs without chewing with that of children who could swallow FGs or LFs without leftover. MTs showed lower swallowability compared to FGs and LFs in children aged 2-6 years, likely because children tend to chew on MTs. In contrast, significantly more children aged 6-11 months could swallow the MTs than those who could swallow all the FGs and LFs. No significant differences were observed in children aged 12-23 months. Palatability and swallowability are important for acceptability. Parents of children aged 6-23 months rated palatability after taking the three formulations. We combined the swallowability and palatability results into a new acceptability analysis. MTs did not differ significantly from FGs and LFs in acceptability for infants, but this new endpoint is useful for evaluating oral pediatric formulations.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 4","pages":"289-297"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Educational Effects of Introducing a Dental Seminar for Pharmacy Students: Questionnaire on Changes in Learning Attitudes and Knowledge Improvement]. 引入药学专业学生牙科讲座的教育效果：学生学习态度变化与知识提升的问卷调查

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00223

Kensuke Yoshida, Anna Kiyomi, Akira Kurokawa, Chie Saito, Munetoshi Sugiura

{"title":"[Educational Effects of Introducing a Dental Seminar for Pharmacy Students: Questionnaire on Changes in Learning Attitudes and Knowledge Improvement].","authors":"Kensuke Yoshida, Anna Kiyomi, Akira Kurokawa, Chie Saito, Munetoshi Sugiura","doi":"10.1248/yakushi.24-00223","DOIUrl":"https://doi.org/10.1248/yakushi.24-00223","url":null,"abstract":"This study evaluated the educational impact of dental seminars involving practicing pharmacists and dentists on pharmacy students. Its primary objective was to assess changes in learning attitudes and improvements in oral care knowledge through lectures and group discussions. The dental seminars were conducted during October-November 2024, and participants included 14 second-year pharmacy students. Participants completed surveys before and after the seminars that addressed topics such as \"antibiotics in dental care\" and \"pharmacist-dentist collaboration.\" Survey results indicated that the proportion of students recognizing the relationship between pharmacy and dentistry increased from 71.5 to 100%. Furthermore, the percentage of students who expressed a desire to learn more about dentistry increased from 42.9 to 85.7%. Knowledge assessments revealed significant improvements in the understanding of appropriate use of antibiotics for tooth extraction and oral care during cancer therapy. However, no improvement was observed in foundational knowledge of dental anatomy, underscoring the necessity of reinforcing basic education. This study provided preliminary insights into the effectiveness of incorporating dental education into the pharmacy curricula. These findings can contribute to the development and refinement of educational programs at other universities and institutions.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 6","pages":"561-569"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Challenges in Development of Appropriate Drugs for Children]. [开发适合儿童的药物面临的挑战]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00171-F

Hiroyuki Kawagishi, Yasunari Kanda

引用次数: 0