Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan最新文献

[Determinants of Pharmaceutical Care Activities among Patients with Diabetes: The Setsuyaku-Bag Campaign]. [糖尿病患者药学服务活动的决定因素：Setsuyaku-Bag运动]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2026-04-01 Epub Date: 2026-01-21 DOI: 10.1248/yakushi.25-00156

Reiko Mizutani, Daisu Saito, Toshinari Mitsuoka

{"title":"[Determinants of Pharmaceutical Care Activities among Patients with Diabetes: The Setsuyaku-Bag Campaign].","authors":"Reiko Mizutani, Daisu Saito, Toshinari Mitsuoka","doi":"10.1248/yakushi.25-00156","DOIUrl":"10.1248/yakushi.25-00156","url":null,"abstract":"This study utilized real-world data from the \"Setsuyaku-Bag Campaign\" conducted by the Hokkaido Pharmaceutical Association to investigate the actual status of leftover medications among patients with diabetes and identify factors associated with pharmacists' pharmaceutical care interventions aimed at addressing this issue. The primary analysis focused on patients who brought their antidiabetic medications,a examining factors related to the implementation of pharmaceutical care. In addition, a supplementary analysis including all patients was performed. The implementation rate of pharmaceutical care activities in the Setsuyaku-Bag Campaign (3.5-67.0%) substantially exceeded national statistics. Patients who brought antidiabetic medications had a significantly greater number of medications (p=0.015) and higher dosing frequency (p<0.001). Multivariate analysis revealed that, in addition to hypoglycemia-risk drugs such as sulfonylureas and glinides, the use of biguanides and α-glucosidase inhibitors was associated with pharmaceutical care activities. These findings suggest that pharmacists provide support and assess medication adherence based on the pharmacological characteristics of drugs. Furthermore, regarding the pharmaceutical care of patients with diabetes, interventions tend to depend on factors such as collaboration with related medical institutions and the establishment of information-sharing systems as opposed to the outcomes of prescription inquiries. Through these frameworks, pharmacies notify prescribing physicians of patients' leftover medications, and under such collaboration, measures against polypharmacy and adjustments of medication regimens are carried out. To realize more effective pharmaceutical care in the future, a comprehensive management system that includes collaboration between physicians and pharmacists needs to be constructed.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":" ","pages":"345-355"},"PeriodicalIF":0.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Linear Transport Technology Opens Up the Future of Factories]. [线性运输技术开启工厂的未来]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2026-01-01 DOI: 10.1248/yakushi.24-00210-3

Katsuhiko Wada, Kousuke Wada

引用次数: 0

[Next-Generation Packaging Line Using a Linear System]. [使用线性系统的下一代包装线]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2026-01-01 DOI: 10.1248/yakushi.24-00210-2

Satoshi Imai

引用次数: 0

[A New Frontier in Cancer Therapy: Exploring the Potential of At-211]. [癌症治疗的新前沿：探索At-211的潜力]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2026-01-01 DOI: 10.1248/yakushi.25-00146-F

Takeshi Fuchigami, Hiroyuki Suzuki

引用次数: 0

[Preventive Measures for Suicide: Clinical Collaboration between a University Hospital Trauma and Resuscitation Center and Community Pharmacy]. 自杀的预防措施：某大学医院创伤与复苏中心与社区药房的临床合作

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2026-01-01 DOI: 10.1248/yakushi.25-00163-1

Yasufumi Miyake, Tatsuro Kuwabara, Nobuhiro Yasuno, Yosiharu Fukuda

引用次数: 0

Evaluating the "Praise Movement" on Social Media: Perceptions of the Human Papillomavirus Vaccine in Japan. 评价社交媒体上的“赞美运动”：对日本人乳头瘤病毒疫苗的看法。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2026-01-01 DOI: 10.1248/yakushi.25-00153

Kanon Nakajima, Yuki Otsuka, Tatsuki Ikejiri, Hayase Hakariya

{"title":"Evaluating the \"Praise Movement\" on Social Media: Perceptions of the Human Papillomavirus Vaccine in Japan.","authors":"Kanon Nakajima, Yuki Otsuka, Tatsuki Ikejiri, Hayase Hakariya","doi":"10.1248/yakushi.25-00153","DOIUrl":"https://doi.org/10.1248/yakushi.25-00153","url":null,"abstract":"Although still controversial in some aspects, the human papillomavirus (HPV) vaccine is widely recognized as a tool for preventing cervical cancer. However, Japan has historically struggled with vaccine hesitancy due to misinformation and public concerns about side effects. This cross-sectional preliminary study investigated an emerging social media trend, the \"praise movement,\" in which users on X (formerly Twitter) commend individuals for receiving the HPV vaccine. Although the data collection period was short in 17 d and limited volume of posts were included in the analysis (n=70), we identified the movement when the term \"HPV vaccination\" appeared on Japan's trending list on X. Through sentiment analysis and content categorization of posts, we found that the majority of posts (91.4%) exhibited positive sentiment, whereas 5.7% were negative. While previous studies have documented negative reactions to HPV vaccination on social media, this study highlights a shift toward positive reinforcement. The praise movement may reflect a broader shift in public attitudes toward HPV vaccination, influenced by both grassroots advocacy and official efforts, including the catch-up vaccination program. Given this study is just a snapshot of a short period and a small volume of trend, a further in-depth study should be warranted. Nevertheless, our findings suggest that online communities can play a meaningful role in influencing public health behaviors, providing insights into potential strategies for improving vaccine uptake. This study offers valuable perspectives on digital health communication and its implications for addressing vaccine hesitancy in Japan and beyond.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"146 4","pages":"339-343"},"PeriodicalIF":0.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Psychiatrist's Perspective on Drug Overdose and the Expected Role of Pharmacists]. 精神科医生对药物过量的看法及药师的预期作用

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2026-01-01 DOI: 10.1248/yakushi.25-00163-2

Yasuhiro Kishi, Kana Yamamoto, Takahiro Takeuchi

{"title":"[Psychiatrist's Perspective on Drug Overdose and the Expected Role of Pharmacists].","authors":"Yasuhiro Kishi, Kana Yamamoto, Takahiro Takeuchi","doi":"10.1248/yakushi.25-00163-2","DOIUrl":"https://doi.org/10.1248/yakushi.25-00163-2","url":null,"abstract":"Suicide remains a critical public health challenge in Japan, with the interaction between physical illness and psychiatric comorbidity emerging as a major determinant of risk. Patients with serious medical conditions face markedly elevated rates of suicidal behavior, particularly when depression or alcohol use disorders are present. Conventional preventive strategies, including screening and provider education, have yielded only modest effects. In contrast, collaborative care models that integrate psychiatrists, primary care physicians, and pharmacists demonstrate superior efficacy, significantly reducing suicidal ideation and attempts. Case management further enhances treatment adherence and clinical outcomes. Internationally, pharmacists play a pivotal role in medication management and suicide risk monitoring; however, in Japan their involvement remains limited by insufficient psychiatric training, institutional constraints, and inadequate reimbursement systems. Addressing these barriers through enhanced education, supportive policy reforms, and structured collaborative care frameworks could expand their role in suicide prevention. A comprehensive, multidisciplinary approach that strengthens pharmacist engagement may contribute substantially to reducing suicide risk among physically ill patients in Japan.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"146 4","pages":"309-314"},"PeriodicalIF":0.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Development of Mesenchymal Stem Cell-derived Extracellular Vesicle Preparations for Practical Application]. [间充质干细胞来源的细胞外囊泡制备的实际应用]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2026-01-01 DOI: 10.1248/yakushi.25-00171-4

Hayato Kurata, Yusuke Mizuno, Koichi Tanaka

{"title":"[Development of Mesenchymal Stem Cell-derived Extracellular Vesicle Preparations for Practical Application].","authors":"Hayato Kurata, Yusuke Mizuno, Koichi Tanaka","doi":"10.1248/yakushi.25-00171-4","DOIUrl":"https://doi.org/10.1248/yakushi.25-00171-4","url":null,"abstract":"Mesenchymal stem cells (MSCs) have emerged as a leading cell source in regenerative medicine due to their multipotency and immunomodulatory capabilities. In recent years, extracellular vesicles (EVs) derived from MSCs have attracted increasing attention as a novel, cell-free therapeutic modality, exhibiting many of the biological effects similar to their parent cells. This review outlines the current status and future prospects of MSC-derived EVs, focusing on their therapeutic mechanisms, standardization efforts, and regulatory trends in Japan and overseas. We further discuss the challenges in the development of EV-based products, including scalable manufacturing, quality control strategies, viral safety, and impurity profiling. The application of Quality by Design (QbD) and single-particle analytics is also highlighted as a means to enhance product consistency and clinical reliability. MSC-EVs have the potential to revolutionize treatment paradigms for various refractory diseases, but their successful implementation will require harmonization of scientific, technical, and regulatory frameworks. This review provides a comprehensive overview of the translational pathway from basic research to clinical and commercial application of MSC-EV therapeutics.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"146 5","pages":"423-432"},"PeriodicalIF":0.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Patient-Reported Symptom Control with an Ibuprofen Gargle in Oral Lichen Planus: An Exploratory Analysis of a Randomized Crossover Trial and Extension. 布洛芬含漱剂对口腔扁平苔藓的长期症状控制：一项随机交叉试验和扩展的探索性分析。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2026-01-01 DOI: 10.1248/yakushi.25-00169

Takeshi Ioroi, Yasumasa Kakei, Yumi Kitahiro, Asami Morioka, Kazuhiro Yamamoto, Tomohiro Omura, Masaya Akashi, Ikuko Yano

{"title":"Long-Term Patient-Reported Symptom Control with an Ibuprofen Gargle in Oral Lichen Planus: An Exploratory Analysis of a Randomized Crossover Trial and Extension.","authors":"Takeshi Ioroi, Yasumasa Kakei, Yumi Kitahiro, Asami Morioka, Kazuhiro Yamamoto, Tomohiro Omura, Masaya Akashi, Ikuko Yano","doi":"10.1248/yakushi.25-00169","DOIUrl":"https://doi.org/10.1248/yakushi.25-00169","url":null,"abstract":"Oral lichen planus (OLP) causes chronic pain and functional limitations. In a randomized, placebo-controlled crossover trial of ibuprofen gargle, short-term analgesia on the visual analog scale (VAS) was not statistically significant, although patient-perceived functional gains were suggested. This study aimed to characterize the long-term patient-centered response patterns to ibuprofen gargling using predefined responder definitions. We performed a secondary exploratory analysis of a single-center trial and its long-term extensions (jRCTs051220009 and jRCTs051220010). Twenty-four participants were followed up on day 176. Endpoints combined within-day analgesia on VAS at 0, 5, and 15 min (VAS0, VAS5, VAS15) with multidimensional symptoms from the 10-item Patient-Reported Oral Mucositis Symptom (PROMS) scale. Time-to-first achievement (TFA) was summarized, and responses were evaluated descriptively and visually. Overall PROMS response (Definition C) occurred in 21/24 participants (median TFA, 5 d). Domain-level responders were frequent (e.g., pain domain D 20/24, eating domain F 18/24; both median 5 d). In contrast, fewer participants met VAS-based endpoints: A 16/24 (between-day VAS) and B 17/24 (within-day VAS) over the observation period. Visual summaries suggested that improvements tended to emerge early and were sustained or recurrent across subsequent weeks in some participants. Although immediate analgesia was modest, this exploratory analysis indicated that regular use of ibuprofen gargling may be associated with early and durable improvements in patient-reported symptoms and function in OLP. These exploratory findings suggest that patient-centered endpoints may be useful for evaluating topical NSAIDs, and should be examined in future studies with larger sample sizes.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"146 5","pages":"507-515"},"PeriodicalIF":0.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Design and Functionalization of Molecules Towards Drug Discovery]. [面向药物发现的分子设计和功能化]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2026-01-01 DOI: 10.1248/yakushi.25-00025

Masaaki Kurihara

引用次数: 0