Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan最新文献_第2页

[Basic Research on Purine Metabolism and Its Clinical Application]. 嘌呤代谢基础研究及临床应用

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.25-00003

Kiyoko Kaneko

{"title":"[Basic Research on Purine Metabolism and Its Clinical Application].","authors":"Kiyoko Kaneko","doi":"10.1248/yakushi.25-00003","DOIUrl":"https://doi.org/10.1248/yakushi.25-00003","url":null,"abstract":"I graduated from the Faculty of Pharmacy and then worked in the Faculty of Medicine, and my research has always focused on applying basic research to clinical practice. I first encountered purine metabolism research when I worked at the Teikyo University School of Medicine. I completed my doctoral studies by applying the measurement of 5'-methylthioadenosine (MTA), a source of adenine, to clinical cases. As part of research into hyperuricemia and gout, which are related to purine metabolism, we established a method for measuring the purine content in foods and reported the amounts of purine in many foodstuffs together with previous values. That research project was largely due to the dedication of students working on their graduation research after moving to the Faculty of Pharmacy. The resulting analytical data are included in treatment guidelines for hyperuricemia and gout, and are used as reference values in lifestyle guidance, especially dietary therapy, for actual patients. Furthermore, we performed micro-analysis of urinary stones, which are a common complication in patients with hyperuricemia and gout. In urinary stones, proteins related to inflammation and immunity were commonly detected, as well as proteins that differed depending on the type of stone, indicating different formation processes. I hope that the results of these research projects can be used to benefit society.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 6","pages":"539-551"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Development of RNA Hydrogels as a Potential System for Intracellular Biomimicry: A Method for the In Vitro Synthesis of ALS/FTD-related (G4C2)n RNA with over 100 Repeats]. [RNA水凝胶作为细胞内仿生学的潜在系统的发展：一种体外合成超过100次重复的ALS/ ftd相关（G4C2）n RNA的方法]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00209-3

Lala Ito, Josephine Galipon

{"title":"[Development of RNA Hydrogels as a Potential System for Intracellular Biomimicry: A Method for the In Vitro Synthesis of ALS/FTD-related (G4C2)n RNA with over 100 Repeats].","authors":"Lala Ito, Josephine Galipon","doi":"10.1248/yakushi.24-00209-3","DOIUrl":"https://doi.org/10.1248/yakushi.24-00209-3","url":null,"abstract":"In the motor neurons of amyotrophic lateral sclerosis (ALS) patients, excessive (G4C2)n repeats in the intronic region of the C9orf72 gene are transcribed to RNA, forming G-quadruplexes that sequester RNA-binding proteins, leading to gelation within the cytoplasm as one of the many mechanisms leading to pathogenesis. While ALS patients frequently harbor over 700 repeats, this kind of 100% GC-rich region is very difficult to clone, and past studies report the necessity to add additional sequences in the middle to clone more than a few dozen repeats. The goal of this study was the in vitro production of the longest repetitive RNA to date consisting solely of (G4C2)n repeats. T4 DNA ligase was used to connect (G4C2)10 stretches of DNA with 3nt overhangs. Then, using a heat-resistant T7 RNA polymerase, the RNA obtained contained transcripts over 100 repeats. Artificial biomimetic RNA gels generated by scaling up this synthesis method are expected to contribute to elucidating the molecular mechanisms of repetitive sequence-related pathogenesis, as well as screening for drugs that can disrupt the gel structure.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 7","pages":"601-607"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Sequence- and Timing- Dependent Manipulation of RNA Methylation]. RNA甲基化的序列和时间依赖性操作。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00209-4

Miki Imanishi

{"title":"[Sequence- and Timing- Dependent Manipulation of RNA Methylation].","authors":"Miki Imanishi","doi":"10.1248/yakushi.24-00209-4","DOIUrl":"https://doi.org/10.1248/yakushi.24-00209-4","url":null,"abstract":"In recent years, chemical modifications of RNA, known as the epitranscriptome, have been shown to influence not only the regulation of gene expression but also diseases such as neurodegenerative disorders and viral infections. Among them, N6-methyladenosine (m6A), which is highly abundant in transcripts, has been shown to regulate RNA stability, localization, and translation and has also been implicated in development, differentiation, and cancer. However, there are limitations in understanding the role of individual m6As in disease and biological phenomena using enzymatic knockdown methods that alter RNA methylation levels throughout the cell; if RNA methylation states can be selectively regulated by RNA sequences, the function of RNA methylation in a variety of biological phenomena can be elucidated. With this background, systems have been developed to selectively and temporally control the methylation state of specific adenosine. Using RNA-binding proteins that can freely alter the sequence of the RNA to which they bind, we created sequence-specific demethylases and methylases and demonstrated that these artificial proteins can regulate the methylation state of adenosine near the target sequence of the RNA-binding protein. In addition, the switching of methylation and demethylation activities by external stimuli is being developed in combination with external stimulus-dependent heterodimeric systems. In this review, developments in molecular tools for the sequence-selective regulation of epitranscriptomes are presented.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 7","pages":"609-616"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[ADMET Analysis of Amorphous β-Carotene and Its Usefulness Evaluation]. [无定形β-胡萝卜素的ADMET分析及其有效性评价]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00173-4

Shinsaku Nakagawa

{"title":"[ADMET Analysis of Amorphous β-Carotene and Its Usefulness Evaluation].","authors":"Shinsaku Nakagawa","doi":"10.1248/yakushi.24-00173-4","DOIUrl":"https://doi.org/10.1248/yakushi.24-00173-4","url":null,"abstract":"In recent years, functional foods have attracted increasing attention due to growing health consciousness. When functional food ingredients are poorly water-soluble, they largely fail to be absorbed due to their low solubility in the digestive tract, limiting their ability to exert their functions. To develop poorly water-soluble compounds into viable functional food ingredients, it is important to increase their gastrointestinal absorption so that they can fully exert their functions, and to ensure their safety and efficacy through ADMET research. β-Carotene exerts physiological activities including antioxidant effects, and functions as a source of vitamin A, but it is completely insoluble in water, so it is poorly absorbed from the digestive tract, rendering it difficult to use efficiently as a functional food ingredient. To overcome this problem, we are conducting research on drug delivery system to improve β-carotene solubility and thereby improve its digestive absorption by applying our unique amorphous solid dispersion production technology. To date, we have produced amorphous solid dispersions with dramatically improved water solubility by adding polymers and emulsifiers to β-carotene and kneading these mixtures under heat. The resultant amorphous solid dispersion showed unprecedentedly high gastrointestinal absorption, enhanced inhibition of allergic dermatitis, and enhanced amelioration of cognitive impairment. No major safety issues associated with long-term continuous administration were observed. In this paper, we introduce our efforts to effectively deliver poorly water-soluble compounds such as β-carotene in functional foods.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 1","pages":"35-39"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Effect of Concomitant Metformin Use on Hematologic Adverse Events in Non-Small-Cell Lung Cancer Patients Undergoing Pemetrexed-Based Chemotherapy: A Study Using a Japanese Claims Database]. [同时使用二甲双胍对接受培美曲塞化疗的非小细胞肺癌患者血液学不良事件的影响：一项使用日本索赔数据库的研究]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00172

Masahiro Hayafune, Shungo Imai, Hayato Kizaki, Masami Tsuchiya, Satoko Hori

{"title":"[Effect of Concomitant Metformin Use on Hematologic Adverse Events in Non-Small-Cell Lung Cancer Patients Undergoing Pemetrexed-Based Chemotherapy: A Study Using a Japanese Claims Database].","authors":"Masahiro Hayafune, Shungo Imai, Hayato Kizaki, Masami Tsuchiya, Satoko Hori","doi":"10.1248/yakushi.24-00172","DOIUrl":"https://doi.org/10.1248/yakushi.24-00172","url":null,"abstract":"Pemetrexed is a folate analog inhibitor for the treatment of non-small-cell lung cancer (NSCLC). Prophylactic supplementation with vitamin B12 and folic acid reduces hematotoxicity associated with pemetrexed. Metformin, the antidiabetic agent, has been associated with the potential side effect of vitamin B12 deficiency. This retrospective observational study aimed to evaluate the effect of concomitant metformin use on hematologic adverse events in patients with NSCLC undergoing pemetrexed-based chemotherapy using the Medical Data Vision Database. Patients with stage III or higher NSCLC who received pemetrexed from April 2008 to May 2021 were categorized into metformin-treated (MTF) and non-metformin-treated (non-MTF) groups. The primary outcome was the proportion of granulocyte colony-stimulating factor (G-CSF) administration during cycle (C) 1 to C2 or C2 to C3 of pemetrexed therapy. Propensity score matching (PSM) was used to balance the baseline characteristics between the groups. A total of 1174 patients met the inclusion criteria (54 in MTF and 1120 in non-MTF). After PSM, 52 patients were included in each group. The median metformin dosage in the MTF group was 500 mg/d before and 625 mg/d after PSM. There were no significant differences between the MTF and non-MTF groups in G-CSF administration (15.4 vs. 21.2%, p=0.446). Multivariate logistic regression analysis also showed that metformin use did not significantly affect hematologic toxicity (odds ratio: 1.208, 95% CI: 0.554-2.634). This suggests that the concomitant use of a relatively low dose of metformin is unlikely to significantly increase the risk of hematotoxicity in Japanese patients with NSCLC receiving pemetrexed-based chemotherapy.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 1","pages":"61-70"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Evaluation of Ixazomib Relative Dose Intensity for IRd Therapy in Elderly Patients with Relapsed or Refractory Multiple Myeloma: A Preliminary Study]. [评估伊沙佐米在老年复发性或难治性多发性骨髓瘤患者 IRd 治疗中的相对剂量强度：初步研究]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00081

Tomoe Kanda, Michio Kimura, Tomoki Sugiyama, Tatsuya Hirose, Shoya Takenaka, Eiseki Usami

{"title":"[Evaluation of Ixazomib Relative Dose Intensity for IRd Therapy in Elderly Patients with Relapsed or Refractory Multiple Myeloma: A Preliminary Study].","authors":"Tomoe Kanda, Michio Kimura, Tomoki Sugiyama, Tatsuya Hirose, Shoya Takenaka, Eiseki Usami","doi":"10.1248/yakushi.24-00081","DOIUrl":"10.1248/yakushi.24-00081","url":null,"abstract":"Ixazomib (IXA) is a convenient oral anticancer drug; however, due to its fixed dosage, IXA tolerability among elderly Japanese individuals may be reduced. Therefore, this study aimed to clarify the difference in relative dose intensity (RDI) of IXA in IRd therapy in elderly patients. Between October 2018 and September 2023, patients who underwent IRd therapy (IXA, lenalidomide, and dexamethasone combination treatment) at Ogaki Municipal Hospital were enrolled in the study and categorized into two age groups: ≥75 years (group O, n=16) and <75 years (group Y, n=6). We retrospectively analyzed RDI of IXA, in IRd therapy. In addition, we evaluated the reasons for dose reduction or delayed treatment. The median initial IXA dose was 3 mg (range: 2.3-4 mg) and 4 mg (range: 3-4 mg) in group O and Y, respectively (p=0.122). The median RDI in group O (65.8%, range: 51.1-91.7%) was significantly lower than in group Y (93.3%, range: 80.5-100.0%) (p=0.002). Among them, anorexia was more common in group O than in group Y (p=0.049). In group O, dose adjustments were made due to anorexia (n=10), diarrhea (n=5), nausea (n=2), and fatigue (n=2). In group Y, adjustments were made due to diarrhea (n=2) and thrombocytopenia (n=1). Upon IXA (4 mg) administration, the rate of dose adjustments due to gastrointestinal symptoms were 75% and 17% in group O and Y, respectively (p=0.051). Overall, RDI was lower in group O owing to gastrointestinal symptoms. This suggests that the fixed IXA dosage (4 mg) is less tolerable in older individuals.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 3","pages":"257-264"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Survey on Characteristics of Potentially Abused Japanese OTC Pharmaceuticals in Japan]. 【日本潜在滥用日系OTC药品特点调查】。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00158

Takashi Imanishi, Riko Uemura

{"title":"[Survey on Characteristics of Potentially Abused Japanese OTC Pharmaceuticals in Japan].","authors":"Takashi Imanishi, Riko Uemura","doi":"10.1248/yakushi.24-00158","DOIUrl":"10.1248/yakushi.24-00158","url":null,"abstract":"Introduction: This study examines current OTC pharmaceuticals in Japan categorized as potential substances for abuse and discusses future initiatives for drug abuse prevention.Methods: The Pharmaceuticals and Medical Devices Agency package inserts search function was used to identify OTC pharmaceuticals containing substances prone to abuse. Subsequently, the corresponding OTC pharmaceuticals containing the designated ingredients were investigated, analyzing their therapeutic and risk categories.Results: In total, 1427 (13.9%) OTC pharmaceuticals contained the designated ingredients, with those containing methylephedrine and dihydrocodeine accounting for the majority (1245/1427, 87.2%). Among the therapeutic categories, oral cold medicines were predominant at 564, followed by antitussives and expectorants at 213, and oral rhinitis medicines at 100. Regarding risk categories, designated schedule II pharmaceuticals predominated in 9 out of 11 therapeutic category classifications.Conclusion: Designated schedule II pharmaceuticals, such as oral cold medicines, antitussives and expectorants, and oral rhinitis medicines, pose a high risk of drug abuse. Addressing this challenge necessitates collaboration between pharmacists and registered sales clerks to implement preventive measures aligned with current trends in drug abuse.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 2","pages":"155-161"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Survey of Health Issues in Public Schools: Identifying Health Issues for the Involvement of School Pharmacists in School Health]. [公立学校健康问题调查：确定学校药剂师参与学校健康的健康问题]

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.25-00007

Maki Shimizu, Yoshiko Imai, Michiko Goromaru-Shinkai, Yukihiro Shinpo

{"title":"[Survey of Health Issues in Public Schools: Identifying Health Issues for the Involvement of School Pharmacists in School Health].","authors":"Maki Shimizu, Yoshiko Imai, Michiko Goromaru-Shinkai, Yukihiro Shinpo","doi":"10.1248/yakushi.25-00007","DOIUrl":"https://doi.org/10.1248/yakushi.25-00007","url":null,"abstract":"Under the School Safety and Health Act, which came into force in 2009, school pharmacists are now required to engage in the duties of health counselling and health guidance in addition to school environmental health. However, the proportion of school pharmacists involved in health education is low, and not all of them are qualified to participate. Therefore, this study targets school principals, school nurse-teachers, physical education supervisors, health coordinators, science supervisors, nutrition teachers (dietitians), and school pharmacists from among the teaching staff of all public schools in Funabashi city. Here, a survey was conducted on issues related to school health that are important at the school site, in which school pharmacists should participate. Health issues identified at school sites included dependence on smartphones or other devices, leftover food, food likes and dislikes, lack of sleep, dealing with food allergies and anaphylaxis, and handling menstrual problems or pain. School pharmacists were also asked about matters of school health in which they would like to participate. These issues differed significantly among those participating in the survey, with responses including correct use of drugs, overdose, drug abuse prevention, prevention of energy drink overdose, anti-smoking education, and infectious disease control.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 8","pages":"723-732"},"PeriodicalIF":0.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Understanding New Pathologies and Novel Treatment Strategies Unraveled from the Microbiome]. [从微生物组中理解新的病理和新的治疗策略]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00190-F

Yoshiaki Kawamura, Takashi Sugita

引用次数: 0

[Studies on Formulations from a Clinical Perspective]. 【从临床角度研究复方】。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00214

Takahiro Uchida

{"title":"[Studies on Formulations from a Clinical Perspective].","authors":"Takahiro Uchida","doi":"10.1248/yakushi.24-00214","DOIUrl":"https://doi.org/10.1248/yakushi.24-00214","url":null,"abstract":"This review highlights the author's research conducted at Mukogawa Women's University from April 2002 to March 2024. The work is categorized into following three areas: (1) Evaluation of the bitterness of oral medications using a taste sensor, (2) Development of drug delivery systems utilizing poly(lactic-co-glycolic acid) (PLGA), and (3) Clinical pharmaceutical evaluation of various injectable formulations. In section (1), the bitterness of oral medications, both alone and in combination with food or beverages, was quantitatively assessed. The taste sensor demonstrated high predictive accuracy, with a significant correlation observed between the sensor's bitter-sensitive outputs and the human taste receptor hT2R14, as documented in BitterDB. Recently, an innovative taste sensor featuring lipid/polymer membranes modified with 2,6-dihydroxybenzoic acid (2,6-DHBA), based on an allosteric mechanism, was developed to improve the detection of bitterness in non-charged compounds. In section (2), PLGA microspheres were engineered for the sustained release of prostaglandin derivatives over one month. Furthermore, polymeric micelles under 100 nm in diameter, composed of PLGA and LL-12 (a mutated fragment of human cathelicidin peptide), exhibited potent antibacterial activity and inhibited the proliferation of various cancer cells. Section (3) focuses on injectable formulations, including the development of a quantitative predictive system to evaluate the risk of insoluble particle formation when mixing ceftriaxone with calcium-containing injections. Additionally, the use of minimum inhibitory concentration (MIC) values and nomograms was explored to predict the clinical efficacy of imipenem derivatives. This research significantly contributes to enhancing the safety and efficacy of clinical treatments for patients.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 5","pages":"433-450"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0