Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan最新文献_第2页

[ADMET Analysis of Amorphous β-Carotene and Its Usefulness Evaluation]. [无定形β-胡萝卜素的ADMET分析及其有效性评价]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00173-4

Shinsaku Nakagawa

{"title":"[ADMET Analysis of Amorphous β-Carotene and Its Usefulness Evaluation].","authors":"Shinsaku Nakagawa","doi":"10.1248/yakushi.24-00173-4","DOIUrl":"https://doi.org/10.1248/yakushi.24-00173-4","url":null,"abstract":"In recent years, functional foods have attracted increasing attention due to growing health consciousness. When functional food ingredients are poorly water-soluble, they largely fail to be absorbed due to their low solubility in the digestive tract, limiting their ability to exert their functions. To develop poorly water-soluble compounds into viable functional food ingredients, it is important to increase their gastrointestinal absorption so that they can fully exert their functions, and to ensure their safety and efficacy through ADMET research. β-Carotene exerts physiological activities including antioxidant effects, and functions as a source of vitamin A, but it is completely insoluble in water, so it is poorly absorbed from the digestive tract, rendering it difficult to use efficiently as a functional food ingredient. To overcome this problem, we are conducting research on drug delivery system to improve β-carotene solubility and thereby improve its digestive absorption by applying our unique amorphous solid dispersion production technology. To date, we have produced amorphous solid dispersions with dramatically improved water solubility by adding polymers and emulsifiers to β-carotene and kneading these mixtures under heat. The resultant amorphous solid dispersion showed unprecedentedly high gastrointestinal absorption, enhanced inhibition of allergic dermatitis, and enhanced amelioration of cognitive impairment. No major safety issues associated with long-term continuous administration were observed. In this paper, we introduce our efforts to effectively deliver poorly water-soluble compounds such as β-carotene in functional foods.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 1","pages":"35-39"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Effect of Concomitant Metformin Use on Hematologic Adverse Events in Non-Small-Cell Lung Cancer Patients Undergoing Pemetrexed-Based Chemotherapy: A Study Using a Japanese Claims Database]. [同时使用二甲双胍对接受培美曲塞化疗的非小细胞肺癌患者血液学不良事件的影响：一项使用日本索赔数据库的研究]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00172

Masahiro Hayafune, Shungo Imai, Hayato Kizaki, Masami Tsuchiya, Satoko Hori

{"title":"[Effect of Concomitant Metformin Use on Hematologic Adverse Events in Non-Small-Cell Lung Cancer Patients Undergoing Pemetrexed-Based Chemotherapy: A Study Using a Japanese Claims Database].","authors":"Masahiro Hayafune, Shungo Imai, Hayato Kizaki, Masami Tsuchiya, Satoko Hori","doi":"10.1248/yakushi.24-00172","DOIUrl":"https://doi.org/10.1248/yakushi.24-00172","url":null,"abstract":"Pemetrexed is a folate analog inhibitor for the treatment of non-small-cell lung cancer (NSCLC). Prophylactic supplementation with vitamin B12 and folic acid reduces hematotoxicity associated with pemetrexed. Metformin, the antidiabetic agent, has been associated with the potential side effect of vitamin B12 deficiency. This retrospective observational study aimed to evaluate the effect of concomitant metformin use on hematologic adverse events in patients with NSCLC undergoing pemetrexed-based chemotherapy using the Medical Data Vision Database. Patients with stage III or higher NSCLC who received pemetrexed from April 2008 to May 2021 were categorized into metformin-treated (MTF) and non-metformin-treated (non-MTF) groups. The primary outcome was the proportion of granulocyte colony-stimulating factor (G-CSF) administration during cycle (C) 1 to C2 or C2 to C3 of pemetrexed therapy. Propensity score matching (PSM) was used to balance the baseline characteristics between the groups. A total of 1174 patients met the inclusion criteria (54 in MTF and 1120 in non-MTF). After PSM, 52 patients were included in each group. The median metformin dosage in the MTF group was 500 mg/d before and 625 mg/d after PSM. There were no significant differences between the MTF and non-MTF groups in G-CSF administration (15.4 vs. 21.2%, p=0.446). Multivariate logistic regression analysis also showed that metformin use did not significantly affect hematologic toxicity (odds ratio: 1.208, 95% CI: 0.554-2.634). This suggests that the concomitant use of a relatively low dose of metformin is unlikely to significantly increase the risk of hematotoxicity in Japanese patients with NSCLC receiving pemetrexed-based chemotherapy.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 1","pages":"61-70"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Evaluation of Ixazomib Relative Dose Intensity for IRd Therapy in Elderly Patients with Relapsed or Refractory Multiple Myeloma: A Preliminary Study]. [评估伊沙佐米在老年复发性或难治性多发性骨髓瘤患者 IRd 治疗中的相对剂量强度：初步研究]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00081

Tomoe Kanda, Michio Kimura, Tomoki Sugiyama, Tatsuya Hirose, Shoya Takenaka, Eiseki Usami

{"title":"[Evaluation of Ixazomib Relative Dose Intensity for IRd Therapy in Elderly Patients with Relapsed or Refractory Multiple Myeloma: A Preliminary Study].","authors":"Tomoe Kanda, Michio Kimura, Tomoki Sugiyama, Tatsuya Hirose, Shoya Takenaka, Eiseki Usami","doi":"10.1248/yakushi.24-00081","DOIUrl":"10.1248/yakushi.24-00081","url":null,"abstract":"Ixazomib (IXA) is a convenient oral anticancer drug; however, due to its fixed dosage, IXA tolerability among elderly Japanese individuals may be reduced. Therefore, this study aimed to clarify the difference in relative dose intensity (RDI) of IXA in IRd therapy in elderly patients. Between October 2018 and September 2023, patients who underwent IRd therapy (IXA, lenalidomide, and dexamethasone combination treatment) at Ogaki Municipal Hospital were enrolled in the study and categorized into two age groups: ≥75 years (group O, n=16) and <75 years (group Y, n=6). We retrospectively analyzed RDI of IXA, in IRd therapy. In addition, we evaluated the reasons for dose reduction or delayed treatment. The median initial IXA dose was 3 mg (range: 2.3-4 mg) and 4 mg (range: 3-4 mg) in group O and Y, respectively (p=0.122). The median RDI in group O (65.8%, range: 51.1-91.7%) was significantly lower than in group Y (93.3%, range: 80.5-100.0%) (p=0.002). Among them, anorexia was more common in group O than in group Y (p=0.049). In group O, dose adjustments were made due to anorexia (n=10), diarrhea (n=5), nausea (n=2), and fatigue (n=2). In group Y, adjustments were made due to diarrhea (n=2) and thrombocytopenia (n=1). Upon IXA (4 mg) administration, the rate of dose adjustments due to gastrointestinal symptoms were 75% and 17% in group O and Y, respectively (p=0.051). Overall, RDI was lower in group O owing to gastrointestinal symptoms. This suggests that the fixed IXA dosage (4 mg) is less tolerable in older individuals.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 3","pages":"257-264"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Survey on Characteristics of Potentially Abused Japanese OTC Pharmaceuticals in Japan]. 【日本潜在滥用日系OTC药品特点调查】。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00158

Takashi Imanishi, Riko Uemura

{"title":"[Survey on Characteristics of Potentially Abused Japanese OTC Pharmaceuticals in Japan].","authors":"Takashi Imanishi, Riko Uemura","doi":"10.1248/yakushi.24-00158","DOIUrl":"10.1248/yakushi.24-00158","url":null,"abstract":"Introduction: This study examines current OTC pharmaceuticals in Japan categorized as potential substances for abuse and discusses future initiatives for drug abuse prevention.Methods: The Pharmaceuticals and Medical Devices Agency package inserts search function was used to identify OTC pharmaceuticals containing substances prone to abuse. Subsequently, the corresponding OTC pharmaceuticals containing the designated ingredients were investigated, analyzing their therapeutic and risk categories.Results: In total, 1427 (13.9%) OTC pharmaceuticals contained the designated ingredients, with those containing methylephedrine and dihydrocodeine accounting for the majority (1245/1427, 87.2%). Among the therapeutic categories, oral cold medicines were predominant at 564, followed by antitussives and expectorants at 213, and oral rhinitis medicines at 100. Regarding risk categories, designated schedule II pharmaceuticals predominated in 9 out of 11 therapeutic category classifications.Conclusion: Designated schedule II pharmaceuticals, such as oral cold medicines, antitussives and expectorants, and oral rhinitis medicines, pose a high risk of drug abuse. Addressing this challenge necessitates collaboration between pharmacists and registered sales clerks to implement preventive measures aligned with current trends in drug abuse.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 2","pages":"155-161"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Survey of Health Issues in Public Schools: Identifying Health Issues for the Involvement of School Pharmacists in School Health]. [公立学校健康问题调查：确定学校药剂师参与学校健康的健康问题]

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.25-00007

Maki Shimizu, Yoshiko Imai, Michiko Goromaru-Shinkai, Yukihiro Shinpo

{"title":"[Survey of Health Issues in Public Schools: Identifying Health Issues for the Involvement of School Pharmacists in School Health].","authors":"Maki Shimizu, Yoshiko Imai, Michiko Goromaru-Shinkai, Yukihiro Shinpo","doi":"10.1248/yakushi.25-00007","DOIUrl":"https://doi.org/10.1248/yakushi.25-00007","url":null,"abstract":"Under the School Safety and Health Act, which came into force in 2009, school pharmacists are now required to engage in the duties of health counselling and health guidance in addition to school environmental health. However, the proportion of school pharmacists involved in health education is low, and not all of them are qualified to participate. Therefore, this study targets school principals, school nurse-teachers, physical education supervisors, health coordinators, science supervisors, nutrition teachers (dietitians), and school pharmacists from among the teaching staff of all public schools in Funabashi city. Here, a survey was conducted on issues related to school health that are important at the school site, in which school pharmacists should participate. Health issues identified at school sites included dependence on smartphones or other devices, leftover food, food likes and dislikes, lack of sleep, dealing with food allergies and anaphylaxis, and handling menstrual problems or pain. School pharmacists were also asked about matters of school health in which they would like to participate. These issues differed significantly among those participating in the survey, with responses including correct use of drugs, overdose, drug abuse prevention, prevention of energy drink overdose, anti-smoking education, and infectious disease control.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 8","pages":"723-732"},"PeriodicalIF":0.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Understanding New Pathologies and Novel Treatment Strategies Unraveled from the Microbiome]. [从微生物组中理解新的病理和新的治疗策略]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00190-F

Yoshiaki Kawamura, Takashi Sugita

引用次数: 0

[Next-generation Health Functional Food Research Pioneered through Collaboration between Pharmaceutical Science and Agricultural Science]. 【医药科学与农业科学合作开创下一代健康功能食品研究】。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00173-F

Kazuya Nagano, Shinsaku Nakagawa

引用次数: 0

Administration of Immune Checkpoint Inhibitors to Patients on Warfarin May Elevate PT-INR. 华法林患者使用免疫检查点抑制剂可能会升高PT-INR。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00087

Kazuya Uenoyama, Masahide Onoue, Toshiro Katayama, Katsuya Makihara, Hiroshi Yamamoto, Mari Takagi, Kazuhiko Omoto, Yoshiyuki Rikitake

引用次数: 0

[Anthracycline-Induced Cardiotoxicity and Exploration of Cardioprotective Drugs]. 蒽环类药物引起的心脏毒性及心脏保护药物的研究

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00185

Akiyoshi Hara

{"title":"[Anthracycline-Induced Cardiotoxicity and Exploration of Cardioprotective Drugs].","authors":"Akiyoshi Hara","doi":"10.1248/yakushi.24-00185","DOIUrl":"10.1248/yakushi.24-00185","url":null,"abstract":"Many anticancer drugs, including anthracycline drugs, pose a risk of cardiovascular damage as an adverse reaction. This can detrimentally impact the prognosis and quality of life of patients, potentially leading to the interruption of cancer chemotherapy and compromising cancer treatment. Recently, onco-cardiology (or cardio-oncology) has developed as a new interdisciplinary field that focuses on the prevention and treatment of cardiovascular toxicity of anticancer drugs. In this review, we explore the mechanism underlying the cardiotoxicity of anthracyclines and examine pharmacological agents that safeguard the heart from anthracycline-induced damage. Anthracycline-induced cardiotoxicity primarily involves oxidative stress, characterized by radical production in mitochondria and subsequent apoptosis in cardiomyocytes. While various antioxidant agents, such as resveratrol, vitamin E, and melatonin have demonstrated efficacy in reducing anthracycline-induced cardiotoxicity in animal models, their clinical effectiveness remains inconclusive. Alternatively, dexrazoxane, an intracellular iron chelator, along with standard heart failure medications, such as β-blockers, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers, reduce anthracycline cardiotoxicity and prevent subsequent heart failure in both animal and human studies. Additionally, statins [hydroxymethylglutaryl (HMG)-CoA reductase inhibitors] and ranolazine have emerged as potential candidates for attenuating anthracycline-induced cardiotoxicity in clinical settings. Notably, recent in vitro findings suggest that everolimus, an autophagy/mitophagy-inducing antitumor drug, may protect cardiomyocytes from anthracycline-induced toxicity without reducing the antitumor effects of anthracycline. Although promising, further clinical research is warranted to validate the potential of everolimus as a safer and more effective anthracycline chemotherapeutic strategy.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 2","pages":"121-132"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Graduation Research in Organic Chemistry: Transformation of Students' Attitude toward Research through Graduation Research]. 有机化学毕业研究：通过毕业研究转变学生的研究态度。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00167-2

Tomoyo Kamei

{"title":"[Graduation Research in Organic Chemistry: Transformation of Students' Attitude toward Research through Graduation Research].","authors":"Tomoyo Kamei","doi":"10.1248/yakushi.24-00167-2","DOIUrl":"https://doi.org/10.1248/yakushi.24-00167-2","url":null,"abstract":"Organic chemistry in pharmaceutical education is indispensable for drug discovery and the understanding of biological phenomena and plays an important role in the identity formation of pharmacists. In the Model Core Curriculum for Pharmacy Education (2022 revision), organic chemistry is one of the most fundamental subjects in basic pharmaceutical sciences and plays an important role in the study of other fields. Based on basic pharmacy, the academic goal of pharmacological research is to develop problem-finding skills and foster the problem-solving abilities necessary for research that contributes to the development of pharmacy and medicine. The author devised ways for students to become interested in their research topics and to work on them independently. Specifically, the author adopted a teaching method that respects students' independence in scheduling and selecting synthetic routes. For example, in research to determine the absolute configuration of metabolites of the antibiotic nabumetone, students managed their own schedules and became able to conduct research with a sense of conviction and responsibility. In addition, in research on the synthesis of thiophene derivatives, presenting multiple synthetic routes and allowing students to choose one enabled them to propose the direction of the experiment based on their own opinions. Therefore, it is necessary to devise and support research procedures tailored to individual students.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 5","pages":"411-414"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0