Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan最新文献_第8页

[Prediction of Severe Skin Disorders Induced by Anti-epidermal Growth Factor Receptor Antibody Drugs]. [抗表皮生长因子受体抗体药物诱导严重皮肤病的预测]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.25-00092

Hiroaki Takahashi

引用次数: 0

[Chemistry and Biological Activity of Diterpenoid Alkaloids]. [二萜类生物碱的化学和生物活性]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00211

Koji Wada

{"title":"[Chemistry and Biological Activity of Diterpenoid Alkaloids].","authors":"Koji Wada","doi":"10.1248/yakushi.24-00211","DOIUrl":"10.1248/yakushi.24-00211","url":null,"abstract":"Diterpenoid alkaloids are major pharmaceutically active constituents of Aconitum plants. In phytochemical investigations on Aconitum japonicum subsp. subcuneatum, Aconitum yesoense var. macroyesoens, and Delphinium elatum cv. Pacific Giant (Ranunclaceae), the structures of isolated C19- and C20-diterpenoid alkaloids were elucidated. Three aconitine-type C19-diterpenoid alkaloids, jesaconitine, aconitine, and mesaconitine, which are main components of A. japonicum subsp. subcuneatum, are significantly toxic to the central nervous system. However, lycoctonine-type C19-diterpenoid alkaloids and C20-diterpenoid alkaloids are less toxic. Several diterpenoid alkaloids from the genera Aconitum and Delphinium and their derivatives exhibited slight cytotoxic activity against several human tumor cell lines [A549 (lung carcinoma), DU145 (prostate carcinoma), MDA-MB-231 (triple-negative breast cancer), MCF-7 (estrogen receptor-positive, HER2-negative breast cancer), KB (identical to cervical carcinoma HeLa derived AV-3 cell line), and multidrug-resistant (MDR) subline KB-VIN]. In our course of studies on synthetic derivatives of the C19-diterpenoid alkaloids delcosine and delpheline and the C20-diterpenoid alkaloids lucidusculine, pseudokobusine, and kobusine, we found several derivatives showing significant cytotoxic activity and, thus, providing promising new leads for further development as antitumor agents. Notably, several diterpenoid alkaloids were more potent against MDR subline KB-VIN cells than the parental drug-sensitive KB cells. Among non-cytotoxic synthetic analogues, several lycoctonine-type C19-diterpenoid alkaloid derivatives effectively and significantly sensitized MDR cells to three anticancer drugs, paclitaxel, vincristine, and doxorubicin.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 4","pages":"313-349"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Formulation Design that Contributes to the Development of Pediatric-friendly Drugs]. [促进儿科友好型药物开发的配方设计]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00171-3

Tsutomu Harada

{"title":"[Formulation Design that Contributes to the Development of Pediatric-friendly Drugs].","authors":"Tsutomu Harada","doi":"10.1248/yakushi.24-00171-3","DOIUrl":"10.1248/yakushi.24-00171-3","url":null,"abstract":"Age-appropriate pediatric formulations are needed to achieve optimal medication adherence in children. In Europe and the United States, mini-tablets (MTs) have garnered interest as a new pediatric formulation that is easier to swallow than liquid formulations (LFs). In Japan, fine granules (FGs) are also common for children. Acceptability of a medicine is likely to have significant impact on pediatric adherence. We examined the acceptability of drug-free MTs and compared it with that of FGs and LFs in children aged 6 months to 8 years who were visiting a pediatric department in Showa University Hospital. The primary endpoint was the measure of acceptability by observation of healthcare professionals according to pre-defined evaluation criteria. We compared the percentage of children who could swallow MTs without chewing with that of children who could swallow FGs or LFs without leftover. MTs showed lower swallowability compared to FGs and LFs in children aged 2-6 years, likely because children tend to chew on MTs. In contrast, significantly more children aged 6-11 months could swallow the MTs than those who could swallow all the FGs and LFs. No significant differences were observed in children aged 12-23 months. Palatability and swallowability are important for acceptability. Parents of children aged 6-23 months rated palatability after taking the three formulations. We combined the swallowability and palatability results into a new acceptability analysis. MTs did not differ significantly from FGs and LFs in acceptability for infants, but this new endpoint is useful for evaluating oral pediatric formulations.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 4","pages":"289-297"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Elucidation of the Molecular Mechanism Underlying Aberrant Formation of RNA Granules in Neurons of ALS Patients and Its Regulation]. [ALS患者神经元中RNA颗粒异常形成的分子机制及其调控的研究]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00209-1

Hitomi Tsuiji

引用次数: 0

[Impact of Promotional Activities on Orexin Receptor Antagonists Prescription Rates and Usage of Sleep and Antipsychotic Medications: An Interrupted Time-series Analysis Study]. [促销活动对食欲素受体拮抗剂处方率和睡眠和抗精神病药物使用的影响：一项中断时间序列分析研究]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00170

Koki Mori, Kengo Ohashi, Michio Kimura, Mitsuyo Yoshida, Kenji Tomida, Eiseki Usami

{"title":"[Impact of Promotional Activities on Orexin Receptor Antagonists Prescription Rates and Usage of Sleep and Antipsychotic Medications: An Interrupted Time-series Analysis Study].","authors":"Koki Mori, Kengo Ohashi, Michio Kimura, Mitsuyo Yoshida, Kenji Tomida, Eiseki Usami","doi":"10.1248/yakushi.24-00170","DOIUrl":"https://doi.org/10.1248/yakushi.24-00170","url":null,"abstract":"Lemborexant, an orexin receptor antagonist (ORA), was introduced as a safer sleep medication at our hospital, but its prescription rate remained low. To address this issue, promotion of ORAs began in August 2022. This study aimed to evaluate the impact of these activities on the number of patients prescribed lemborexant. And it aimed to evaluate prescription conditions non-benzodiazepine drugs (NBDs) and delirium treatment antipsychotics (DTAs). The study spanned from August 2021 to March 2024, with August 2022 serving as the intervention point. The drugs analyzed included lemborexant, zolpidem and eszopiclone (NBDs), and risperidone and quetiapine (DTAs). Analyzed using interrupted time-series analysis, and assess changes in the number of patients prescribed these medications and the number of patients with abnormal indications. The promotion of ORAs significantly increased lemborexant prescriptions [level change 18 (95% confidence interval 0.07 to 35: p=0.049), slope change 2.7 (0.57 to 4.9: p=0.015)]. Concurrently, prescriptions for NBDs decreased [level change -56 (-86 to -25: p<0.001), slope change -30 (-54 to -5.7: p=0.017)], and the slope change for DTAs with abnormal instructions also decreased [-1.2 (-2.3 to -0.11: p=0.032)]. No significant differences were found for the other items. Promoting ORAs increased its use, and led to a reduction in the prescriptions of NBDs and DTAs with abnormal indications. Although there was no change in patient conditions, given the adverse effects associated with NBDs and DTAs these changes suggest a shift toward safer drug treatment practices.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 7","pages":"629-637"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The Roles and Operations of Registered Conformity Assessment Body]. [注册合格评定机构的角色和运作]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00164-3

Takayuki Asakura

{"title":"[The Roles and Operations of Registered Conformity Assessment Body].","authors":"Takayuki Asakura","doi":"10.1248/yakushi.24-00164-3","DOIUrl":"10.1248/yakushi.24-00164-3","url":null,"abstract":"As of August 2023, 99 organizations were registered as conformity assessment bodies by the Ministry of Health, Labour, and Welfare in accordance with Article 33 of the Food Sanitation Act. These registered organizations are authorized to conduct inspections of imported food as well as domestic expropriation inspections. In recent years, we have actively participated in a project to develop new test methods, aiming to enhance our contribution as a registered testing organization and to maintain food hygiene by widely applying these developed methods. There is a need to develop new test methods for pesticides and veterinary medicines used in Japan, as well as for several drugs used internationally. Previously, gas chromatography and high-performance liquid chromatography were the standard methods, and only parent compounds were analyzed. Recently, the demand for test methods applicable not only to agricultural products but also to livestock and marine foods has increased, necessitating the analysis of metabolites in addition to parent compounds. Although developing analytical methods to detect certain metabolites has been challenging, advancements in the variety of separation and pretreatment columns, along with the widespread use of LC-MS/MS and GC-MS/MS techniques, have enabled the development of test methods for many compounds. In this study, we introduce a method to solve the challenges and problems associated with test method development.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 2","pages":"105-108"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Anti-skin Aging Effects of Kale-derived Exosome-like Nanoparticles]. [甘蓝衍生的外泌体样纳米颗粒的抗皮肤衰老作用]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00173-3

Shigeru Katayama

{"title":"[Anti-skin Aging Effects of Kale-derived Exosome-like Nanoparticles].","authors":"Shigeru Katayama","doi":"10.1248/yakushi.24-00173-3","DOIUrl":"https://doi.org/10.1248/yakushi.24-00173-3","url":null,"abstract":"In an aging society, there is a growing interest in functional foods that offer anti-aging benefits. Food-derived bioactive compounds such as carotenoids and polyphenols can enhance skin elasticity and delay aging. However, the mechanisms by which these orally ingested compounds directly impact the skin are not fully understood. Recent studies on exosomes have suggested significant physiological functions, including their potential for intercellular communication. Similar to mammalian exosomes, plant-derived exosomes are known for their functional roles, including cross-kingdom communication, and their ability to target specific organs in animal models as delivery vehicles. The authors have been investigating the anti-aging effects of kale and have previously reported its benefits on cognitive function and skin aging in mouse models. Long-term oral administration of glucoraphanin-enriched kale suppresses the senescence symptoms in skin and hair and increases type I collagen and antioxidant enzyme expression in skin tissues, indicating its role in promoting skin health. Exosome-like nanoparticles (ELNs) from glucoraphanin-enriched kale appear to modulate the expression of extracellular matrix-related genes. Kale-derived ELNs exhibit great potential for ameliorating skin aging, suggesting their ability to promote skin health through targeted cellular mechanisms and supporting their use as an active natural compound in nutraceuticals and functional beverages.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 1","pages":"29-33"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Antithrombotic Action of Resveratrol: Particularly Regarding Inhibition of Platelet Aggregation]. [白藜芦醇的抗血栓作用：特别是对血小板聚集的抑制]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.25-00033

Kazumi Ekawa, Mikio Marumo, Ichiro Wakabayashi

{"title":"[Antithrombotic Action of Resveratrol: Particularly Regarding Inhibition of Platelet Aggregation].","authors":"Kazumi Ekawa, Mikio Marumo, Ichiro Wakabayashi","doi":"10.1248/yakushi.25-00033","DOIUrl":"https://doi.org/10.1248/yakushi.25-00033","url":null,"abstract":"Resveratrol is a representative polyphenol compound contained in red wine that shows a preventive effect on ischemic heart disease and was originally reported to explain the cause of the French paradox. Alcoholic beverages, including red wine, have been shown to prevent ischemic heart disease when consumed in small amounts. Red wine, which contains alcohol (ethanol) as well as polyphenols, was reportedly more effective than other alcoholic beverages for reducing the incidence of ischemic heart disease. Resveratrol is known to inhibit the functions of platelets, which play a crucial role in atherosclerosis. In an in vitro study, resveratrol inhibited platelet Ca2+ influx and subsequent aggregation in a concentration-dependent manner. When administered simultaneously with ethanol, resveratrol at concentrations that did not affect platelet aggregation alone inhibited platelet aggregation more potently than did ethanol alone. Thus, resveratrol and ethanol show an additive inhibitory effect on platelet aggregation. A major mechanism by which resveratrol inhibits platelet aggregation is its antioxidant action that scavenges reactive oxygen species, which cause platelet adhesion and aggregation. In addition, resveratrol inhibits capacitative Ca2+ influx, a G protein-coupled pathway, which is crucial for platelet activation. Resveratrol also has direct inhibitory effects on cycloxygenase-1 and phospholipase A2, resulting in decreased production of thromboxane A2, a potent intrinsic activator of platelets. In addition to suppression of platelet function, resveratrol retards progression of atherosclerosis through inhibiting oxidation of low-density lipoprotein (LDL) cholesterol and preventing diabetes and obesity. Thus, resveratrol possesses multiple actions against atherosclerosis and thrombosis.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 9","pages":"765-776"},"PeriodicalIF":0.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Development of Drug Delivery Systems Based on New Concepts]. [基于新概念的给药系统的发展]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.25-00023

Chikamasa Yamashita

引用次数: 0

[Graduation Research: Fostering Mutual Understanding between Teachers and Students]. [毕业研究：促进师生之间的相互理解]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00167-1

Keiko Odera

{"title":"[Graduation Research: Fostering Mutual Understanding between Teachers and Students].","authors":"Keiko Odera","doi":"10.1248/yakushi.24-00167-1","DOIUrl":"https://doi.org/10.1248/yakushi.24-00167-1","url":null,"abstract":"In the Model Core Curriculum for Pharmaceutical Education, revised in 2022, graduation research is mainly conducted in the later years of undergraduate studies and is designed to cultivate scientific inquiry. At pharmaceutical universities, graduation research spans diverse fields. Furthermore, there are two programs in the Faculty of Pharmacy: a 6-year and 4-year program, leading to different career paths for undergraduate students depending on the program taken. Some students aiming to become pharmacists may be unable to actively work on their graduation research because of the uncertainty of its relevance to their future careers. On the other hand, many Japanese university faculty members face challenges balancing teaching and research activities. To achieve the learning goals of graduation research, both faculty members and students must solve their own problems. In this symposium review, I would like to address the current situation of graduation research at pharmaceutical universities and consider how we should approach it in the future to make it meaningful for both the students who conduct graduation research and the faculty involved.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 5","pages":"405-410"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0