World journal of clinical oncology最新文献

{"title":"Lynch syndrome association and clinicopathological features in early-onset colorectal cancers: A single-center retrospective study.","authors":"Yunus Sür, Emine Özlem Gür, Fevzi Cengiz, Aslı Subaşıoğlu, İsmail Güzeliş, Sinem Demir, Aysegul Akder Sari, Mehmet Haciyanli, Osman Nuri Dilek","doi":"10.5306/wjco.v16.i9.109182","DOIUrl":"10.5306/wjco.v16.i9.109182","url":null,"abstract":"<p><strong>Background: </strong>Hereditary factors are more prevalent in early-onset colorectal cancers (EOCRC) etiology. Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome that results from mutations in DNA mismatch repair (MMR) genes. This phenomenon is defined as microsatellite instability (MSI). Immunohistochemistry (IHC) is a widely used, practical, and cost-effective method for the screening of MSI. However, using IHC alone may be insufficient to identify patients with MSI and LS.</p><p><strong>Aim: </strong>To determine the clinicopathological features in EOCRC, IHC performance, and the frequency of genetic testing for EOCRC patients.</p><p><strong>Methods: </strong>A retrospective review was conducted on patients with CRC aged ≤ 50 years who underwent surgery at our center between January 2014 and July 2021. MMR proteins were screened using IHC. Of the 131 patients included, IHC was performed on 130. Patients were classified as MSI or microsatellite-stable (MSS), and their features were compared. Additionally, data from patients who received genetic counseling were analyzed.</p><p><strong>Results: </strong>Thirty patients with MSI were designated as group 1, whereas 100 with MSS were defined as group 2. The mean age in group 1 was the lowest (median age: 42 <i>vs</i> 46, <i>P</i> < 0.05). Group 1 exhibited a higher frequency of tumors in the right colon and a lower frequency in the rectum. Lymph node involvement and distant metastases were less common in group 1, and in group 2, tumors were generally diagnosed at a more advanced stage. Genetic testing was performed in 53 patients (40%), with a definitive LS diagnosis established in 13/17 patients (76.4%) in group 1 and 1/36 (2.7%) patients in group 2, resulting in a total of 14 patients (26.4%) with confirmed LS.</p><p><strong>Conclusion: </strong>MSI tumors show a better prognosis. IHC is very effective for screening MSI, but may not be sufficient alone. Low genetic counseling rates highlight the need for hospital-based surveillance programs.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 9","pages":"109182"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the impact of prehabilitation on patients undergoing upper gastrointestinal tract tumor surgery.","authors":"Xiao Shao, Yan-Yan Zhu, Bin Shang, Feng-Juan Cai, Xiao-Yan Wang, Kun Zhou, Cai-Feng Luo","doi":"10.5306/wjco.v16.i9.110130","DOIUrl":"10.5306/wjco.v16.i9.110130","url":null,"abstract":"<p><strong>Background: </strong>Upper gastrointestinal cancer (UGIC), including esophageal and gastric cancers, poses a major global health challenge due to its high morbidity and mortality. During the preoperative period, patients often face functional decline, malnutrition, and psychological stress, which can impair recovery. Prehabilitation, a multidisciplinary preoperative intervention, shows promise in optimizing patients' physical and mental status.</p><p><strong>Aim: </strong>To evaluate the impact of prehabilitation on patients undergoing UGIC surgery and provide a basis for implementation of the prehabilitation compound plan.</p><p><strong>Methods: </strong>A computerized search of databases including Web of Science, PubMed, EMBASE, The Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, China National Knowledge Infrastructure, Wanfang, and Chinese Science and Technology Journal Database was used to collect clinical trials on the impact of prehabilitation on patients undergoing UGIC surgery. After screening, a meta-analysis was conducted using Review Manager 5.0 software, and linear regression analysis was performed on the prehabilitation duration and outcome indicators.</p><p><strong>Results: </strong>A total of 13 clinical trials were ultimately included, with 8 literature quality evaluations at A level and 5 literature quality evaluations at B level. The meta-analysis results showed that compared with conventional nursing, the prehabilitation group had higher six-minute walk distance, lower postoperative complications and mortality rates, and shorter hospital stays, with statistically significant differences; there were no statistically significant differences in intensive care unit monitoring time and albumin levels between the two groups; regression analysis between prehabilitation duration and outcome indicators showed no significant relationship.</p><p><strong>Conclusion: </strong>Prehabilitation can improve the perioperative functional ability of patients with UGIC and promote postoperative recovery, but its impact on nutrition, psychology, and quality of life needs to be further explored through more high-quality trials; in addition, further research is needed on the prehabilitation time, location, and specific plan.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 9","pages":"110130"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of artificial intelligence in screening and medical imaging of precancerous gastric diseases.","authors":"Sergey M Kotelevets","doi":"10.5306/wjco.v16.i9.107993","DOIUrl":"10.5306/wjco.v16.i9.107993","url":null,"abstract":"<p><p>Serological screening, endoscopic imaging, morphological visual verification of precancerous gastric diseases and changes in the gastric mucosa are the main stages of early detection, accurate diagnosis and preventive treatment of gastric precancer. Laboratory - serological, endoscopic and histological diagnostics are carried out by medical laboratory technicians, endoscopists, and histologists. Human factors have a very large share of subjectivity. Endoscopists and histologists are guided by the descriptive principle when formulating imaging conclusions. Diagnostic reports from doctors often result in contradictory and mutually exclusive conclusions. Erroneous results of diagnosticians and clinicians have fatal consequences, such as late diagnosis of gastric cancer and high mortality of patients. Effective population serological screening is only possible with the use of machine processing of laboratory test results. Currently, it is possible to replace subjective imprecise description of endoscopic and histological images by a diagnostician with objective, highly sensitive and highly specific visual recognition using convolutional neural networks with deep machine learning. There are many machine learning models to use. All machine learning models have predictive capabilities. Based on predictive models, it is necessary to identify the risk levels of gastric cancer in patients with a very high probability.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 9","pages":"107993"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous cholangiocarcinoma and cervical squamous cell carcinoma managed <i>via</i> a multidisciplinary approach: A case report.","authors":"Zhi-Jian Wu, Bin Wang, Si-Cong Zhao, Zhan-Teng Pan","doi":"10.5306/wjco.v16.i9.109644","DOIUrl":"10.5306/wjco.v16.i9.109644","url":null,"abstract":"<p><strong>Background: </strong>Multiple primary cancers refer to the presence of two or more distinct malignant tumors in a single individual, either simultaneously or sequentially. The synchronous occurrence of cholangiocarcinoma (CCA) and cervical squamous cell carcinoma (SCC) is extremely rare. This case highlights the diagnostic challenges and significance of a multidisciplinary team in managing complex malignancies involving both the hepatobiliary and gynecologic systems. The 8^th edition of the American Joint Committee on Cancer staging system was as follows: T1aN0M0 intrahepatic CCA; the 2018 edition of the International Federation of Gynecology and Obstetrics staging system was stage IB1 cervical SCC.</p><p><strong>Case summary: </strong>A 74-year-old postmenopausal woman (Karnofsky performance status = 80) presented with a one-day history of vaginal bleeding. Cross-sectional imaging (contrast-enhanced computed tomography, liver magnetic resonance imaging, and positron emission tomography/computed tomography) first demonstrated a single 3-cm lesion in liver segment V and a hypermetabolic cervical mass. Subsequent ultrasound-guided liver biopsy confirmed CCA, whereas cervical biopsy revealed SCC. After multidisciplinary discussion, the patient underwent laparoscopic liver resection. Pelvic external-beam radiotherapy was delivered at 45 grays in 25 fractions (6-megavolt photons) over 5 weeks, followed by high-dose-rate ¹⁹²Ir intracavitary brachytherapy, at 35 grays in 7 fractions (International Commission on Radiation Units and Measurements A-point). She received eight cycles of systemic therapy with lenvatinib, capecitabine, and camrelizumab. Over a 12-month follow-up, she remained disease-free with no signs of recurrence or metastasis.</p><p><strong>Conclusion: </strong>Multidisciplinary management offers a promising strategy for treating synchronous complex malignancies with individualized treatment plans.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 9","pages":"109644"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects and challenges of novel natural marine-derived compounds in melanoma treatment.","authors":"Kai Zheng, Yuan Zhou, Te Ba, Zi-Wei Yang","doi":"10.5306/wjco.v16.i9.109079","DOIUrl":"10.5306/wjco.v16.i9.109079","url":null,"abstract":"<p><p>The increasing incidence of melanoma poses significant challenges for conventional treatment approaches, plagued by drug resistance and adverse side effects. Natural marine-derived compounds have gained prominence in melanoma research for their unique bioactivities and diversity. This review delves into the therapeutic potential of these compounds in melanoma treatment, emphasizing their distinctive advantages such as multi-target mechanisms and immune modulation, which distinguish them from traditional therapies. Additionally, we discuss the challenges in translating these agents into clinical applications, including formulation stability, bioavailability, and regulatory hurdles. Recent advancements in preclinical models such as organoids and completed clinical trials further support the exploration of marine-derived compounds in melanoma management. By consolidating current research, this review underscores the potential of these agents to enhance treatment efficacy and foster new therapeutic strategies.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 9","pages":"109079"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Path analysis the influence of self-efficacy and professional identity on attitudes toward prescriptive authority among oncology nurse specialists.","authors":"Cheng-Ping Qiao, Bin Yang, Jiao Ma, Qin Chen, Xin-Ying He, Xue Han","doi":"10.5306/wjco.v16.i9.110994","DOIUrl":"10.5306/wjco.v16.i9.110994","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Global tumor incidence rises and therapies advance, driving oncology nursing specialization. Granting nurses prescriptive authority optimizes care but polarizes nurses' attitudes due to factors like risk and competence, hindering policy implementation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate the current status of the attitudes of oncology specialist nurses toward having prescribing authority, specifically concerning symptom management and supportive care in oncology practice, and we conducted a path analysis of their influencing factors.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;As participants in the survey, oncology specialist nurses working in hospitals of different grades in Jiangsu Province were selected from March 2025 to May 2025 using a stratified sampling method. The questionnaires were administered using the general information questionnaire, the beliefs and attitudes about nurses' prescriptive authority scale, the nurses' professional identity scale, and the self-efficacy scale. Pearson's method was used to analyze the correlation between beliefs and attitudes about the prescriptive authority, professional identity, and self-efficacy of nurses. Multiple linear regression was performed to analyze the factors influencing the beliefs and attitudes of nurses' prescriptive authority. The Amos plug-in was used to construct structural equation models to analyze the influencing pathways.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 329 questionnaires were distributed, and 328 valid questionnaires were returned (effective recovery rate: 99.70%). The total score of the 328 oncology nurses on the beliefs and attitudes about nurses' prescriptive authority scale was 101.88 ± 15.13, indicating a moderately high level. Univariate analysis revealed that gender and hospital grade were associated with this score (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The Pearson correlation analysis revealed that self-efficacy was positively correlated with the scores of the beliefs and attitudes about nurses' prescriptive authority scale and the nurses' professional identity scale (&lt;i&gt;r&lt;/i&gt; = 0.4999, &lt;i&gt;P&lt;/i&gt; &lt; 0.0001 and &lt;i&gt;r&lt;/i&gt; = 0.7048, &lt;i&gt;P&lt;/i&gt; &lt; 0.05, respectively), whereas occupational identity was positively correlated only with the former (&lt;i&gt;r&lt;/i&gt; = 0.6209, &lt;i&gt;P&lt;/i&gt; &lt; 0.05). Multiple linear regression analysis revealed occupational identity and self-efficacy as the factors influencing the scores of the beliefs and attitudes about nurses' prescriptive authority scale (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The results of the path analysis revealed that self-efficacy significantly positively affected nurses' occupational identity and their beliefs and attitudes about having prescriptive authority; occupational identity played a mediating role between the two, with a mediating effect accounting for 54.46% of the total effect, and the structural equation model was well-fitted.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Oncology nurses have more positive attitudes toward prescriptive autho","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 9","pages":"110994"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swollen lymph node metastasis in gastric cancer: A forgotten prognostic signal in need of clinical action.","authors":"Keykavous Parang, Amir Nasrolahi Shirazi","doi":"10.5306/wjco.v16.i9.109711","DOIUrl":"10.5306/wjco.v16.i9.109711","url":null,"abstract":"<p><p>Gastric cancer (GC) remains a leading cause of cancer mortality. While the extent of nodal involvement is a well-known prognostic factor, the specific entity of swollen lymph node metastasis (SLNM), bulky nodal tumor deposits detectable radiologically or pathologically, has received little attention in staging. Recent data from a study by Cui <i>et al</i> demonstrated that SLNM is an independent predictor of very poor survival in GC. Through robust data and rigorous propensity-matched analyses, SLNM emerged not merely as an anatomical finding but as an independent predictor of poor prognosis, even among patients undergoing curative resection. As precision oncology advances, the findings by Cui <i>et al</i> urge a fundamental rethinking of how SLNM is incorporated into clinical decision-making for GC management. In this editorial, we critically examine the prognostic significance of SLNM, challenge its omission from traditional staging frameworks, and advocate for its formal integration into preoperative risk stratification and treatment planning. Recognizing SLNM at diagnosis could unlock intensified neoadjuvant therapy strategies and optimize outcomes for a historically high-risk patient subgroup.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 9","pages":"109711"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibody-drug conjugates in metastatic urothelial cancer: Highway to heaven.","authors":"Alberto D'Angelo, Martina Catalano, Irene De Gennaro Aquino, Valeria Gangi, Giandomenico Roviello","doi":"10.5306/wjco.v16.i9.106646","DOIUrl":"10.5306/wjco.v16.i9.106646","url":null,"abstract":"<p><p>Metastatic urothelial carcinoma (mUC) is a challenging malignancy with historically limited treatment options. Advances in understanding its biology have enabled the development of innovative therapies, including immune checkpoint inhibitors and antibody-drug conjugates (ADCs). ADCs, such as enfortumab vedotin, sacituzumab govitecan, and trastuzumab deruxtecan, represent transformative advancements, offering targeted delivery of cytotoxic agents. This review highlights the evolving role of ADCs in mUC, examining their mechanisms, clinical efficacy, patient selection criteria, genetic insights, and future directions in personalized treatment strategies.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 9","pages":"106646"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responsive mesoporous silica nanocarriers in glioma therapy: A step forward in overcoming biological barriers.","authors":"Yasmeen Tarek Abdel-Maksoud, Ahmed Helmy Abdelhaseb, Amr Abd-Elraheem Abdo, Ahmed Mohamed Kamel, Mohamed Tallat Elsebay, Mohamed Salah Attia","doi":"10.5306/wjco.v16.i9.108731","DOIUrl":"10.5306/wjco.v16.i9.108731","url":null,"abstract":"<p><p>Gliomas are the most common primary tumors of the central nervous system; among them, glioblastoma multiforme stands out as the most aggressive and lethal subtype, characterized by high therapeutic resistance and frequent recurrences. Glioblastoma's complex pathology is driven by biological and molecular factors that compromise conventional therapies, including blood-brain and blood-tumor barriers, angiogenesis, immune evasion, and aberrant signaling pathways, along with genetic drivers of drug resistance. In cancer therapy, mesoporous silica nanoparticles (MSNs) have shown promise as nanocarriers thanks to the unique attributes of their mesostructure, including large surfaces, uniform pore sizes, high loading efficiency, and flexibility of chemical modifications. Several studies have proposed MSNs to address a number of challenges facing drug delivery in gliomas, including limited penetration across the blood-brain barrier, non-specific biodistribution, and systemic adverse reactions. Moreover, MSNs can be functionalized with tumor-targeting ligands so that cancer cells are selectively taken up, while they can also release therapeutic agents in response to internal and external stimuli, enabling controlled drug delivery within tumor microenvironments. Herein, we review the integration of the MSN-based delivery approach with advances in molecular oncology to improve clinical outcomes for glioma therapeutics, while highlighting the concerns around their limited clinical translation and potential toxicity.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 9","pages":"108731"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant treatment in resectable pancreatic cancer: Why is upfront surgery so hard to be beaten?","authors":"Pedro Luiz Serrano Uson Junior, Kunal C Kadakia, Raphael L C Araujo","doi":"10.5306/wjco.v16.i9.108955","DOIUrl":"10.5306/wjco.v16.i9.108955","url":null,"abstract":"<p><p>Neoadjuvant treatment is being extensively evaluated in pancreatic ductal adenocarcinoma (PDAC). This interest is appropriate given the dismal long-term prognosis for most patients who undergo upfront surgery. Despite prospective, retrospective and randomized trials supporting the role of neoadjuvant therapy in general for PDAC, the long-term benefit specifically for patients with resectable PDAC remains unclear. The phase III PREOPANC trial showed an improvement in overall survival in borderline resectable PDAC with neoadjuvant gemcitabine-based chemoradiation compared to upfront surgery alone, however, no such benefit was observed in the resectable cohort. Notably, three randomized trials (PANACHE01-PRODIGE 48, NORPACT-1, and PREOPANC-2) failed to show a clear improvement in overall survival with a neoadjuvant approach. The ongoing NeoFOL-R, PREOPANC-3, and the Alliance A021806 will help clarify the role of neoadjuvant therapy in resectable PDAC. In this minireview article we summarize the data surrounding neoadjuvant therapy in resectable pancreatic cancer and discuss future considerations of trials in this subgroup.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 9","pages":"108955"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}