World Journal of Cardiology最新文献

{"title":"Mood alteration and heart rate variability in patients with cancer on treatment.","authors":"Yun-Chen Chang, Wei-Nung Liu, Felicia Lin, Gen-Min Lin","doi":"10.4330/wjc.v17.i6.107114","DOIUrl":"10.4330/wjc.v17.i6.107114","url":null,"abstract":"<p><p>In this article, Deng and Song showed compelling evidence on the connection between heart rate variability (HRV) alterations and cancer in 127 cancer patients compared with healthy reference individuals, highlighting autonomic nervous system dysfunction as a significant physiological manifestation in cancer patients. We discussed that the reduced HRV may be associated with cancer treatments, <i>e.g.</i>, operation, chemotherapy and pain control and psychological response such as depression and anxiety related to the affected cancer. A management such as medicine to mood disturbances related to cancer has been shown a benefit to improve HRV in cancer patients.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 6","pages":"107114"},"PeriodicalIF":1.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute myocardial infarction in the young: A 3-year retrospective study.","authors":"Ahmed Hegazi Abdelsamie, Hani Omar Abdelhadi, Ahmed Taha Abdelwahed","doi":"10.4330/wjc.v17.i6.106445","DOIUrl":"10.4330/wjc.v17.i6.106445","url":null,"abstract":"<p><strong>Background: </strong>Acute myocardial infarction (AMI) is rare among patients aged ≤ 40 years but imposes significant morbidity, psychological distress, and economic burden. Approximately 10% of AMI hospitalizations involve patients under 45 years, underscoring the need to study this group. Compared to older patients, young AMI patients exhibit fewer traditional risk factors (<i>e.g.</i>, hypertension, diabetes) but higher rates of smoking, obesity, and non-atherosclerotic causes like spontaneous coronary artery dissection or coronary spasm, often linked to substance use. Global trends show rising obesity and dyslipidemia in young populations, with smoking contributing to 62%-90% of AMI cases in this age group. Family history of coronary artery disease also elevates risk, particularly in acute coronary syndrome. Studies like Bhardwaj <i>et al</i> report that young AMI patients are predominantly male with single-vessel disease, unlike the multi-vessel disease typical in older cohorts. This study characterizes AMI in young adults (≤ 40 years) at a single center, focusing on presentation, risk factors, angiographic findings, and management to guide preventive strategies.</p><p><strong>Aim: </strong>To describe the characteristics of AMI in young patients, including presentation, risk factors, coronary angiography (CAG) findings, and management strategies.</p><p><strong>Methods: </strong>This retrospective cross-sectional study analyzed 91 patients aged 20-40 years diagnosed with AMI at Mouwasat Hospital Dammam, from June 2020 to May 2023. Data on clinical presentation, cardiovascular risk factors, CAG findings, and treatments were collected from medical records. Descriptive statistics were used to summarize findings.</p><p><strong>Results: </strong>Of 91 patients (96.7% male, mean age 35.9 years ± 3.4 years), 43.9% were obese (body mass index > 30 kg/m²). Hyperlipidemia was the most prevalent risk factor (69.2%), followed by smoking (49.5%), diabetes mellitus (33.0%), and hypertension (26.4%). ST-elevation myocardial infarction (STEMI) was the most common presentation (57.1%). The left anterior descending artery was frequently affected (78.0%), with single-vessel disease predominant (72.5%). Most patients underwent percutaneous coronary intervention (PCI) (74.7%), while 8.8% required surgery.</p><p><strong>Conclusion: </strong>Young AMI patients are predominantly obese males with hyperlipidemia and smoking as key risk factors, presenting with STEMI and single-vessel disease amenable to PCI.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 6","pages":"106445"},"PeriodicalIF":1.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic myocarditis due to parasitic infection: A case-based minireview.","authors":"Thang Viet Luong, Tien Anh Hoang, Nong Ni Pham, Suong Thi Mai Nguyen, Quoc Bao Tran, Hung Minh Nguyen, Thang Chi Doan, Binh Anh Ho, Hai Nguyen Ngoc Dang","doi":"10.4330/wjc.v17.i6.107729","DOIUrl":"10.4330/wjc.v17.i6.107729","url":null,"abstract":"<p><p>Eosinophilic myocarditis (EM) is a rare inflammatory condition of the heart, often associated with eosinophilic infiltration. While its causes range from allergies to autoimmune and infectious diseases, parasitic infections are an uncommon but critical etiology. This mini-review focuses on a case of EM in a 47-year-old male from Vietnam, linked to <i>Schistosoma spp.</i>, <i>Strongyloides stercoralis</i>, and <i>Toxocara spp.</i> infections. The patient presented with severe chest pain and recovered fully after treatment with corticosteroids and albendazole. Drawing insights from this case and existing literature, we discuss the pathophysiology, diagnostic approaches, and therapeutic strategies for parasite-induced EM. Early diagnosis and tailored treatment are essential to improve clinical outcomes, especially in endemic parasitic areas.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 6","pages":"107729"},"PeriodicalIF":1.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic-dysfunction associated steatotic liver disease and atrial fibrillation: A review of pathogenesis.","authors":"Inderjeet Singh Bharaj, Ajit Singh Brar, Jasraj Kahlon, Anmol Singh, Priya Hotwani, Vikash Kumar, Aalam Sohal, Akash Batta","doi":"10.4330/wjc.v17.i6.106147","DOIUrl":"10.4330/wjc.v17.i6.106147","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) significantly contributes to cardiovascular morbidity, with cardiovascular disease being the leading cause of mortality among affected individuals. Atrial fibrillation (AF), the most common cardiac arrhythmia, is frequently observed in patients with MASLD. While shared metabolic risk factors such as obesity, diabetes, dyslipidemia, and hypertension are implicated, underlying pathophysiological mechanisms that include systemic inflammation, oxidative stress, insulin resistance, endothelial dysfunction, and activation of the renin-angiotensin-aldosterone system (RAAS) are proposed to play significant part in the increased risk of AF in MASLD. The aim is to review the pathogenesis linking MASLD and AF. A comprehensive literature review was conducted, focusing on studies that explore the epidemiology, pathogenesis, and clinical implications of MASLD and AF. Databases searched included PubMed, Scopus, and Web of Science, with keywords such as \"metabolic associated steatotic liver disease\", \"non fibrotic metabolic associated steatohepatitis\", \"Nonalcoholic fatty liver disease\", \"metabolic syndrome\", \"atrial fibrillation\", \"antifibrotic therapies\", \"pathogenesis\", and \"cardiovascular risk\". Chronic low-grade inflammation and oxidative stress in MASLD contribute to atrial structural and electrical remodeling, fostering an arrhythmogenic substrate. Insulin resistance, a hallmark of MASLD, exacerbates metabolic dysfunction and promotes atrial fibrosis. Dysregulated lipid metabolism and gut microbiota alterations further compound cardiovascular risk. Aldosterone dysregulation and systemic inflammation stemming from RAAS activation contributes to the shared pathophysiology. The severity of MASLD does not seem to directly influence the risk of AF, suggesting that even early stages of liver disease can increase susceptibility to this arrhythmia. Effective management of MASLD requires targeted risk-factor modification strategies, including weight management, glycemic control, and pharmacological interventions. A multidisciplinary approach is essential for comprehensive assessment and management of MASLD patients, with a focus on cardiovascular risk assessment and arrhythmia prevention. Future research should explore the impact of emerging MASLD therapeutic agents on the incidence and recurrence of cardiac arrhythmias. Early detection and comprehensive management of MASLD and AF are crucial to mitigate the dual burden of these conditions.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 6","pages":"106147"},"PeriodicalIF":1.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteosarcopenia in older adults undergoing transcatheter aortic valve replacement: A narrative review of mortality and frailty implications.","authors":"Peng Li, Hui-Ping Zhang","doi":"10.4330/wjc.v17.i5.107320","DOIUrl":"10.4330/wjc.v17.i5.107320","url":null,"abstract":"<p><p>This narrative review examines osteosarcopenia, characterized by the concurrent loss of muscle mass and bone density, as a pivotal marker of frailty in older adults. Its implications for patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis remain underexplored. This review examines the association between osteosarcopenia and adverse clinical outcomes in older adults undergoing TAVR, with an emphasis on mortality. It also evaluates the integration of osteosarcopenia into pre-procedural risk assessments. Contemporary studies were reviewed, focusing on older adults undergoing TAVR. Key parameters included pre-procedural assessments of muscle mass (psoas cross-sectional area) and bone density (lumbar trabecular attenuation) using computed tomography. Clinical correlations with frailty indices, nutritional deficiencies, functional disability and mortality were analyzed. Studies including the FRAILTY-AVR cohort indicate that osteosarcopenia affects 15%-20% of TAVR patients and independently predicts 1-year mortality. Combined deficits in muscle and bone health are associated with elevated risks of post-TAVR complications, prolonged hospitalizations, and worsening disability compared to isolated sarcopenia or osteoporosis (<i>P</i> < 0.05). Incorporating osteosarcopenia into risk stratification models could enhance predictive accuracy for adverse outcomes. Osteosarcopenia serves as a critical biomarker for frailty and should be routinely assessed in pre-TAVR evaluations. Targeted interventions, such as resistance training and nutritional optimization, may mitigate its impact and improve clinical outcomes. Early identification facilitates personalized management strategies, enhancing survival and quality of life in this high-risk cohort.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"107320"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating microRNAs in predicting fibrosis in hypertrophic cardiomyopathy: A systematic review.","authors":"Maneeth Mylavarapu, Lakshmi Sai Meghana Kodali, Roopeessh Vempati, Jai Sivanandan Nagarajan, Ankit Vyas, Rupak Desai","doi":"10.4330/wjc.v17.i5.106123","DOIUrl":"10.4330/wjc.v17.i5.106123","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and interstitial fibrosis, which contribute to adverse outcomes such as heart failure and sudden cardiac death. While cardiac magnetic resonance (CMR) imaging is commonly used to detect myocardial fibrosis, circulating microRNAs (miRNAs) have emerged as promising noninvasive biomarkers for this condition due to their stability in blood plasma and resistance to pH and temperature variance.</p><p><strong>Aim: </strong>To explore the role of specific circulating miRNAs in identifying myocardial fibrosis in patients with HCM.</p><p><strong>Methods: </strong>Using PubMed/MEDLINE and Google Scholar, we reviewed studies from 2014 to 2024 examining the link between circulating miRNAs and myocardial fibrosis in HCM. We included studies measuring miRNA expression in blood samples from HCM patients and assessing fibrosis <i>via</i> imaging, mostly CMR. Data extraction concentrated on the population, methodology, and findings related to the correlation between miRNA levels and fibrosis.</p><p><strong>Results: </strong>Seven studies involving 365 HCM patients with a mean age of 49.37 ± 10.5 years, 116 (31.78%) females, and one animal study identified miR-21, miR-29a, miR-133, miR-4454, and miR-221 as frequently dysregulated markers associated with fibrosis. Elevated levels of miR-21 and miR-29a correlated with more extensive fibrosis, as assessed by late gadolinium enhancement in CMR imaging, with miR-29a consistently linked to both fibrosis and hypertrophy across the studies.</p><p><strong>Conclusion: </strong>Circulating miRNAs, particularly miR-21, miR-29a, and miR-221, show significant potential as biomarkers for myocardial fibrosis in HCM. Further research should validate these findings and investigate the clinical application of miRNA-based diagnostics in HCM.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"106123"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of myocardial damage induced by doxorubicin <i>via</i> calumenin-regulated mitochondrial dynamics and the calcium-Cx43 pathway.","authors":"He Shi, Song-Ao Yang, Ling-Yu Bai, Jian-Jun Du, Zhe Wu, Zhi-Hui He, Hao Liu, Jia-Yue Cui, Ming Zhao","doi":"10.4330/wjc.v17.i5.104839","DOIUrl":"10.4330/wjc.v17.i5.104839","url":null,"abstract":"<p><strong>Background: </strong>The clinical application of doxorubicin (DOX) is limited by its potential to cause cardiac cardiotoxicity.</p><p><strong>Aim: </strong>To investigate the correlation between calumenin (CALU) and mitochondrial kinetic-related proteins in rats with DOX cardiomyopathy.</p><p><strong>Methods: </strong>A rat model of DOX-induced cardiomyopathy was used to evaluate the effects of DOX. We observed the effect of DOX on electrical conduction in cardiomyocytes using the electromapping technique. Masson staining was performed to evaluate myocardium fibrosis. Electron microscopy was used to observe the changes in pathological ultrastructure of the myocardium. Western blotting and ELISAs were performed to detect protein levels and intracellular free Ca²⁺ concentration.</p><p><strong>Results: </strong>DOX slowed conduction and increased conduction dispersion in cardiomyocytes. The myocardial pathology in rats treated with DOX exhibited a significant deterioration, as demonstrated by an increase in mitochondrial Ca²⁺ concentration and a decrease in the expression of CALU, optic atrophy-1, and Bcl-2. Additionally, there was an increase in the expression of connexin 43 (Cx43) and the mitochondrial mitotic proteins dynamin-related protein 1, CHOP, Cytochrome C, and Bax in DOX rats. Decreased expression of CALU in cardiomyocytes triggered an increase in cytoplasmic free calcium concentration, which would normally be taken up by mitochondria, but decreased expression of mitochondrial outer membrane fusion proteins triggered a decrease in mitochondrial Ca²⁺ uptake, and the increase in cytoplasmic free calcium concentration triggered cell apoptosis.</p><p><strong>Conclusion: </strong>Increased cytoplasmic free calcium ion concentration induces calcium overload in ventricular myocytes, leading to decreased Cx43 protein, slowed conduction in myocytes, and increased conduction dispersion, resulting in arrhythmias.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"104839"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal analgesia in cardiac surgery: Impact on postoperative medication consumption and cognitive function.","authors":"Qin Wang, Xiao-Qiong Yan, Xiao-Mei Ma, Rui Yan, Zhi-Hua Wang, Yu-Jie Ma, Hai-Bin Wang","doi":"10.4330/wjc.v17.i5.103168","DOIUrl":"10.4330/wjc.v17.i5.103168","url":null,"abstract":"<p><strong>Background: </strong>Patients who undergo cardiac surgery often face postoperative pain and potential cognitive issues. Multimodal analgesia may address these problems. We hypothesized that multimodal analgesia can reduce opioid use and improve cognitive recovery.</p><p><strong>Aim: </strong>To investigate the effects of multimodal analgesia on postoperative opioid consumption and cognitive recovery in patients who underwent cardiac surgery.</p><p><strong>Methods: </strong>A prospective, randomized controlled trial at General Hospital from January 2020 to April 2023 recruited a total of 150 adult patients who underwent elective cardiac surgery. The patients were randomly divided into two groups. Group A had patient-controlled intravenous analgesia with sufentanil and flurbiprofen axil. Group B had flurbiprofen axil and paravertebral nerve block. Data were analyzed with appropriate statistical methods.</p><p><strong>Results: </strong>Group B had lower postoperative patient-controlled intravenous analgesia drug consumption (2.21 mL/hour <i>vs</i> 4.26 mL/hour, <i>P</i> < 0.001), shorter extubation time (2.32 hours <i>vs</i> 3.81 hours, <i>P</i> < 0.001), and intensive care unit stay (15.32 h <i>vs</i> 28.63 h, <i>P</i> < 0.001). Visual Analogue Scale pain scores were lower in group B (<i>P</i> < 0.001). Group B had fewer postoperative complications (no respiratory depression <i>vs</i> 37.9% in group A, <i>P</i> < 0.05), a lower postoperative cognitive dysfunction incidence (16.0% <i>vs</i> 28.0%, <i>P</i> < 0.05), and higher Barthel Index scores (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Multimodal analgesia with paravertebral nerve block and flurbiprofen axil reduces opioid use and improves cognitive outcomes in patients who underwent cardiac surgery.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"103168"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between heart rate variability and cancer management.","authors":"Takashi Kikuchi, Takatoshi Kasai","doi":"10.4330/wjc.v17.i5.107434","DOIUrl":"10.4330/wjc.v17.i5.107434","url":null,"abstract":"<p><p>In patients with advanced cancer, the prevalence rate of cardiac autonomic neuropathy (CAN) is high, and the prognosis of patients with CAN is generally poor. Although mechanisms including inflammation, infection, metabolism, neurodegeneration, toxic processes, and cancer treatment have been proposed as etiologies of CAN in cancer patients, these mechanisms have not been completely elucidated, and their relationship has only been described indirectly. A study involving 127 cancer patients revealed that both the disease and its treatments can lead to a decrease in heart rate variability (HRV) indicating the autonomic imbalance. Because managing CAN is essential for improving the survival and quality of life of patients with cancer, patients and specialists can work together to customize cancer treatment and management using HRV as an index.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"107434"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible dilated cardiomyopathy caused by primary hyperparathyroidism: A case report.","authors":"Wei Jiang, Yu-Zhi Qiu, Hu-Tao Xi, Hui-Hui Ma, Xin Wu, Xiao-Mei Yuan, Wen-Yan Wang, Hong Kong, Xiao-Ping Li","doi":"10.4330/wjc.v17.i5.105670","DOIUrl":"10.4330/wjc.v17.i5.105670","url":null,"abstract":"<p><strong>Background: </strong>Dilated cardiomyopathy (DCM) is a common cause of systolic heart failure, and is the most prevalent type of non-ischemic cardiomyopathy. Primary hyperparathyroidism (PHPT) is characterized by hypercalcemia and excessive secretion of parathyroid hormone (PTH). Generally, PHPT is asymptomatic and is incidentally identified during routine laboratory assessments.</p><p><strong>Case summary: </strong>This case report details a 52-year-old man diagnosed with DCM and refractory hypercalcemia, who presented with clinical manifestations including dyspnea, recurrent anorexia, and abdominal distention. Laboratory investigations indicated an elevated serum PTH level, and the sestamibi scan suggested the presence of a parathyroid adenoma. Hence, the patient underwent a parathyroidectomy, which pathologically confirmed the diagnosis of a parathyroid adenoma. Postoperatively, the patient's hypercalcemia was corrected, the dimensions of the cardiac chambers were reduced, and there was a marked improvement in cardiac function.</p><p><strong>Conclusion: </strong>Our findings emphasize the importance of PTH assessment in patients with DCM and concurrent hypercalcemia.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"105670"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}