World Journal of Cardiology最新文献

{"title":"Predictive value of the systemic immune inflammation index in recurrence of atrial fibrillation after radiofrequency catheter ablation.","authors":"Alexander E Berezin","doi":"10.4330/wjc.v17.i1.102981","DOIUrl":"10.4330/wjc.v17.i1.102981","url":null,"abstract":"<p><p>The recurrence of atrial fibrillation (AF) in patients after successful radiofrequency catheter ablation (RFCA) appears to be an unresolved clinical issue and needs to be clearly elucidated. There are many factors associated with AF recurrence, such as duration of AF, male sex, concomitant heart failure, hemodynamic parameters, chronic obstructive pulmonary disease, hypertension, obstructive sleep apnea, hyperthyroidism, smoking and obesity. However, the inflammatory changes are strongly associated with electrical and structural cardiac remodeling, cardiac damage, myocardial fibrotic changes, microvascular dysfunction and altered reparative response. In this context, biomarkers reflecting the different stages of AF pathogenesis deserve thorough investigation. The authors of the retrospective study revealed that one-year recurrence rate of non-valvular AF in the high systemic immune inflammation (SII) index group was significantly increased compared to that of the low SII index group and provided additional predictive value to the APPLE. Furthermore, the authors suggest that this biomarker may help physicians to optimize the selection of AF patients and to develop a personalized treatment approach. In conclusion, the SII index may serve as a valuable indicator of recurrent AF in patients after RFCA and may be a biomarker with plausible predictive value for poor clinical outcomes.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 1","pages":"102981"},"PeriodicalIF":1.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profiling and bioinformatics analyses of circular RNAs in myocardial ischemia/reperfusion injury model in mice.","authors":"Jiao-Ni Wang, Ying-Ying Zhou, Yong-Wei Yu, Jun Chen","doi":"10.4330/wjc.v17.i1.102147","DOIUrl":"10.4330/wjc.v17.i1.102147","url":null,"abstract":"<p><strong>Background: </strong>Myocardial ischemia/reperfusion (I/R) injury, which is associated with high morbidity and mortality, is a main cause of unexpected myocardial injury after acute myocardial infarction. However, the underlying mechanism remains unclear. Circular RNAs (circRNAs), which are formed from protein-coding genes, can sequester microRNAs or proteins, modulate transcription and interfere with splicing. Authoritative studies suggest that circRNAs may play an important role in myocardial I/R injury.</p><p><strong>Aim: </strong>To explore the role and mechanism of circRNAs in myocardial I/R injury.</p><p><strong>Methods: </strong>We constructed a myocardial I/R injury model using ligation of the left anterior descending coronary artery, and evaluated the success of the validated model using triphenyltetrazolium chloride and hematoxylin-eosin staining. Then, left ventricular samples from different groups were selected for mRNA-sequence, and differential gene screening was performed on the obtained results. The differentially obtained mRNAs were divided into up-regulated and down-regulated according to their expression levels, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis were performed, respectively. Then, the obtained circRNA and microRNA (miRNA) were paired for analysis, and the binding sites of miRNA and mRNA were virtual screened. Finally, the obtained circRNA, miRNA and mRNA were constructed by ceRNA mutual most useful network.</p><p><strong>Results: </strong>We used an RNA sequencing array to investigate the expression signatures of circRNAs in myocardial I/R injury using three samples from the I/R group and three samples from the sham group. A total of 142 upregulated and 121 downregulated circRNAs were found to be differentially expressed (fold change ≥ 2, <i>P</i> < 0.05). GO and KEGG functional analyses of these circRNAs were performed. GO analysis revealed that these circRNAs were involved mainly in cellular and intracellular processes. KEGG analysis demonstrated that 6 of the top 20 pathways were correlated with cell apoptosis. Furthermore, a circRNA-miRNA coexpression network and ceRNA network based on these genes were constructed, revealing that mmu-circ-0001452, mmu-circ-0001637, and mmu-circ-0000870 might be key regulators of myocardial I/R injury.</p><p><strong>Conclusion: </strong>This research provides new insights into the mechanism of myocardial I/R, which mmu-circ-0001452, mmu-circ-0001637, and mmu-circ-0000870 are expected to be new therapeutic targets for myocardial I/R injury.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 1","pages":"102147"},"PeriodicalIF":1.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocturnal sentry duty and cardiometabolic characteristics in armed forces personnel.","authors":"Yen-Po Lin, Yi-Chiung Hsu, Ko-Huan Lin, Kun-Zhe Tsai, Chen-Chih Chu, Yen-Chen Lin, Gen-Min Lin","doi":"10.4330/wjc.v16.i12.751","DOIUrl":"10.4330/wjc.v16.i12.751","url":null,"abstract":"<p><strong>Background: </strong>Sleep deprivation can lead to increased body weight and blood pressure (BP), but the latent effects of partial sleep deprivation related to required night sentry duties within a short-term period on cardiometabolic characteristic changes in military personnel are unclear.</p><p><strong>Aim: </strong>To investigate the association between night sentry duty frequency in the past 3 months and cardiometabolic characteristics in armed forces personnel.</p><p><strong>Methods: </strong>A total of 867 armed forces personnel who were aged 18-39 years and did not take any antihypertensive medications in Taiwan in 2020 were included. The frequency of night sentry duty was self-reported <i>via</i> a questionnaire (average number of night sentry shifts per month for the past 3 months). Hemodynamic status was assessed <i>via</i> the resting BP and pulse rate (PR). Cardiometabolic risk factors were defined according to the International Diabetes Federation criteria. Multivariable linear regression analyses of the associations between night sentry duties and PR, BP, and other metabolic syndrome (MetS) marker levels were performed, with adjustments for age, sex, substance use, body mass index and aerobic fitness. Multiple logistic regression analysis was carried out to determine the associations between night sentry duties and the prevalence of each MetS feature.</p><p><strong>Results: </strong>There was an association between night sentry duties and PR [standardized β (standard error) = 0.505 (0.223), <i>P</i> =0.02], whereas there was no association with systolic and diastolic BP. In addition, there was an inverse association between night sentry duties and high-density lipoprotein cholesterol (HDL-C) levels [standardized β = -0.490 (0.213), <i>P</i> = 0.02], whereas there was no association with the other metabolic marker levels. Compared with personnel without night sentry duties, those with ≥ 1 night sentry shift/month had a greater risk of impaired fasting glucose (≥ 100 mg/dL) [odds ratio: 1.415 (confidence interval: 1.016-1.969)], whereas no associations with other MetS features were found.</p><p><strong>Conclusion: </strong>Among military personnel, the burden of night sentry duty was positively associated with the resting PR but inversely associated with HDL-C levels. In addition, personnel with partial sleep deprivation may have a greater risk of impaired fasting glucose than those without partial sleep deprivation.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 12","pages":"751-759"},"PeriodicalIF":1.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing bleeding, thrombosis and myocardial injury: A call for balance and precision medicine for aspirin in neurosurgery.","authors":"Subhrashis Guha Niyogi, Akash Batta, Bishav Mohan","doi":"10.4330/wjc.v16.i12.673","DOIUrl":"10.4330/wjc.v16.i12.673","url":null,"abstract":"<p><p>Perioperative management of antiplatelet therapy involves a delicate balancing of the risk of periprocedural blood loss with the cardiovascular and thrombotic risk to the patient. Due to the unique nature of neurosurgery, perioperative bleeding may have devastating consequences and cause major morbidity and mortality. The recommendation to discontinue aspirin prior to major neurosurgical procedures rests upon conventional practice, expert consensus with priority given to avoidance of any major bleed. On the contrary recent prospective data do not support the existence of additional bleeding risk in patients continuing aspirin compared to those who stop aspirin prior to procedure. Patients with cardiovascular and metabolic comorbidities are increasingly encountered in the operation theatre these days. In these patients, prevention of myocardial injury after non-cardiac surgery (MINS) is an important focus for perioperative risk reduction. Prolonged (≥ 7 days) cessation of antiplatelets is one of the most important predictors of MINS. This complicated milieu of risks and benefits highlights the difficulty of practicing evidence-based medicine and minimizing harm in patients on aspirin needing neurosurgery.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 12","pages":"673-676"},"PeriodicalIF":1.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-cigarettes and arterial health: A review of the link between vaping and atherosclerosis progression.","authors":"Muhammad Hassan, Julia Vinagolu-Baur, Vivian Li, Kelly Frasier, Grace Herrick, Tiffany Scotto, Erica Rankin","doi":"10.4330/wjc.v16.i12.707","DOIUrl":"10.4330/wjc.v16.i12.707","url":null,"abstract":"<p><p>Recent studies have suggested an evolving understanding of the association between vaping, specifically electronic cigarette (e-cigarette) use, and the progression of atherosclerosis, a significant contributor to cardiovascular disease. Despite the prevailing perception of vaping as a safer alternative to traditional tobacco smoking, accumulating evidence suggests that the aerosols emitted by e-cigarettes contain harmful constituents that may promote endothelial dysfunction, oxidative stress, inflammation, and dyslipidemia-key mechanisms implicated in atherosclerosis pathogenesis. While past research, including experimental studies and clinical investigations, has shed light on the potential cardiovascular risks associated with vaping, gaps in knowledge persist. Future research endeavors should focus on interpreting the long-term effects of vaping on atherosclerosis development and progression, exploring the impact of different e-cigarette formulations and user demographics, and identifying effective strategies for mitigating the cardiovascular consequences of vaping. By identifying and addressing these research gaps, we can enhance our understanding of the cardiovascular implications of vaping and inform evidence-based interventions and policies to safeguard public health.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 12","pages":"707-719"},"PeriodicalIF":1.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative breakthrough: Umbilical cord mesenchymal stem cells <i>vs</i> bone marrow mesenchymal stem cells in heart failure treatment.","authors":"Peng Li","doi":"10.4330/wjc.v16.i12.776","DOIUrl":"10.4330/wjc.v16.i12.776","url":null,"abstract":"<p><p>In this article, we evaluate the comparative efficacy and safety of mesenchymal stem cells (MSCs) derived from bone marrow (BM-MSCs) and umbilical cord (UC-MSCs) in the treatment of heart failure and myocardial infarction. MSCs have gained importance as living bio drug due to their regenerative potential, with BM-MSCs being the most extensively studied. However, UC-MSCs offer unique advantages, such as noninvasive collection and fewer ethical concerns. This systematic review and meta-analysis summarizes data from 13 randomized controlled trials, which included a total of 693 patients. Their study shows that UC-MSCs significantly improved left ventricular ejection fraction by 5.08% at 6 months and 2.78% at 12 months compared with controls, while BM-MSCs showed no significant effect. Neither cell type showed significant changes in 6-minute walk distance. In addition, UC-MSCs and BM-MSCs had comparable safety profiles, with no significant differences in major adverse cardiac events, except for a lower rehospitalization rate observed with BM-MSCs. These results position UC-MSCs as a promising alternative in MSC-based therapies for cardiac disease, offering potential improvements in cardiac function while maintaining a favorable safety profile. Future research should focus on optimizing administration protocols and further exploring the long-term benefits and mechanisms of UC-MSCs in cardiac repair.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 12","pages":"776-780"},"PeriodicalIF":1.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in cardiovascular and cerebrovascular health scores in the Kailuan population from 2006 to 2011.","authors":"Yao Yu, Zhao-Xu Zhang, Su-Feng Yin, Shou-Ling Wu, Zun-Jing Liu","doi":"10.4330/wjc.v16.i12.731","DOIUrl":"10.4330/wjc.v16.i12.731","url":null,"abstract":"<p><strong>Background: </strong>The American Heart Association defines cardiovascular health in terms of four behaviors (smoking, diet, physical activity, and body weight) and three factors (plasma glucose, cholesterol, and blood pressure). By this definition, the prevalence of ideal cardiovascular health behaviors and factors (ICHBF) is negatively correlated with all-cause mortality and risks of cardiovascular and cerebrovascular diseases and malignancy.</p><p><strong>Aim: </strong>To investigate the changing trends of cardiovascular and cerebrovascular health scores in the Kailuan study population from 2006 to 2011.</p><p><strong>Methods: </strong>The Kailuan population data from three health checkups held in 2006-2007, 2008-2009, and 2010-2011 were analyzed, and the constituent ratios of cardiovascular and cerebrovascular health behaviors and factors at ideal, intermediate, and poor levels were calculated by using Huffman and Capewell method. Simultaneously, the cardiovascular and cerebrovascular health behavior and factor scores were calculated.</p><p><strong>Results: </strong>From 2006 to 2007, the proportion of people with ideal physical exercise, low salt diet, ideal body mass index, ideal total cholesterol level, no smoking, ideal blood sugar, and ideal blood pressure was 13.12%, 9.34%, 49.17%, 64.20%, 49.27%, 69.99%, and 20.55%, respectively, in men with a health score of 8.46, and 12.00%, 9.13%, 61.60%, 64.28%, 98.19%, 78.90% and 36.92% in women, with a score of 10.02. From 2008 to 2009, the proportion was 16.09%, 14.04%, 51.94%, 65.02%, 40.18%, 66.44%, and 17.04% in men, with a score of 8.18, and 16.860%, 17.360%, 64.010%, 67.433%, 98.220%, 76.370%, and 42.340% in women, with a score of 10.12. From 2010 to 2011, the proportion was 12.22%, 17.65%, 49.40%, 68.33%, 48.17%, 64.67%, and 14.68% in males, having a score of 8.21, while in females, the proportion was 11.83%, 18.09%, 49.40%, 67.85%, 98.82%, 74.52%, and 37.78%, with a score of 9.90.</p><p><strong>Conclusion: </strong>The prevalence of ideal cardiovascular and cerebrovascular health behaviors and factors is low in the Kailuan study population due to inadequate scores of relevant health metrics.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 12","pages":"731-739"},"PeriodicalIF":1.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-dependent glucose transporter 2 inhibitors: Transforming diabetic cardiomyopathy management.","authors":"Chun-Han Cheng, Wen-Rui Hao, Tzu-Hurng Cheng","doi":"10.4330/wjc.v16.i12.781","DOIUrl":"10.4330/wjc.v16.i12.781","url":null,"abstract":"<p><p>This article addresses the substantial findings of a study on sodium-dependent glucose transporter 2 inhibitors (SGLT2is) and their effects on myocardial function in patients with type 2 diabetes and asymptomatic heart failure. The editorial explores the broader implications of the study findings for clinical practice, thus highlighting the pivotal role of SGLT2is in improving cardiac function, reducing oxidative stress, and attenuating inflammation. It emphasizes the importance of early intervention with SGLT2is in preventing the progression of diabetic cardiomyopathy; hence, these inhibitors have the potential to transform the management of asymptomatic heart failure in patients with diabetes.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 12","pages":"781-786"},"PeriodicalIF":1.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right ventricular diverticulum following a pulmonary valve placement for correction of tetralogy of Fallot: A case report.","authors":"David Martinez Juarez, Omar Gomez Monterrosas, Alonso Tlecuitl Mendoza, Francisco Zamora Rosales, Rodrigo Álvarez Calderón, Daniel A Cepeda Ortiz, Erick E Espinosa Solis","doi":"10.4330/wjc.v16.i12.760","DOIUrl":"10.4330/wjc.v16.i12.760","url":null,"abstract":"<p><strong>Background: </strong>Ventricular diverticula are a rare congenital cardiac disorder presenting with an extremely low incidence. The presence of an apical diverticulum of the right ventricle has been associated with other congenital heart diseases such as tetralogy of Fallot. An important defining characteristic of ventricular diverticula that separates them from aneurysms through imaging techniques, is that they possess myocardial contraction synchronous to the adjacent walls, contributing to the ventricular stroke volume, so they do not usually require surgical treatment.</p><p><strong>Case summary: </strong>A 15-year-old male, currently asymptomatic, in follow up due to a pulmonary valve prosthesis placement and a history of corrected tetralogy of Fallot at 18 months old, underwent a cardiac magnetic resonance imaging in February 2024. A diverticulum was detected in the apical inferolateral wall of the right ventricle, which was not documented in the cardiac magnetic resonance imaging prior to valve prosthesis placement.</p><p><strong>Conclusion: </strong>Right ventricular diverticula are a rare entity. To this date we could not find another case of a pulmonary valve placement, followed by a right ventricular diverticulum appearance.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 12","pages":"760-767"},"PeriodicalIF":1.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of a new inflammation predictor in predicting recurrence of atrial fibrillation after radiofrequency catheter ablation.","authors":"Yu-Jie Wang, Ke-Sen Liu, Xiang-Jiang Meng, Xue-Fu Han, Lu-Jing Nie, Wen-Jiu Feng, Yan-Bo Chen","doi":"10.4330/wjc.v16.i12.740","DOIUrl":"10.4330/wjc.v16.i12.740","url":null,"abstract":"<p><strong>Background: </strong>Radiofrequency catheter ablation (RFCA) has become an important strategy for treating atrial fibrillation (AF), and postoperative recurrence represents a significant and actively discussed clinical concern. The recurrence after RFCA is considered closely related to inflammation. Systemic immune inflammation index (SII) is a novel inflammation predictor based on neutrophils, platelets, and lymphocytes, and is considered a biomarker that comprehensively reflects the immune inflammatory status of the body.</p><p><strong>Aim: </strong>To explore the predictive effect of the SII on AF recurrence after RFCA and its predictive value in combination with the existing APPLE score for AF recurrence after RFCA in patients with non-valvular AF (NVAF).</p><p><strong>Methods: </strong>We retrospectively included 457 patients with NVAF first receiving RFCA and classified them into the recurrent or non-recurrent group. We also investigated the predictive role of SII on AF recurrence following RFCA. Finally, we explored and compared the additional predictive value of the SII after combining with the APPLE score.</p><p><strong>Results: </strong>After 12 months of follow-up, 113 (24.7%) patients experienced recurrence. High SII has been demonstrated to be an independent predictor for postoperative AF recurrence. Receiver operating characteristic and decision curve analysis (DCA), as well as net reclassification improvement (NRI) and integrated discrimination improvement (IDI) results, showed that SII combined with the APPLE score had higher predictive efficiency than using the SII or APPLE score alone. The area under the curve of the combined model (0.662, 95% confidence interval: 0.602-0.722) significantly increased compared with that of the SII and APPLE scores alone (<i>P</i> < 0.001). The combined model resulted in an NRI of 29.6% and 34.1% and IDI of 4.9% and 3.5% in predicting AF recurrence compared with the SII and APPLE scores alone, respectively (all <i>P</i> < 0.001). The SII, APPLE score, and their combination demonstrated greater clinical utility than did the treat-all and treat-none strategies over the 20-80% risk threshold according to the DCA.</p><p><strong>Conclusion: </strong>The SII was a predictor of recurrence after RFCA of AF. Moreover, the SII enhanced the predictability of the APPLE score for post-RFCA AF recurrence, providing valuable insights for physicians to optimise patient selection and develop personalised treatment plans.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 12","pages":"740-750"},"PeriodicalIF":1.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}