Acta Biomaterialia最新文献

{"title":"Corrigendum to “Stiffness memory nanohybrid scaffolds generated by indirect 3D printing for biologically responsive soft implants” [Acta Biomaterialia, 80, 2018, 188-202]","authors":"Linxiao Wu , Jatinder Virdee , Elizabeth Maughan , Arnold Darbyshire , Gavin Jell , Marilena Loizidou , Mark Emberton , Peter Butler , Ashley Howkins , Alan Reynolds , Ian W. Boyd , Martin Birchall , Wenhui Song","doi":"10.1016/j.actbio.2025.01.052","DOIUrl":"10.1016/j.actbio.2025.01.052","url":null,"abstract":"","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 523-525"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An injectable and adaptable system for the sustained release of hydrogen sulfide for targeted diabetic wound therapy by improving the microenvironment of inflammation regulation and angiogenesis","authors":"Hao Zhang ,&nbsp;Xianzhen Dong ,&nbsp;Yuhang Liu ,&nbsp;Ping Duan ,&nbsp;Changjiang Liu ,&nbsp;Kun Liu ,&nbsp;Yifeng Yu ,&nbsp;Xinyue Liang ,&nbsp;Honglian Dai ,&nbsp;Aixi Yu","doi":"10.1016/j.actbio.2025.02.048","DOIUrl":"10.1016/j.actbio.2025.02.048","url":null,"abstract":"<div><div>The combined effects of persistent chronic inflammation, oxidative stress, microcirculation disorders, and dysregulated cellular energy metabolism often hinder the repair of diabetic skin wounds. Traditional treatment methods are typically insufficient in simultaneously addressing these complex factors, resulting in delayed wound healing and a high propensity for recurrence and chronic ulceration. This study developed an innovative strategy based on reactive oxygen species (ROS)–responsive nanoparticles loaded with an ultraviolet (UV)-light-responsive hydrogen sulfide (H₂S) donor. This approach leverages the endogenous ROS present in diabetic wounds and external UV light as dual triggers to facilitate the controlled and stepwise release of H₂S. The material design explicitly targets the critical challenges in diabetic wound repair, including the inhibition of chronic inflammation, oxidative stress reduction, microcirculation improvement, and support of cellular energy metabolism, thereby significantly accelerating wound healing. This adaptive release of signaling molecules effectively modulates the wound regeneration microenvironment, enhancing the repair process and offering a promising solution for diabetic skin wound management.</div></div><div><h3>Statement of significance</h3><div>This study developed an innovative strategy based on reactive oxygen species (ROS)–responsive nanoparticles loaded with an ultraviolet (UV)-light-responsive hydrogen sulfide (H₂S) donor. This approach leverages the endogenous ROS present in diabetic wounds and external UV light as dual triggers to facilitate the controlled and stepwise release of H₂S. The material design explicitly targets the critical challenges in diabetic wound repair, including the inhibition of chronic inflammation, oxidative stress reduction, microcirculation improvement, and support of cellular energy metabolism, thereby significantly accelerating wound healing. This adaptive release of signaling molecules effectively modulates the wound regeneration microenvironment, enhancing the repair process and offering a promising solution for diabetic skin wound management.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 364-379"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity in cranial dura mater at the microscale: An In-situ and ex-vivo structural and mechanical investigation of sulcus and gyrus Dura","authors":"Mohammad Tabatabaei,&nbsp;Lakiesha N. Williams","doi":"10.1016/j.actbio.2025.02.053","DOIUrl":"10.1016/j.actbio.2025.02.053","url":null,"abstract":"<div><div>This study examines cranial dura mater's structural and mechanical heterogeneity, focusing on the distinct properties between the sulcus and gyrus regions. Microscale analyses using two-photon microscopy and atomic force microscopy (AFM) revealed significant regional differences in thickness (p &lt; 0.05), with sulcus dura being 1.34 times thicker than gyrus dura. Differences in effective Young's modulus were observed, with values of 6.75 ± 5.12 kPa in the sulcus and 10.48 ± 7.13 kPa in the gyrus. These findings highlight the dura mater's pronounced variability in stiffness and anisotropy, with the periosteal layer being substantially stiffer than the meningeal layer. These results underscore the critical role of collagenous architecture in determining dura's mechanical behavior, particularly in the transfer of loads across the brain. This study provides valuable insights into the functional heterogeneity of the dura mater and emphasizes the importance of these variations in the design of biomimetic dural grafts. The quantitative data generated in this study has significant implications for enhancing the biofidelity of computational models used in brain biomechanics and advancing tissue engineering strategies to develop dural substitutes.</div></div><div><h3>Statement of Significance</h3><div>This study presents a comprehensive analysis of the structural and mechanical heterogeneity of cranial dura mater at the nanoscale, focusing on the differences between sulcus and gyrus regions. By employing advanced techniques such as atomic force microscopy (AFM) and two photon microscopies, the findings are crucial for understanding the dura's protective functions and its role in load transfer across the brain. The implications of this study are significant for the development of biomimetic dural grafts, as it offers detailed quantitative data necessary for designing grafts that closely mimic the native dura's structural and mechanical. Additionally, this research could help develop more accurate finite element models (FEM) to study traumatic brain injuries (TBI) and brain dynamics.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 222-232"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A conductive polymer restores connexin43 expression through the suppression of mitogen-activated protein kinases to improve intercellular communication and alleviate atrial fibrillation","authors":"Chong-yu Zhang ,&nbsp;Cheng Fan ,&nbsp;Shu-hong Li ,&nbsp;Jun Wu ,&nbsp;Yvonne Ziyi Peng ,&nbsp;Hsing-wen Sung ,&nbsp;Shiming Liu ,&nbsp;Ren-Ke Li","doi":"10.1016/j.actbio.2025.02.058","DOIUrl":"10.1016/j.actbio.2025.02.058","url":null,"abstract":"<div><div>Conductive biomaterials have shown promising results for correcting pathological cardiac electrical signaling. However, their mechanisms of operation are still largely unclear. One reason behind disrupted cardiac intercellular communication, though, is lowered expression of the gap junction protein connexin43 (Cx43), which may be alleviated by conductive biomaterials. In this study, we aimed to test this hypothesis, using the self-doping conductive biomaterial poly-3-amino-4-methoxybenzoic acid-gelatin (PAMB-G). An <em>in vitro</em> model was established, in which cardiomyocytes (CMs) were treated with anisomycin, while the <em>in vivo</em> model involved anisomycin-treated mice subjected to electrical pacing to induce atrial fibrillation (AF). Cx43 expression, Ca²⁺ transient propagation, and CM electrical conduction <em>in vitro</em>, as well as the <em>in vivo</em> effects of PAMB-G on AF, were evaluated; additionally, the underlying molecular mechanisms were identified. We found that anisomycin, at different concentrations, down-regulated Cx43; this was counteracted by PAMB-G, which restored proper Cx43 expression, coupled with improved Ca²⁺ signal and electrical conduction. Cx43 restoration was due to PAMB-G suppressing anisomycin-induced activation of MAPKs P38 and JNK, which are involved in phosphorylating Cx43 for degradation. Similar observations were also found <em>in vivo</em>, where a PAMB-G patch acted against anisomycin-induced Cx43 downregulation and impaired atrial cell communication, subsequently alleviating pacing-induced AF. Therefore, PAMB-G suppresses MAPKs, in turn upregulating Cx43, leading to improved electrical signal transduction. As a result, modulating the MAPK-Cx43 pathway, such as with PAMB-G, could serve as a potential therapeutic strategy for cardiac arrhythmia.</div></div><div><h3>Statement of significance</h3><div>Disruption of atrial intercellular gap junction channels, comprised of connexins, leads to atrial fibrillation (AF), the most prevalent arrhythmia, with poor clinical outcomes. Current AF treatments are associated with adverse effects, and only focus on managing symptoms, thereby necessitating innovative treatment strategies. One such strategy is conductive biomaterials, which show promising results for correcting pathological cardiac electrical signaling. We synthesized a self-doping conductive biomaterial, poly-3-amino-4-methoxybenzoic acid-gelatin (PAMB-G), and found that it counteracts against anisomycin-induced connexin43 (Cx43) downregulation, subsequently improving cardiac electrical conduction and alleviating pacing-induced AF. This is owed to PAMB-G suppressing anisomycin-associated activation of mitogen-activated kinases P38 and JNK, which are involved in phosphorylating Cx43 for degradation. Therefore, PAMB-G modulation of MAPK-Cx43 pathway could aid in cardiac arrhythmia treatment.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 123-135"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical characterization of nonlinear elasticity of growing intestinal organoids with a microinjection method","authors":"Jidong Xiu ,&nbsp;Rui Xue ,&nbsp;Xiaocen Duan ,&nbsp;Fangyun Yao ,&nbsp;Xiaozhi Liu ,&nbsp;Fanlu Meng ,&nbsp;Chunyang Xiong ,&nbsp;Jianyong Huang","doi":"10.1016/j.actbio.2025.02.054","DOIUrl":"10.1016/j.actbio.2025.02.054","url":null,"abstract":"<div><div>Mechanical properties of intestinal organoids are crucial for intestinal development, homeostatic renewal, and pathogenesis. However, characterizing these properties remains challenging. Here, we developed a microinjection-based method to quantify the growth time-dependent nonlinear elasticity of intestinal organoids. With aid of the neo-Hookean hyperelastic constitutive model, we discovered that the global elastic modulus of intestinal organoids increased linearly during the early stages of culture, followed by a sharp rise, indicating a time-dependent nonlinear hardening behaviour during growth. The global modulus of intestinal organoids was found to correlate with the cell phenotype ratio, revealing a significant relationship between mechanical properties and biological phenotypes. Furthermore, we developed a biomechanical model on the basis of the unsteady Bernoulli equation to quantitatively explore the global mechanical responses of intestinal organoids, which showed good agreement with the experimental data. The work not only elucidated the mechanical response and modulus characteristics of small intestinal organoids from a biomechanical perspective, but also presented a new microinjection-based methodology for quantifying the mechanical properties of organoids, offering significant potential for various organoid-related applications.</div></div><div><h3>Statement of significance</h3><div>Mechanical properties of intestinal organoids are essential for intestinal development, homeostatic renewal, and pathogenesis. However, how to quantitatively characterize their global mechanical properties remains challenging. Here, we developed a new microinjection-based experimental platform to quantify spatiotemporal dynamics of mechanical responses and global elasticity of intestinal organoids. Unlike traditional nanoindentation methods, the proposed characterization technique can quantitatively measure the global mechanical properties of organoids, which is crucial for detecting the inherent relationship between the global mechanical properties and the biological phenotypes of organoids. Likewise, it established a methodological foundation for revealing the mechanobiological characteristics associated with the growth and development of various organoids. This can enhance our understanding of mechanobiological mechanisms of organoids and is beneficial for various organoid-related applications.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 271-280"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"cGAS-mediated antibacterial immunotherapy against tuberculosis by macrophage-targeted manganese dioxide nanoagonist","authors":"Kangsheng Liao ,&nbsp;Ruihong Chen ,&nbsp;Jinwei Zhang ,&nbsp;Yongdui Ruan ,&nbsp;Xueqin Huang ,&nbsp;Yuhe Huang ,&nbsp;Jiaojiao Xia ,&nbsp;Daina Zhao ,&nbsp;Lingming Chen ,&nbsp;Yi Zhao ,&nbsp;Fen Yang ,&nbsp;Jun-Fa Xu ,&nbsp;Ling Shen ,&nbsp;Jiang Pi","doi":"10.1016/j.actbio.2025.03.002","DOIUrl":"10.1016/j.actbio.2025.03.002","url":null,"abstract":"<div><div>Tuberculosis (TB), induced by <em>Mycobacterium tuberculosis</em> (<em>Mtb</em>) infection, remains one of the top killers among infectious diseases. The pathogenesis hallmarks for TB are complex immune escape mechanisms of <em>Mtb</em> and low targeting effects of anti-TB drugs. cGAS signaling, which is responsible for triggering host antibacterial immunity against <em>Mtb</em> infection, has shown potentials to serve as targets for anti-TB immunotherapy. As cGAS agonist manganese ions (Mn²⁺) can activate cGAS-mediated autophagy to inhibit intracellular <em>Mtb</em> in macrophages, we constructed a functional nanoagonist targeting cGAS signaling based on manganese dioxide nanoparticles, naming Tuf-Rif@HA-MnO₂ NPs, for synergistic macrophage-targeted drug delivery and anti-TB immuno-therapeutics. Tuf-Rif@HA-MnO₂ NPs can actively target macrophages for rifampicin delivery and react with intracellular glutathione (GSH) to release Mn²⁺ for cGAS-STING signaling activation, which further promote autophagy and antibacterial M1 polarization of <em>Mtb</em> infected macrophages to achieve synergistic intracellular <em>Mtb</em> clearance. Furthermore, Tuf-Rif@HA-MnO₂ NPs can potentiate dendritic cell maturation, CD4+ Th1 cell and CD8+ cytotoxic T cell activation <em>in vivo</em>, which collectively attribute to reduced <em>Mtb</em> burdens and alleviated tissue inflammations in lung of <em>Mtb</em>-infected mice without systemic toxicity. This macrophage targeted drug delivery nanoagonist system is expected to develop rational immunotherapy strategy targeting cGAS signaling against TB and drug-resistant TB.</div></div><div><h3>Statement of Significance</h3><div>cGAS-mediated autophagy plays a critical role in <em>Mtb</em> clearance in macrophages.</div><div>Tuf-Rif@HA-MnO₂ NPs specifically deliver rifampicin into macrophage for <em>Mtb</em> clearance.</div><div>Tuf-Rif@HA-MnO₂ NPs activate cGAS-mediated macrophage autophagy for <em>Mtb</em> clearance.</div><div>Tuf-Rif@HA-MnO₂ NPs synergize cGAS-mediated immunotherapy with targeted drug delivery for more effective anti-TB treatment.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 471-486"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing and characterising bovine decellularized extracellular matrix hydrogels to biofabricate female reproductive tissues","authors":"E. Ribes Martinez ,&nbsp;Y. Franko ,&nbsp;R. Franko ,&nbsp;G.A. Ferronato ,&nbsp;A.E.S. Viana ,&nbsp;E. Windenbach ,&nbsp;J.B. Stoeckl ,&nbsp;T. Fröhlich ,&nbsp;M.A.M.M. Ferraz","doi":"10.1016/j.actbio.2025.03.009","DOIUrl":"10.1016/j.actbio.2025.03.009","url":null,"abstract":"<div><div>This study investigated the development and characterization of decellularized extracellular matrix (dECM) hydrogels tailored for the biofabrication of female reproductive tissues, specifically targeting ovarian cortex, endometrium, ovarian medulla, and oviduct tissues. We aimed to evaluate the cytocompatibility, biomechanical properties, and overall efficacy of these dECMs in promoting cell viability, proliferation, and morphology using the bovine model. Bovine species provide a valuable model due to their accessibility from slaughterhouse tissues, offering a practical alternative to human samples, which are often limited in availability. Additionally, bovine tissue closely mirrors certain physiological and biological characteristics of humans, making it a relevant model for translational research. Our findings revealed that these dECMs exhibited high biocompatibility with embryo development and cell viability, supporting micro vascularization and cellular morphology without the need for external growth factors. It is important to note that the addition of alginate was crucial for maintaining the structural integrity of the hydrogel during long-term cultures. These hydrogels displayed biomechanical properties that closely mimicked native tissues, which was vital for maintaining their functional integrity and supporting cellular activities. The printability assessments showed that dECMs, particularly those from cortex tissues, achieved high precision in replicating the intended structures, though challenges such as low porosity remained. The bioprinted constructs demonstrated robust cell growth, with over 97% viability observed by day 7, indicating their suitability for cell culture. This work represented a significant advancement in reproductive tissue biofabrication, demonstrating the potential of dECM-based hydrogels in creating structurally and viable tissue constructs. By tailoring each dECM to match the unique biomechanical properties of different tissues, we paved the way for more effective and reliable applications in reproductive medicine and tissue engineering.</div></div><div><h3>Statement of Significance</h3><div>This research explores the use of decellularized extracellular matrix (dECM) hydrogels as bio-inks for creating reproductive tissues. Ovarian cortex and medulla, oviduct and endometrium dECMs demonstrated biomechanical properties that mimicked native tissues, which is essential for maintaining functional integrity and supporting cellular processes. Notably, these hydrogels exhibited high biocompatibility with embryo development and cell viability, promoting microvascularization and cell differentiation without the need for supplemental growth factors. The successful bioprinting of these bio-inks underscores their potential for creating more complex models. This work represents a significant advancement in tissue engineering, offering promising new avenues for reproductive medicine.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 152-170"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Engineering a nano-drug delivery system to regulate m6A modification and enhance immunotherapy in gastric cancer” [Acta Biomaterialia, 191, 2025, 412-427]","authors":"Zhengshuo Li ,&nbsp;Xiaoyue Zhang ,&nbsp;Can Liu ,&nbsp;Yangge Wu ,&nbsp;Yuqing Wen ,&nbsp;Run Zheng ,&nbsp;Chenxiao Xu ,&nbsp;Junrui Tian ,&nbsp;Qiu Peng ,&nbsp;Xiang Zheng ,&nbsp;Jia Wang ,&nbsp;Qun Yan ,&nbsp;Lingyu Wei ,&nbsp;Jian Ma","doi":"10.1016/j.actbio.2025.01.056","DOIUrl":"10.1016/j.actbio.2025.01.056","url":null,"abstract":"","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Page 532"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and considerations in annulus fibrosus in vitro model design","authors":"AL Castro ,&nbsp;RM Gonçalves","doi":"10.1016/j.actbio.2025.01.060","DOIUrl":"10.1016/j.actbio.2025.01.060","url":null,"abstract":"<div><div>Annulus Fibrosus (AF) tissue integrity maintains intervertebral disc (IVD) structure, essential to spine mobility and shock absorption. However, this tissue, which confines nucleus pulposus (NP), has been poorly investigated, partially due to the lack of appropriate study models. This review provides a comprehensive analysis of AF <em>in vitro</em> models. By critically assessing the current AF <em>in vitro</em> models, this works thoroughly identifies key gaps in replicating the tissue's complex microenvironment. Finally, we outline the essential criteria for developing more accurate and reliable AF models, emphasizing the importance of biomaterial composition, architecture, and microenvironmental cues. By advancing <em>in vitro</em> models, we aim to deepen the understanding of AF failure mechanisms and support the development of novel therapeutic strategies for IVD herniation. Insights gained from this review may also have broader applications in regenerative medicine, particularly in the study and treatment of other connective tissue disorders.</div></div><div><h3>Statement of significance</h3><div>This review evaluates the current <em>in vitro</em> models of the annulus fibrosus (AF), a key component of the intervertebral disc (IVD). By identifying gaps in these models, particularly in replicating tissue's complex microenvironment, we propose essential criteria for the development of more accurate AF models, to better understand the pathomechanisms and potentially aid the development of therapeutic approaches for spinal disorders. The findings also extend to broader studies of musculoskeletal tissue disorders in the context of regenerative medicine, appealing to a diverse biomedical research readership.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"195 ","pages":"Pages 42-51"},"PeriodicalIF":9.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Application of Nature-inspired High-performance Mechanical Materials","authors":"Jiandong Cui ,&nbsp;Yan Xia ,&nbsp;Yingqing Yu ,&nbsp;Hong Xu ,&nbsp;Nan Zhang ,&nbsp;Zhiwei Tuo ,&nbsp;Zirui Liu ,&nbsp;Zhaohua Lin ,&nbsp;Suqian Ma ,&nbsp;Yunhong Liang ,&nbsp;Luquan Ren","doi":"10.1016/j.actbio.2025.01.007","DOIUrl":"10.1016/j.actbio.2025.01.007","url":null,"abstract":"<div><div>Natural materials are valued for their lightweight properties, high strength, impact resistance, and fracture toughness, often outperforming human-made materials. This paper reviews recent research on biomimetic composites, focusing on how composition, microstructure, and interfacial characteristics affect mechanical properties like strength, stiffness, and toughness. It explores biological structures such as mollusk shells, bones, and insect exoskeletons that inspire lightweight designs, including honeycomb structures for weight reduction and impact resistance. The paper also discusses the flexibility and durability of fibrous materials like arachnid proteins and evaluates traditional and modern fabrication techniques, including machine learning. The development of superior, multifunctional, and eco-friendly materials will benefit transportation, mechanical engineering, architecture, and biomedicine, promoting sustainable materials science.</div></div><div><h3>Statement of Significance</h3><div>Natural materials excel in strength, lightweight, impact resistance, and fracture toughness. This review focuses on biomimetic composites inspired by nature, examining how composition, microstructure, and interfacial characteristics affect mechanical properties like strength, stiffness, and toughness. It analyzes biological structures such as shells, bones, and exoskeletons, emphasizing honeycomb strength and lightness. The review also explores the flexibility and durability of fibrous materials like arachnid proteins and discusses fabrication techniques for biomaterials. It highlights impact-resistant materials that combine soft and hard components for enhanced strength and toughness, as well as lightweight, wear-resistant biomimetic materials that respond uniquely to cyclic stress. The article aims to advance sustainable materials science by exploring innovations in multifunctional and eco-friendly materials for various applications.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"195 ","pages":"Pages 1-41"},"PeriodicalIF":9.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}