World Journal of Gastrointestinal Oncology最新文献

{"title":"Multidisciplinary collaborative enhanced recovery after surgery nursing in patients with colorectal cancer: A comparative study.","authors":"Li-Fen You, Ping Zhang, Qin-Qin Zhang","doi":"10.4251/wjgo.v17.i8.104569","DOIUrl":"10.4251/wjgo.v17.i8.104569","url":null,"abstract":"<p><strong>Background: </strong>Prolonged recovery following colorectal cancer (CRC) surgery can result in physiological discomfort and psychological stress, underscoring the importance of effective perioperative care to enhance patient outcomes.</p><p><strong>Aim: </strong>To evaluate the impact of multidisciplinary collaborative enhanced recovery after surgery (ERAS) nursing on patients undergoing CRC surgery.</p><p><strong>Methods: </strong>This study included 100 patients who underwent CRC surgery between August 2022 and August 2024. Patients were divided into two groups based on the perioperative nursing approach. The control group (<i>n</i> = 50) received conventional nursing care, whereas the observation group (<i>n</i> = 50) received multidisciplinary collaborative ERAS nursing. Postoperative recovery time, disease perception, pain levels, coping strategies, self-management efficacy, and quality of life were compared between the two groups.</p><p><strong>Results: </strong>Compared with the control group, the observation group exhibited significantly shorter times to ambulation, gastrointestinal motility, first meal intake, and hospital stay (<i>P</i> < 0.05). No significant differences were observed in pre-nursing indicators between the two groups (<i>P</i> > 0.05). After nursing, both groups showed improvements in disease perception scores, self-management efficacy, and quality of life scores, along with reductions in pain levels and coping strategy scores, except for the confrontative and venting dimensions. The observation group demonstrated significantly greater improvements in these scores, with significant intergroup and intragroup differences (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Multidisciplinary collaborative ERAS nursing can facilitate postoperative recovery in patients with CRC, enhance disease cognition, alleviate pain, and encourage active coping, thereby improving self-management efficacy and quality of life.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"104569"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in the diagnosis of esophageal cancer with intramural gastric metastasis: Two case reports.","authors":"Hao-Ying Wang, Chun Song, Jing Ma, Hai-Qing Sun, Peng Yuan, Zhen-Xiong Liu, Wei-Jia Dou","doi":"10.4251/wjgo.v17.i8.110206","DOIUrl":"10.4251/wjgo.v17.i8.110206","url":null,"abstract":"<p><strong>Background: </strong>Esophageal squamous cell carcinoma (ESCC) is a prevalent gastrointestinal malignancy associated with significant morbidity and mortality rates. Tumor metastasis leads to a poor prognosis for patients. Intramural gastric metastasis (IGM), is an uncommon pathway of ESCC metastasis, and is more likely to occur when <i>in situ</i> tumor cells show deep infiltration. In this study, we describe the diagnosis and management of two rare cases of T1-stage ESCC with IGM in clinical practice.</p><p><strong>Case summary: </strong>Case 1: In this patient, the submucosal tumor-like lesion was initially thought to be a gastrointestinal stromal tumor. T1-stage ESCC was then diagnosed by gastro-endoscopy during subsequent evaluation. The lesion was finally confirmed to be submucosal metastasis of ESCC following pathological analysis. The patient has been receiving treatment for over seven months, with an encouraging outcome. Case 2: In this patient, the initial diagnostic phase showed esophageal and gastric lesions which were classified as two distinct conditions: Early-stage ESCC and a gastrointestinal stromal tumor, respectively. However, postoperative pathology revealed ESCC with IGM. The patient received adjuvant chemotherapy following surgical intervention. Regrettably, the patient was lost to follow-up shortly after surgery.</p><p><strong>Conclusion: </strong>The occurrence of IGM in T1-stage ESCC is rare. IGM should be taken into consideration when diagnosing submucosal tumor-like lesions to prevent misdiagnosis and missed diagnosis.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"110206"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lifestyle factors and disease progression in patients with colorectal polyps and early-stage cancer.","authors":"Fang-Fang Lin, Jun-Ting Ye, Xia-Yan Mao, Xue-Juan Mao, Hui-Hua Ye","doi":"10.4251/wjgo.v17.i8.108452","DOIUrl":"10.4251/wjgo.v17.i8.108452","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Colorectal cancer (CRC) typically progresses from benign colorectal polyps, which represent a precursor to malignancy. Identifying the factors influencing this progression is crucial for early intervention and prevention. Although genetic and environmental factors have been widely studied, the role of lifestyle factors such as physical activity, diet, smoking, sleep, and stress remains underexplored, especially in patients with early stage CRC or polyps. Recent evidence suggests that lifestyle behaviors may influence cancer progression by modulating inflammatory pathways, metabolic health, and immune function. For instance, high levels of physical activity are linked to a reduced risk of CRC development, whereas poor dietary habits, smoking, and inadequate sleep have all been implicated in increased cancer risk and progression. Moreover, early-stage CRC patients, who are often asymptomatic or have minimal symptoms, may particularly benefit from lifestyle modifications to slow disease progression and improve overall prognosis. The gap in understanding the specific influence of these lifestyle factors on colorectal polyps and early stage cancer progression underscores the need for comprehensive studies. By assessing several modifiable lifestyle factors and their association with disease progression, clinicians can identify practical intervention points. These interventions could ultimately reduce the need for more aggressive treatments and improve the long-term outcomes in affected patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate the association between lifestyle factors and disease progression in patients with colorectal polyps and early stage cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this observational study conducted from January 2022 to December 2023, we recruited 120 patients with colorectal polyps or early stage cancer from Jiangshan People's Hospital. Lifestyle factors, including physical activity, dietary patterns, smoking status, sleep quality, and stress levels, were assessed using validated questionnaires. Disease progression was evaluated using standardized follow-up colonoscopies and pathological examinations. Cox proportional hazards models were used to analyze the association between lifestyle factors and disease progression after adjusting for potential confounders.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;During the median follow-up of 18.4 months, 42 (35.0%) patients experienced disease progression. High levels of physical activity were associated with reduced progression risk [adjusted hazard ratio (HR) 0.55, 95% confidence interval (CI): 0.38-0.80, &lt;i&gt;P&lt;/i&gt; = 0.002] compared to low activity levels. High adherence to a healthy dietary pattern showed similar protective effects (adjusted HR 0.62, 95%CI: 0.43-0.89, &lt;i&gt;P&lt;/i&gt; = 0.009). Current smoking (adjusted HR 1.92, 95%CI: 1.35-2.73, &lt;i&gt;P&lt;/i&gt; &lt; 0.001) and poor sleep quality (adjusted HR 1.38, 95%CI: 1.05-1.82, &lt;i&gt;P&lt;/i&gt; = 0.021) were associated with incr","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"108452"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and proposed solutions to the adoption of cell free DNA in screening, detecting and prognosticating colorectal cancer.","authors":"Megan Wern-Ee Chua, Dedrick Kok-Hong Chan","doi":"10.4251/wjgo.v17.i8.106663","DOIUrl":"10.4251/wjgo.v17.i8.106663","url":null,"abstract":"<p><p>Detection and treatment of colorectal cancer (CRC) at an early stage is vital for long-term survival. Liquid biopsy has emerged as a promising new avenue for non-invasive screening of CRC as well as prognostication and surveillance of minimal residual disease. Cell free DNA (cfDNA) is a promising liquid biopsy analyte and has been approved for use in clinical practice. Here, we explore the current challenges of utilizing cfDNA in the screening and prognostication of CRC but also for detecting driver mutations in healthy, presymptomatic patients with normal colonic crypts. CfDNA for the detection of cancerous or premalignant colonic lesions has already been extensively explored, however few have considered utilizing cfDNA in the detection of driver mutations in healthy patients. Theoretically, this would allow us to detect patients who are at a higher risk of tumorigenesis decades in advance of established malignancy and stratify them into higher risk groups for early-intervention screening programs. We also explore the solutions necessary to overcome the challenges that prevent liquid biopsy from entering mainstream clinical use. The potential for liquid biopsy is immense if these challenges are successfully circumvented, and can dramatically reduce CRC rates as well as improve survival in patients.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"106663"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorectal cancer liver metastases: A radiologic point of view.","authors":"Alfonso Reginelli, Vittorio Patanè, Salvatore Cappabianca","doi":"10.4251/wjgo.v17.i8.103473","DOIUrl":"10.4251/wjgo.v17.i8.103473","url":null,"abstract":"<p><p>Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Despite advances in early detection and treatment, approximately half of patients with CRC develop liver metastases (LM), complicating therapeutic strategies and reducing survival rates. Radiological imaging is critical in managing colorectal LM by guiding detection, staging, treatment planning, and response evaluation. This letter to the editor provides a comprehensive overview of both traditional and emerging imaging modalities, including computed tomography, magnetic resonance imaging, and positron emission tomography, and their specific roles in clinical decision-making. It further explores advanced techniques such as radiomics, artificial intelligence, and radiogenomics, which integrate quantitative imaging features with genetic and clinical data to enhance prognostication and tailor personalized treatment approaches. Specific examples of how these innovations are applied in treatment response assessment and pre-surgical planning are highlighted. The discussion also emphasizes the need for large-scale prospective clinical trials and standardized protocols to validate current predictive models and fully integrate these advanced methodologies into clinical practice.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"103473"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning radiomics: Redefining precision oncology through noninvasive insights into the tumor immune microenvironment.","authors":"Mesut Tez","doi":"10.4251/wjgo.v17.i7.108175","DOIUrl":"10.4251/wjgo.v17.i7.108175","url":null,"abstract":"<p><p>Computed tomography-based deep learning radiomics provides a novel, noninvasive approach to predicting the tumor immune microenvironment in colorectal cancer, revolutionizing precision oncology. The retrospective study by Zhou <i>et al</i> analyzed preoperative computed tomography scans from 315 patients using convolutional neural networks, achieving robust predictive performance (area under the curve: 0.851-0.892) for critical tumor immune microenvironment features, such as tumor-stroma ratio and lymphocyte infiltration, without requiring invasive biopsies. This editorial explores how this technique advances personalized immunotherapy, chemotherapy, and targeted therapies; challenges conventional oncology practices; and paves the way for a future of precision medicine. By integrating advanced imaging with immune profiling, deep learning radiomics redefines colorectal cancer management, highlighting the need to re-evaluate the interplay of technology, biology, and ethics in gastrointestinal oncology.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"108175"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of endoscopic ultrasound in staging of pancreatic cancer.","authors":"Xin Yang, Nan Ge","doi":"10.4251/wjgo.v17.i7.107670","DOIUrl":"10.4251/wjgo.v17.i7.107670","url":null,"abstract":"<p><p>Pancreatic cancer is recognized as one of the leading causes of cancer mortality, representing the second most common source of cancer-related deaths within the gastrointestinal domain. Surgical resection is currently the only definitive treatment; however, the subtle emergence of symptoms often leads to a diagnosis at an advanced stage, with merely 10%-15% of patients being eligible for surgical intervention. The primary obstacle to achieving a potential radical resection is the presence of distant metastatic disease or invasion of adjacent major vascular structures. This review aims to highlight the critical role of endoscopic ultrasound in the diagnosis and staging of pancreatic tumors. We systematically searched PubMed, MEDLINE and Web of Science by using 'pancreatic cancer' and 'endoscopic ultrasonography' as keywords. Relevant studies were reviewed and analyzed. Endoscopic ultrasonography (EUS) is efficient in the diagnosis and staging of pancreatic cancer, past studies reported the accuracy of EUS is 63% to 94% for T-staging and 44% to 82% for N-staging but there are still limitations that need to be comprehensively applied with other diagnostic methods to evaluation of distant metastasis for surgical resectability. Our review aims to reveal the value for the staging of pancreatic cancer.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"107670"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flap endonuclease-1 promotes pancreatic cancer progression <i>via</i> AKT/mTOR signaling pathway.","authors":"Yu Xia, Na Guo, Cheng-Lou Zhu, Jie-Yun Gao, Ming-Xu Da","doi":"10.4251/wjgo.v17.i7.104402","DOIUrl":"10.4251/wjgo.v17.i7.104402","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic cancer (PC) remains one of the most lethal malignancies. While flap endonuclease-1 (FEN1) has been implicated in various cancers, its role in PC remains unclear.</p><p><strong>Aim: </strong>To investigate the biological functions and mechanisms of FEN1 in PC progression.</p><p><strong>Methods: </strong>FEN1 expression and its prognostic significance were analyzed using Gene Expression Omnibus, The Cancer Genome Atlas, and Genotype-Tissue Expression databases. FEN1 was knocked down or overexpressed in PC cell lines using lentiviral vectors. Cell proliferation, migration, and invasion were assessed <i>in vitro</i>, while tumorigenicity was evaluated in nude mouse xenografts. Molecular mechanisms were explored through RNA-sequencing and validated by western blot analysis.</p><p><strong>Results: </strong>FEN1 was significantly upregulated in PC tissues and correlated with poor prognosis. FEN1 promoted PC cell proliferation, migration, and invasion <i>in vitro</i>, as well as xenograft tumor growth <i>in vivo</i>. Mechanistically, FEN1 regulated epithelial-mesenchymal transition through the AKT/mTOR signaling pathway.</p><p><strong>Conclusion: </strong>FEN1 functions as an oncogenic driver in PC progression <i>via</i> the AKT/mTOR signaling pathway, suggesting its potential as a therapeutic target.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"104402"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insurance coverage and patient outcomes: Understanding changes in esophageal cancer treatment.","authors":"Arvind Mukundan, Yaswanth Nagisetti, Riya Karmakar, Hsiang Chen Wang","doi":"10.4251/wjgo.v17.i7.107154","DOIUrl":"10.4251/wjgo.v17.i7.107154","url":null,"abstract":"<p><p>The article by Wu <i>et al</i> highlights the growing incidence of esophageal tumor patients, particularly in China, where the high frequency and death rate are significant problems. The article also examined the impact of health insurance on treatment availability and patient outcomes, demonstrating that the type of insurance can affect the financial burden on patients. This study investigates the effects of different types of health care coverage, namely Urban Employee Basic Medical Insurance <i>vs</i> Urban-Rural Resident Basic Medical Insurance, and the personal spending ratio on treatment decisions and survival outcomes. The database used is derived from esophageal tumor patient continuation from Chongqing University Hospital in China. A total of 2543 patients were included in the study, allowing for the formation of research cohorts. Patient information included demographic characteristics. The study followed various processes to maintain consistency, including data sources, inclusion and exclusion criteria, follow-up duration, health insurance, and statistical analysis. The average age at diagnosis ranged from 57-74 years, and predominantly included men, married people, and those of Han ethnic background, comprising 2088 and 2519 individuals, respectively. Upon controlling for age, sex, relationship status, country of origin, pathological evaluation, tumor stage, and biochemical indicators, individuals who had Urban Employee Basic Medical Insurance exhibited a higher propensity to opt for radiotherapy, chemotherapy, immunotherapy, and targeted therapy compared to those covered by the Urban-Rural Resident Basic Medical Insurance. During the follow-up phase of the study, a total of 1438 deaths were documented, with 1106 ascribed to esophageal cancer. Additionally, individuals with Urban-Rural Resident Basic Medical Insurance had a significantly elevated risk of esophageal cancer, particularly mortality, compared to those without Urban-Rural Resident Basic Medical Insurance.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"107154"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances and challenges in drug repurposing in precision therapeutics of colorectal cancer.","authors":"Xin-Ning Yu, Hua-Tao Wu, Bing-Xuan Wu, Shu-Feng Zhi, Yang-Zheng Lan, Wen-Jia Chen, Jing Liu","doi":"10.4251/wjgo.v17.i7.107681","DOIUrl":"10.4251/wjgo.v17.i7.107681","url":null,"abstract":"<p><p>Colorectal cancer (CRC) ranks as the third most common cancer globally and the second leading cause of cancer-related deaths, representing a significant health burden. Despite advancements in traditional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, these approaches still face challenges, including high costs, limited efficacy, and drug resistance. Drug repurposing has emerged as a promising strategy for CRC treatment, offering advantages with reduced development timelines, lower costs, and improved drug accessibility. This review explores drug repurposing strategies for CRC, supported by multidisciplinary technologies, and discusses the current challenges in the field.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"107681"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}