World Journal of Gastrointestinal Oncology最新文献

{"title":"Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma.","authors":"Jian-Di Li, Rong-Quan He, Yi-Wu Dang, Zhi-Guang Huang, Dan-Dan Xiong, Lu Zhang, Xiu-Fang Du, Gang Chen","doi":"10.4251/wjgo.v17.i2.92437","DOIUrl":"10.4251/wjgo.v17.i2.92437","url":null,"abstract":"<p><strong>Background: </strong>Although transmembrane protein 106C (TMEM106C) has been elucidated to be overexpressed in cancers, its underlying mechanisms have not yet been fully understood.</p><p><strong>Aim: </strong>To investigate the expression levels and molecular mechanisms of TMEM106C across 34 different cancer types, including liver hepatocellular carcinoma (LIHC).</p><p><strong>Methods: </strong>We analyzed TMEM106C expression patterns in pan-cancers using microenvironment cell populations counter to evaluate its association with the tumor microenvironment. Gene set enrichment analysis was conducted to identify molecular pathways related to TMEM106C. Chromatin immunoprecipitation followed by sequencing (ChIP-seq) analysis was conducted to identify upstream transcriptional regulators of TMEM106C. In LIHC, we examined mRNA profiles, performed in-house quantitative polymerase chain reaction, immunohistochemistry, and constructed a co-expression gene network. Functional assays, including cell counting kit-8, cell cycle, apoptosis, migration, and invasion, were conducted. The effect of nitidine chloride (NC) on LIHC xenograft was evaluated through RNA sequencing and molecular docking. Finally, potential therapeutic agents targeting TMEM106C were predicted.</p><p><strong>Results: </strong>TMEM106C was significantly overexpressed in 27 different cancer types and presaged poor prognosis in four of these types, including LIHC. Across pan-cancers, TMEM106C was inversely correlated to the abundances of immune and stromal cells. Furthermore, TMEM106C was significantly linked to cell cycle and DNA replication pathways in pan-cancers. ChIP-seq analysis predicted CCCTC-binding factor as a pivotal transcriptional factor targeting the <i>TMEM106C</i> gene in pan-cancers. Integrated analysis showed that TMEM106C was upregulated in 4657 LIHC compared with 3652 normal liver tissue [combined standardized mean difference = 1.31 (1.09, 1.52)]. In-house LIHC samples verified the expression status of TMEM106C. Higher TMEM106C expression signified worse survival conditions in LIHC patients treated with sorafenib, a tyrosine kinase inhibitor (TKI). Co-expressed analysis revealed that TMEM106C were significantly enriched in the cell cycle pathway. Knockout experiments demonstrated that TMEM106C plays a crucial role in LIHC cell proliferation, migration, and invasion, with cell cycle arrest occurring at the DNA synthesis phase, and increased apoptosis. Notably, TMEM106C upregulation was attenuated by NC treatment. Finally, TMEM106C expression levels were significantly correlated with the drug sensitivity of anti-hepatocellular carcinoma agents, including JNJ-42756493, a TKI agent.</p><p><strong>Conclusion: </strong>Overexpressed TMEM106C was predicted as an oncogene in pan-cancers, which may serve as a promising therapeutic target for various cancers, including LIHC. Targeting TMEM106C could potentially offer a novel direction in overcoming TKI resistance specific","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 2","pages":"92437"},"PeriodicalIF":2.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between gastric mucosal atrophy by endoscopy and non-ampullary duodenal epithelial tumors.","authors":"Kazuya Ohno, Eiji Nakatani, Takafumi Kurokami, Asami Kawai, Ryosuke Itai, Masanori Matsuda, Yuichi Masui, Tatsunori Satoh, Shinya Ikeda, Taiyo Hirata, Shodai Takeda, Makoto Suzuki, Ken Haruma","doi":"10.4251/wjgo.v17.i2.100545","DOIUrl":"10.4251/wjgo.v17.i2.100545","url":null,"abstract":"<p><strong>Background: </strong>The pathogenesis of non-ampullary duodenal epithelial tumors (NADETs) is not fully understood. NADETs that express gastric-type mucin phenotypes (G-NADETs) are noteworthy because of their high malignancy. Gastric foveolar metaplasia, from which G-NADETs originate, protects the duodenal mucosa from gastric acidity. As gastric acid secretion is affected by endoscopic gastric mucosal atrophy (EGMA), we hypothesized that EGMA would be associated with G-NADETs.</p><p><strong>Aim: </strong>To evaluate the association between EGMA and the occurrence of G-NADETs.</p><p><strong>Methods: </strong>This cross-sectional retrospective study investigated the relationship between EGMA and NADETs in 134 patients. The duodenum was divided into parts 1 (bulb), 2 (superior duodenal angle to the papilla), and 3 (anal side of the papilla to the horizontal part). The effects of gastric acidity and presence of Brunner's glands were considered. EGMA was divided into types C (no or mild atrophy) and O (severe atrophy). Mucin phenotype expressions in NADETs were divided into gastric, intestinal, gastrointestinal, and unclassifiable.</p><p><strong>Results: </strong>When NADETs were classified according to EGMA, 105 were classified as type C and 29 as type O. G-NADETs were present in 11.9% (16 cases) of all cases, and all 16 cases were of type C. Among G-NADETs, 93.8% (15 cases) were present in part 1 or 2. There was an association between G-NADETs and type C in part 1, and 50.0% (eight of 16 cases) of G-NADETs were associated with a current or previous <i>Helicobacter pylori</i> infection status. Additionally, all eight cases occurred in part 1.</p><p><strong>Conclusion: </strong>G-NADETs were significantly associated with type C. Gastric acidity and Brunner's gland growth may be associated with G-NADETs.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 2","pages":"100545"},"PeriodicalIF":2.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed food, obesity, and colon cancer: A systematic review and meta-analysis.","authors":"Justin Tin, Henry Lee, Alfonso Gonzalez Trejo, Kevin Tin","doi":"10.4251/wjgo.v17.i2.101211","DOIUrl":"10.4251/wjgo.v17.i2.101211","url":null,"abstract":"<p><strong>Background: </strong>Recently, there has been a significant increase in the consumption of ultra-processed foods worldwide. However, the association between the consumption of ultra-processed food, obesity, and the prevalence of colon cancer remains controversial.</p><p><strong>Aim: </strong>To find out the association between the consumption of ultra-processed food, obesity, and the prevalence of colon cancer.</p><p><strong>Methods: </strong>A comprehensive systematic literature search of PubMed, Scopus, Web of Science, and Google Scholar for grey literature was done for articles published before 8^th March 2023. The search was done to retrieve potential peer-reviewed articles that explored the association between the consumption of ultra-processed food, obesity, and the prevalence of colon cancer.</p><p><strong>Results: </strong>Of the 246 potential articles assessed, 17 met the inclusion criteria. Meta-analysis results demonstrated that high consumption of ultra-processed food is associated with an increased risk of obesity [odds ratio (OR): 1.65; 95%CI: 1.07-2.45; <i>P</i> < 0.05]. Consequently, there is a positive association between obesity and an increased risk of colon cancer (OR 1.48; 95%CI: 0.77-2.87; <i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Consuming ultra-processed foods increases the risk of obesity and colon cancer.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 2","pages":"101211"},"PeriodicalIF":2.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a nomogram model for predicting overall survival in patients with gastric carcinoma.","authors":"Guan-Zhong Liang, Xiao-Sheng Li, Zu-Hai Hu, Qian-Jie Xu, Fang Wu, Xiang-Lin Wu, Hai-Ke Lei","doi":"10.4251/wjgo.v17.i2.95423","DOIUrl":"10.4251/wjgo.v17.i2.95423","url":null,"abstract":"<p><strong>Background: </strong>The prevalence and mortality rates of gastric carcinoma are disproportionately elevated in China, with the disease's intricate and varied characteristics further amplifying its health impact. Precise forecasting of overall survival (OS) is of paramount importance for the clinical management of individuals afflicted with this malignancy.</p><p><strong>Aim: </strong>To develop and validate a nomogram model that provides precise gastric cancer prevention and treatment guidance and more accurate survival outcome prediction for patients with gastric carcinoma.</p><p><strong>Methods: </strong>Data analysis was conducted on samples collected from hospitalized gastric cancer patients between 2018 and 2020. Least absolute shrinkage and selection operator, univariate, and multivariate Cox regression analyses were employed to identify independent prognostic factors. A nomogram model was developed to predict gastric cancer patient outcomes. The model's predictability and discriminative ability were evaluated <i>via</i> receiver operating characteristic curves. To evaluate the clinical utility of the model, Kaplan-Meier and decision curve analyses were performed.</p><p><strong>Results: </strong>A total of ten independent prognostic factors were identified, including body mass index, tumor-node-metastasis (TNM) stage, radiation, chemotherapy, surgery, albumin, globulin, neutrophil count, lactate dehydrogenase, and platelet-to-lymphocyte ratio. The area under the curve (AUC) values for the 1-, 3-, and 5-year survival prediction in the training set were 0.843, 0.850, and 0.821, respectively. The AUC values were 0.864, 0.820, and 0.786 for the 1-, 3-, and 5-year survival prediction in the validation set, respectively. The model exhibited strong discriminative ability, with both the time AUC and time C-index exceeding 0.75. Compared with TNM staging, the model demonstrated superior clinical utility. Ultimately, a nomogram was developed <i>via</i> a web-based interface.</p><p><strong>Conclusion: </strong>This study established and validated a novel nomogram model for predicting the OS of gastric cancer patients, which demonstrated strong predictive ability. Based on these findings, this model can aid clinicians in implementing personalized interventions for patients with gastric cancer.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 2","pages":"95423"},"PeriodicalIF":2.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-programmed death-1 immunotherapy-promising treatment for metastatic colorectal cancer: A case report.","authors":"Tian-Hao Guo, Sheng-Wei Hong, Wen-Jian Zhu, Yi-Fan Hui, Wen-Li Qiu, Yan Wu, Xuan Li, Fei Ke, Liu Li, Hai-Bo Cheng","doi":"10.4251/wjgo.v17.i2.100954","DOIUrl":"10.4251/wjgo.v17.i2.100954","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is the third most prevalent form of cancer worldwide. Among patients with CRC, colorectal liver metastasis (CRLM) is the foremost direct contributor to mortality. In recent years, immunotherapy has swiftly risen to prominence as a vital approach for treating a range of solid tumors, including CRC. We present a unique case of a patient suffering from CRLM, with the goal of offering an insightful example and relevant references for the treatment of CRLM.</p><p><strong>Case summary: </strong>We report a patient who experienced liver metastasis after undergoing successful surgical removal of CRC, with the postoperative pathological stage identified as pT4N2aM0. The patient has been receiving a combination treatment of Western and Traditional Chinese Medicine. Regular assessments of the patient's condition have been conducted, encompassing evaluations of serum carcinoembryonic antigen levels, carbohydrate antigen 199, and observations of the tongue complexion and its coating. The patient achieved clinical remission after anti-programmed death-1 immunotherapy when various systemic therapies failed. Since the diagnosis of CRLM, the patient has survived for more than 6 years, surpassing the expected survival time for those with advanced CRC.</p><p><strong>Conclusion: </strong>This case illustrates the considerable promise of anti-programmed death-1 immunotherapy in managing CRLM, especially in scenarios of drug resistance and disease progression.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 2","pages":"100954"},"PeriodicalIF":2.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative applications and research progress of hepatic arterial infusion chemotherapy in the treatment of advanced hepatocellular carcinoma.","authors":"Ting-Fang Yang, Mo-Wei Kong","doi":"10.4251/wjgo.v17.i2.99332","DOIUrl":"10.4251/wjgo.v17.i2.99332","url":null,"abstract":"<p><p>This article provides an in-depth analysis of the study conducted by Wang <i>et al</i>, which explores hepatic arterial infusion chemotherapy and its synergistic strategies in managing advanced hepatocellular carcinoma (HCC). HCC ranks as the fourth most common cause of cancer-related mortality globally and is frequently associated with portal vein tumor thrombus (PVTT). The approach to managing HCC, particularly when PVTT is present, diverges markedly between Eastern and Western practices. These differences are rooted in variations in epidemiology, etiology, pathology, comorbidities, and prognosis. The paper delves into the diagnosis, classification, and treatment strategies for HCC with PVTT, as well as the evolving role and advancements of hepatic arterial infusion chemotherapy in the therapeutic landscape of HCC.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 2","pages":"99332"},"PeriodicalIF":2.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA PCAT6 promotes progression and metastasis of colonic neuroendocrine carcinoma <i>via</i> MAPK pathway.","authors":"Fei Wang, Hai-Feng Mu, Chun Wang, Yue Tang, Ming-Yuan Si, Jing Peng","doi":"10.4251/wjgo.v17.i2.96230","DOIUrl":"10.4251/wjgo.v17.i2.96230","url":null,"abstract":"<p><strong>Background: </strong>Colonic neuroendocrine carcinomas (NECs) are highly malignant and invasive with poor prognosis. Long noncoding RNAs (LncRNAs) participate in the tumorigenesis and metastasis of multiple cancers.</p><p><strong>Aim: </strong>To detect the roles and mechanisms of lncRNA prostate cancer associated transcript 6 (PCAT6) in the progression of colonic NEC.</p><p><strong>Methods: </strong>Human NEC and adjacent normal samples were collected for immunohistochemistry staining of CgA and real-time quantitative polymerase chain reaction (RT-qPCR) of PCAT6 mRNA level. Subcutaneous xenograft tumor model and lung metastasis model were established in nude mice. The lung tissues were stained by hematoxylin and eosin to assess pulmonary metastasis. The expression of epithelial-mesenchymal transition (EMT)-related markers and pathway-related genes was measured by RT-qPCR and western blotting. CD56 expression was assessed by immunofluorescence staining. The biological functions of PCAT6 were examined by cell counting kit-8, colony formation assays, Transwell assays and wound healing assays. The interaction between PCAT6 and its potential downstream target was verified by luciferase reporter assays.</p><p><strong>Results: </strong>LncRNA PCAT6 was upregulated in human NEC samples and LCC-18 cells, and its high expression was positively correlated with poor prognosis in patients with colonic NEC. Additionally, the expression of PCAT6 was positively associated with the proliferation, migration, invasion, and EMT of LCC-18 cells. Moreover, PCAT6 facilitated tumor growth, lung metastasis and EMT in xenografts. Mechanistically, PCAT6 promoted the activation of MAPK to enhance the EMT in colonic NEC by targeting miR-326.</p><p><strong>Conclusion: </strong>In conclusion, lncRNA PCAT6 accelerates the process of colonic NEC by activating ERK/p38 MAPK signaling through targeting miR-326. These results might provide useful information for exploring the potential therapeutic targets in colonic NEC.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 2","pages":"96230"},"PeriodicalIF":2.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversies around the treatment of peritoneal metastases of colorectal cancer.","authors":"Francisco J Morera-Ocon, Clara Navarro-Campoy, Ticiano Guastella, Francisco Landete-Molina","doi":"10.4251/wjgo.v17.i1.100199","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.100199","url":null,"abstract":"<p><p>In this editorial we examine the article by Wu <i>et al</i> published in the <i>World Journal of Gastrointestinal Oncology</i>. Surgical resection for peritoneal metastases from colorectal cancer (CRC) has been gradually accepted in the medical oncology community. A randomized trial (PRODIGE 7) on cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) failed to prove any benefit of oxaliplatin in the overall survival of patients with peritoneal metastases from colorectal origin. Nevertheless, isolated systemic chemotherapy for CRC stage IV has demonstrated a reduced response in peritoneal metastases than that obtained in other metastatic sites such as the liver. Another tool is required in those patients to achieve more local control of the disease. Surgical groups in peritoneal surgery continue to use HIPEC in their procedures, using other agents than oxaliplatin for peritoneal cavity infusion, such as mitomycin C. These patients present with complex surgical issues to manage, and consequently a large burden of complications has to be anticipated. Therefore, identifying patients who will benefit from CRS with or without HIPEC would be of great interest.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"100199"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple liver metastases of unknown origin: A case report.","authors":"Ying-Jin Wang, Ze-Chuan Liu, Jian Wang, Yin-Mo Yang","doi":"10.4251/wjgo.v17.i1.100210","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.100210","url":null,"abstract":"<p><strong>Background: </strong>The liver is the most common site of digestive system tumor metastasis, but not all liver metastases can be traced back to the primary lesions. Although it is unusual, syphilis can impact the liver, manifesting as syphilitic hepatitis with inflammatory nodules, which might be misdiagnosed as metastasis.</p><p><strong>Case summary: </strong>This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three months. No definitive diagnosis of a tumor had been made in the past decades, but signs of multiple liver metastases were recognized after a computed tomography scan without evidence of primary lesions. With positive serological tests for syphilis and a biopsy of the liver nodules, a diagnosis of hepatic syphilis was made and confirmed with follow-up nodule reduction after anti-syphilis therapy.</p><p><strong>Conclusion: </strong>Clinicians must be aware of the possibility that syphilis can cause hepatic inflammatory masses, especially when liver metastasis is suspected without evidence of primary lesions. A definitive diagnosis should be established in conjunction with a review of the patient's medical history for accurate therapeutic intervention.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"100210"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis.","authors":"Zhi-Da Long, Xiao Yu, Zhi-Xiang Xing, Rui Wang","doi":"10.4251/wjgo.v17.i1.96598","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.96598","url":null,"abstract":"<p><strong>Background: </strong>The liver, as the main target organ for hematogenous metastasis of colorectal cancer, early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of patients. Herein, this study aims to investigate the application value of a combined machine learning (ML) based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis (MLM).</p><p><strong>Aim: </strong>To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal cancer.</p><p><strong>Methods: </strong>We retrospectively analyzed 301 patients with rectal cancer confirmed by surgical pathology at Jingzhou Central Hospital from January 2017 to December 2023. All participants were randomly assigned to the training or validation queue in a 7:3 ratio. We first apply generalized linear regression model (GLRM) and random forest model (RFM) algorithm to construct an MLM prediction model in the training queue, and evaluate the discriminative power of the MLM prediction model using area under curve (AUC) and decision curve analysis (DCA). Then, the robustness and generalizability of the MLM prediction model were evaluated based on the internal validation set between the validation queue groups.</p><p><strong>Results: </strong>Among the 301 patients included in the study, 16.28% were ultimately diagnosed with MLM through pathological examination. Multivariate analysis showed that carcinoembryonic antigen, and magnetic resonance imaging radiomics were independent predictors of MLM. Then, the GLRM prediction model was developed with a comprehensive nomogram to achieve satisfactory differentiation. The prediction performance of GLRM in the training and validation queue was 0.765 [95% confidence interval (CI): 0.710-0.820] and 0.767 (95%CI: 0.712-0.822), respectively. Compared with GLRM, RFM achieved superior performance with AUC of 0.919 (95%CI: 0.868-0.970) and 0.901 (95%CI: 0.850-0.952) in the training and validation queue, respectively. The DCA indicated that the predictive ability and net profit of clinical RFM were improved.</p><p><strong>Conclusion: </strong>By combining multiparameter magnetic resonance imaging with the effectiveness and robustness of ML-based predictive models, the proposed clinical RFM can serve as an insight tool for preoperative assessment of MLM risk stratification and provide important information for individual diagnosis and treatment of rectal cancer patients.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"96598"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}