World Journal of Gastrointestinal Oncology最新文献

{"title":"Research progress on the development of hepatocyte growth factor/c-Met signaling pathway in gastric cancer: A review.","authors":"Wu-Jie Wei, Ya-Li Hong, Yi Deng, Guan-Liang Wang, Jiang-Tao Qiu, Fang Pan","doi":"10.4251/wjgo.v16.i8.3397","DOIUrl":"10.4251/wjgo.v16.i8.3397","url":null,"abstract":"<p><p>Hepatocyte growth factor (HGF) and its receptor, c-Met, play important roles in the occurrence, development, and treatment of gastric cancer (GC). This review explored the function of the HGF/c-Met signaling pathway in GC and its potential targeted therapeutic mechanisms. As one of the most common malignant tumors worldwide, GC has a complex pathogenesis and limited therapeutic options. Therefore, a thorough understanding of the molecular mechanism of GC is very important for the development of new therapeutic methods. The HGF/c-Met signaling pathway plays an important role in the proliferation, migration, and invasion of GC cells and has become a new therapeutic target. This review summarizes the current research progress on the role of HGF/c-Met in GC and discusses targeted therapeutic strategies targeting this signaling pathway, providing new ideas and directions for the treatment of GC.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current trends and hotspots of depressive disorders with colorectal cancer: A bibliometric and visual study.","authors":"Zi-Wei Yan, Ying-Nan Liu, Qian Xu, Yuan Yuan","doi":"10.4251/wjgo.v16.i8.3687","DOIUrl":"10.4251/wjgo.v16.i8.3687","url":null,"abstract":"<p><strong>Background: </strong>Depression is strongly associated with colorectal cancer (CRC). Few bibliometric analyses have systematically summarized the research focus and recent progress in this field.</p><p><strong>Aim: </strong>To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between CRC and depression.</p><p><strong>Methods: </strong>Articles on depression in CRC patients were collected from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to visualize bibliometric networks.</p><p><strong>Results: </strong>From 2001 to 2022, <i>Supportive Care in Cancer</i>, the United States, Tilburg University, and Mols were the most productive and influential journal, country, institution, and author name. Co-occurrence cluster analysis of keywords placed quality of life, anxiety, and psychological stress in the center of the visual network diagram. Further clustering was performed for the clusters with studies of the relevant mechanism of action, which showed that: (1) Cytokines have a role essential for the occurrence and development of depressive disorders in CRC; (2) MicroRNAs have a role essential for the development of depressive disorders in CRC; (3) Some anticancer drugs have pro-depressant activity; and (4) Selective serotonin reuptake inhibitors have both antitumor and antidepressant activity.</p><p><strong>Conclusion: </strong>Life quality and psychological nursing of the cancer population were key topics. The roles of cytokines and microRNAs, the pro-depression activity of anticancer drugs and their antitumor properties deserve in-depth study.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of perioperative chemotherapy on resection of isolated pulmonary metastases from colorectal cancer: A single center experience.","authors":"Zhao Gao, Xuan Jin, Ying-Chao Wu, Shi-Jie Zhang, Shi-Kai Wu, Xin Wang","doi":"10.4251/wjgo.v16.i8.3457","DOIUrl":"10.4251/wjgo.v16.i8.3457","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have assessed surgical resection as a standard treatment option for patients with colorectal cancer (CRC) and resectable pulmonary metastases (PM). However, the role of perioperative chemotherapy after complete resection of isolated PM from patients with CRC patients remains controversial. We hypothesize that perioperative chemotherapy does not provide significant survival benefits for patients undergoing resection of PM from CRC.</p><p><strong>Aim: </strong>To determine whether perioperative chemotherapy affects survival after radical resection of isolated PM from CRC.</p><p><strong>Methods: </strong>We retrospectively collected demographic, clinical, and pathologic data on patients who underwent radical surgery for isolated PM from CRC. Cancer-specific survival (CSS) and disease-free survival were calculated using Kaplan-Meier analysis. Inter-group differences were compared using the log-rank test. For multivariate analysis, Cox regression was utilized when indicated.</p><p><strong>Results: </strong>This study included 120 patients with a median age of 61.6 years. The 5-year CSS rate was 78.2%, with 36.7% experiencing recurrence. Surgical resection for isolated PM resulted in a 5-year CSS rate of 50.0% for second metastases. Perioperative chemotherapy (<i>P</i> = 0.079) did not enhance survival post-resection. Factors associated with improved survival included fewer metastatic lesions [hazard ratio (HR): 2.51, <i>P</i> = 0.045], longer disease-free intervals (HR: 0.35, <i>P</i> = 0.016), and wedge lung resections (HR: 0.42, <i>P</i> = 0.035). Multiple PM predicted higher recurrence risk (HR: 2.22, <i>P</i> = 0.022). The log-rank test showed no significant difference in CSS between single and repeated metastasectomy (<i>P</i> = 0.92).</p><p><strong>Conclusion: </strong>Perioperative chemotherapy shows no survival benefit post-PM resection in CRC. Disease-free intervals and fewer metastatic lesions predict better survival. Repeated metastasectomy is warranted for eligible patients.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive fibromatosis of the sigmoid colon: A case report.","authors":"Pan-Pan Yu, Xin-Chun Liu, Lu Yin, Guang Yin","doi":"10.4251/wjgo.v16.i8.3716","DOIUrl":"10.4251/wjgo.v16.i8.3716","url":null,"abstract":"<p><strong>Background: </strong>Aggressive fibromatosis (AF), also known as desmoid tumor or desmoid-type fibromatosis, is a rare soft tissue neoplasm that can occur in almost any part of the body. Although it is a benign disease, AF is aggressive and infiltrative and has a high recurrence rate after surgery. Common sites for intra-abdominal AF are the small bowel mesentery, retroperitoneum, and pelvis. AF in the colon is extremely rare.</p><p><strong>Case summary: </strong>Here, we report the first case of sigmoid colon AF, which was accidentally discovered in a 27-year-old woman during laparoscopic myomectomy. Computed tomography confirmed a slightly enhanced mass in the sigmoid colon. Subsequent colonoscopy did not reveal a mass in the colonic lumen, but a suspected external compress was found in the sigmoid colon. Surgical disease involving a gastrointestinal stromal tumor was suspected. The patient underwent laparoscopic exploration, and sigmoidectomy with a negative margin was performed to excise the mass. Postoperative immunohistochemistry revealed that the mass was an AF. The patient recovered well and was recurrence-free at the 30-month follow-up without adjuvant therapy.</p><p><strong>Conclusion: </strong>AF should be considered in the differential diagnosis of subepithelial colon masses. Radical resection alone can achieve good outcomes.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the effect of pyroptosis on the occurrence, development, invasion and metastasis of colorectal cancer.","authors":"Xu Wang, Qi-Hang Yin, Lin-Lu Wan, Ruo-Lan Sun, Gang Wang, Jun-Fei Gu, De-Cai Tang","doi":"10.4251/wjgo.v16.i8.3410","DOIUrl":"10.4251/wjgo.v16.i8.3410","url":null,"abstract":"<p><p>Pyroptosis is a type of programmed cell death mediated by gasdermines (GSDMs). The N-terminal domain of GSDMs forms pores in the plasma membrane, causing cell membrane rupture and the release of cell contents, leading to an inflammatory response and mediating pyrodeath. Pyroptosis plays an important role in inflammatory diseases and malignant tumors. With the further study of pyroptosis, an increasing number of studies have shown that the pyroptosis pathway can regulate the tumor microenvironment and antitumor immunity of colorectal cancer and is closely related to the occurrence, development, treatment and prognosis of colorectal cancer. This review aimed to explore the molecular mechanism of pyroptosis and the role of pyroptosis in the occurrence, development, treatment and prognosis of colorectal cancer (CRC) and to provide ideas for the clinical diagnosis and treatment of CRC.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining lymph node ratio to develop prognostic models for postoperative gastric neuroendocrine neoplasm patients.","authors":"Wen Liu, Hong-Yu Wu, Jia-Xi Lin, Shu-Ting Qu, Yi-Jie Gu, Jin-Zhou Zhu, Chun-Fang Xu","doi":"10.4251/wjgo.v16.i8.3507","DOIUrl":"10.4251/wjgo.v16.i8.3507","url":null,"abstract":"<p><strong>Background: </strong>Lymph node ratio (LNR) was demonstrated to play a crucial role in the prognosis of many tumors. However, research concerning the prognostic value of LNR in postoperative gastric neuroendocrine neoplasm (NEN) patients was limited.</p><p><strong>Aim: </strong>To explore the prognostic value of LNR in postoperative gastric NEN patients and to combine LNR to develop prognostic models.</p><p><strong>Methods: </strong>A total of 286 patients from the Surveillance, Epidemiology, and End Results database were divided into the training set and validation set at a ratio of 8:2. 92 patients from the First Affiliated Hospital of Soochow University in China were designated as a test set. Cox regression analysis was used to explore the relationship between LNR and disease-specific survival (DSS) of gastric NEN patients. Random survival forest (RSF) algorithm and Cox proportional hazards (CoxPH) analysis were applied to develop models to predict DSS respectively, and compared with the 8^th edition American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging.</p><p><strong>Results: </strong>Multivariate analyses indicated that LNR was an independent prognostic factor for postoperative gastric NEN patients and a higher LNR was accompanied by a higher risk of death. The RSF model exhibited the best performance in predicting DSS, with the C-index in the test set being 0.769 [95% confidence interval (CI): 0.691-0.846] outperforming the CoxPH model (0.744, 95%CI: 0.665-0.822) and the 8^th edition AJCC TNM staging (0.723, 95%CI: 0.613-0.833). The calibration curves and decision curve analysis (DCA) demonstrated the RSF model had good calibration and clinical benefits. Furthermore, the RSF model could perform risk stratification and individual prognosis prediction effectively.</p><p><strong>Conclusion: </strong>A higher LNR indicated a lower DSS in postoperative gastric NEN patients. The RSF model outperformed the CoxPH model and the 8^th edition AJCC TNM staging in the test set, showing potential in clinical practice.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin for gastric cancer: Mechanism prediction <i>via</i> network pharmacology, docking, and <i>in vitro</i> experiments.","authors":"Peng-Hui Yang, Ya-Nan Wei, Bi-Juan Xiao, Si-Yi Li, Xin-Long Li, Liang-Jun Yang, Hua-Feng Pan, Geng-Xin Chen","doi":"10.4251/wjgo.v16.i8.3635","DOIUrl":"10.4251/wjgo.v16.i8.3635","url":null,"abstract":"<p><strong>Background: </strong>Curcumin originates from the natural herb turmeric, and its antitumor effects have been known about for a long time. However, the mechanism by which curcumin affects gastric cancer (GC) has not been elucidated<b>.</b></p><p><strong>Aim: </strong>To elucidate the potential mechanisms of curcumin in the treatment of GC.</p><p><strong>Methods: </strong>Network pharmacological approaches were used to perform network analysis of Curcumin. We first analyzed Lipinski's Rule of Five for the use of Curcumin. Curcumin latent targets were predicted using the PharmMapper, SwissTargetPrediction and DrugBank network databases. GC disease targets were mined through the GeneCard, OMIM, DrugBank and TTD network databases. Then, GO enrichment, KEGG enrichment, protein-protein interaction (PPI), and overall survival analyses were performed. The results were further verified through molecular docking, differential expression analysis and cell experiments.</p><p><strong>Results: </strong>We identified a total of 48 curcumin-related genes with 31 overlapping GC-related targets. The intersection targets between curcumin and GC have been enriched in 81 GO biological processes and 22 significant pathways. Following PPI analysis, 6 hub targets were identified, namely, <i>estrogen receptor 1</i> (<i>ESR1</i>), <i>epidermal growth factor receptor</i> (<i>EGFR</i>), <i>cytochrome P450 family 3 subfamily A member 4</i> (<i>CYP3A4</i>), <i>mitogen-activated protein kinase 14</i> (<i>MAPK14</i>), <i>cytochrome P450 family 1 subfamily A member 2</i> (<i>CYP1A2</i>), and <i>cytochrome p450 family 2 subfamily B member 6</i> (<i>CYP2B6</i>). These factors are correlated with decreased survival rates among patients diagnosed with GC. Molecular docking analysis further substantiated the strong binding interactions between Curcumin and the hub target genes. The experimental findings demonstrated that curcumin not only effectively inhibits the growth of BGC-823 cells but also suppresses their proliferation. mRNA levels of hub targets <i>CYP3A4</i>, <i>MAPK14</i>, <i>CYP1A2</i>, and <i>CYP2B6</i> in BGC-823 cells were significantly increased in each dose group.</p><p><strong>Conclusion: </strong>Curcumin can play an anti-GC role through a variety of targets, pathways and biological processes.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum.","authors":"Li-Li Yin, Ping-Qian Qi, Yun-Fei Hu, Xiao-Jun Fu, Rui-Shan He, Meng-Meng Wang, Yan-Juan Deng, Su-Yi Xiong, Qi-Wen Yu, Jin-Ping Hu, Lv Zhou, Zhi-Bin Zhou, Ying Xiong, Huan Deng","doi":"10.4251/wjgo.v16.i8.3600","DOIUrl":"10.4251/wjgo.v16.i8.3600","url":null,"abstract":"<p><strong>Background: </strong>Colorectal polyps, which are characterized by a high recurrence rate, represent preneoplastic conditions of the intestine. Due to unclear mechanisms of pathogenesis, first-line therapies for non-hereditary recurrent colorectal polyps are limited to endoscopic resection. Although recent studies suggest a mechanistic link between intestinal dysbiosis and polyps, the exact compositions and roles of bacteria in the mucosa around the lesions, rather than feces, remain unsettled.</p><p><strong>Aim: </strong>To clarify the composition and diversity of bacteria in the mucosa surrounding or 10 cm distal to recurrent intestinal polyps.</p><p><strong>Methods: </strong>Mucosal samples were collected from four patients consistently with adenomatous polyps (Ade), seven consistently with non-Ade (Pol), ten with current Pol but previous Ade, and six healthy individuals, and bacterial patterns were evaluated by 16S rDNA sequencing. Linear discriminant analysis and Student's <i>t</i>-tests were used to identify the genus-level bacteria differences between groups with different colorectal polyp phenotypes. Pearson's correlation coefficients were used to evaluate the correlation between intestinal bacteria at the genus level and clinical indicators.</p><p><strong>Results: </strong>The results confirmed a decreased level of probiotics and an enrichment of pathogenic bacteria in patients with all types of polyps compared to healthy individuals. These changes were not restricted to the mucosa within 0.5 cm adjacent to the polyps, but also existed in histologically normal tissue 10 cm distal from the lesions. Significant differences in bacterial diversity were observed in the mucosa from individuals with normal conditions, Pol, and Ade. Increased abundance of Gram-negative bacteria, including <i>Klebsiella</i>, <i>Plesiomonas</i>, and <i>Cronobacter</i>, was observed in Pol group and Ade group, suggesting that resistance to antibiotics may be one risk factor for bacterium-related harmful environment. Meanwhile, age and gender were linked to bacteria changes, indicating the potential involvement of sex hormones.</p><p><strong>Conclusion: </strong>These preliminary results support intestinal dysbiosis as an important risk factor for recurrent polyps, especially adenoma. Targeting specific pathogenic bacteria may attenuate the recurrence of polyps.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of early detection of esophageal cancer before the tumor progresses too much for effective treatment.","authors":"Takashi Ono","doi":"10.4251/wjgo.v16.i8.3382","DOIUrl":"10.4251/wjgo.v16.i8.3382","url":null,"abstract":"<p><p>This editorial comments on an article by Qu <i>et al</i> published in the <i>World Journal of Gastrointestinal Oncology</i>. It focuses on the importance of early detection of esophageal cancer, including recurrence or secondary malignancy after chemoradiotherapy (CRT). Endoscopic resection is the first choice for treatment for esophageal cancer remaining within the mucous membrane, while surgery or radical CRT are treatment options for advanced stages depending on the patient's general condition and desire. Although these treatments are potentially curative, they are more invasive than endoscopic resection. Early-stage esophageal cancer is often asymptomatic and difficult to detect. Uniform periodic endoscopy is unrealistic. Although less burdensome tests exist, including liquid biopsy and urinary biomarkers, these have not yet been widely used in clinical practice. Early detection is important after radical CRT because the local recurrence rate is higher than that after surgery. However, endoscopic resection or photodynamic therapy is indicated if detected in the early stages, and positive results have been reported. Early detection of esophageal cancer is crucial. Endoscopy is the main diagnostic method; however, new and less burdensome methods should be established to ensure early treatment for patients with esophageal cancer.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular structural changes in esophageal squamous cell carcinoma pathology according to intrapapillary capillary loop types under magnifying endoscopy.","authors":"Wei-Yang Shu, Yan-Yan Shi, Jiu-Tian Huang, Ling-Mei Meng, He-Jun Zhang, Rong-Li Cui, Yuan Li, Shi-Gang Ding","doi":"10.4251/wjgo.v16.i8.3471","DOIUrl":"10.4251/wjgo.v16.i8.3471","url":null,"abstract":"<p><strong>Background: </strong>The intrapapillary capillary loop (IPCL) characteristics, visualized using magnifying endoscopy, are commonly assessed for preoperative evaluation of the infiltration depth of esophageal squamous cell carcinoma (ESCC). Japan Esophageal Society (JES) classification is the most widely used classification. Microvascular structural changes are evaluated by magnifying endoscopy for the presence or absence of each morphological factor: tortuosity, dilatation, irregular caliber, and different shapes. However, the pathological characteristics of IPCLs have not been thoroughly investigated, especially the microvascular structures corresponding to the deepest parts of the lesions' infiltration.</p><p><strong>Aim: </strong>To investigate differences in pathological microvascular structures of ESCC, which correspond to the deepest parts of the lesions' infiltration.</p><p><strong>Methods: </strong>Patients with ESCC and precancerous lesions diagnosed at Peking University Third Hospital were enrolled between January 2019 and April 2023. Patients first underwent magnified endoscopic examination, followed by endoscopic submucosal dissection or surgical treatment. Pathological images were scanned using a three-dimensional slice scanner, and the pathological structural differences in different types, according to the JES classification, were analyzed using nonparametric tests and <i>t</i>-tests.</p><p><strong>Results: </strong>The 35 lesions were divided into four groups according to the JES classification: A, B1, B2, and B3. Statistical analyses revealed significant differences (^a <i>P</i> < 0.05) in the short and long calibers, area, location, and density between types A and B. Notably, there were no significant differences in these parameters between types B1 and B2 and between types B2 and B3 (<i>P</i> > 0.05). However, significant differences in the short calibers, long calibers, and area of IPCL were observed between types B1 and B3 (^a <i>P</i> < 0.05); no significant differences were found in the density or location (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Pathological structures of IPCLs in the deepest infiltrating regions differ among various IPCL types classified by the JES classification under magnifying endoscopy, especially between the types A and B.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}