World Journal of Gastrointestinal Oncology最新文献

{"title":"Intensive care unit outcomes and prognostic factors of esophageal cancer: A cross-sectional study in Chinese cancer-specialized hospitals.","authors":"Jiang-Feng Tang, Rui Xia, Xue-Zhong Xing, Chang-Song Wang, Gang Ma, Hong-Zhi Wang, Biao Zhu, Jiang-Hong Zhao, Dong-Min Zhou, Li Zhang, Ming-Guang Huang, Rong-Xi Quan, Yong Ye, Guo-Xing Zhang, Zheng-Ying Jiang, Bing Huang, Shan-Ling Xu, Yun Xiao, Lin-Lin Zhang, Rui-Yun Lin, Shu-Liang Ma, Yu-An Qiu, Zhen Zheng, Ni Sun, Le-Wu Xian, Ji Li, Ming Zhang, Zhi-Jun Guo, Yong Tao, Xiang-Zhe Zhou, Wei Chen, Dao-Xie Wang, Ji-Yan Chi, Dong-Hao Wang, Kai-Zhong Liu","doi":"10.4251/wjgo.v17.i8.106688","DOIUrl":"10.4251/wjgo.v17.i8.106688","url":null,"abstract":"<p><strong>Background: </strong>Esophageal cancer patients had the highest intensive care unit (ICU) admitted rate in cancer patients. But their prognosis and evaluation methods were rarely studied.</p><p><strong>Aim: </strong>To depict the short-term mortality outcome and identify the potential prognostic factors of esophageal cancer patients admitted into ICU.</p><p><strong>Methods: </strong>A multicenter cross-sectional study was performed from May 10, 2021 to July 10, 2021 at ICU departments of 37 cancer specialized hospitals in China. Patients aged ≥ 14 years with ICU duration ≥ 24 hours were included. Clinical records of patients with primary esophageal cancer diagnosis were reviewed. Patients were separated into groups according to the 90 days survival. Characteristics between groups were compared. Single and multi-variate regression tests were applied to analyze the correlated factors of ICU outcomes. Predictive values of disease severity scores were assessed using receiver operating characteristic curve analysis.</p><p><strong>Results: </strong>Total 180 esophageal cancer patients were included. The 90 days mortality was 22.2%. Patients with mortality outcome showed differences from those survived mostly in disease severity and unplanned transfer from clinical ward. The current evaluation tools, including Sequential Organ Failure Assessment and Acute Physiology and Chronic Health Evaluation II scores had low accuracy in prediction of short-term death. ICU admitted esophageal cancer patients have poor prognosis, especially those with acute illness.</p><p><strong>Conclusion: </strong>The prognostic tools for these patients need to be further optimized.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"106688"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative laparoscopic ultrasound-guided resection and microwave ablation for colorectal liver metastases.","authors":"Hao-Ran Wu, Hao Bu, You-Yuan Liu, Hou-Ping Zhou, Jing-Song Ye, Hua Chen","doi":"10.4251/wjgo.v17.i8.107526","DOIUrl":"10.4251/wjgo.v17.i8.107526","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) frequently metastasizes to the liver, significantly compromising patient survival. While surgical resection improves outcomes for resectable cases, many patients have limited therapeutic options.</p><p><strong>Aim: </strong>To evaluate the role of laparoscopic ultrasound in resection and ablation of colorectal liver metastases (CRLM).</p><p><strong>Methods: </strong>Between June 2018 and June 2020, 300 patients with CRC and liver metastases were admitted to our hospital. They were divided into two groups (150 cases each) based on treatment method: The control group (ethoxybenzyl diethylenetriamine penta-acetic acid enhanced magnetic resonance imaging) and the observation group [contrast-enhanced ultrasound with Sonazoid (S-CEUS)].</p><p><strong>Results: </strong>The study group demonstrated better efficacy (<i>P</i> < 0.05), fewer adverse events (<i>P</i> < 0.05), and better survival outcomes compared to the control group (1-year: 80% <i>vs</i> 62%; 3-year: 54% <i>vs</i> 33%; 5-year: 32% <i>vs</i> 18%; median survival: 48 months <i>vs</i> 30 months; hazard ratio = 0.63, 95%CI: 0.48-0.83, <i>P</i> < 0.001). Although Karnofsky Performance Status scores improved in both groups, the scores were significantly higher in the observation group (<i>P</i> < 0.05). Multivariate analysis confirmed intraoperative S-CEUS and tumor differentiation as independent prognostic factors (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Laparoscopic ultrasound-guided resection/ablation improved outcomes in CRLM, reducing complications and enhancing survival. Intraoperative S-CEUS was an independent prognostic factor, supporting its clinical value.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"107526"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallbladder and biliary tract cancer burden trends in Brazil, Russian Federation, India, China, and South Africa in 1990-2021.","authors":"Yun-Long Cui, Xu Bao, Dong-Ming Liu, Han Mu, Ge Yu","doi":"10.4251/wjgo.v17.i8.109245","DOIUrl":"10.4251/wjgo.v17.i8.109245","url":null,"abstract":"<p><strong>Background: </strong>Gallbladder and biliary tract cancer (GBTC) is a highly aggressive malignant tumor with a high fatality rate. The global incidence and mortality of GBTC continue to increase, presenting a significant challenge to public health. Strategies for preventing and controlling GBTC in Brazil, Russian Federation, India, China and South Africa (BRICS) countries offer valuable lessons for other developing nations.</p><p><strong>Aim: </strong>To investigate GBTC burden trends in BRICS countries and perform an age-period-cohort (APC) analysis of Global Burden of Disease (GBD) from 1990-2021.</p><p><strong>Methods: </strong>Data on the incidences and crude incidence rates, the number of deaths and crude mortality rates, and the age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) of GBTC were obtained for BRICS countries from the GBD study 2021. Joinpoint regression analysis was employed to examine the trends in disease burden from 1990 to 2021. The APC model was utilized to assess the age, period, and birth cohort effects on the changes in GBTC disease burden worldwide and in the BRICS countries during the same time frame. Bayesian APC analysis was used to estimate the future burden.</p><p><strong>Results: </strong>The increases in incidence and deaths were 101.09% and 74.26%, respectively, compared with 1990. The ASMRs in Brazil, Russia, and China decreased, while those in India and South Africa increased. Among the BRICS countries, in most age groups in Brazil, Russia, India, and South Africa, the crude incidence and mortality rates in women were higher than those in men, whereas in China, the situation was the opposite. Joinpoint regression analysis revealed that from 1990 to 2021, the overall ASIR of gallbladder and bile duct cancer exhibited a declining trend. Although the incidence rate in China showed an increasing trend, the mortality rate exhibited a declining trend, which became more pronounced over time.</p><p><strong>Conclusion: </strong>In BRICS countries, the number of incident cases and deaths from GBTC increased between 1990 and 2021, primarily due to rapid population growth. Nevertheless, the ASIR and ASMR declined during the same period.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"109245"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA SNHG5 modulates cell proliferation and migration through the miR-92a-3p/BTG2 axis in gastric cancer by the PI3K/AKT pathway.","authors":"Qi-Qi Mao, Mei-Lin Zhang, Liang Zhong, Xu-Dong Xu, Xin-Hai Wang, Du-Yi Pan, Fu-Sheng Zhou, Jia-Xin Huang, Xian-Guang Zhao, Jia-Jie Chen, Xiao-Yun Jiang, Xu Sun, Wei-Qun Ding","doi":"10.4251/wjgo.v17.i8.105321","DOIUrl":"10.4251/wjgo.v17.i8.105321","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer (GC) is a widespread malignancy and associated with high rates of morbidity and mortality worldwide.</p><p><strong>Aim: </strong>To examine the functional role of long non-coding RNAs small nucleolar RNA host gene 5 (SNHG5) and its regulation of miR-92a-3p and B-cell translocation gene 2 (BTG2) in GC progression.</p><p><strong>Methods: </strong>Quantitative reverse transcription PCR and western blot analysis determined the expression of SNHG5, miR-92a-3p, and BTG2 in GC and adjacent non-neoplastic mucosa. Dual-luciferase assays demonstrated interactions of SNHG5 with miR-92a-3p and BTG2. AGS cells were transfected with SNHG5 overexpression and miR-92a-3p knockdown models. Various assays, including CCK-8, colony formation, scratch wound healing, and Transwell assays, were used to determine cell proliferation and migration. An experimental model of a xenograft mouse was used to determine <i>in vivo</i> tumor growth. At the same time histological changes were evaluated by hematoxylin and eosin staining, with western blot analysis used to evaluate signaling pathway protein expression.</p><p><strong>Results: </strong>BTG2 and SNHG5 were downregulated in GC tissues, and miR-92a-3p was upregulated. Overexpression of SNHG5 or knockdown of miR-92a-3p reduced GC cell proliferation and migration, and increased BTG2 expression while decreasing PI3K/AKT signaling activity. The dual-luciferase assays demonstrated direct binding of miR-92a-3p to SNHG5 and BTG2. Tumor volume and weight were significantly reduced in mice transplanted with AGS cells treated with miR-92a-3p inhibitor or SNHG5 overexpression compared with control AGS cells. Hematoxylin and eosin staining revealed that treated tumors exhibited degenerative characteristics, including irregular morphology and nucleolysis.</p><p><strong>Conclusion: </strong>LncRNA SNHG5 inhibited GC cell growth and migration by modulating the PI3K/AKT pathway <i>via</i> the miR-92a-3p/BTG2 axis.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"105321"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cell apoptosis through the CaMKII-Ca²⁺ pathway.","authors":"Jia-Yan Chen, Jing-Yi Wen, Jia-Long Lin, Yan Li, Yi-Zhang Wu, Li-Qin Lou, Yong-Liang Lou, Zhi-Gui Zuo, Xiang Li","doi":"10.4251/wjgo.v17.i8.107453","DOIUrl":"10.4251/wjgo.v17.i8.107453","url":null,"abstract":"<p><strong>Background: </strong>Deoxycholic acid (DCA), a secondary bile acid, is associated with colorectal carcinogenesis, but its mechanisms remain unclear.</p><p><strong>Aim: </strong>To investigate how DCA regulates apoptosis in colorectal cancer (CRC) cells.</p><p><strong>Methods: </strong>SW480 and DLD-1 CRC cell lines were used to investigate the mechanism of apoptosis by western blotting, flow cytometry, confocal microscopy, and other methods.</p><p><strong>Results: </strong>DCA significantly induced apoptosis, with rates increasing to 7.2% ± 1.5% in SW480 cells and 14.3% ± 0.6% in DLD-1 cells after treatment, compared to 4.7% ± 1.0% and 11.6% ± 0.8% in controls (<i>P</i> < 0.05). Western blot analysis showed upregulation of pro-apoptotic proteins Bax and Cleaved-PARP, with a significant increase in the Cleaved-PARP/PARP ratio (<i>P</i> < 0.001). DCA treatment also increased the intracellular reactive oxygen species (ROS) levels of SW480 and DLD-1 cells to 1.2-fold and 1.3-fold, respectively (<i>P</i> < 0.01), while the increase of mitochondrial ROS levels in these cells was statistically significant under confocal microscopy. Additionally, cytosolic and mitochondrial Ca²⁺ levels increased 1.3-fold and 1.2-fold, respectively, in SW480 cells (<i>P</i> < 0.01), and 1.1-fold and 1.1-fold, respectively, in DLD-1 cells compared with controls (<i>P</i> < 0.05). p-CaMKII protein levels were also elevated (<i>P</i> < 0.01), indicating activation of the Ca²⁺-CaMKII signaling pathway. Pharmacological inhibition with BAPTA-AM (1 μM) reduced mitochondrial Ca²⁺ accumulation and ROS levels in SW480 cells (<i>P</i> < 0.05), and suppressed apoptosis.</p><p><strong>Conclusion: </strong>DCA activates the Ca²⁺-CaMKII pathway, leading to ROS-mediated apoptosis in CRC cells, providing insights for potential therapeutic targets.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"107453"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the association between <i>SF3B4</i> and <i>HMGB1</i> expression and the clinicopathological features and prognosis of gastric cancer.","authors":"Min-Yue Shou, Yu-Qing Liu, Yong-Qian Shu","doi":"10.4251/wjgo.v17.i8.109120","DOIUrl":"10.4251/wjgo.v17.i8.109120","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer ranks among the leading malignancies worldwide, noted for its high morbidity and mortality, and remains a significant challenge to global public health.</p><p><strong>Aim: </strong>To investigate the association between the expression of splicing factor 3b subunit 4 (<i>SF3B4</i>) and high mobility group box 1 (<i>HMGB1</i>) with the clinical characteristics and prognostic outcomes of gastric cancer patients.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted involving 114 individuals diagnosed with gastric cancer and admitted to our institution from January 2020 to December 2021. A comparison group of 90 patients diagnosed with benign gastric disorders during the same period was also included. Expression levels of <i>SF3B4</i> and <i>HMGB1</i> were assessed using real-time quantitative polymerase chain reaction. Expression patterns were analyzed in relation to various clinicopathological features. Receiver operating characteristic curves were constructed to evaluate the ability of <i>SF3B4</i> and <i>HMGB1</i>, alone and in combination, to predict unfavorable one-year outcomes. Multivariate logistic regression was utilized to identify independent predictors of mortality. Kaplan-Meier survival curves were generated to examine survival differences based on <i>SF3B4</i> and <i>HMGB1</i> expression levels.</p><p><strong>Results: </strong>Both <i>SF3B4</i> and <i>HMGB1</i> were markedly upregulated in tumor tissues of gastric cancer patients compared to adjacent normal tissues and to tissues from non-malignant gastric disease patients (^a <i>P</i> < 0.05). Higher expression levels of these two genes were significantly associated with aggressive pathological features, including poor differentiation, tumor size > 5 cm, deep infiltration (T3-T4), lymph node involvement, and advanced clinical stage (III-IV) (^a <i>P</i> < 0.05). Receiver operating characteristic analysis revealed that the combined use of <i>SF3B4</i> and <i>HMGB1</i> yielded an area under the curve of 0.914, surpassing the predictive performance of either marker alone (<i>SF3B4</i>: 0.776; <i>HMGB1</i>: 0.757). Multivariate analysis identified <i>SF3B4</i> ≥ 1.45, <i>HMGB1</i> ≥ 0.93, poor differentiation, larger tumor size, deeper invasion, lymph node metastasis, and advanced clinical tumor-node-metastasis staging as independent factors contributing to one-year mortality (^a <i>P</i> < 0.05). Survival analysis indicated that patients with elevated <i>SF3B4</i> and <i>HMGB1</i> levels had a shorter median survival (25.74 ± 5.46 months) compared to those with lower expression levels (33.29 ± 6.71 months, log-rank = 10.534, ^a <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Elevated <i>SF3B4</i> and <i>HMGB1</i> expression in gastric cancer tissue is significantly associated with tumor aggressiveness, worse prognosis, and reduced survival. These biomarkers may offer clinical ","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"109120"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatty acid-binding protein 4 as a biomarker for colon adenocarcinoma risk and prognosis: Challenges and future directions.","authors":"Si-Rui Wang, Ting-Lan Cao, Hui-Zhong Jiang","doi":"10.4251/wjgo.v17.i8.106621","DOIUrl":"10.4251/wjgo.v17.i8.106621","url":null,"abstract":"<p><p>In this letter, we have commented on the study by Zhang <i>et al</i>, which utilized bioinformatics and immunohistochemistry to assess the value of fatty acid-binding protein 4 (FABP4) as a biomarker for colon adenocarcinoma (COAD). Their findings improve our understanding of FABP4 in cancer cell adhesion and immune cell infiltration. However, differential expression analysis was insufficient to demonstrate a direct association between FABP4 expression and the occurrence and progression of COAD. Using Mendelian randomization for causal inferences can provide a solid biological foundation for model construction. Furthermore, integrating machine and deep learning approaches may yield more robust and precise prognostic outcomes than using a single Cox regression model. In addition, integrating genome-wide association study data to identify additional pathogenic genes involved in the regulation of fatty acid metabolism may facilitate the development of a multi-target strategy. This approach could potentially mitigate the compensatory effects associated with targeting FABP4 alone, and enhance therapeutic efficacy. Enhancing experimental validation would further improve the reliability of the results. With the continuous advancement of machine learning, multi-omics technologies, and experimental techniques, future studies may systematically integrate diverse sequencing datasets to offer novel insights into the early diagnosis, individualized treatment, and prognostic evaluation of COAD.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"106621"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of coagulation markers in locally advanced gastric cancer following neoadjuvant immunochemotherapy.","authors":"Arunkumar Krishnan, Diptasree Mukherjee","doi":"10.4251/wjgo.v17.i8.105099","DOIUrl":"10.4251/wjgo.v17.i8.105099","url":null,"abstract":"<p><p>Gastric cancer (GC) has remained one of the leading causes of cancer-related deaths globally. The development of noninvasive biomarkers in cancer diagnosis and treatment has gained substantial traction in recent years. Recent evidence highlights hypercoagulation as a promising prognostic biomarker, particularly in locally advanced GC (LAGC) who underwent radical resection after neoadjuvant immunochemotherapy (NICT). A recent study by Li <i>et al</i> showed that hypercoagulation is a valuable prognostic indicator for patients with LAGC who have undergone radical resection following NICT. While the study addresses an important clinical issue and provides insightful findings, the present study offered valuable insights; the applicability of these findings was constrained by the retrospective design, the focus on a single center, and the small sample size of the existing studies. Additionally, vital confounders, such as preoperative comorbidities and systemic inflammation, are inadequately addressed. Future studies should focus on prospective multicenter trials, incorporating advanced predictive models such as machine learning algorithms to integrate coagulation markers with other clinical variables for personalized risk stratification. In addition, we are required to validate findings to examine the biological mechanisms correlating hypercoagulation to tumor progression. Integrating machine learning, comprehensive biomarker panels, and real-world data would allow the researchers to have personalized risk stratification, improve predictive accuracy, and optimize clinical decision-making. Finally, A multidisciplinary approach, including lifestyle interventions and imaging modalities, is essential to improve outcomes among patients with GC.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"105099"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of circulating tumor DNA methylation in gastric cancer initiation and progression: A comprehensive review.","authors":"Hai-Yu Huang, Jiang Lan, Wei Zhuang","doi":"10.4251/wjgo.v17.i8.107412","DOIUrl":"10.4251/wjgo.v17.i8.107412","url":null,"abstract":"<p><p>Circulating tumor DNA (ctDNA) is the free DNA released by tumor or circulating tumor cells, which is associated with many tumor characteristics and can be used as a biomarker for early screening, monitoring, prognosis, and prediction of therapeutic response in patients with cancer. The field of gastric cancer is very attractive because there are no high-quality screening, monitoring, or prediction methods. Gastric cancer is characterized by great tumor heterogeneity, great differences in genetic and epigenetic characteristics among different subgroups of gastric cancer, and high sensitivity and specificity of methylated ctDNA, which is conducive to the identification of tumor genotypes and the formulation of accurate diagnostic and treatment strategies. In addition, many studies have confirmed that methylated DNA has unique advantages in predicting treatment response, adjuvant therapy, and drug resistance and can be used to increase the efficacy of chemotherapy regimens, improve the chemotherapy response of patients in the future, and even treat multidrug resistance. However, methylated ctDNA also faces many problems, such as low sensitivity and specificity in a single target, limited association between some gastric cancer subtypes and ctDNA, risk of off-target effects, and lack of large-sample and high-quality clinical research evidence. This review mainly summarizes the current research on the DNA methylation of circulating gastric cancer tumors and links these findings with the early screening of gastric cancer, recurrence monitoring, and potential treatment opportunities. With the advancement of technology and the deepening of cross-research between doctors and professionals, ctDNA detection will reveal more disease information and become an important basis for the field of gastric cancer and precision medicine treatment.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"107412"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different titration protocols in pain management after radical gastrectomy for gastric cancer patients.","authors":"Bin-Bin Chen, Wei Tu, Ai-Dan Xia, Miao-Yong Zhu, Zi-Jie Wang","doi":"10.4251/wjgo.v17.i8.108238","DOIUrl":"10.4251/wjgo.v17.i8.108238","url":null,"abstract":"<p><strong>Background: </strong>Effective pain management after radical gastrectomy is crucial for patient recovery. With the promotion of enhanced recovery after surgery protocols, postoperative pain management has become a core component of perioperative care. However, controversy remains regarding the optimal frequency of analgesic titration for pain control.</p><p><strong>Aim: </strong>To compare the efficacy of 12-hour <i>vs</i> 24-hour titration regimens in postoperative pain management following radical gastrectomy for gastric cancer.</p><p><strong>Methods: </strong>This retrospective comparative study analyzed data from 120 patients who underwent radical gastrectomy between January 2021 and December 2022, with 52 patients receiving a 12-hour titration regimen and 68 patients receiving a 24-hour titration regimen. All patients received patient-controlled intravenous analgesia containing sufentanil and tropisetron postoperatively with identical initial settings.</p><p><strong>Results: </strong>The 12-hour titration group demonstrated significantly lower pain scores at 12 hours postoperatively compared to the 24-hour group (3.2 <i>vs</i> 4.8, <i>P</i> < 0.001); total analgesic consumption (morphine equivalents) was reduced by 28.6% (30 mg <i>vs</i> 42 mg, <i>P</i> < 0.001); postoperative nausea and vomiting decreased by 50% (15% <i>vs</i> 30%, <i>P</i> = 0.02); respiratory depression was less frequent (2% <i>vs</i> 8%, <i>P</i> = 0.04); patient satisfaction was higher (85% <i>vs</i> 65% reporting \"very satisfied\" or \"satisfied\", <i>P</i> < 0.001); and hospital stay was shortened by 12.5% (4.2 days <i>vs</i> 4.8 days, <i>P</i> = 0.02). Cox regression analysis showed that the 12-hour regimen was associated with a lower risk of prolonged high-intensity pain (hazard ratio = 0.65, 95% confidence interval: 0.45-0.93, <i>P</i> = 0.02), and multivariate regression analysis confirmed that the 12-hour regimen was an independent predictor of better overall recovery (β = -0.32, <i>P</i> = 0.01).</p><p><strong>Conclusion: </strong>Compared to the 24-hour titration regimen, the 12-hour titration regimen provided more effective control of early postoperative pain after radical gastrectomy, reduced total analgesic consumption, lowered the incidence of related adverse reactions, improved patient satisfaction, and shortened hospital stays.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 8","pages":"108238"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}