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Early Transcriptional Changes in Feline Herpesvirus-1-Infected Crandell-Rees Feline Kidney Cells. 猫疱疹病毒-1 感染的克兰代尔-里斯猫肾细胞的早期转录变化。
IF 2 2区 农林科学
Veterinary Sciences Pub Date : 2024-10-30 DOI: 10.3390/vetsci11110529
Xiuqing Xiao, Fuqiang Xu, Fan Jia
{"title":"Early Transcriptional Changes in Feline Herpesvirus-1-Infected Crandell-Rees Feline Kidney Cells.","authors":"Xiuqing Xiao, Fuqiang Xu, Fan Jia","doi":"10.3390/vetsci11110529","DOIUrl":"10.3390/vetsci11110529","url":null,"abstract":"<p><p>FHV-1 is a highly contagious pathogen that significantly threatens feline health and contributes to rising pet healthcare costs. The mechanisms underlying FHV-1 and host interactions remain poorly understood. For the first time, we conducted a systematic analysis of transcriptomic changes in CRFK cells following FHV-1 infection using RNA-seq. The differentially expressed genes (DEGs) displayed significant associations with cellular components, particularly the chromatin structure. Pathway analysis of the DEGs highlighted key host immune responses, including Toll-like receptors (TLRs), IL-17, TNF, MAPK, and Rap1 signaling pathways. By integrating the RNA-seq and RT-qPCR results, we identified CXCL8, CXCL10, MMP1, MMP9, CSF2, CSF3, CCL20, TLR2, TLR3, TLR4, TNF, and FOS as potentially important genes in the host's immune response to FHV-1. These findings provide valuable insights into the mechanisms underlying FHV-1 and host interactions.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"11 11","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive Overview of Methods of Pregnancy Termination in Macaques and Marmosets. 猕猴和狨猴终止妊娠方法综述。
IF 2 2区 农林科学
Veterinary Sciences Pub Date : 2024-10-30 DOI: 10.3390/vetsci11110527
Tommaso Virgilio, Remco A Nederlof, Mallory G Brown, Jaco Bakker
{"title":"Comprehensive Overview of Methods of Pregnancy Termination in Macaques and Marmosets.","authors":"Tommaso Virgilio, Remco A Nederlof, Mallory G Brown, Jaco Bakker","doi":"10.3390/vetsci11110527","DOIUrl":"10.3390/vetsci11110527","url":null,"abstract":"<p><p>Limited information is available concerning the termination of pregnancy in non-human primates. Thus, a comprehensive review of this topic will be beneficial for veterinary staff in laboratories, zoos, and wildlife rehabilitation centers. The most relevant studies concerning the termination of viable and non-viable pregnancy in non-human primates were analyzed, and dosages, administration routes, adverse effects, and the efficacy of the drugs used are reported. The literature revealed that termination of pregnancy is most commonly performed in marmosets and macaques. The combination of mifepristone and misoprostol was reported to be effective and fast-acting in terminating first-trimester pregnancy in macaques, while cloprostenol was identified as the best agent for use in marmosets. This review also provides insights about the limitations of previously described methods of pregnancy termination and discusses potential alternatives and areas for future investigation.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"11 11","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Evaluation of the Thermotolerance of Various Formulations of Freeze-Dried and Reconstituted Peste des Petits Ruminant Vaccines. 对冻干和冲调型小反刍兽疫疫苗各种配方耐热性的评估
IF 2 2区 农林科学
Veterinary Sciences Pub Date : 2024-10-29 DOI: 10.3390/vetsci11110525
Amadou Diallo, Moipone Christina Motsoane, Hassen Belay Gelaw, Jean-De-Dieu Baziki, Cisse R Moustapha Boukary, Gelagay Ayelet Melesse, Ethel Chitsungo, Meseret Gebresillassie, Yebechaye Degefa Tessema, Babasola O Olugasa, Olayinka Ishola, Nick Nwankpa, Charles S Bodjo
{"title":"An Evaluation of the Thermotolerance of Various Formulations of Freeze-Dried and Reconstituted Peste des Petits Ruminant Vaccines.","authors":"Amadou Diallo, Moipone Christina Motsoane, Hassen Belay Gelaw, Jean-De-Dieu Baziki, Cisse R Moustapha Boukary, Gelagay Ayelet Melesse, Ethel Chitsungo, Meseret Gebresillassie, Yebechaye Degefa Tessema, Babasola O Olugasa, Olayinka Ishola, Nick Nwankpa, Charles S Bodjo","doi":"10.3390/vetsci11110525","DOIUrl":"10.3390/vetsci11110525","url":null,"abstract":"<p><p>Peste des Petits Ruminants (PPR) disease is widely distributed in Africa. Live attenuated PPR vaccines are produced using approved Nigeria 75/1 and Sungri/96 strains by the World Organisation of Animal Health (WOAH) to control the disease. These PPR vaccines are very efficacious; however, the main challenge is the maintaining of the cold chain during vaccine distribution and delivery. This study evaluated the thermotolerance of freeze-dried and reconstituted PPR Nigeria 75/1 vaccines from vaccine manufacturers using eight stabilizer formulations (lactalbumin hydrolysate and sucrose, sucrose and peptone, Weybridge medium, trehalose, Lactose and N-Z Amine, lactalbumin hydrolysate, sucrose and L glutamine, skimmed milk, and lactalbumin hydrolysate, maltose and gelatine). Aliquots of the reconstituted PPR vaccine batches were titrated after 2, 4, and 6 h of storage at 4 °C and 40 °C. The PPR vaccines were also titrated after storage at 40 °C and 45 °C for 3 and 5 days. The results showed that reconstituted PPR vaccine stabilized with lactalbumin hydrolysate-sucrose promoted tolerance at 40 °C for 6 h. It was also noted that all reconstituted PPR vaccine formulations except the formulation stabilized with lactalbumin hydrolysate-maltose-gelatine maintained the titre above a 10<sup>2.5</sup> TCID<sub>50</sub>/dose after 4 h of storage at 4 °C. Furthermore, the results showed that the PPR vaccine formulation containing lactalbumin hydrolysate sucrose was as the only one that maintained the titres above 10<sup>2.5</sup> TCID<sub>50</sub>/dose after storage at 45 °C for 5 days, with a titre loss of 10<sup>0.95</sup> TCID<sub>50</sub>/dose. Therefore, vaccine manufacturers producing PPR vaccines for use in tropical field regions could preferably use lactalbumin hydrolysate-sucrose stabilizer in vaccine formulation.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"11 11","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Camel Whey Protein Attenuates Acute Heat Stress-Induced Kidney Injury in Rats by Up-Regulating CYP2J Activity and Activating PI3K/AKT/eNOS to Inhibit Oxidative Stress. 骆驼乳清蛋白通过上调 CYP2J 活性和激活 PI3K/AKT/eNOS 以抑制氧化应激,减轻急性热应激诱发的大鼠肾损伤。
IF 2 2区 农林科学
Veterinary Sciences Pub Date : 2024-10-28 DOI: 10.3390/vetsci11110524
Xiaoxia Jing, Donghua Du, Bin Hou, Deng Zhan, Surong Hasi
{"title":"Camel Whey Protein Attenuates Acute Heat Stress-Induced Kidney Injury in Rats by Up-Regulating CYP2J Activity and Activating PI3K/AKT/eNOS to Inhibit Oxidative Stress.","authors":"Xiaoxia Jing, Donghua Du, Bin Hou, Deng Zhan, Surong Hasi","doi":"10.3390/vetsci11110524","DOIUrl":"10.3390/vetsci11110524","url":null,"abstract":"<p><p>Camel whey protein (CWP) is a potent natural antioxidant, noted for its abundance of antioxidant amino acids. Despite its promising properties, the precise mechanisms underlying its effects remain inadequately explored. This study aims to investigate the impact of CWP on kidney damage induced by acute heat stress in rats, as well as to elucidate its mechanism of action. We assessed CWP's influence on cytochrome P450 2J (CYP2J) activity during heat stress, measured oxidative stress levels, and evaluated renal injury using CYP2J knockout rats. Our findings indicate that acute heat stress reduces CYP2J expression, while CWP administration restores CYP2J activity and enhances PI3K/Akt signaling. However, CWP did not mitigate oxidative stress-induced kidney damage in CYP2J<sup>-/-</sup> rats, suggesting the necessity of CYP2J for its protective effects.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"11 11","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Interface Between Veterinary and Behavioral Management of Chimpanzees (Pan troglodytes) in a United States Sanctuary Demonstrated by Two Clinical Cases. 从两个临床案例看美国保护区黑猩猩(Pan troglodytes)兽医管理与行为管理之间的关系。
IF 2 2区 农林科学
Veterinary Sciences Pub Date : 2024-10-28 DOI: 10.3390/vetsci11110523
Raven Jackson, Rebekah Lewis, Amy Fultz
{"title":"The Interface Between Veterinary and Behavioral Management of Chimpanzees (<i>Pan troglodytes</i>) in a United States Sanctuary Demonstrated by Two Clinical Cases.","authors":"Raven Jackson, Rebekah Lewis, Amy Fultz","doi":"10.3390/vetsci11110523","DOIUrl":"10.3390/vetsci11110523","url":null,"abstract":"<p><p>Chimp Haven is a private, nonprofit organization that serves as the largest chimpanzee sanctuary in the world. The National Institutes of Health supports the federal sanctuary system, which is operated by Chimp Haven, to provide lifetime care for chimpanzees who have retired from biomedical research. Chimp Haven is home to over 300 chimpanzees, with a wide variety of individual health needs including infectious diseases. The chimpanzees live in large, mixed-sex social groups within corrals, multi-dimensional enclosures, and naturally forested habitats, which presents challenges for monitoring and balancing individual versus group needs. Primate veterinarians and animal behavior directors have an obligation to collaborate for the best possible health and welfare outcomes for the species in their care. This manuscript details how veterinarians and behavioral staff at Chimp Haven interface to enhance clinical management and improve chimpanzee welfare using two clinical cases to illustrate this relationship. This is accomplished through the development of individual care plans that include the utilization of welfare assessment metrics and positive reinforcement training programs collaboratively developed between the veterinarians and behaviorists to facilitate voluntary medical procedures without the need for social isolation. Specifically, welfare metrics such as monitoring chimpanzee wounding levels and severity, as well as targeted assessments, involve the input of both the veterinarians and behaviorists. Positive reinforcement training initiatives such as weight loss, heart health, and wound care also require the interface between the two disciplines. The authors aim to demonstrate that working together provides optimal levels of expert care for both the physical and mental health of the chimpanzees in our care.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"11 11","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimation of Height at Withers Based on Long Bone Measurements of Living Cats. 根据活猫的长骨测量值估算其腰高。
IF 2 2区 农林科学
Veterinary Sciences Pub Date : 2024-10-28 DOI: 10.3390/vetsci11110522
Dominik Poradowski, Zihni Mutlu, Yusuf Altundağ, Aleksander Chrószcz, Özlem Sarıtaş, Joanna Wolińska, Vedat Onar
{"title":"Estimation of Height at Withers Based on Long Bone Measurements of Living Cats.","authors":"Dominik Poradowski, Zihni Mutlu, Yusuf Altundağ, Aleksander Chrószcz, Özlem Sarıtaş, Joanna Wolińska, Vedat Onar","doi":"10.3390/vetsci11110522","DOIUrl":"10.3390/vetsci11110522","url":null,"abstract":"<p><p>In this study, coefficients enabling estimation of shoulder height were obtained by taking morphometric measurements from radiographic images of live cats using the radiogrammetric method. For this purpose, a total of 37 adult cats, including 17 females and 20 males, were involved. While the effect of sexual dimorphism was observed on the morphometric data, the presence of sexual dimorphism was only evident in the coefficients (factors) of the humerus and talus. No significant effect of gender was found on the shoulder height estimation coefficients (factors) for other thoracic and pelvic limb bones. Gender had an impact on the slenderness index in all thoracic limbs, but only on the tibia slenderness index among the pelvic limb bones. Generally, female individuals were found to have more slender limbs. It is believed that the obtained coefficients (factors) and index data will contribute significantly to the prediction of archaeological cat morphology.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"11 11","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathology-Based Animal Cancer Registry of Abruzzo and Molise Regions (Central Italy): A Ten-Year Retrospective Study (2014-2023). 意大利中部阿布鲁佐和莫利塞地区基于病理学的动物癌症登记:十年回顾性研究(2014-2023)》。
IF 2 2区 农林科学
Veterinary Sciences Pub Date : 2024-10-26 DOI: 10.3390/vetsci11110521
Giovanni Di Teodoro, Francesca Cito, Romolo Salini, Marina Baffoni, Sabrina V P Defourny, Antonio Cocco, Nicola D'Alterio, Chiara Palmieri, Antonio Petrini
{"title":"Pathology-Based Animal Cancer Registry of Abruzzo and Molise Regions (Central Italy): A Ten-Year Retrospective Study (2014-2023).","authors":"Giovanni Di Teodoro, Francesca Cito, Romolo Salini, Marina Baffoni, Sabrina V P Defourny, Antonio Cocco, Nicola D'Alterio, Chiara Palmieri, Antonio Petrini","doi":"10.3390/vetsci11110521","DOIUrl":"10.3390/vetsci11110521","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Pets have a crucial role in cancer research. Specifically, dogs and cats share the same environment as their owners and thus may serve as sentinels of naturally occurring tumors that are linked to the exposure to environmental hazards. Quantitative comparison of tumor types may reveal unusual cancer frequencies, providing directions for research and generation of hypotheses of cancer causation in a specific area and identification of risk factors. The aim of this study was to describe the data collected by the pathology-based animal cancer registry, managed by Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise (IZSAM), during 10 years of activity (2014-2023) and to assess its potential epidemiological relevance. Frequencies of tumor topography and morphology in dogs and cats were described, analyzed and compared. Proportional morbidity ratios (PMRs) were calculated, taking into consideration some potential risk factors such as species, breed, sex, diet and living environment. The database comprises 5311 tumors (n = 4719 in dogs and n = 592 in cats), with a higher prevalence in females (67.3% in dogs and 61.2% in cats). The mean age at the first diagnosis of tumors was similar between sexes and slightly lower in dogs compared to cats. PMRs highlighted certain risk and \"protective\" factors for the development of tumors in specific topography. The risk of developing tumors of the blood and hematopoietic system (PMR = 0.44; 95% CI: 0.21-0.94), skin and subcutaneous tissues (PMR = 0.70; 95% CI: 0.61-0.80), oral cavity and pharynx (PMR = 0.60; 95% CI: 0.24-0.89), urinary organs (PMR = 0.33; 95% CI: 0.11-0.99) and bones, joints and cartilage (PMR = 0.72; 95% CI: 0.22-0.98) was lower in non-neutered male dogs than in neutered male dogs. Non-spayed female dogs had a greater risk of developing tumors of the mammary gland (PMR = 1.75; 95% CI: 1.57-1.96), female sexual organs (PMR = 2.12; 95% CI: 1.01-4.36) and respiratory system (PMR = 2.25; 95% CI: 1.55-6.74) but less risk for cutaneous and subcutaneous tissue tumors (PMR = 0.44; 95% CI: 0.38-0.51) and blood/hematopoietic system tumors (PMR = 0.47; 95% CI: 0.26-0.85) compared to spayed female dogs. Compared with mixed breed, purebred dogs had a significantly greater risk of developing mammary gland tumors (PMR = 1.36; 95% CI: 1.20-1.54) and lower risk for respiratory (PMR = 0.15; 95% CI: 0.07-0.32), gastrointestinal (PMR = 0.63; 95% CI: 0.34-0.94) and oral (PMR = 0.59; 95% CI: 0.36-0.96) neoplasia. Non-neutered male cats had a lower risk of developing skin and subcutaneous tumors (PMR = 0.68; 95% CI: 0.50-0.92) compared with neutered cats. The risk of developing skin and subcutaneous tissues tumors was higher for dogs and cats that lived mostly outdoor (PMR dogs = 1.21; 95% CI: 1.10-1.33; PMR cats = 1.18; 95% CI: 1.08-1.47), while dogs that live mainly indoor had a greater risk to develop mammary gland tumors (PMR = 0.78; 95% CI: 0.68-0.89). Results described herein highlight the fundame","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"11 11","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth Performance, Dietary Energetics, Blood Metabolites, Carcass Traits, Meat Quality, and Gene Expression of Lambs Supplemented with a Polyherbal Phytogenic Additive. 添加多草本植物添加剂的羔羊的生长性能、日粮能量、血液代谢物、胴体性状、肉质和基因表达。
IF 2 2区 农林科学
Veterinary Sciences Pub Date : 2024-10-25 DOI: 10.3390/vetsci11110520
José Felipe Orzuna-Orzuna, Alejandro Lara-Bueno, Adrián Gloria-Trujillo, Germán David Mendoza-Martínez, Luis Alberto Miranda-Romero, Pedro Abel Hernández-García
{"title":"Growth Performance, Dietary Energetics, Blood Metabolites, Carcass Traits, Meat Quality, and Gene Expression of Lambs Supplemented with a Polyherbal Phytogenic Additive.","authors":"José Felipe Orzuna-Orzuna, Alejandro Lara-Bueno, Adrián Gloria-Trujillo, Germán David Mendoza-Martínez, Luis Alberto Miranda-Romero, Pedro Abel Hernández-García","doi":"10.3390/vetsci11110520","DOIUrl":"10.3390/vetsci11110520","url":null,"abstract":"<p><p>This study aimed to evaluate the effects of supplementation with a polyherbal phytogenic additive (PPA) on the productive performance, dietary energetics, blood metabolites, carcass traits, meat quality, and gene expression of finishing lambs. Thirty-six male Pelibuey lambs (23.61 ± 0.57 kg body weight (BW)) were housed in individual pens and assigned to four treatments (<i>n</i> = 9) with different doses of PPA: 0 (CON), 2.5 (PPAL), 5 (PPAM), and 7.5 (PPAH) g of PPA/kg of DM for 56 days. Average daily gain, dry matter intake, and observed dietary net energy for maintenance and weight gain increased linearly (<i>p</i> < 0.05) in lambs supplemented with PPAH. A linear reduction (<i>p</i> = 0.02) in FCR was detected in lambs fed PPAM and PPAH. The PPAH supplementation linearly increased (<i>p</i> < 0.001) <i>Longissimus dorsi</i> muscle area, but other carcass traits were not affected (<i>p</i> > 0.05) by PPA doses. The physicochemical characteristics of the meat and the hematological parameters of the lambs were not affected (<i>p</i> > 0.05) by the PPA doses. The glucose, uric acid, creatinine, and bilirubin serum concentrations decreased linearly (<i>p</i> < 0.05) in lambs supplemented with PPAM and PPAH. Gene ontology analyses showed that nine biological processes were modified (<i>p</i> < 0.05), including DNA replication, drug metabolism-cytochrome P450, oxidative phosphorylation, and chemical carcinogenesis-reactive oxygen species. In conclusion, high doses (7.5 g/kg DM) of PPA can improve growth performance and dietary energy utilization efficiency in finishing lambs. Likewise, gene expression analysis indicates that supplementation with high doses of PPA could improve energy production and antioxidant status in finishing lambs.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"11 11","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of Meloxicam in Different Animal Species: A Comprehensive Review. 美洛昔康在不同动物物种中的药代动力学:全面回顾
IF 2 2区 农林科学
Veterinary Sciences Pub Date : 2024-10-24 DOI: 10.3390/vetsci11110519
Raul de la Puente, Raquel Diez, M Jose Diez, Nelida Fernandez, Ana M Sahagun, Jose M Rodriguez, Juan J Garcia, Cristina Lopez
{"title":"Pharmacokinetics of Meloxicam in Different Animal Species: A Comprehensive Review.","authors":"Raul de la Puente, Raquel Diez, M Jose Diez, Nelida Fernandez, Ana M Sahagun, Jose M Rodriguez, Juan J Garcia, Cristina Lopez","doi":"10.3390/vetsci11110519","DOIUrl":"10.3390/vetsci11110519","url":null,"abstract":"<p><p>Meloxicam is a non-steroidal anti-inflammatory in the oxicam group. It has been extensively used in human and veterinary medicine for their anti-inflammatory, analgesic and antipyretic activities. Meloxicam has shown high therapeutic potential for disorders such as osteoarthritis, musculoskeletal disorder, acute respiratory infection, puerperal septicemia, mastitis and mastitis-metritis-agalactia syndrome. Although meloxicam pharmacokinetic has been described for numerous species, no paper summarizes the existing literature on this field. Thus, the aim of this review was to carry out a review of the literature on the pharmacokinetics of meloxicam in different animal species and gather the data in a single review article. A comprehensive review of the available literature in the PubMed, Web of Science and Scopus databases was performed. Meloxicam shows good bioavailability after oral and parenteral administration in most animal species (85-95%), with the lowest values in sheep after oral administration. It presents a rapid distribution with a small volume of distribution, which can be attributed to relatively high ionization state of meloxicam at physiological pH and its high plasma protein binding (close to 99%). It is extensively metabolized in the liver in several inactive polar metabolites, which are excreted, like unchanged meloxicam in urine and feces. Meloxicam also shows a long elimination half-life and low clearance.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"11 11","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming Challenges in Interdisciplinary Collaboration Between Human and Veterinary Medicine. 克服人类医学与兽医学跨学科合作的挑战。
IF 2 2区 农林科学
Veterinary Sciences Pub Date : 2024-10-23 DOI: 10.3390/vetsci11110518
Louise Han, Yerhee Lee, Hyunsu Lee, Hyejin Lee, Jeong-Ik Lee
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