Veterinary Sciences最新文献_第7页

Qualitative Risk Assessment of Foot-and-Mouth Disease Virus Introduction and Transmission to Dairy Farms via Raw Milk Transportation in Thailand: A Scenario-Based Approach. 泰国口蹄疫病毒通过原料奶运输传入奶牛场的定性风险评估：基于情景的方法。

IF 2.3 2区农林科学

Veterinary Sciences Pub Date : 2025-06-27 DOI: 10.3390/vetsci12070623

Patidpong Chumsang, Tawatchai Singhla, Warangkhana Chaisowwong

{"title":"Qualitative Risk Assessment of Foot-and-Mouth Disease Virus Introduction and Transmission to Dairy Farms via Raw Milk Transportation in Thailand: A Scenario-Based Approach.","authors":"Patidpong Chumsang, Tawatchai Singhla, Warangkhana Chaisowwong","doi":"10.3390/vetsci12070623","DOIUrl":"10.3390/vetsci12070623","url":null,"abstract":"Foot-and-mouth disease (FMD) significantly impacts global livestock industries, with raw milk transportation posing a recognized pathway for viral dissemination, particularly in endemic regions. This study aimed to evaluate the risk of FMD virus (FMDV) introduction and transmission to dairy farms via raw milk transportation in Ban Thi District, Thailand. A qualitative risk assessment methodology, adhering to WOAH guidelines, was employed. Data were collected through structured farmer surveys (n = 109), expert interviews (n = 12), and reviews of national disease surveillance data and scientific literature. The risk assessment, utilizing a scenario tree approach for domestic dairy cattle, revealed a moderate overall risk of FMDV transmission. This finding is primarily attributed to critical gaps in on-farm biosecurity practices, potential contamination at milk collection centers, and significant challenges in detecting subclinical carrier animals. While the qualitative approach presented inherent limitations and uncertainties, the study successfully highlighted key vulnerabilities. The results underscore the urgent necessity for implementing targeted biosecurity protocols, developing more robust surveillance strategies for FMDV carriers, and establishing standardized risk assessment frameworks to mitigate potential outbreaks and protect the regional dairy industry.","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12300104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Low Crude Protein Diets with Coated Cysteamine Hydrochloride and Exogenous Alkaline Protease Supplementation in Broiler Chickens. 肉仔鸡包被半胱胺和外源碱性蛋白酶对低粗蛋白质饲粮的优化

IF 2.3 2区农林科学

Veterinary Sciences Pub Date : 2025-06-27 DOI: 10.3390/vetsci12070622

Hafiz Abu Bakar Siddique, Ehsaan Ullah Khan, Muhammad Muneeb, Saima Naveed, Elham Assadi Soumeh, Sohail Ahmad, Rashed A Alhotan, Abdulrahman S Alharthi, Ala E Abudabos

{"title":"Optimizing Low Crude Protein Diets with Coated Cysteamine Hydrochloride and Exogenous Alkaline Protease Supplementation in Broiler Chickens.","authors":"Hafiz Abu Bakar Siddique, Ehsaan Ullah Khan, Muhammad Muneeb, Saima Naveed, Elham Assadi Soumeh, Sohail Ahmad, Rashed A Alhotan, Abdulrahman S Alharthi, Ala E Abudabos","doi":"10.3390/vetsci12070622","DOIUrl":"10.3390/vetsci12070622","url":null,"abstract":"Decreasing crude protein (CP) in broiler diets can improve sustainability but may compromise growth performance. Feed additives like coated cysteamine hydrochloride (CSH) and exogenous alkaline protease (EAP) can enhance protein utilization and promote gut health. While CSH modulates metabolism, EAP improves digestibility, but their combined effects in low CP diets remain unclear. This study examines the synergistic impact of CSH and EAP on broiler growth, gut histology, carcass traits, immune response, and nutrient digestibility, aiming to optimize performance while reducing environmental impact. Six-hundred, 1-day-old broiler Ross-308 chicks (male) were allotted to four treatments, each consisting of six replicates of twenty-five birds, in a factorial arrangement using a completely randomized design. The treatments comprised two inclusion levels of coated CSH (0.2 and 0.4 g/kg with or without EAP (0 and 0.2 g/kg) in reduced CP diets. A ten percent reduction in CP from the standard requirements of Ross-308 (20.7% vs. 23% in the starter, 19.35% vs. 21.5% in the grower, and 17.55% vs. 19.5% in the finisher phase) was made in all the dietary treatments. A notable interaction (p ≤ 0.05) between CSH and EAP was detected in body weight gain (BWG), feed conversion ratio (FCR), carcass characteristics, and gut morphology during the whole study duration. Similarly, nutrient digestibility and immune response were also influenced by the combined use of CSH and EAP. The synergistic use of coated CSH at 0.2 g/kg or 0.4 g/kg with EAP in reduced CP broiler diets can enhance performance, intestinal health, carcass characteristics, immune response, and nutrient digestibility. Implications of these findings in commercial feeding practices could substantially improve the efficiency and sustainability of broiler production systems.","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of Urinary miRNA Biomarkers for Canine Urothelial Carcinoma Diagnostics. 尿miRNA生物标志物在犬尿路上皮癌诊断中的应用

IF 2.3 2区农林科学

Veterinary Sciences Pub Date : 2025-06-27 DOI: 10.3390/vetsci12070621

Alexandra Kehl, Heike Aupperle-Lellbach, Maria Brockmann, Anna-Lena van de Weyer, Marielle Appenzeller, Katja Steiger

{"title":"Utility of Urinary miRNA Biomarkers for Canine Urothelial Carcinoma Diagnostics.","authors":"Alexandra Kehl, Heike Aupperle-Lellbach, Maria Brockmann, Anna-Lena van de Weyer, Marielle Appenzeller, Katja Steiger","doi":"10.3390/vetsci12070621","DOIUrl":"10.3390/vetsci12070621","url":null,"abstract":"Urothelial carcinoma (UC) is one of the most frequent tumors in dogs. Besides cytology, histology, and testing for a BRAF mutation, non-invasive biomarkers would benefit the early detection and therapy of UC. This study aimed to compare the detectability of miRNAs in urine sediment and supernatant and to assess their potential as biomarkers for UC. The study involved two phases with 47 canine samples in total; in a pilot trial, ten different miRNAs (miR-16, 21, 103b, 106b, 146, 155, 182, 221, 222, and 375) were isolated from the urine sediments and supernatants from seven healthy control dogs and seven dogs with UC. In a further step, eight miRNAs were isolated from urine sediments from 18 healthy dogs, 11 dogs with purulent cystitis, and 18 dogs with UC. The detectability of miRNAs was improved when isolated from the urine sediment compared with the supernatant. MiR-16 was not deregulated, and miR-106b showed significantly lower expression in cystitis compared with the control. Lower copy numbers were seen for miR-21, 182, 221, and 222 in cystitis cases compared with the controls and UC, respectively. Deregulation was observed for miR-155 and miR-375 between all three groups. A panel including miR-182, 221, 222, 155, and 375 has the potential to discriminate among all three groups in a two-step approach.","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variants in Nucleotide Sequences; Gene Expression; and Hematological, Immune, and Antioxidant Biomarkers Linked to Pneumonia Risk in Holstein Calves. 核苷酸序列变异；基因表达;以及与荷斯坦小牛肺炎风险相关的血液学、免疫和抗氧化生物标志物。

IF 2.3 2区农林科学

Veterinary Sciences Pub Date : 2025-06-26 DOI: 10.3390/vetsci12070620

Ahmed El-Sayed, Attia Eissa, Doaa Ebrahim, Ahmed Ateya, Hossam Gadalla, Hanan M Alharbi, Khairiah M Alwutayd, Manal A Babaker, Aya Aly Elzeer

{"title":"Variants in Nucleotide Sequences; Gene Expression; and Hematological, Immune, and Antioxidant Biomarkers Linked to Pneumonia Risk in Holstein Calves.","authors":"Ahmed El-Sayed, Attia Eissa, Doaa Ebrahim, Ahmed Ateya, Hossam Gadalla, Hanan M Alharbi, Khairiah M Alwutayd, Manal A Babaker, Aya Aly Elzeer","doi":"10.3390/vetsci12070620","DOIUrl":"10.3390/vetsci12070620","url":null,"abstract":"Pneumonia is a major issue that affects calves' health and performance and causes numerous losses despite treatment. Investigating genetic and molecular differences, as well as immunological and antioxidant responses, in calves at risk for pneumonia was the aim of this study. A total of 225 calves were studied, including 180 Holstein calves with respiratory signs and 45 calves that were apparently healthy. Blood samples were collected for CBC, RNA extractions, and immunological and antioxidant analysis. In contrast to the control group, the pneumonic one showed a considerable (p < 0.05) increase in the expression levels of cytokines and antioxidant genes IL1α, IL-1β, IL-6, IFN-γ, TNF-α, and NOX4. In contrast, the values of IL10, PRDX6, ATG7, and NDUFS6 were in the opposite range. The pneumonic and healthy calves were found to differ in the nucleotide sequences of the genes under analysis. In pneumonic calves, a substantial (p ˂0.05) reduction was detected in RBCs, Hb count, PCV%, and lymphocytes count, and a notable (p ˂ 0.05) increase in WBCs and neutrophil count was correlated with healthy control calves. The findings of the serum profile showed that there was a meaningful (p ˂ 0.05) rise in the serum values of IL-1α, IL-1β, IL-6, TNF-α, IFN-γ, and MDA, with significant reductions in the SOD, GSH, TAC, and IL-10 in the pneumonic compared to the healthy calves. Our results provide valuable information about the nucleotide sequence, gene expression, and serum profile differences of putative indicators for pneumonia in calves. This could be applied in monitoring calves' pneumonia through the discriminate breeding of naturally resistant animals.","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12300230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Digital Rectal Thermometry and a Non-Contact Veterinary Infrared Thermometer in Cats: Identifying Alternative Sites to Rectal Measurement. 数字直肠体温计和非接触式兽医红外体温计在猫中的比较：确定直肠测量的替代位置。

IF 2.3 2区农林科学

Veterinary Sciences Pub Date : 2025-06-25 DOI: 10.3390/vetsci12070618

Carlotta Tombolani, Daniela Alberghina, Mauro Gioè, Fausto Quintavalla

{"title":"Comparison of Digital Rectal Thermometry and a Non-Contact Veterinary Infrared Thermometer in Cats: Identifying Alternative Sites to Rectal Measurement.","authors":"Carlotta Tombolani, Daniela Alberghina, Mauro Gioè, Fausto Quintavalla","doi":"10.3390/vetsci12070618","DOIUrl":"10.3390/vetsci12070618","url":null,"abstract":"Background: Rectal temperature measurement in cats, while crucial, can cause discomfort and stress. This study evaluated non-contact infrared thermometry as a less invasive alternative.Methods: A total of 95 cats were enrolled in this study. The cats were categorized into three age groups: Group I (n = 20 kittens, 2-6 months), Group II (n = 34 young cats, 7-24 months), and Group III (n = 41 adult cats, >24 months).Results: The mean rectal temperature in cats was approximately 38 °C, which was significantly higher than both ocular temperature (p < 0.0001) and auricular pinna temperature (p < 0001). No statistically significant difference was found between rectal and perineal temperatures, nor in body temperatures between the age groups. Ocular temperature (p < 0.05) and auricular temperature (p < 0.0001) were influenced by ambient temperature. Perineal infrared temperatures showed a strong correlation and low bias compared to rectal temperature and were not affected by ambient temperature.Conclusions: Non-contact infrared thermometry offers advantages for feline temperature monitoring. Perineal infrared temperatures appear to be a useful, non-invasive alternative to rectal measurements in cats.","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Cardiomegaly in Dogs Using the Manubrium Heart Score Method and Determination of Its Diagnostic Accuracy in Comparison with the Vertebral Heart Score. 用胸针心脏评分法评价犬心脏肥大及其与椎体心脏评分比较的诊断准确性

IF 2.3 2区农林科学

Veterinary Sciences Pub Date : 2025-06-25 DOI: 10.3390/vetsci12070619

Bengü Bilgiç, Onur İskefli, Michela Pugliese, Mehmet Erman Or

{"title":"Evaluation of Cardiomegaly in Dogs Using the Manubrium Heart Score Method and Determination of Its Diagnostic Accuracy in Comparison with the Vertebral Heart Score.","authors":"Bengü Bilgiç, Onur İskefli, Michela Pugliese, Mehmet Erman Or","doi":"10.3390/vetsci12070619","DOIUrl":"10.3390/vetsci12070619","url":null,"abstract":"Vertebral Heart Score (VHS) is one of the commonly used methods for detecting cardiomegaly in dogs. However, this method has diagnostic limitations due to factors such as breed variations, orthopedic disorders, anatomical anomalies, and operator-dependent subjectivity. The aim of this study was to evaluate the diagnostic utility of the Manubrium Heart Score (MHS) as an alternative to VHS in the assessment of cardiomegaly in dogs. A total of 490 dogs were classified and grouped based on body weight and cardiac health status. On the right lateral thoracic radiographs, MHS was calculated as the ratio of manubrium length (ML) to the sum of the long-axis heart length (cLAL) and short-axis heart length (cSAL). Similarly, VHS was determined. A positive correlation between VHS and MHS, as well as between ML and cSAL/cLAL, were observed in all groups except for the group of medium sized dogs with heart diseases. No correlations were found between MHS and LA or the LA/Ao ratio. In pairwise comparisons of VHS and MHS between heart-diseased and healthy dogs, the mean VHS showed a statistically significant difference in heart-diseased dogs (p < 0.001), and not across all groups (p > 0.05). MHS may not consider a useful method as an alternative to VHS.","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12300707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Energy Computed Tomography for the Detection of Bone Edema-Like Lesions in the Equine Foot: Standing Horses and Cadaveric Specimens. 双能计算机断层扫描检测马足骨水肿样病变：站立的马和尸体标本。

IF 2.3 2区农林科学

Veterinary Sciences Pub Date : 2025-06-24 DOI: 10.3390/vetsci12070614

Jolien Germonpré, Ina Lorenz, Louis M J Vandekerckhove, Luc Duchateau, Torsten Diekhoff, Katrien Vanderperren

{"title":"Dual-Energy Computed Tomography for the Detection of Bone Edema-Like Lesions in the Equine Foot: Standing Horses and Cadaveric Specimens.","authors":"Jolien Germonpré, Ina Lorenz, Louis M J Vandekerckhove, Luc Duchateau, Torsten Diekhoff, Katrien Vanderperren","doi":"10.3390/vetsci12070614","DOIUrl":"10.3390/vetsci12070614","url":null,"abstract":"Dual-energy computed tomography (DECT) is a promising advancement for detecting bone edema-like lesions (BME). However, its application in horses remains limited. The aim of this study was to evaluate DECT virtual-non-calcium (VNCa) imaging in the equine foot and establish which confounding factors could influence its applicability in clinical practice. The DECT VNCa map of 14 standing and 5 cadaveric (recumbent) cases with foot-related lameness was scored in consensus by two readers in comparison to MRI. Overall, 17/19 cases demonstrated BME on MRI, whereas 2 did not. Agreement between DECT VNCa and MRI was found in 15/19 feet (78.9%). Disagreement in 4/19 cases with BME was due to sclerosis (1/19), mild BME extent on MRI (2/19), or scan artifacts (1/19). The extent of BME was significantly underestimated using DECT VNCa compared to MRI (p = 0.016). No significant correlation was found between sclerosis score and the BME extent underestimation on DECT (p = 0.056). Between standing and post-mortem cases, there was no significant difference in the agreement between DECT and MRI (p = 0.53) or DECT VNCa image quality (p = 0.22). In conclusion, DECT VNCa effectively identified moderate and severe BME, and its use was feasible in standing positioning. In case of sclerosis, a case-by-case assessment is recommended.","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motion-Status-Driven Piglet Tracking Method for Monitoring Piglet Movement Patterns Under Sow Posture Changes. 运动状态驱动仔猪跟踪方法监测母猪姿态变化下仔猪运动模式。

IF 2.3 2区农林科学

Veterinary Sciences Pub Date : 2025-06-24 DOI: 10.3390/vetsci12070616

Aqing Yang, Shimei Li, Shuqin Tu, Na Han, Lei Zhang, Yizhi Luo, Yueju Xue

{"title":"Motion-Status-Driven Piglet Tracking Method for Monitoring Piglet Movement Patterns Under Sow Posture Changes.","authors":"Aqing Yang, Shimei Li, Shuqin Tu, Na Han, Lei Zhang, Yizhi Luo, Yueju Xue","doi":"10.3390/vetsci12070616","DOIUrl":"10.3390/vetsci12070616","url":null,"abstract":"Understanding how piglets move around sows during posture changes is crucial for their safety and healthy growth. Automated monitoring can reduce farm labor and help prevent accidents like piglet crushing. Current methods (called Joint Detection-and-Tracking-based, abbreviated as JDT-based) struggle with problems like misidentifying piglets or losing track of them due to crowding, occlusion, and shape changes. To solve this, we developed MSHMTracker, a smarter tracking system that introduces a motion-status hierarchical architecture to significantly improve tracking performance by adapting to piglets' motion statuses. In MSHMTracker, a score- and time-driven hierarchical matching mechanism (STHM) was used to establish the spatio-temporal association by the motion status, helping maintain accurate tracking even in challenging conditions. Finally, piglet group aggregation or dispersion behaviors in response to sow posture changes were identified based on the tracked trajectory information. Tested on 100 videos (30,000+ images), our method achieved 93.8% tracking accuracy (MOTA) and 92.9% identity consistency (IDF1). It outperformed six popular tracking systems (e.g., DeepSort, FairMot). The mean accuracy of behavior recognition was 87.5%. In addition, the correlations (0.6 and 0.82) between piglet stress responses and sow posture changes were explored. This research showed that piglet movements are closely related to sow behavior, offering insights into sow-piglet relationships. This work has the potential to reduce farmers' labor and improve the productivity of animal husbandry.","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood Leukocyte Ratios as Predictive Markers of Chronic Enteropathy Phenotypes in Cats. 血白细胞比率作为猫慢性肠病表型的预测指标。

IF 2.3 2区农林科学

Veterinary Sciences Pub Date : 2025-06-24 DOI: 10.3390/vetsci12070613

Alexandros O Konstantinidis, Katerina K Adamama-Moraitou, Ashley Griggs, Margaret L Musser, Ariel S Nenninger, Nektarios Soubasis, Dimitra Pardali, Mathios E Mylonakis, Albert E Jergens

{"title":"Blood Leukocyte Ratios as Predictive Markers of Chronic Enteropathy Phenotypes in Cats.","authors":"Alexandros O Konstantinidis, Katerina K Adamama-Moraitou, Ashley Griggs, Margaret L Musser, Ariel S Nenninger, Nektarios Soubasis, Dimitra Pardali, Mathios E Mylonakis, Albert E Jergens","doi":"10.3390/vetsci12070613","DOIUrl":"10.3390/vetsci12070613","url":null,"abstract":"This retrospective study assessed the potential of blood leukocyte ratios as diagnostic biomarkers in cats with chronic enteropathies (CE). Absolute neutrophil-to-lymphocyte (NLR), neutrophil-to-monocyte (NMR), and lymphocyte-to-monocyte (LMR) ratios were calculated from the hematological profiles of 221 cats, including healthy controls (n = 73), and those diagnosed with food-responsive enteropathy (FRE, n = 59), steroid-responsive enteropathy (SRE, n = 56), or small cell lymphoma (SCL, n = 33). SCL cats had higher NLRs than SRE (p = 0.002) and FRE (p = 0.028), and lower LMRs than SRE (p = 0.012) and FRE (p = 0.001). Healthy cats had lower NLRs compared to the FRE (p < 0.001), SRE (p < 0.001), and SCL (p < 0.001) cats and higher LMRs compared to the FRE (p < 0.001), SRE (p < 0.001), and SCL (p < 0.001) cats. Receiver operating characteristic (ROC) curve analysis demonstrated that NLR ≥ 11.6 differentiated SCL from SRE with 87.5% specificity but low sensitivity (39.4%). NMR ≥ 34.5 distinguished FRE from SRE with 52.5% sensitivity and 69.6% specificity. LMR ≥ 3.72 differentiated SRE from SCL with 67.9% sensitivity and 60.6% specificity. Although significant differences in leukocyte ratios were observed among groups, their diagnostic accuracy in differentiating CE phenotypes was suboptimal. These findings suggest that the utility of NLR, NMR, and LMR as standalone diagnostic tools is limited.","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Pulmonary Vein Diameters in Cavalier King Charles Spaniels with Myxomatous Mitral Valve Disease. 骑士查理王犬二尖瓣黏液瘤性疾病的肺静脉直径评估。

IF 2.3 2区农林科学

Veterinary Sciences Pub Date : 2025-06-24 DOI: 10.3390/vetsci12070615

Carlotta Ferri, Juliette Besso, Hugues Gaillot, Yannick Ruel, Albert Agoulon, Christophe Bourguignon, Clémence Mey, Vassiliki Gouni

{"title":"Assessment of Pulmonary Vein Diameters in Cavalier King Charles Spaniels with Myxomatous Mitral Valve Disease.","authors":"Carlotta Ferri, Juliette Besso, Hugues Gaillot, Yannick Ruel, Albert Agoulon, Christophe Bourguignon, Clémence Mey, Vassiliki Gouni","doi":"10.3390/vetsci12070615","DOIUrl":"10.3390/vetsci12070615","url":null,"abstract":"The present study aimed to compare pulmonary vein (PV) diameters between Cavalier King Charles Spaniels (CKCSs) with myxomatous mitral valve disease (MMVD) and healthy CKCSs, assess correlations between PV diameters and echocardiographic parameters, and identify the optimal PV diameter cut-off value that distinguishes stage C from stage B2. CKCSs were recruited both retrospectively and prospectively and classified according to the ACVIM guidelines (stages A, B1, B2, and C). From a left apical view, the diameters of three PVs (PV1, PV2, and PV3) were measured with high reproducibility. In healthy dogs, the PV2 diameter showed no correlation with body weight. The PV2 diameter was significantly higher in stage B2 compared to B1 and in stage C compared to B2, while no difference was found between stages A and B1. The median (IQR) PV2 diameters were 4.9 mm (3.9-5.2) in stage A, 5.1 mm (4.0-6.0) in stage B1, 9.3 mm (7.3-11.1) in stage B2, and 13.7 mm (9.9-15.1) in stage C. Positive correlations were observed between the PV2 diameter and the left ventricular internal diameter normalized for body weight, the left atrium-to-aorta ratio, mitral E wave peak velocity, tricuspid regurgitation pressure gradient, and regurgitant fraction. A PV2 diameter cut-off value of 12.8 mm discriminated stage C from stage B2 with 57% sensitivity and 93% specificity. The PV2 diameter is a reproducible echocardiographic measure that increases with MMVD severity and could assist in the early detection of congestive heart failure. However, the modest sensitivity observed reflects the overlap of PV2 measurements between stages B2 and C. Therefore, PV2 should be interpreted with caution and considered a supportive, rather than exclusive, tool in disease staging and therapeutic decision-making.","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12299408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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